Preliminary results of a randomized study (NPC-9902 Trial) on therapeutic gain by concurrent chemotherapy and/or accelerated fractionation for locally advanced nasopharyngeal carcinoma

International Journal of Radiation Oncology Biology Physics

Volumn 66, Issue 1, 2006, Pages 142-151

  Lee, Anne W M ^a   Tung, Stewart Y ^b   Chan, Anthony T C ^c   Chappell, Rick ^d   Fu, Yiu Tong ^e   Lu, Tai Xiang ^f   Tan, Terence ^g   Chua, Daniel T T ^h   O'Sullivan, Brian ⁱ   Xu, Shirley L ^j   Pang, Ellie S Y ^j   Sze, Wai Man ^a   Leung, To Wai ^b   Kwan, Wing Hong ^c   Chan, Paddy T M ^e   Liu, Xiu Fang ^f   Tan, Eng Huat ^g   Sham, Jonathan S T ^h   Siu, Lillian ⁱ   Lau, Wai Hon ^e  

^a PAMELA YOUDE NETHERSOLE EASTERN HOSPITAL   (Hong Kong)

^b TUEN MUN HOSPITAL   (Hong Kong)

^c CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^d UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^e QUEEN ELIZABETH HOSPITAL   (Hong Kong)

^f SUN YAT SEN UNIVERSITY   (China)

^g NATIONAL CANCER CENTER   (Japan)

^h QUEEN MARY HOSPITAL   (Hong Kong)

ⁱ PRINCESS MARGARET HOSPITAL   (Canada)

^j CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

more..

Author keywords

Accelerated fractionation; Chemoradiotherapy; Nasopharyngeal carcinoma

Indexed keywords

ACCELERATED FRACTIONATION; CHEMORADIOTHERAPY; NASOPHARYNGEAL CARCINOMA; THERAPEUTIC RATIO;

CATHODE RAY TUBES; PATIENT MONITORING; RADIOTHERAPY; TOXICITY; TUMORS;

CHEMOTHERAPY;

CISPLATIN; FLUOROURACIL;

ADULT; AGED; ANEMIA; ARTICLE; BRAIN NECROSIS; CANCER ADJUVANT THERAPY; CANCER CHEMOTHERAPY; CANCER CONTROL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; CRANIAL NEUROPATHY; DIABETES MELLITUS; DIARRHEA; DISEASE FREE SURVIVAL; DRUG SAFETY; EAR NOSE THROAT DISEASE; FEMALE; FOLLOW UP; FRACTIONATION; HAZARD ASSESSMENT; HEARING LOSS; HEART INFARCTION; HUMAN; KIDNEY DYSFUNCTION; LEUKOPENIA; MAJOR CLINICAL STUDY; MALE; MORBIDITY; MUCOSA INFLAMMATION; MULTIMODALITY CANCER THERAPY; MULTIVARIATE ANALYSIS; NASOPHARYNX CARCINOMA; NEUROLOGIC DISEASE; PNEUMONIA; PRIORITY JOURNAL; RADIATION DOSE; RANDOMIZED CONTROLLED TRIAL; SKIN MANIFESTATION; STOMATITIS; TEMPORAL LOBE; THROMBOCYTOPENIA; TIME SERIES ANALYSIS; VOMITING;

ADULT; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARCINOMA; CISPLATIN; COMBINED MODALITY THERAPY; DOSE FRACTIONATION; FEMALE; FLUOROURACIL; HUMANS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NASOPHARYNGEAL NEOPLASMS; NEOPLASM STAGING; TREATMENT OUTCOME;

EID: 33746799334     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2006.03.054     Document Type: Article

References (23)

