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Volumn 103, Issue 6, 2011, Pages 538-549

Cutaneous melanoma: A model to study cancer metastasis

Author keywords

melanoma; metastasis

Indexed keywords

ALPHA2B INTERFERON; ANTINEOPLASTIC AGENT; AUTOANTIBODY; BCG VACCINE; CARBOPLATIN; DACARBAZINE; EPIDERMAL GROWTH FACTOR RECEPTOR; GLYCOPROTEIN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GSK 2118436; IPILIMUMAB; LACTATE DEHYDROGENASE; LEVODOPA; MELANOMA INHIBITING ACTIVITY PROTEIN; MELPHALAN; ONCOLYTIC HERPES VIRUS; PACLITAXEL; PEGINTERFERON ALPHA2B; PEPTIDE VACCINE; PHOSPHATIDYLINOSITOL 3 KINASE; PLX 4032; PROTEIN S100B; SECRETORY PROTEIN; SORAFENIB; TEMOZOLOMIDE; TUMOR ASSOCIATED ANTIGEN 90 IMMUNE COMPLEX; TUMOR MARKER; TUMOR NECROSIS FACTOR; TYROSINE; UNCLASSIFIED DRUG; VELIMOGENE ALIPLASMID;

EID: 79953897102     PISSN: 00224790     EISSN: 10969098     Source Type: Journal    
DOI: 10.1002/jso.21816     Document Type: Article
Times cited : (41)

References (138)
  • 1
    • 74949143594 scopus 로고    scopus 로고
    • Final version of 2009 AJCC melanoma staging and classification
    • Epub 2009 Nov 16.
    • Balch CM, Gershenwald JE, Soong SJ, et al.: Final version of 2009 AJCC melanoma staging and classification. J Clin Oncol 2009; 27: 6199-6206. Epub 2009 Nov 16.
    • (2009) J Clin Oncol , vol.27 , pp. 6199-6206
    • Balch, C.M.1    Gershenwald, J.E.2    Soong, S.J.3
  • 2
    • 0037302994 scopus 로고    scopus 로고
    • Pathology of malignant melanoma
    • DOI 10.1016/S0039-6109(03)00003-3
    • Liu V, Mihm M,: Pathology of malignant melanoma. Surg Clin North Am 2003; 83: 31-60, v. (Pubitemid 36384359)
    • (2003) Surgical Clinics of North America , vol.83 , Issue.1 , pp. 31-60
    • Liu, V.1    Mihm, M.C.2
  • 3
    • 0036791943 scopus 로고    scopus 로고
    • The surgical management of metastatic melanoma
    • Allen P, Coit D,: The surgical management of metastatic melanoma. Ann Surg Oncol Oct 2002; 98: 762-770.
    • (2002) Ann Surg Oncol Oct , vol.98 , pp. 762-770
    • Allen, P.1    Coit, D.2
  • 5
    • 0023752647 scopus 로고
    • Metastatic patterns in autopsy cases of cutaneous melanoma
    • Akslen L, Heuch I, Hartveit F,: Metastatic patterns in autopsy cases of cutaneous melanoma. Invasion Metastasis 1988; 8: 193-204.
    • (1988) Invasion Metastasis , vol.8 , pp. 193-204
    • Akslen, L.1    Heuch, I.2    Hartveit, F.3
  • 7
    • 0037302053 scopus 로고    scopus 로고
    • Surgical treatment of malignant melanoma
    • DOI 10.1016/S0039-6109(02)00205-0
    • Essner R,: Surgical treatment of malignant melanoma. Surg Clin North Am 2003; 83: 109-156. (Pubitemid 36384363)
    • (2003) Surgical Clinics of North America , vol.83 , Issue.1 , pp. 109-156
    • Essner, R.1
  • 8
    • 50549121134 scopus 로고
    • The distribution of secondary growths in cancer of the breast
    • Paget S,: The distribution of secondary growths in cancer of the breast. Lancet 1889; 1: 571-573.
    • (1889) Lancet , vol.1 , pp. 571-573
    • Paget, S.1
  • 9
    • 0038481970 scopus 로고    scopus 로고
    • The pathogenesis of cancer metastasis: The 'seed and soil' hypothesis revisited
    • DOI 10.1038/nrc1098
    • Fidler I,: The pathogenesis of cancer metastasis: The 'seed and soil' hypothesis revisited. Nat Rev Cancer 2003; 3: 453-458. (Pubitemid 37328849)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.6 , pp. 453-458
    • Fidler, I.J.1
  • 10
    • 0026590057 scopus 로고
    • Technical details of intraoperative lymphatic mapping for early stage melanoma
    • Morton D, Wen D, Wong J, et al.: Technical details of intraoperative lymphatic mapping for early stage melanoma. Arch Surg 1992; 127: 392-399.
