Management of sepsis: A 47-year-old woman with an indwelling intravenous catheter and sepsis

JAMA

Volumn 305, Issue 14, 2011, Pages 1469-1477

  Angus, Derek C ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTIBIOTIC AGENT; ASPARTATE AMINOTRANSFERASE; BICARBONATE; CEFEPIME; CEFTRIAXONE; CREATININE; DAPTOMYCIN; HYDROCORTISONE; HYPERTENSIVE FACTOR; LACTIC ACID; METRONIDAZOLE;

ABDOMINAL PAIN; ADULT; ARTICLE; BLOOD PRESSURE MEASUREMENT; BODY TEMPERATURE; BREATHING RATE; CASE REPORT; CATHETER INFECTION; CHILL; DISEASE SEVERITY; DRUG DOSE TITRATION; DRUG WITHDRAWAL; FATIGUE; FEMALE; FLUID RESUSCITATION; HEART RATE; HIP PAIN; HUMAN; INDWELLING CATHETER; INTRAVENOUS CATHETER; LEUKOCYTE COUNT; MYALGIA; NAUSEA; OXYGEN SATURATION; PRIORITY JOURNAL; SEPSIS; VOMITING;

EID: 79953902565     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.2011.438     Document Type: Article

References (61)

1. Bone RC, Balk RA, Cerra FB, et al; ACCP/SCCM Consensus Conference Committee. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Chest. 2009;136(5)(suppl):e28.
2. Levy MM, Fink MP, Marshall JC, et al; SCCM/ESICM/ACCP/ATS/SIS. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med. 2003;31(4):1250-1256. (Pubitemid 36444440)
3. Dellinger RP, Levy MM, Carlet JM, et al; International Surviving Sepsis Campaign Guidelines Committee; American Association of Critical-Care Nurses; American College of Chest Physicians; American College of Emergency Physicians; Canadian Critical Care Society; European Society of Clinical Microbiology and Infectious Diseases; European Society of Intensive Care Medicine; European Respiratory Society; International Sepsis Forum; Japanese Association for Acute Medicine; Japanese Society of Intensive Care Medicine; Society of Critical Care Medicine; Society of Hospital Medicine; Surgical Infection Society; World Federation of Societies of Intensive and Critical Care Medicine. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med. 2008; 36(1):296-327.
4. Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med. 2001;29(7):1303-1310. (Pubitemid 32641789)
5. Sands KE, Bates DW, Lanken PN, et al; Academic Medical Center Consortium Sepsis Project Working Group. Epidemiology of sepsis syndrome in 8 academic medical centers. JAMA. 1997;278(3):234-240.
6. Linde-Zwirble WT, Angus DC. Severe sepsis epidemiology: sampling, selection, and society. Crit Care. 2004;8(4):222-226. (Pubitemid 39144709)
7. Wunsch H, Angus DC, Harrison DA, et al. Variation in critical care services across North America and Western Europe. Crit Care Med. 2008;36(10):2787-2793.
8. Riedemann NC, Guo R-F, Ward PA. Novel strategies for the treatment of sepsis. Nat Med. 2003;9(5):517-524. (Pubitemid 36597096)
9. Wheeler AP, Bernard GR. Treating patients with severe sepsis. N Engl J Med. 1999;340(3):207-214. (Pubitemid 29063218)
10. Hotchkiss RS, Karl IE. The pathophysiology and treatment of sepsis. N Engl J Med. 2003;348(2):138-150. (Pubitemid 36056721)
11. Kellum JA, Kong L, Fink MP, et al. Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) study. Arch Intern Med. 2007;167(15):1655-1663. (Pubitemid 47280347)
12. Sørensen TIA, Nielsen GG, Andersen PK, Teasdale TW. Genetic and environmental influences on premature death in adult adoptees. N Engl J Med. 1988; 318(12):727-732. (Pubitemid 18090256)
13. Angus DC, Wax RS. Epidemiology of sepsis: an update. Crit Care Med. 2001; 29(7)(suppl):S109-S116. (Pubitemid 32681592)
14. Lin MT, Albertson TE. Genomic polymorphisms in sepsis. Crit Care Med. 2004; 32(2):569-579. (Pubitemid 38234143)
15. Vincent JL, Abraham E. The last 100 years of sepsis. Am J Respir Crit Care Med. 2006;173(3):256-263. (Pubitemid 43209078)
16. Angus DC, Birmingham MC, Balk RA, et al; E5 Study Investigators. E5 murine monoclonal antiendotoxin antibody in gram-negative sepsis: a randomized controlled trial. JAMA. 2000;283(13):1723-1730. (Pubitemid 30196213)
17. Abraham E, Reinhart K, Opal S, et al; OPTIMIST Trial Study Group. Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: a randomized controlled trial. JAMA. 2003;290(2):238-247. (Pubitemid 37430063)
