Cytogenetic toxicity of neem

Food and Chemical Toxicology

Volumn 41, Issue 10, 2003, Pages 1325-1328

  Khan, P K ^a   Awasthy, K S ^b  

^a Patna Women's College   (India)

^b KKM College   (India)

Author keywords

[No Author keywords available]

Indexed keywords

AZADIRACHTA INDICA EXTRACT; AZADIRACHTIN; CARCINOGEN; MUTAGENIC AGENT; PLANT EXTRACT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AZADIRACHTA INDICA; CELL STRUCTURE; CHROMOSOME ABERRATION; CHROMOSOME STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; GENOTOXICITY; GERM CELL; MALE; MEIOSIS; METAPHASE; MOUSE; MUTAGENICITY; NONHUMAN; SPERMATOCYTE; SPERMATOZOON; SPERMATOZOON COUNT; SYNAPSE; ANIMAL; CELL DIVISION; CHEMISTRY; CHROMOSOME; DRUG EFFECT; IN VITRO STUDY; PLANT LEAF; SPERMATOGONIUM; ULTRASTRUCTURE;

AZADIRACHTA INDICA; MURINAE;

ANIMALS; AZADIRACHTA; CARCINOGENS; CELL DIVISION; CHROMOSOMES; MALE; MEIOSIS; MICE; MUTAGENS; PLANT EXTRACTS; PLANT LEAVES; SPERM COUNT; SPERM HEAD; SPERMATOGONIA;

EID: 0141767079     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-6915(03)00123-6     Document Type: Article

References (24)

1. Adler I.D. Mouse spermatogonia and spermatocyte sensitivity to chemical mutagens. Cytogenetics and Cell Genetics. 33:1982;95-100.
2. Awasthy K.S., Chaurasia O.P., Sinha S.P. Genotoxic effects of crude extract of neem (Azadirachta indica) in bone marrow cells of mice. Cytologia. 60:1995;189-195.
3. Awasthy K.S., Chaurasia O.P., Sinha S.P. Prolonged murine genotoxic effects of crude extracted from neem. Phytotherapy Research. 11:1999;81-83.
4. Awasthy K.S., Chaurasia O.P., Sinha S.P., Khan P.K. Differential genotoxicity of the crude leaf extract of a medicinal plant, Casearia tomentosa. Biomedical and Environmental Sciences. 13:2000;12-18.
5. Das R.K., Nayak R. Spermatocyte chromosome alterations in mice inoculated with antirabies vaccine and tetanus toxoid separately and in combination. Mutation Research. 204:1988;277-282.
6. Downie N.M., Heath R.E. Basic Statistical Methods. 1970;Harper and Row Publishers, New York.
7. Evenson D.P., Bear R.K., Jost L.K., Gesch R.W. Toxicity of thiotepa on mouse spermatogenesis as determined by dual-parameter flow cytometry. Toxicology and Applied Pharmacology. 82:1986;151-163.
8. Khan P.K., Awasthy K.S. Differential genotoxicity of endosulfan (a synthetic pesticide) and the crude extracted from neem (a biopesticidal plant). Manna G.K., Roy S.C. Perspectives in Cytology and Genetics, vol. 10. 2001;759-762 All India Congress of Cytology and Genetics, Kalyani University, Kalyani.
9. Manna G.K. The living mutagens. Roy S.C. Laboratory Manual of Instructional Workshop on Perspectives in Chromosome Research. 1985;55-72 Calcutta University Press, Calcutta.
10. Meistrich M.L. Evaluation of reproductive toxicity by testicular sperm head counts. Journal of American College of Toxicology. 8:1989;551-567.
11. Neem: A tree for Solving Global Problems. 1992;National Academy Press, Washington DC.
12. Rastogi P.B., Levin R.E. Induction of sperm abnormalities in mice by quercetin. Environmental Mutagenesis. 9:1987;255-260.
13. Riar S.S., Sawhney R.C., Ilavazhagan G., Roy J.B., Khan A.K., Thomas P., Singh R., Singh B., Devakumar C., Singh M., Sawhney R.C. Neem as contraceptive. Proceedings of IV World Neem Conference, Bangalore. Neem Newsletter (Indian Agricultural Research Institute, New Delhi). 10:1993;85. (Abstract).
14. Rojanapo W., Tepsuwan A. Matagenic and antimutagenic activities of some vegetables (in Thai). Bulletin of the Department of Medical Services. 17:1992;461-469.
15. Rosenkranz H.S., Klopman G. An examination of the potential genotoxic carcinogenicity of a biopesticide derived from neem tree. Environmental and Molecular Mutagenesis. 26:1995;255-260.
16. Rosenkranz H.S., Klopman G. Relationship between electronegativity and genotoxicity. Mutation Research. 328:1995;215-227.
17. Salvadori D.M.F., Ribeiro L.R., Pereira C.A.B., Becak W. Cytogenetic effects of malathion insecticide on somatic and germ cells of mice. Mutation Research. 204:1988;283-287.
18. Sinha K.C., Riar S.S., Timmary R.C., Dhawan A.K., Bardhan J., Thomas P., Khan A.K., Jain R.K. Neem oil as marginal contraceptive. Indian Journal of Medical Research. 79:1984;131-136.
19. Singh R.N., Karnan P., Kulshrestha V., Sinha S.S. Neem to control pests of tasar. Indian Silk. 32:1993;42-44.
20. Stone R. A biopesticidal tree begins to blossom. Science. 255:1992;1070-1071.
21. Topham J.C. Do induced sperm head abnormalities in mice specifically identify mammalian mutagens rather than carcinogens? Mutation Research. 74:1980;379-387.
22. Upadhyay S.N., Talwar G.P. Antifertility effects of neem, A. Indica, oil in male rats by single intra-vas administration: An alternate approach to vasectomy. Journal of Andrology. 14:1993;275-281.
23. Wyrobek A.J., Gordon L.A., Burkhart J.G., Francis M.W., Kapp R.W., Letz G., Malling H.V., Topham J.C., Whorton M.D. An evaluation of the mouse sperm morphology test and other spem tests in non-human animals. a report of the US Environmental protection Agency Gene-Tox Program Mutation Research. 115:1983;1-72.
24. Wyrobek A.J., Watchmaker G., Gordon L.A. Sperm Morphology testing in mice. Killbey B.J., Legator M., Nichols M., Ramel C. Handbook of Mutagenicity Test Procedures. 1984;739-750 Elsevier, Amsterdam.