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Volumn 134, Issue 3, 2011, Pages 931-937

Evaluation of mutagenic and antimutagenic activities of neem (Azadirachta indica) seed oil in the in vitro Ames Salmonella/microsome assay and in vivo mouse bone marrow micronucleus test

Author keywords

Ames test; Antimutagenicity; DMSO extract; Micronucleus test; Mutagenicity; Neem oil

Indexed keywords

AROCLOR 1254; AZADIRACHTA INDICA EXTRACT; DIMETHYL SULFOXIDE; DIMETHYLBENZ[A]ANTHRACENE; MITOMYCIN; NEEM OIL;

EID: 79954419323     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2011.02.003     Document Type: Article
Times cited : (26)

References (33)
  • 1
    • 0025902273 scopus 로고
    • Endogenous mutagens and the cause of aging and cancer
    • B.N. Ames, and L.S. Gold Endogenous mutagens and the cause of aging and cancer Mutation Research 250 1991 3 16
    • (1991) Mutation Research , vol.250 , pp. 3-16
    • Ames, B.N.1    Gold, L.S.2
  • 2
    • 0028797228 scopus 로고
    • Genotoxic effects of crude extract of neem (Azadirachta indica) in bone marrow cells of mice
    • K.S. Awasthy, O.P. Chaurasia, and S.P. Sinha Genotoxic effects of crude extract of neem (Azadirachta indica) in bone marrow cells of mice Cytologia 60 1995 189 195
    • (1995) Cytologia , vol.60 , pp. 189-195
    • Awasthy, K.S.1    Chaurasia, O.P.2    Sinha, S.P.3
  • 3
    • 0002925047 scopus 로고    scopus 로고
    • Biological activities and medicinal properties of neem (Azadirachta indica)
    • K. Biswas, I. Chattopadhyay, R.K. Banerjee, and U. Bandhopadhyay Biological activities and medicinal properties of neem (Azadiractha indica) Current Science 82 2002 1336 1345 (Pubitemid 135695234)
    • (2002) Current Science , vol.82 , Issue.11 , pp. 1336-1345
    • Biswas, K.1    Chattopadhyay, I.2    Banerjee, R.K.3    Bandyopadhyay, U.4
  • 4
    • 3242694307 scopus 로고    scopus 로고
    • Neem-an omnipotent plant: A retrospection
    • G. Brahmachari Neem-an omnipotent plant: a retrospection Chembiochem 5 2004 408 421
    • (2004) Chembiochem , vol.5 , pp. 408-421
    • Brahmachari, G.1
  • 5
    • 0029154491 scopus 로고
    • Evaluation of modified bacterial mutagenicity assay for the genotoxicity testing of mineral oils
    • T.M. Brooks, R.A.J. Priston, A.S. Wright, and W.P. Watson Evaluation of modified bacterial mutagenicity assay for the genotoxicity testing of mineral oils Mutagenesis 10 1995 409 415
    • (1995) Mutagenesis , vol.10 , pp. 409-415
    • Brooks, T.M.1    Priston, R.A.J.2    Wright, A.S.3    Watson, W.P.4
  • 6
    • 2442473888 scopus 로고    scopus 로고
    • Genotoxic effects of cadmium chloride and azadirachtin treated singly and in combination in fish
    • DOI 10.1016/j.ecoenv.2004.01.010, PII S0147651304000181
    • P. Chandra, and A.R. Khuda-bukhsh Genotoxic effects of cadmium chloride and azadirachtin treated singly and in combination in fish Ecotoxicology Environmental Safety 58 2004 194 201 (Pubitemid 38638535)
    • (2004) Ecotoxicology and Environmental Safety , vol.58 , Issue.2 , pp. 194-201
    • Chandra, P.1    Khuda-Bukhsh, A.R.2
  • 7
    • 0027416997 scopus 로고
    • Toxicological studies on debitterized Neem oil (Azadirachta indica)
    • DOI 10.1016/0278-6915(93)90079-E