    • (1992) Arch Surg , vol.127 , pp. 392-399
    • Morton, D.1    Wen, D.2    Wong, J.3
  • 12
    • 3843119131 scopus 로고    scopus 로고
    • Sentinel lymph node mapping and selective lymphadenectomy: The standard of care for melanoma
    • Leong SP,: Sentinel lymph node mapping and selective lymphadenectomy: The standard of care for melanoma. Curr Treat Options Oncol 2004; 5: 185-194. (Pubitemid 39359619)
    • (2004) Current Treatment Options in Oncology , vol.5 , Issue.3 , pp. 185-194
    • Leong, S.P.L.1
  • 13
    • 0037302080 scopus 로고    scopus 로고
    • Selective sentinel lymphadenectomy for malignant melanoma
    • DOI 10.1016/S0039-6109(02)00206-2
    • Leong SP,: Selective sentinel lymphadenectomy for malignant melanoma. Surg Clin North Am 2003; 83: 157-185, vii. (Pubitemid 36384364)
    • (2003) Surgical Clinics of North America , vol.83 , Issue.1 , pp. 157-185
    • Leong, S.P.L.1
  • 14
    • 0028150831 scopus 로고
    • Natural history of small breast cancers
    • Hellman S,: Natural history of small breast cancer. J Clin Oncol 1994; 12: 2229-2234. (Pubitemid 24356043)
    • (1994) Journal of Clinical Oncology , vol.12 , Issue.10 , pp. 2229-2234
    • Hellman, S.1
  • 15
    • 2942640198 scopus 로고    scopus 로고
    • Paradigm of metastasis for melanoma and breast cancer based on the sentinel lymph node experience
    • Leong SP,: Paradigm of metastasis for melanoma and breast cancer based on the sentinel lymph node experience. Ann Surg Oncol 2004; 11: 192S-197S.
    • (2004) Ann Surg Oncol , vol.11
    • Leong, S.P.1
  • 16
    • 0041309091 scopus 로고    scopus 로고
    • Melanoma of the Skin
    • In: Greene F.L., Page D.L., Fleming I.D., et al., editors., 6th edition. New York: Springer Verlag.
    • Balch C,: Melanoma of the Skin. In:, Greene FL, Page DL, Fleming ID, et al., editors. AJCC cancer staging manual, 6th edition. New York: Springer Verlag; 2002.
    • (2002) AJCC Cancer Staging Manual
    • Balch, C.1
  • 19
    • 77952532215 scopus 로고    scopus 로고
    • Multivariate analysis of prognostic factors among 2,313 patients with stage III melanoma: Comparison of nodal micrometastases versus macrometastases
    • Balch C, Gershenwald J, Soong S, et al.: Multivariate analysis of prognostic factors among 2,313 patients with stage III melanoma: Comparison of nodal micrometastases versus macrometastases. J Clin Oncol 2010; 28: 2452-2459.
    • (2010) J Clin Oncol , vol.28 , pp. 2452-2459
    • Balch, C.1    Gershenwald, J.2    Soong, S.3
  • 20
    • 77954787488 scopus 로고    scopus 로고
    • TNM staging system for cutaneous melanoma and beyond
    • Gershenwald J, Soong S, Balch C,: TNM staging system for cutaneous melanoma and beyond. Ann Surg Oncol 2010; 17: 1475-1477.
    • (2010) Ann Surg Oncol , vol.17 , pp. 1475-1477
    • Gershenwald, J.1    Soong, S.2    Balch, C.3
  • 21
    • 77954952885 scopus 로고    scopus 로고
    • Predicting survival outcome of localized melanoma: An electronic prediction tool based on the AJCC Melanoma Database
    • Soong S, Ding S, Coit D, et al.: Predicting survival outcome of localized melanoma: An electronic prediction tool based on the AJCC Melanoma Database. Ann Surg Oncol 2010; 17: 2006-2014.
    • (2010) Ann Surg Oncol , vol.17 , pp. 2006-2014
    • Soong, S.1    Ding, S.2    Coit, D.3
  • 22
    • 0026518244 scopus 로고
    • Predicting survival and recurrence in localized melanoma: A multivariate approach
    • Soong S, Shaw H, Balch C, et al.: Predicting survival and recurrence in localized melanoma: A multivariate approach. World J Surg 1991; 16: 191-195.
    • (1991) World J Surg , vol.16 , pp. 191-195
    • Soong, S.1    Shaw, H.2    Balch, C.3
  • 23
    • 77954952211 scopus 로고    scopus 로고
    • Conditional survival estimates improve over 5 years for melanoma survivors with node-positive disease
    • Bowles T, Xing Y, Hu C, et al.: Conditional survival estimates improve over 5 years for melanoma survivors with node-positive disease. Ann Surg Oncol 2010; 17: 2015-2023.
    • (2010) Ann Surg Oncol , vol.17 , pp. 2015-2023
    • Bowles, T.1    Xing, Y.2    Hu, C.3
  • 24
    • 77951491533 scopus 로고    scopus 로고
    • Conditional survival estimates improve over time for patients with advanced melanoma: Results from a population-based analysis
    • Xing Y, Chang G, Hu C, et al.: Conditional survival estimates improve over time for patients with advanced melanoma: Results from a population-based analysis. Cancer 2010; 116: 2234-2241.
    • (2010) Cancer , vol.116 , pp. 2234-2241
    • Xing, Y.1    Chang, G.2    Hu, C.3
  • 25
    • 70449629449 scopus 로고    scopus 로고
    • Parametric modeling of localized melanoma prognosis and outcome
    • Ding S, Soong S, Lin H, et al.: Parametric modeling of localized melanoma prognosis and outcome. J Biopharm Stat 2009; 19: 732-747.
    • (2009) J Biopharm Stat , vol.19 , pp. 732-747
    • Ding, S.1    Soong, S.2    Lin, H.3
  • 28
    • 67249148924 scopus 로고    scopus 로고
    • LDH correlation with survival in advanced melanoma from two large, randomised trials (Oblimersen GM301 and EORTC 18951)
    • Agarwala S, Keilholz U, Gilles E, et al.: LDH correlation with survival in advanced melanoma from two large, randomised trials (Oblimersen GM301 and EORTC 18951). Eur J Cancer 2009; 45: 1807-1814.