1. Shanmugarantnam K., and Sobin L.H. Histological typing of tumors of the upper respiratory tract and ear. 2nd ed. (1991), Springer-Verlag, New York 32-33
2. Al-Sarraf M., LeBlanc M., Giri P.G., et al. Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer. Phase III randomized Intergroup Study 0099. J Clin Oncol 16 (1998) 1310-1317
3. Lee A.W.M., Lau W.H., Tung S.Y., et al. Preliminary results of a randomized study on therapeutic gain by concurrent chemotherapy for regionally-advanced nasopharyngeal carcinoma. NPC-9901 Trial by the Hong Kong Nasopharyngeal Cancer Study Group. J Clin Oncol 23 (2005) 6966-6975
4. Overgaard J., Sand Hansen H., Specht L., et al. Five compared with six fractions per week of conventional radiotherapy of squamous cell carcinoma of head and neck. DAHANCA 6&7 randomized controlled trial. Lancet 362 (2003) 933-940
5. Lee A.W.M., Sze W.M., Yau T.K., et al. Retrospective analysis on treating nasopharyngeal carcinoma with accelerated fractionation (6 fractions per week) in comparison with conventional fractionation (5 fractions per week). Report on 3-year tumor control and normal tissue toxicity. Radiother Oncol 58 (2001) 121-130
6. Fleming I.D., Cooper J.S., Henson D.E., et al. American Joint Committee on Cancer. AJCC Cancer Staging Manual. 5th ed. (1997), Lippincott-Raven, Philadelphia, PA 31-39
7. Sobin L.H., and Wittekind Ch. International Union Against Cancer (UICC). TNM classification of malignant tumors. 5th ed. (1997), Wiley-Liss, New York 25-32
8. Freedman J., Furberg C., and DeMets D. Fundamentals of clinical trials (1998), Springer-Verlag, New York 65
9. Cox J.D., Stetz J., and Pajak T.F. Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC). Int J Radiat Oncol Biol Phys 31 (1995) 1341-1346
10. Miller A.B., Hoogstraten B., Staquet M., et al. Reporting results of cancer treatment. Cancer 47 (1981) 207-214
11. Kaplan E.L., and Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 53 (1958) 457-481
12. Peto R., Pike M.C., Armitage P., et al. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. Br J Cancer 35 (1977) 1-39
13. Green S., Benedetti J., and Crowley J. Clinical trials in oncology. 2nd ed. (2003), Chapman and Hall, London 86
14. Cox D.R. Regression models and life tables. J Roy Stat Soc B 34 (1972) 187-220
15. Al-Sarraf M., LeBlanc M., Giri P.G.S., et al. Chemo-radiotherapy (CT-RT) vs radiotherapy (RT) in patients (PTS) with advanced nasopharyngeal cancer (NPC). Intergroup (0099) (SWOG 8892, RTOG 8817, ECOG 2388) Phase III: Final report. [Abstract]. J Clin Oncol 17 (1998) 385a
16. Wee J., Tan E.H., Tai B.C., et al. Randomized trial of radiotherapy versus concurrent chemoradiotherapy followed by adjuvant chemotherapy in patients with American Joint Committee on Cancer/International Union Against Cancer Stage III and IV nasopharyngeal cancer of the endemic variety. J Clin Oncol 23 (2005) 6730-6738
17. Lin J.C., Jan J.S., Hsu C.Y., et al. Concurrent chemoradiotherapy versus radiotherapy alone for advanced nasopharyngeal carcinoma. Positive effect on overall and progression-free survival. J Clin Oncol 21 (2003) 631-637
18. Chan A.T.C., Leung S.F., Ngan R.K., et al. Overall survival after concurrent cisplatin-radiotherapy compared with radiotherapy alone in locoregionally advanced nasopharyngeal carcinoma. J Natl Cancer Inst 97 (2005) 536-539
19. Kwong D.L.W., Sham J.S.T., Au G.K.H., et al. Concurrent and adjuvant chemotherapy for nasopharyngeal carcinoma. A factorial study. J Clin Oncol 22 (2004) 2643-2653
20. Teo P.M.L., Leung S.F., Chan A.T.C., et al. Final report of a randomized trial on altered-fractionated radiotherapy in nasopharyngeal carcinoma prematurely terminated by significant increase in neurological complications. Int J Radiat Oncol Biol Phys 48 (2000) 1311-1322
21. Lin J.C., Liang W.M., Jan J.S., et al. Another way to estimate outcome of advanced nasopharyngeal carcinoma-Is concurrent chemoradiotherapy adequate. Int J Radiat Oncol Biol Phys 60 (2004) 156-164
22. Lin J.C., Chen K.Y., Jan J.S., et al. Partially hyperfractionated accelerated radiotherapy and concurrent chemotherapy for advanced nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys 36 (1996) 1127-1136
23. Wolden S.L., Zelefsky M.J., Kraus D.H., et al. Accelerated concomitant boost radiotherapy and chemotherapy for advanced nasopharyngeal carcinoma. J Clin Oncol 19 (2001) 1105-1110