    • N. Chinnasamy, N. Harishankar, P.U. Kumar, and C. Rukmini Toxicological studies on debitterized neem oil (Azadirachta indica) Food and Chemical Toxicology 31 1993 297 301 (Pubitemid 23122370)
    • (1993) Food and Chemical Toxicology , vol.31 , Issue.4 , pp. 297-301
    • Chinnasamy, N.1    Harishankar, N.2    Uday Kumar, P.3    Rukmini, C.4
  • 10
    • 0031924055 scopus 로고    scopus 로고
    • Immunocontraceptive activity guided fractionation and characterization of active constituents of neem (Azadirachta indica) seed extracts
    • DOI 10.1016/S0378-8741(97)00157-8, PII S0378874197001578
    • S. Garg, G.P. Talwar, and S.N. Upadhyay Immunocontraceptive activity guided fractionation and characterization of active constituents of neem (A. indica) seed extracts Journal of Ethnopharmacology 60 1998 235 246 (Pubitemid 28203812)
    • (1998) Journal of Ethnopharmacology , vol.60 , Issue.3 , pp. 235-246
    • Garg, S.1    Talwar, G.P.2    Upadhyay, S.N.3
  • 11
    • 0018355376 scopus 로고
    • Application of a simple Giemsa-staining method in the micronucleus test
    • B. Gollapudi, and O.P. Kamra Application of a simple Giemsa-staining method in the micronucleus test Mutation Research 64 1979 45 46 (Pubitemid 9098077)
    • (1979) Mutation Research , vol.64 , Issue.1 , pp. 45-46
    • Gollapudi, B.1    Kamra, O.P.2
  • 12
    • 0021091387 scopus 로고
    • Mutagenicity testing of two tropical plant materials with pesticidal potential in Salmonella typhimurium: Phytolacca dodecandra berries and oil from seeds of Azadirachta indica
    • W.M. Jongen, and J.H. Koeman Mutagenicity testing of two tropical plant materials with pesticidal potential in Salmonella typhimurium: Phytolacca dodecandra berries and oil from seeds of Azadirachta indica Environmental Mutagenesis 5 1983 687 694 (Pubitemid 14241701)
    • (1983) Environmental Mutagenesis , vol.5 , Issue.5 , pp. 687-694
    • Jongen, W.M.F.1    Koeman, J.H.2
  • 13
    • 0141767079 scopus 로고    scopus 로고
    • Cytogenetic toxicity of neem
    • DOI 10.1016/S0278-6915(03)00123-6
    • P.K. Khan, and K.S. Awasthy Cytogenetic toxicity of neem Food and Chemical Toxicology 41 2003 1325 1328 (Pubitemid 37289180)
    • (2003) Food and Chemical Toxicology , vol.41 , Issue.10 , pp. 1325-1328
    • Khan, P.K.1    Awasthy, K.S.2
  • 14
    • 0034693788 scopus 로고    scopus 로고
    • In vivo rodent micronucleus assay: Protocol, conduct and data interpretation
    • G. Krishna, and M. Hayashi In vivo rodent micronucleus assay: protocol, conduct and data interpretation Mutation Research 455 2000 155 166
    • (2000) Mutation Research , vol.455 , pp. 155-166
    • Krishna, G.1    Hayashi, M.2
  • 15
    • 0032101097 scopus 로고    scopus 로고
    • Effects of neem flowers, Thai and Chinese bitter gourd fruits and sweet basil leaves on hepatic monooxygenases and glutathione S-transferase activities, and in vitro metabolic activation of chemical carcinogens in rats
    • DOI 10.1016/S0278-6915(98)00011-8, PII S0278691598000118
    • W.R. Kusamran, A. Ratnavila, and A. Tepsuwan Effects of neem flowers, Thai and Chinese bitter gourd fruits and sweet basil leaves on hepatic monoxygenases and glutathione S-transferase activities and in vitro metabolic activation of chemical carcinogens in rats Food and Chemical Toxicology 36 1998 475 484 (Pubitemid 28293744)