18. Bernard GR, Vincent JL, Laterre PF, et al; Recombinant Human Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) Study Group. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med. 2001; 344(10):699-709. (Pubitemid 32204987)
19. Kumar A, Zarychanski R, Pinto R, et al; Canadian Critical Care Trials Group H1N1 Collaborative. Critically ill patients with 2009 influenza A(H1N1) infection in Canada. JAMA. 2009;302(17):1872-1879.
20. Domínguez-Cherit G, Lapinsky SE, Macias AE, et al. Critically ill patients with 2009 influenza A(H1N1) in Mexico. JAMA. 2009;302(17):1880-1887.
21. Webb SA, Pettilä V, Seppelt I, et al; ANZIC Influenza Investigators. Critical care services and 2009 H1N1 influenza in Australia and New Zealand. N Engl J Med. 2009;361(20):1925-1934.
22. Kumar A, Roberts D, Wood KE, et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med. 2006;34(6):1589-1596. (Pubitemid 43810035)
23. Rivers E, Nguyen B, Havstad S, et al; Early Goal-Directed Therapy Collaborative Group. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med. 2001;345(19):1368-1377.
24. Carlbom DJ, Rubenfeld GD. Barriers to implementing protocol-based sepsis resuscitation in the emergency department-results of a national survey. Crit Care Med. 2007;35(11):2525-2532. (Pubitemid 351339012)
25. Reade MC, Huang DT, Bell D, et al; British Association for Emergency Medicine; UK Intensive Care Society; UK Society for Acute Medicine; Australasian Resuscitation in Sepsis Evaluation Investigators; Protocolized Care for Early Septic Shock Investigators. Variability in management of early severe sepsis. Emerg Med J. 2010; 27(2):110-115.
26. ClinicalTrials.gov. Protocolized Care for Early Septic Shock (ProCESS). http: //www.clinicaltrials.gov/ct2/show/NCT00510835?term=ProCESS&rank=1. Accessed December 2010.
27. ISRCTN. The clinical and cost-effectiveness of early, goal-directed, protocolised resuscitation for emerging septic shock (ProMISe). http://www.controlled-trials.com/ISRCTN36307479/ProMISe. Accessed December 2010.
28. Australian New Zealand Clinical Trials Registry. Australasian Resuscitation in Sepsis Evaluation Randomised Controlled Trial (ARISE). http://www.anzctr.org.au/trial-view.aspx?ID=82563. Accessed December 2010.
29. Jones AE, Shapiro NI, Trzeciak S, Arnold RC, Claremont HA, Kline JA; Emergency Medicine Shock Research Network (EMShockNet) Investigators. Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial. JAMA. 2010;303(8):739-746.
30. De Backer D, Biston P, Devriendt J, et al; SOAP II Investigators. Comparison of dopamine and norepinephrine in the treatment of shock. N Engl J Med. 2010; 362(9):779-789.
31. Kumar A, Ellis P, Arabi Y, et al; Cooperative Antimicrobial Therapy of Septic Shock Database Research Group. Initiation of inappropriate antimicrobial therapy results in a fivefold reduction of survival in human septic shock. Chest. 2009; 136(5):1237-1248.
32. Deans KJ, Haley M, Natanson C, Eichacker PQ, Minneci PC. Novel therapies for sepsis: a review. J Trauma. 2005;58(4):867-874. (Pubitemid 40592766)
33. Annane D, Sé bille V, Charpentier C, et al. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock [published correction appears in JAMA. 2008;300(14):1652].
34. JAMA. 2002; 288(7):862-871.
35. Sprung CL, Annane D, Keh D, et al; CORTICUS Study Group. Hydrocortisone therapy for patients with septic shock. N Engl J Med. 2008;358(2):111-124.
36. Annane D, Bellissant E, Bollaert PE, et al. Corticosteroids in the treatment of severe sepsis and septic shock in adults: a systematic review. JAMA. 2009; 301(22):2362-2375.
37. Jaeschke R, Angus DC. Living with uncertainty in the intensive care unit: should patients with sepsis be treated with steroids? JAMA. 2009;301(22):2388-2390.
38. Nadel S, Goldstein B, Williams MD, et al; Researching Severe Sepsis and Organ Dysfunction in Children: aGlobal Perspective (RESOLVE) Study Group. Drotrecogin alfa (activated) in children with severe sepsis: a multicentre phase III randomised controlled trial. Lancet. 2007;369(9564):836-843. (Pubitemid 46365900)
39. Abraham E, Laterre P-F, Garg R, et al; Administration of Drotrecogin Alfa (Activated) in Early Stage Severe Sepsis (ADDRESS) Study Group. Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death. N Engl J Med. 2005;353(13):1332-1341. (Pubitemid 41362701)