    • (2009) Eur J Cancer , vol.45 , pp. 1807-1814
    • Agarwala, S.1    Keilholz, U.2    Gilles, E.3
  • 29
    • 0030996579 scopus 로고    scopus 로고
    • Serum S100 - A marker for disease monitoring in metastatic melanoma
    • Henze G, Dummer R, Joller-Jemelka H, et al.: Serum S100-A marker for disease monitoring in metastatic melanoma. Dermatology 1997; 194: 208-212. (Pubitemid 27216030)
    • (1997) Dermatology , vol.194 , Issue.3 , pp. 208-212
    • Henze, G.1    Dummer, R.2    Joller-Jemelka, H.I.3    Boni, R.4    Burg, G.5
  • 31
    • 0032968036 scopus 로고    scopus 로고
    • S100B protein detection in serum is a significant prognostic factor in metastatic melanoma
    • DOI 10.1159/000011989
    • Hauschild A, Engel G, Brenner W, et al.: S100B protein detection in serum is a significant prognostic factor in metastatic melanoma. Oncology 1999; 56: 338-344. (Pubitemid 29240361)
    • (1999) Oncology , vol.56 , Issue.4 , pp. 338-344
    • Hauschild, A.1    Engel, G.2    Brenner, W.3    Glaser, R.4    Monig, H.5    Henze, E.6    Christophers, E.7
  • 33
    • 0027462251 scopus 로고
    • Purification and analysis of growth regulating proteins secreted by a human melanoma cell line
    • Apfel R, Lottspeich F, Hoppe J, et al.: Purification and analysis of growth regulating proteins secreted by a human melanoma cell line. Melanoma Res 1992; 2: 327-336. (Pubitemid 23084479)
    • (1993) Melanoma Research , vol.2 , Issue.5-6 , pp. 327-336
    • Apfel, R.1    Lottspeich, F.2    Hoppe, J.3    Behl, C.4    Durr, G.5    Bogdahn, U.6
  • 39
    • 0035863552 scopus 로고    scopus 로고
    • Increased serum concentration of angiogenic factors in malignant melanoma patients correlates with tumor progression and survival
    • Ugurel S, Rappl G, Tilgen W, et al.: Increased serum concentration of angiogenic factors in malignant melanoma patients correlates with tumor progression and survival. J Clin Oncol 2001; 19: 577-583. (Pubitemid 32112873)
    • (2001) Journal of Clinical Oncology , vol.19 , Issue.2 , pp. 577-583
    • Ugurel, S.1    Rappl, G.2    Tilgen, W.3    Reinhold, U.4
  • 40
    • 63149188174 scopus 로고    scopus 로고
    • Angiopoietin-2 levels are associated with disease progression in metastatic malignant melanoma
    • Helfrich I, Edler L, Sucker A, et al.: Angiopoietin-2 levels are associated with disease progression in metastatic malignant melanoma. Clin Cancer Res 2009; 15: 1384-1392.
    • (2009) Clin Cancer Res , vol.15 , pp. 1384-1392
    • Helfrich, I.1    Edler, L.2    Sucker, A.3
  • 41
    • 33847127827 scopus 로고    scopus 로고
    • Serologic and immunohistochemical prognostic biomarkers of cutaneous malignancies
    • DOI 10.1007/s00403-006-0726-5
    • Utikal J, Schadendorf D, Ugurel S,: Serologic and immunohistochemical prognostic biomarkers of cutaneous malignancies. Arch Dermatol Res 2007; 298: 469-477. (Pubitemid 46295062)
    • (2007) Archives of Dermatological Research , vol.298 , Issue.10 , pp. 469-477
    • Utikal, J.1    Schadendorf, D.2    Ugurel, S.3
  • 43
    • 77952469658 scopus 로고    scopus 로고
    • Phase III trial comparing adjuvant treatment with pegylated interferon Alfa-2b versus observation: Prognostic significance of autoantibodies-EORTC 18991
    • Bouwhuis M, Suciu S, Testori A, et al.: Phase III trial comparing adjuvant treatment with pegylated interferon Alfa-2b versus observation: Prognostic significance of autoantibodies-EORTC 18991. J Clin Oncol 2010; 28: 2460-2466.
    • (2010) J Clin Oncol , vol.28 , pp. 2460-2466
    • Bouwhuis, M.1    Suciu, S.2    Testori, A.3
  • 44
    • 67449138506 scopus 로고    scopus 로고
    • EORTC Melanoma Group and the Nordic Melanoma Group. Autoimmune antibodies and recurrence-free interval in melanoma patients treated with adjuvant interferon
    • Bouwhuis M, Suciu S, Collette S, et al.: EORTC Melanoma Group and the Nordic Melanoma Group. Autoimmune antibodies and recurrence-free interval in melanoma patients treated with adjuvant interferon. J Natl Cancer Inst 2009; 101: 869-877.
    • (2009) J Natl Cancer Inst , vol.101 , pp. 869-877
    • Bouwhuis, M.1    Suciu, S.2    Collette, S.3
  • 46
    • 65549146787 scopus 로고    scopus 로고
    • Serum amyloid A as a prognostic marker in melanoma identified by proteomic profiling
    • Findeisen P, Zapatka M, Peccerella T, et al.: Serum amyloid A as a prognostic marker in melanoma identified by proteomic profiling. J Clin Oncol 2009; 27: 2199-2208.