    • (1998) Food and Chemical Toxicology , vol.36 , Issue.6 , pp. 475-484
    • Kusamran, W.R.1    Ratanavila, A.2    Tepsuwan, A.3
  • 18
    • 0020533372 scopus 로고
    • Revised methods for Salmonella mutagenicity test
    • D.M. Maron, and B.N. Ames Revised methods for Salmonella mutagenicity test Mutation Research 113 1983 175 215
    • (1983) Mutation Research , vol.113 , pp. 175-215
    • Maron, D.M.1    Ames, B.N.2
  • 19
    • 0024272898 scopus 로고
    • N,N-diethylphenylacetamide, an insect repellent: Absence of mutagenic response in the in vitro ames test and in vivo mouse micronucleus test
    • DOI 10.1016/0278-6915(88)90215-3
    • G.P. Meshram, and K.M. Rao N, N'-diethylphenyl acetamide, an insect repellent: absence of mutagenic response in the in vitro Ames test and in vivo mouse micronucleus test Food and Chemical Toxicology 26 1988 791 796 (Pubitemid 19024529)
    • (1988) Food and Chemical Toxicology , vol.26 , Issue.9 , pp. 791-796
    • Meshram, G.P.1    Rao, K.M.2
  • 20
    • 0026653096 scopus 로고
    • Mutagenicity of N, N'-dimethyl urea and methylamine hydrochloride in the Ames Salmonella/microsome test: Absence of mutagenicity response
    • G.P. Meshram, R. Padma Malini, and K.M. Rao Mutagenicity of N, N'-dimethyl urea and methylamine hydrochloride in the Ames Salmonella/microsome test: absence of mutagenicity response Mutation Research 279 1992 275 280
    • (1992) Mutation Research , vol.279 , pp. 275-280
    • Meshram, G.P.1    Padma Malini, R.2    Rao, K.M.3
  • 21
    • 0034693731 scopus 로고    scopus 로고
    • The Ames Salmonella/microsome mutagenicity assay
    • K. Mortelmans, and E. Zeiger The Ames Salmonella/microsome mutagenicity assay Mutation Research 455 2000 29 60
    • (2000) Mutation Research , vol.455 , pp. 29-60
    • Mortelmans, K.1    Zeiger, E.2
  • 22
    • 0031666308 scopus 로고    scopus 로고
    • Inhibition of clastogenic effect of cyclophosphamide and mitomycin C by Neem leaf-extract in mice
    • DOI 10.1002/(SI CI)1099-15 73(19980 9)12:6<4 09::AID-PTR 324>3.0.CO;2-5
    • M.J. Mukhophadhyay, and A. Mukherjee Inhibition of clastogenic effect of cyclophosphamide and mitomycin C by neem leaf extract in mice Phytotherapy Research 12 1998 409 412 (Pubitemid 28442650)
    • (1998) Phytotherapy Research , vol.12 , Issue.6 , pp. 409-412
    • Mukhopadhyay, M.J.1    Mukherjee, A.2
  • 23
    • 85040956029 scopus 로고
    • National Research Council National Academic Press Washington, DC
    • National Research Council Neem: a tree for solving global problems 1992 National Academic Press Washington, DC
    • (1992) Neem: A Tree for Solving Global Problems
  • 24
    • 0024500146 scopus 로고
    • Comparative antimutagenicity of 5 compounds against 5 mutagenic complex mixtures in Salmonella typhimurium strain TA98
    • T. Ong, W.Z. Whong, J.D. Stewart, and H.E. Brockman Comparative antimutagenicity of 5 compounds against 5 mutagenic complex mixtures in Salmonella typhimurium strain TA98 Mutation Research 222 1989 19 25 (Pubitemid 19013113)
    • (1989) Mutation Research , vol.222 , Issue.1 , pp. 19-25
    • Ong, T.1    Whong, W.-Z.2    Stewart, J.D.3    Brockman, H.E.4
  • 25
    • 3442902875 scopus 로고    scopus 로고
    • Ayurveda and natural products drug discovery
