Quantitative determination of phenothiazine derivatives in human plasma using monolithic silica solid-phase extraction tips and gas chromatography-mass spectrometry

Journal of Chromatography A

Volumn 1218, Issue 18, 2011, Pages 2521-2527

  Kumazawa, Takeshi ^a   Hasegawa, Chika ^b   Uchigasaki, Seisaku ^c   Lee, Xiao Pen ^a   Suzuki, Osamu ^d   Sato, Keizo ^a  

^a SHOWA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOHO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Gas chromatography; Mass spectrometry; Monolithic silica; Phenothiazine; Pipette tip; Solid phase extraction

Indexed keywords

COEFFICIENT OF VARIATION; DRUG CONCENTRATION; EXTRACTION PROCESS; GAS CHROMATOGRAPHS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMAN PLASMAS; HUMAN SUBJECTS; LIMITS OF QUANTIFICATION; LOADING CAPACITIES; MASS SPECTROMETRY ANALYSIS; MICRO-PIPETTE; MONOLITHIC SILICA; ORAL ADMINISTRATION; PHENOTHIAZINE; PHENOTHIAZINE DERIVATIVES; PIPETTE TIP; PLASMA CONCENTRATION; PLASMA SAMPLES; PRE-TREATMENT; PROMETHAZINE; QUANTITATIVE DETERMINATIONS; RAPID METHOD; SOLID-PHASE EXTRACTION; VALIDATED METHODS;

CONFORMATIONS; GAS CHROMATOGRAPHY; INSECTICIDES; MASS SPECTROMETRY; METHANOL; PLASMA (HUMAN); PLASMAS; SILICA;

EXTRACTION;

ALIMEMAZINE TARTRATE; CHLORPROMAZINE; LEVOMEPROMAZINE; METHANOL; PROMAZINE; PROMETHAZINE; SILICON DIOXIDE; TRIFLUPROMAZINE;

ACCURACY; ADULT; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG ISOLATION; ELUTION; FEMALE; HUMAN; HUMAN EXPERIMENT; MASS FRAGMENTOGRAPHY; NORMAL HUMAN; PRIORITY JOURNAL; PRODUCT RECOVERY; QUANTITATIVE ANALYSIS; SOLID PHASE EXTRACTION; SOLVENT EXTRACTION; VOLUNTEER;

ADULT; DRUG STABILITY; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; LINEAR MODELS; METHOTRIMEPRAZINE; PHENOTHIAZINES; POROSITY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SILICON DIOXIDE; SOLID PHASE EXTRACTION;

EID: 79954419565     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2011.02.070     Document Type: Article

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