    • (2009) J Clin Oncol , vol.27 , pp. 2199-2208
    • Findeisen, P.1    Zapatka, M.2    Peccerella, T.3
  • 47
    • 0021743724 scopus 로고
    • A study of tumor progression: The precursor lesions of superficial spreading and nodular melanoma
    • Clark WH, Jr., Elder D, Guerry D, IV, et al.: A study of tumor progression: The precursor lesions of superficial spreading and nodular melanoma. Hum Pathol 1984; 15: 1147-1165. (Pubitemid 15128121)
    • (1984) Human Pathology , vol.15 , Issue.12 , pp. 1147-1165
    • Clark Jr., W.H.1    Elder, D.E.2    Guerry, D.3
  • 51
    • 65549107322 scopus 로고    scopus 로고
    • A multi-marker assay to distinguish benign nevi from malignant melanomas
    • Kashani-Sabet M, Rangel J, Torabian S, et al.: A multi-marker assay to distinguish benign nevi from malignant melanomas. Proc Natl Acad Sci USA 2009; 106: 6268-6272.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 6268-6272
    • Kashani-Sabet, M.1    Rangel, J.2    Torabian, S.3
  • 52
    • 72549092919 scopus 로고    scopus 로고
    • A multi-marker prognostic assay for melanoma
    • Kashani-Sabet M, Venna S, Rangel J, et al.: A multi-marker prognostic assay for melanoma. Clin Cancer Res 2009; 15: 6987-6992.
    • (2009) Clin Cancer Res , vol.15 , pp. 6987-6992
    • Kashani-Sabet, M.1    Venna, S.2    Rangel, J.3
  • 54
    • 37449031252 scopus 로고    scopus 로고
    • Osteopontin as a molecular prognostic marker for melanoma
    • Rangel J, Nosrati M, Torabian S, et al.: Osteopontin as a molecular prognostic marker for melanoma. Cancer 2008; 112: 144-150.
    • (2008) Cancer , vol.112 , pp. 144-150
    • Rangel, J.1    Nosrati, M.2    Torabian, S.3
  • 55
    • 49249129411 scopus 로고    scopus 로고
    • Novel role for RGS1 in melanoma progression
    • Rangel J, Nosrati M, Leong S, et al.: Novel role for RGS1 in melanoma progression. Am J Surg Pathol 2008; 32: 1207-1212.
    • (2008) Am J Surg Pathol , vol.32 , pp. 1207-1212
    • Rangel, J.1    Nosrati, M.2    Leong, S.3
  • 56
    • 0029925375 scopus 로고    scopus 로고
    • Prognostic value of tumor infiltrating lymphocytes in the vertical growth phase of primary cutaneous melanoma
    • DOI 10.1002/(SICI)1097-0142(19960401)77:7<1303::AID-CNCR12>3.0. CO;2-5
    • Clemente CG, et al.: Prognostic value of tumor infiltrating lymphocytes in the vertical growth phase of primary cutaneous melanoma. Cancer 1996; 77: 1303-1310. (Pubitemid 26102328)
    • (1996) Cancer , vol.77 , Issue.7 , pp. 1303-1310
    • Clemente, C.G.1    Mihm Jr., M.C.2    Bufalino, R.3    Zurrida, S.4    Collini, P.5    Cascinelli, N.6
  • 57
    • 0029738930 scopus 로고    scopus 로고
    • Tumour-infiltrating lymphocytes in metastatic malignant melanoma and response to interferon alpha treatment
    • Hakansson A, et al.: Tumour-infiltrating lymphocytes in metastatic malignant melanoma and response to interferon alpha treatment. Br J Cancer 1996; 74: 670-676. (Pubitemid 26300755)
    • (1996) British Journal of Cancer , vol.74 , Issue.5 , pp. 670-676
    • Hakansson, A.1    Gustafsson, B.2    Krysander, L.3    Hakansson, L.4
  • 58
    • 0030052833 scopus 로고    scopus 로고
    • Tumor infiltrating lymphocytes in lymph node melanoma metastases: A histopathologic prognostic indicator and an expression of local immune response
    • Mihm MC, Jr., Clemente C, Cascinelli N,: Tumor infiltrating lymphocytes in lymph node melanoma metastases: A histopathologic prognostic indicator and an expression of local immune response. Lab Invest 1996; 74: 43-47. (Pubitemid 26041007)
    • (1996) Laboratory Investigation , vol.74 , Issue.1 , pp. 43-47
    • Mihm Jr., M.C.1    Clemente, C.G.2    Cascinelli, N.3
  • 59
    • 33745989541 scopus 로고    scopus 로고
    • Neoadjuvant treatment of regional stage IIIB melanoma with high-dose interferon alfa-2b induces objective tumor regression in association with modulation of tumor infiltrating host cellular immune responses
    • DOI 10.1200/JCO.2005.05.2498
    • Moschos SJ, et al.: Neoadjuvant treatment of regional stage IIIB melanoma with high-dose interferon alfa-2b induces objective tumor regression in association with modulation of tumor infiltrating host cellular immune responses. J Clin Oncol 2006; 24: 3164-3171. (Pubitemid 46638955)
    • (2006) Journal of Clinical Oncology , vol.24 , Issue.19 , pp. 3164-3171
    • Moschos, S.J.1    Edington, H.D.2    Land, S.R.3    Rao, U.N.4    Jukic, D.5    Shipe-Spotloe, J.6    Kirkwood, J.M.7
  • 63
    • 0035339880 scopus 로고    scopus 로고
    • High-dose interferon alfa-2b significantly prolongs relapse-free and overall survival compared with the GM2-KLH/QS-21 vaccine in patients with resected stage IIB-III melanoma: Results of intergroup trial E1694/S9512/C509801