    • B. Patwardhan, A.D.B. Vaidya, and M. Chorgade Ayurveda and natural products drug discovery Current Science 86 2004 789 799 (Pubitemid 39169379)
    • (2004) Current Science , vol.86 , Issue.6 , pp. 789-799
    • Patwardhan, B.1    Vaidya, A.D.B.2    Chorghade, M.3
  • 26
    • 0023472693 scopus 로고
    • Mutagenicity tests of cashewnut shell liquid, rice-bran oil and other vegetable oils using the Salmonella typhimurium/microsome system
    • DOI 10.1016/0278-6915(87)90231-6
    • K. Polasa, and C. Rukmini Mutagenicity tests of cashew nut shell liquid, rice-bran oil and other vegetable oils using the Salmonella typhimurium/ microsome system Food and Chemical Toxicology 25 1987 763 766 (Pubitemid 18003006)
    • (1987) Food and Chemical Toxicology , vol.25 , Issue.10 , pp. 763-766
    • Polasa, K.1    Rukmini, C.2
  • 28
    • 0028828358 scopus 로고
    • An examination of the potential genotoxic carcinogenicity of a biopesticide derived from neem tree
    • H.S. Rosenkranz, and G. Klopman An examination of the potential genotoxic carcinogenicity of a biopesticide derived from neem tree Environmental and Molecular Mutagenesis 26 1995 255 260
    • (1995) Environmental and Molecular Mutagenesis , vol.26 , pp. 255-260
    • Rosenkranz, H.S.1    Klopman, G.2
  • 29
    • 0018826061 scopus 로고
    • Towards an improved micronucleus test: Studies on 3 model agents, mitomycin C, cyclophosphamide and dimethylbenzanthracene
    • M. Salamone, J. Heddle, E. Stuart, and M. Katz Towards an improved micronucleus test-studies on three model agents, mitomycin C, cyclophosphamide and dimethylbenzanthracene Mutation Research 74 1980 347 356 (Pubitemid 10053733)
    • (1980) Mutation Research , vol.74 , Issue.5 , pp. 347-356
    • Salamone, M.1    Heddle, J.2    Stuart, E.3    Katz, M.4
  • 30
    • 0030561381 scopus 로고    scopus 로고
    • Mechanism of action of NIM-76: A novel vaginal contraceptive from neem oil
    • DOI 10.1016/S0010-7824(96)00204-1, PII S0010782496002049
    • S.K. Sharma, M. Sairam, G. Ilavazhagan, K. Devendra, S.S. Shivaji, and W. Selvamurthy Mechanism of action of NIM-76: a novel vaginal contraceptive from neem oil Contraception 54 1996 373 378 (Pubitemid 26419296)
    • (1996) Contraception , vol.54 , Issue.6 , pp. 373-378
    • Sharma, S.K.1    SaiRam, M.2    Ilavazhagan, G.3    Devendra, K.4    Shivaji, S.S.5    Selvamurthy, W.6
  • 31
    • 0021126381 scopus 로고
    • The mutagenicities of seven coumarin derivatives and a furan derivative (nimbolide) isolated from three medicinal plants
    • A.O. Uwaifo The mutagenicities of seven coumarins derivatives and a furan derivative (nimbolide) isolated from three medicinal plants Journal of Toxicology and Environmental Health 13 1984 521 530 (Pubitemid 14029074)
    • (1984) Journal of Toxicology and Environmental Health , vol.13 , Issue.4-6 , pp. 521-530
    • Uwaifo, A.O.1
  • 33
    • 0021357541 scopus 로고
    • The hair dye reagent 2-(2′,4′-diaminophenoxy) ethanol is mutagenic to Salmonella tyhimurium
    • S. Venitt, C. Crofton-Sleigh, and M.R. Osborne The hair dye reagent 2-(2′,4′-diaminophenoxy) ethanol is mutagenic to Salmonella tyhimurium Mutation Research 135 1984 31 47
    • (1984) Mutation Research , vol.135 , pp. 31-47
    • Venitt, S.1    Crofton-Sleigh, C.2    Osborne, M.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.