A fatal case of potential chronic overdoses of prescribed and proprietary remedies

Human and Experimental Toxicology

Volumn 29, Issue 8, 2010, Pages 695-699

  Takase, Izumi ^a,b   Yamamoto, Yoshio ^b,c   Nakagawa, Tokiko ^b   Nishi, Katsuji ^b  

^a YAMAGUCHI UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^c MIE UNIVERSITY   (Japan)

Author keywords

intoxication; misuse of drugs; proprietary remedies; pulmonary edema

Indexed keywords

BROTIZOLAM; CAFFEINE; CHLORPHENIRAMINE; CHLORPROMAZINE; CLOMIPRAMINE; CLOTIAZEPAM; DIAZEPAM; DIHYDROCODEINE; ETHYL LOFLAZEPATE; ETIZOLAM; FAT DROPLET; FLUNITRAZEPAM; FLUVOXAMINE MALEATE; METHYLEPHEDRINE; MILNACIPRAN; NORTRIPTYLINE; PARACETAMOL; PERPHENAZINE; PHENOBARBITAL; PROMETHAZINE; TANDOSPIRONE; TRIMIPRAMINE;

ADULT; ARTICLE; AUTOPSY; BLADDER CAPACITY; CARDIOPULMONARY ARREST; CASE REPORT; DEPRESSION; DISEASE SEVERITY; DRUG BLOOD LEVEL; DRUG FATALITY; DRUG OVERDOSE; DRUG URINE LEVEL; EMERGENCY WARD; HEART MUSCLE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOLOGY; HUMAN; HUMAN TISSUE; LIVER HISTOLOGY; LIVER NECROSIS; LUNG CONGESTION; LUNG EDEMA; LUNG HEMORRHAGE; MALE; MASS FRAGMENTOGRAPHY; POLICE; PRESCRIPTION; PRIORITY JOURNAL; RECTUM TEMPERATURE; RESUSCITATION; SPOUSE; SUICIDE ATTEMPT; SWELLING; TEA; TIME TO MAXIMUM PLASMA CONCENTRATION; TOXICOLOGY; WRIST INJURY;

ADULT; ANALGESICS; CAFFEINE; CHLORPROMAZINE; CLOMIPRAMINE; FATAL OUTCOME; HEART ARREST; HUMANS; LIVER; LUNG; MALE; OVERDOSE; PULMONARY EDEMA; SUBSTANCE ABUSE DETECTION;

EID: 77955195582     PISSN: 09603271     EISSN: 14770903     Source Type: Journal    
DOI: 10.1177/0960327109360116     Document Type: Article

References (19)

1. Cantor CH Substances involved in fatal drug overdoses in Brisbane, 1979-1987. Acta Psychiatrica Scandinavia 1989 ; 354: 69-71.
2. Takayasu T., Nishigami J., Ohshima T., et al. [A fatal case due to intoxication with seven drugs detected by GC-MS and TDx methods]. [Article in Japanese] Nihon Hoigaku Zasshi 1993 ; 47: 63-71.
3. Jonasson BB Among fatal poisoning dextropropoxyphene predominates in younger people, antidepressants in the middle aged and sedatives in the elderly. J Forensic Sci 2000 ; 45: 7-10.
4. Gossop M., Stewart D., Treacy S., Marsden J. A prospective study of mortality among drug misusers during a 4-year period after seeking treatment. Addiction 2002 ; 97: 39-47.
5. Lahti RA, Vuori E. Fatal drug poisonings: medico-legal reports and mortality statistics. Forensic Sci Int 2003 ; 136: 35-46.
6. Kinoshita H., Nishiguchi M., Kasuda S. Forensic toxicological implication of an autopsy case of mixed drug overdose involving clomipramine, chlorpromazine and flunitrazepam. Soudní lékarství 2008 ; 3: 28-30.
7. Lambert MT Paranoid psychoses after abuse of proprietary cold remedies. Br J Psychiatry 1987 ; 151: 548-550.
8. Brown TM, Golden RN, Evans DL Organic affective psychosis associated with the routine use of non-prescription cold preparations. Br J Psychiatry 1990 ; 156: 572-575.
9. Dewsnap P., Libby G. A case of affective psychosis after routine use of proprietary cold remedy containing phenylpropanolamine. Human Exper Toxicol 1992 ; 11: 295-296.
10. Chaturvedi AK, Rao NGS, Hurly MP Toxicological findings in a multi-drug death involving propoxyphene, caffeine, phenacetin, acetaminophen and salicylate. Forensic Sci Int 1983 ; 23: 255-264.
11. Chaturvedi AK, Rao NGS, McCoy FE A multi-chemical death involving caffeine, nicotine and malathon. Forensic Sci Int 1983 ; 23: 265-275.
12. Guerrero RM, Shifrar KA Diagnosis and treatment of neuroleptic malignant syndrome. Clin Pharmacol 1988 ; 7: 697-701.
13. Nishioka Y., Miyazaki M., Kubo S., et al. Acute renal failure in neuroleptic malignant syndrome. Renal Failure 2002 ; 24: 539-543.
14. Ebadi M., Pfeiffer RF, Murrin LC Pathogenesis and treatment of neuroleptic malignant syndrome. Gen Pharmacol 1990 ; 21: 367-386.
15. Sanai T., Matsui R., Hirano T., et al. Successful treatment of six patients with neuroleptic malignant syndrome associated with myoglobulinemic acute renal failure. Renal Failure 2006 ; 28: 51-55.
16. Chandran GJ, Mikler JR, Keegan DL Neuroleptic malignant syndrome: case report and discussion. Can Med Assoc J 2003 ; 169: 439-442.
17. Sari A., Fukuda Y., Sakabe T., et al. Effects of psychotropic drugs on canine cerebral metabolism and circulation related to EEG-diazepam, clomipramine, and chlorpromazine. J Neurol Neurosurg Psychiatry 1975, 38: 838-444.
18. Kusano I., Haba K., Morimoto R., Yatani R., Shiraishi T. Cardiac rupture due to severe fatty infiltration in the right ventricular wall. J Forensic Sci 1991 ; 36: 1246-1250.
19. Soumerai SB, Avorn J., Gortmaker S., Hawley S. Effect of government and commercial warnings on reducing prescription misuse: the case of propoxyphene. Aus J Politics History 1987 ; 77: 1518-1523.