    • Kirkwood JM, et al.: High-dose interferon alfa-2b significantly prolongs relapse-free and overall survival compared with the GM2-KLH/QS-21 vaccine in patients with resected stage IIB-III melanoma: Results of intergroup trial E1694/S9512/C509801. J Clin Oncol 2001; 19: 2370-2380. (Pubitemid 32391207)
    • (2001) Journal of Clinical Oncology , vol.19 , Issue.9 , pp. 2370-2380
    • Kirkwood, J.M.1    Ibrahim, J.G.2    Sosman, J.A.3    Sondak, V.K.4    Agarwala, S.S.5    Ernstoff, M.S.6    Rao, U.7
  • 65
    • 1842533233 scopus 로고    scopus 로고
    • A Pooled Analysis of Eastern Cooperative Oncology Group and Intergroup Trials of Adjuvant High-Dose Interferon for Melanoma
    • DOI 10.1158/1078-0432.CCR-1103-3
    • Kirkwood JM, et al.: A pooled analysis of eastern cooperative oncology group and intergroup trials of adjuvant high-dose interferon for melanoma. Clin Cancer Res 2004; 10: 1670-1677. (Pubitemid 38435557)
    • (2004) Clinical Cancer Research , vol.10 , Issue.5 , pp. 1670-1677
    • Kirkwood, J.M.1    Manola, J.2    Ibrahim, J.3    Sondak, V.4    Ernstoff, M.S.5    Rao, U.6
  • 67
    • 0041409703 scopus 로고    scopus 로고
    • Does adjuvant interferon-α for high-risk melanoma provide a worthwhile benefit? A meta-analysis of the randomised trials
    • DOI 10.1016/S0305-7372(03)00074-4
    • Wheatley K, Ives N, Hancock B, et al.: Does adjuvant interferon-alpha for high-risk melanoma provide a worthwhile benefit? A meta-analysis of the randomised trials. Cancer Treat Rev 2003; 29: 241-252. (Pubitemid 37069655)
    • (2003) Cancer Treatment Reviews , vol.29 , Issue.4 , pp. 241-252
    • Wheatley, K.1    Ives, N.2    Hancock, B.3    Gore, M.4    Eggermont, A.5    Suciu, S.6
  • 68
    • 35649015750 scopus 로고    scopus 로고
    • Interferon-alfa as adjuvant therapy for melanoma: An individual patient data meta-analysis of randomised trials
    • Wheatley K, Eggermont A, Kirkwood J,: Interferon-alfa as adjuvant therapy for melanoma: An individual patient data meta-analysis of randomised trials. In ASCO Annual Meeting. 2007. Chicago.
    • ASCO Annual Meeting. 2007. Chicago
    • Wheatley, K.1    Eggermont, A.2    Kirkwood, J.3
  • 69
    • 77950576363 scopus 로고    scopus 로고
    • Interferon alpha adjuvant therapy in patients with high-risk melanoma: A systematic review and meta-analysis
    • Mocellin S, Pasquali S, Rossi CR, et al.: Interferon alpha adjuvant therapy in patients with high-risk melanoma: A systematic review and meta-analysis. J Natl Cancer Inst 2010; 102: 493-501.
    • (2010) J Natl Cancer Inst , vol.102 , pp. 493-501
    • Mocellin, S.1    Pasquali, S.2    Rossi, C.R.3
  • 71
    • 0032954684 scopus 로고    scopus 로고
    • Are locoregional cutaneous metastases in melanoma predictable
    • DOI 10.1007/s10434-999-0315-x
    • Borgstein PJ, Meijer S, van Diest PJ,: Are locoregional cutaneous metastases in melanoma predictable? Ann Surg Oncol 1999; 6: 315-321. (Pubitemid 29221020)
    • (1999) Annals of Surgical Oncology , vol.6 , Issue.3 , pp. 315-321
    • Borgstein, P.J.1    Meijer, S.2    Van Diest, P.J.3
  • 72
    • 0027273476 scopus 로고
    • Selective lymphadenectomy: Emerging role for lymphatic mapping and sentinel node biopsy in the management of early stage melanoma
    • Ross MI, Reintgen D, Balch CM,: Selective lymphadenectomy: Emerging role for lymphatic mapping and sentinel node biopsy in the management of early stage melanoma. Semin Surg Oncol 1993; 9: 219-223. (Pubitemid 23154458)
    • (1993) Seminars in Surgical Oncology , vol.9 , Issue.3 , pp. 219-223
    • Ross, M.I.1    Reintgen, D.2    Balch, C.M.3
  • 75
    • 0026318663 scopus 로고
    • The prognostic implications of microscopic satellites in patients with clinical stage i melanoma
    • Leon P, Daly JM, Synnestredt M, et al.: The prognostic implications of microscopic satellites in patients with clinical stage I melanoma. Arch Surg 1991; 126: 1461-1468.
    • (1991) Arch Surg , vol.126 , pp. 1461-1468
    • Leon, P.1    Daly, J.M.2    Synnestredt, M.3
  • 76
    • 0019783718 scopus 로고
    • Malignant melanoma. Prognostic significance of 'microscopic satellites' in the reticular dermis and subcutaneous fat
    • Day CL, Jr., Harrist TJ, Gorstein F, et al.: Malignant melanoma. Prognostic significance of "microscopic satellites" in the reticular dermis and subcutaneous fat. Ann Surg 1981; 194: 108-112. (Pubitemid 12197159)
    • (1981) Annals of Surgery , vol.194 , Issue.1 , pp. 108-112
    • Day Jr., C.L.1    Harrist, T.J.2    Gorstein, F.3
  • 77
    • 78651031713 scopus 로고
    • Chemotherapy of cancer: Regional perfusion utilizing an extracorporeal circuit
    • Creech O, Jr., Krementz ET, Ryan RF, et al.: Chemotherapy of cancer: Regional perfusion utilizing an extracorporeal circuit. Ann Surg 1958; 148: 616-632.