40. ClinicalTrials.gov. Investigation of the Efficacy and Safety of Drotrecogin Alfa (Activated) in Pediatric Severe Sepsis (PROWESS) Shock. http://clinicaltrials.gov/ct2/show/NCT00049764?term=Drotrecogin+Alfa&rank=1. Accessed December 2010.
41. Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med. 2000;342(18):1301-1308.
42. Bellomo R, Cass A, Cole L, et al; RENAL Replacement Therapy Study Investigators. Intensity of continuous renal-replacement therapy in critically ill patients. N Engl J Med. 2009;361(17):1627-1638.
43. Palevsky PM, Zhang JH,O'Connor TZ, et al; VA/NIH Acute Renal Failure Trial Network. Intensity of renal support in critically ill patients with acute kidney injury. N Engl J Med. 2008;359(1):7-20. (Pubitemid 351931092)
44. Vinsonneau C, Camus C, Combes A, et al; Hemodiafe Study Group. Continuous venovenous haemodiafiltration vs intermittent haemodialysis for acute renal failure in patients with multiple-organ dysfunction syndrome: a multicentre randomised trial. Lancet. 2006;368(9533):379-385. (Pubitemid 44108121)
45. Kress JP, Pohlman AS, O'Connor MF, Hall JB. Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med. 2000;342(20):1471-1477. (Pubitemid 30318270)
46. Girard TD, Kress JP, Fuchs BD, et al. Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled Trial): a randomised controlled trial. Lancet. 2008;371(9607):126-134.
47. Doig GS, Simpson F, Finfer S, et al; Nutrition Guidelines Investigators of the ANZICS Clinical Trials Group. Effect of evidence-based feeding guidelines on mortality of critically ill adults: a cluster randomized controlled trial. JAMA. 2008; 300(23):2731-2741.
48. Jones NE, Heyland DK. Implementing nutrition guidelines in the critical care setting: a worthwhile and achievable goal? JAMA. 2008;300(23):2798-2799.
49. van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in the critically ill patients. N Engl J Med. 2001;345(19):1359-1367.
50. Brunkhorst FM, Engel C, Bloos F, et al; German Competence Network Sepsis (SepNet). Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med. 2008;358(2):125-139.
51. Finfer S, Chittock DR, Su SY, et al; NICE-SUGAR Study Investigators. Intensive versus conventional glucose control in critically ill patients. N Engl J Med. 2009; 360(13):1283-1297.
52. Friedman G, Silva E, Vincent JL. Has the mortality of septic shock changed with time? Crit Care Med. 1998;26(12):2078-2086. (Pubitemid 29016694)
53. Quartin AA, Schein RM, Kett DH, Peduzzi PN; Department of Veterans Affairs Systemic Sepsis Cooperative Studies Group. Magnitude and duration of the effect of sepsis on survival. JAMA. 1997;277(13):1058-1063. (Pubitemid 27147544)
54. Kaplan V, Clermont G, Griffin MF, et al. Pneumonia: still the old man's friend? Arch Intern Med. 2003;163(3):317-323. (Pubitemid 36183860)
55. Weycker D, Akhras KS, Edelsberg J, Angus DC, Oster G. Long-term mortality and medical care charges in patients with severe sepsis. Crit Care Med. 2003; 31(9):2316-2323. (Pubitemid 37100834)
56. Yende S, D'Angelo G, Kellum JA, et al; GenIMS Investigators. Inflammatory markers at hospital discharge predict subsequent mortality after pneumonia and sepsis. Am J Respir Crit Care Med. 2008;177(11):1242-1247. (Pubitemid 351860933)
57. Yende S, Angus DC. Long-term outcomes from sepsis. Curr Infect Dis Rep. 2007;9(5):382-386. (Pubitemid 47422770)
58. Cook D, Rocker G, Marshall J, et al; Level of Care Study Investigators; Canadian Critical Care Trials Group. Withdrawal of mechanical ventilation in anticipation of death in the intensive care unit. N Engl J Med. 2003;349(12):1123-1132. (Pubitemid 37122324)
59. Angus DC, Crowther MA. Unraveling severe sepsis: why did OPTIMIST fail and what's next? JAMA. 2003;290(2):256-258. (Pubitemid 37430066)
60. Ferrer R, Artigas A, Levy MM, et al; Edusepsis Study Group. Improvement in process of care and outcome after a multicenter severe sepsis educational program in Spain. JAMA. 2008;299(19):2294-2303. (Pubitemid 351724396)
61. Pronovost P, Needham D, Berenholtz S, et al. An intervention to decrease catheter- related bloodstream infections in the ICU. N Engl J Med. 2006;355(26): 2725-2732. (Pubitemid 46021509)