    • (1958) Ann Surg , vol.148 , pp. 616-632
    • Creech, Jr.O.1    Krementz, E.T.2    Ryan, R.F.3
  • 78
    • 73949133664 scopus 로고    scopus 로고
    • Analysis of factors influencing outcome in patients with in-transit malignant melanoma undergoing isolated limb perfusion using modern treatment parameters
    • Alexander HR, Fraker DL, Bartlett DL, et al.: Analysis of factors influencing outcome in patients with in-transit malignant melanoma undergoing isolated limb perfusion using modern treatment parameters. J Clin Oncol 2010; 28: 114-118.
    • (2010) J Clin Oncol , vol.28 , pp. 114-118
    • Alexander, H.R.1    Fraker, D.L.2    Bartlett, D.L.3
  • 79
    • 73349133717 scopus 로고    scopus 로고
    • Phase II clinical trial of a granulocyte-macrophage colony-stimulating factor-encoding, second-generation oncolytic herpesvirus in patients with unresectable metastatic melanoma
    • Senzer NN, Kaufman HL, Amatruda T, et al.: Phase II clinical trial of a granulocyte-macrophage colony-stimulating factor-encoding, second-generation oncolytic herpesvirus in patients with unresectable metastatic melanoma. J Clin Oncol 2009; 27: 5763-5771.
    • (2009) J Clin Oncol , vol.27 , pp. 5763-5771
    • Senzer, N.N.1    Kaufman, H.L.2    Amatruda, T.3
  • 80
    • 79251496376 scopus 로고    scopus 로고
    • Chemoablation of metastatic melanoma with rose Bengal (PV10)
    • Abstract 8534.
    • Agarwala S, Thompson J, Smithers B, et al.: Chemoablation of metastatic melanoma with rose Bengal (PV10). J Clin Oncol 2010; 619s: Abstract 8534.
    • (2010) J Clin Oncol , vol.619 S
    • Agarwala, S.1    Thompson, J.2    Smithers, B.3
  • 82
    • 0034085811 scopus 로고    scopus 로고
    • Relative reciprocity of NRAS and PTEN/MMAC1 alterations in cutaneous melanoma cell lines
    • Tsao H, Zhang X, Fowlkes K, et al.: Relative reciprocity of NRAS and PTEN/MMAC1 alterations in cutaneous melanoma cell lines. Cancer Res 2000; 60: 1800-1804. (Pubitemid 30207633)
    • (2000) Cancer Research , vol.60 , Issue.7 , pp. 1800-1804
    • Tsao, H.1    Zhang, X.2    Fowlkes, K.3    Haluska, F.G.4
  • 84
    • 63849114060 scopus 로고    scopus 로고
    • Benign nodal nevi frequently harbor the activating V600E BRAF mutation
    • Taube J, Begum S, Shi C, et al.: Benign nodal nevi frequently harbor the activating V600E BRAF mutation. Am J Surg Pathol 2009; 33: 568-571.
    • (2009) Am J Surg Pathol , vol.33 , pp. 568-571
    • Taube, J.1    Begum, S.2    Shi, C.3
  • 85
    • 67349212438 scopus 로고    scopus 로고
    • Melanocytic nevus-like hyperplasia and melanoma in transgenic BRAFV600E mice
    • Goel V, Ibrahim N, Jiang G, et al.: Melanocytic nevus-like hyperplasia and melanoma in transgenic BRAFV600E mice. Oncogene 2009; 28: 2289-2298.
    • (2009) Oncogene , vol.28 , pp. 2289-2298
    • Goel, V.1    Ibrahim, N.2    Jiang, G.3
  • 86
    • 65649147543 scopus 로고    scopus 로고
    • BRafV600E cooperates with Pten loss to elicit metastatic melanoma
    • Dankort D, Curley D, Cartlidge R, et al.: BRafV600E cooperates with Pten loss to elicit metastatic melanoma. Nat Genet 2009; 41: 544-552.
    • (2009) Nat Genet , vol.41 , pp. 544-552
    • Dankort, D.1    Curley, D.2    Cartlidge, R.3
  • 87
    • 77956030786 scopus 로고    scopus 로고
    • Phase i study of PLX4032: Proof of concept for V600E BRAF mutation as a therapeutic target in human cancer [abstract]
    • Flaherty K, Puzanov I, Sosman J, et al.: Phase I study of PLX4032: proof of concept for V600E BRAF mutation as a therapeutic target in human cancer [abstract]. N Engi J Med 2010; 363: 809-819.
    • (2010) N Engi J Med , vol.363 , pp. 809-819
    • Flaherty, K.1    Puzanov, I.2    Sosman, J.3
  • 90
    • 77957350123 scopus 로고    scopus 로고
    • Phase I/II study of GSK2118436, a selective inhibitor of oncogenic mutant BRAF kinase, in patients with metastatic melanoma and other solid tumors
    • Kefford R, Arkenau H, Brown M, et al.: Phase I/II study of GSK2118436, a selective inhibitor of oncogenic mutant BRAF kinase, in patients with metastatic melanoma and other solid tumors. J Clin Oncol 2010; 28: 8503.
    • (2010) J Clin Oncol , vol.28 , pp. 8503
    • Kefford, R.1    Arkenau, H.2    Brown, M.3
  • 91
    • 43749103335 scopus 로고    scopus 로고
    • Phase i pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers
    • Adjei A, Cohen R, Franklin W, et al.: Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers. J Clin Oncol 2008; 26: 2139-2146.
    • (2008) J Clin Oncol , vol.26 , pp. 2139-2146
    • Adjei, A.1    Cohen, R.2    Franklin, W.3
  • 94
    • 33746257209 scopus 로고    scopus 로고
    • The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
    • DOI 10.1038/nrg1879, PII NRG1879
    • Engelman J, Luo J, Cantley L,: The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet 2006; 7: 606-619. (Pubitemid 44100518)
    • (2006) Nature Reviews Genetics , vol.7 , Issue.8 , pp. 606-619
    • Engelman, J.A.1    Luo, J.2    Cantley, L.C.3
  • 95
    • 1342321750 scopus 로고    scopus 로고
    • PI 3-kinase, Akt and cell survival
    • DOI 10.1016/j.semcdb.2004.01.002
    • Downward J,: PI 3-kinase, Akt and cell survival. Semin Cell Dev Biol 2004; 15: 177-182. (Pubitemid 38251646)
    • (2004) Seminars in Cell and Developmental Biology , vol.15 , Issue.2 , pp. 177-182
    • Downward, J.1
  • 96
    • 0033551070 scopus 로고    scopus 로고
    • New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
    • DOI 10.1073/pnas.96.8.4240
    • Cantley L, Neel B,: New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc Natl Acad Sci USA 1999; 96: 4240-4245. (Pubitemid 29190320)
    • (1999) Proceedings of the National Academy of Sciences of the United States of America , vol.96 , Issue.8 , pp. 4240-4245
    • Cantley, L.C.1    Neel, B.G.2
  • 97
    • 0037115394 scopus 로고    scopus 로고
    • Constitutive activation of Akt/protein kinase B in melanoma leads to up-regulation of nuclear factor-κB and tumor progression
    • Dhawan P, Singh A, Ellis D, et al.: Constitutive activation of Akt/protein kinase B in melanoma leads to up-regulation of nuclear factor-κB and tumor progression. Cancer Res 2002; 62: 7335-7342. (Pubitemid 36025257)
    • (2002) Cancer Research , vol.62 , Issue.24 , pp. 7335-7342
    • Dhawan, P.1    Singh, A.B.2    Ellis, D.L.3    Richmond, A.4
  • 98
    • 0030777104 scopus 로고    scopus 로고
    • Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma
    • Guldberg P, thor Straten P, Birck A, et al.: Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma. Cancer Res 1997; 57: 3660-3663. (Pubitemid 27381203)
    • (1997) Cancer Research , vol.57 , Issue.17 , pp. 3660-3663
    • Guldberg, P.1    Thor Straten, P.2    Birck, A.3    Ahrenkiel, V.4    Kirkin, A.F.5    Zeuthen, J.6
  • 99
    • 0012746941 scopus 로고    scopus 로고
    • Allelic losses on chromosome arm 10q and mutation of the PTEN (MMAC1) tumour suppressor gene in primary and metastatic malignant melanomas
    • DOI 10.1007/s004280050477
    • Reifenberger J, Wolter M, Boström J, et al.: Allelic losses on chromosome arm 10q and mutation of the PTEN (MMAC1) tumour suppressor gene in primary and metastatic malignant melanomas. Virchows Arch 2000; 436: 487-493. (Pubitemid 30312165)
    • (2000) Virchows Archiv , vol.436 , Issue.5 , pp. 487-493
    • Reifenberger, J.1    Wolter, M.2    Bostrom, J.3    Buschges, R.4    Schulte, K.W.5    Megahed, M.6    Ruzicka, T.7    Reifenberger, G.8
  • 100
  • 101
    • 14944352371 scopus 로고    scopus 로고
    • Prognostic significance of activated Akt expression in melanoma: A clinicopathologic study of 292 cases
    • Dai D, Martinka M, Li G,: Prognostic significance of activated Akt expression in melanoma: A clinicopathologic study of 292 cases. J Clin Oncol 2005; 23: 1473-1482.
    • (2005) J Clin Oncol , vol.23 , pp. 1473-1482
    • Dai, D.1    Martinka, M.2    Li, G.3
  • 102
    • 84878756656 scopus 로고    scopus 로고
    • ClinicalTrials.gov. Available at: (accessed on June 26, 2010).
    • Dose-escalation study of GSK2126458. ClinicalTrials.gov. Available at: (accessed on June 26, 2010).
    • Dose-escalation Study of GSK2126458
  • 105
    • 66149090765 scopus 로고    scopus 로고
    • Molecular pathogenesis of cutaneous melanocytic neoplasms
    • Ibrahim N, Haluska F,: Molecular pathogenesis of cutaneous melanocytic neoplasms. Annu Rev Pathol 2009; 4: 551-579.
    • (2009) Annu Rev Pathol , vol.4 , pp. 551-579
    • Ibrahim, N.1    Haluska, F.2
  • 107
    • 51049109033 scopus 로고    scopus 로고
    • Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity
    • Maira S, Stauffer F, Brueggen J, et al.: Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity. Mol Cancer Ther 2008; 7: 1851-1863.
    • (2008) Mol Cancer Ther , vol.7 , pp. 1851-1863
    • Maira, S.1    Stauffer, F.2    Brueggen, J.3
  • 108
    • 0023694835 scopus 로고
    • The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus
    • Chabot B, Stephenson D, Chapman V, et al.: The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus. Nature 1988; 335: 88-89.
    • (1988) Nature , vol.335 , pp. 88-89
    • Chabot, B.1    Stephenson, D.2    Chapman, V.3
  • 109
    • 0024280901 scopus 로고
    • The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene
    • Geissler E, Ryan M, Housman D,: The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene. Cell 1988; 55: 185-192.
    • (1988) Cell , vol.55 , pp. 185-192
    • Geissler, E.1    Ryan, M.2    Housman, D.3
  • 110
    • 33749021085 scopus 로고    scopus 로고
    • Somatic activation of KIT in distinct subtypes of melanoma
    • DOI 10.1200/JCO.2006.06.2984
    • Curtin J, Busam K, Pinkel D, et al.: Somatic activation of KIT in distinct subtypes of melanoma. J Clin Oncol 2006; 24: 4340-4346. (Pubitemid 46630793)
    • (2006) Journal of Clinical Oncology , vol.24 , Issue.26 , pp. 4340-4346
    • Curtin, J.A.1    Busam, K.2    Pinkel, D.3    Bastian, B.C.4
  • 112
    • 33646268037 scopus 로고    scopus 로고
    • Multicenter phase II trial of high-dose imatinib mesylate in metastatic melanoma: Significant toxicity with no clinical efficacy
    • DOI 10.1002/cncr.21834
    • Wyman K, Atkins M, Prieto V, et al.: Multicenter phase II trial of high-dose imatinib mesylate in metastatic melanoma: Significant toxicity with no clinical efficacy. Cancer 2006; 106: 2005-2011. (Pubitemid 43673217)
    • (2006) Cancer , vol.106 , Issue.9 , pp. 2005-2011
    • Wyman, K.1    Atkins, M.B.2    Prieto, V.3    Eton, O.4    McDermott, D.F.5    Hubbard, F.6    Byrnes, C.7    Sanders, K.8    Sosman, J.A.9
  • 113
    • 68949132133 scopus 로고    scopus 로고
    • A phase II study of imatinib mesylate (IM) for patients with advanced melanoma harboring somatic alterations of KIT [abstract]
    • Abstract 9001.
    • Carvajal R, Chapman P, Wolchok J, et al.: A phase II study of imatinib mesylate (IM) for patients with advanced melanoma harboring somatic alterations of KIT [abstract]. J Clin Oncol 2009; 27: Abstract 9001.
    • (2009) J Clin Oncol , vol.27
    • Carvajal, R.1    Chapman, P.2    Wolchok, J.3
  • 114
    • 79953901003 scopus 로고    scopus 로고
    • Sunitinib therapy for metastatic melanomas with KIT aberrations
    • Minor D, O'Day S, Kashani-Sabet M, et al.: Sunitinib therapy for metastatic melanomas with KIT aberrations. J Clin Oncol 2010; 28: 8545.
    • (2010) J Clin Oncol , vol.28 , pp. 8545
    • Minor, D.1    O'Day, S.2    Kashani-Sabet, M.3
  • 115
    • 79953896726 scopus 로고    scopus 로고
    • A phase II trial of dasatinib in patients with unresectable locally advanced or stage IV mucosal, acral, and solar melanomas: An Eastern Cooperative Oncology Group study (E2607)
    • Kalinsky K, Lee S, Lawrence D, et al.: A phase II trial of dasatinib in patients with unresectable locally advanced or stage IV mucosal, acral, and solar melanomas: An Eastern Cooperative Oncology Group study (E2607). J Clin Oncol 2010; 28: TPS312.
    • (2010) J Clin Oncol , vol.28
    • Kalinsky, K.1    Lee, S.2    Lawrence, D.3
  • 116
    • 0034773992 scopus 로고    scopus 로고
    • The EGFR family and its ligands in human cancer: Signalling mechanisms and therapeutic opportunities
    • PII S0959804901002301
    • Yarden Y,: The EGFR family and its ligands in human cancer: Signalling mechanisms and therapeutic opportunities. Eur J Cancer 2001; 37: S3-S8. (Pubitemid 32938123)
    • (2001) European Journal of Cancer , vol.37 , Issue.SUPPL. 4
    • Yarden, Y.1
  • 117
    • 0032986967 scopus 로고    scopus 로고
    • Differential expression of epidermal growth factor receptor in melanocytic tumours demonstrated by immunohistochemistry and mRNA in situ hybridization
    • DOI 10.1046/j.1440-0960.1999.00310.x
    • Sparrow L, Heenan P,: Differential expression of epidermal growth factor receptor in melanocytic tumours demonstrated by immunohistochemistry and mRNA in situ hybridization. Australas J Dermatol 1999; 40: 19-24. (Pubitemid 29128086)
    • (1999) Australasian Journal of Dermatology , vol.40 , Issue.1 , pp. 19-24
    • Sparrow, L.E.1    Heenan, P.J.2
  • 118
    • 44949117528 scopus 로고    scopus 로고
    • Heregulin-induced activation of ErbB3 by EGFR tyrosine kinase activity promotes tumor growth and metastasis in melanoma cells
    • DOI 10.1002/ijc.23465
    • Ueno Y, Sakurai H, Tsunoda S, et al.: Heregulin-induced activation of ErbB3 by EGFR tyrosine kinase activity promotes tumor growth and metastasis in melanoma cells. Int J Cancer 2008; 123: 340-347. (Pubitemid 351842018)
    • (2008) International Journal of Cancer , vol.123 , Issue.2 , pp. 340-347
    • Ueno, Y.1    Sakurai, H.2    Tsunoda, S.3    Choo, M.-K.4    Matsuo, M.5    Koizumi, K.6    Saiki, I.7
  • 119
    • 67849099218 scopus 로고    scopus 로고
    • ErbB receptor tyrosine kinases contribute to proliferation of malignant melanoma cells: Inhibition by gefitinib (ZD1839)
    • Djerf E, Trinks C, Abdiu A, et al.: ErbB receptor tyrosine kinases contribute to proliferation of malignant melanoma cells: Inhibition by gefitinib (ZD1839). Melanoma Res 2009; 19: 156-166.
    • (2009) Melanoma Res , vol.19 , pp. 156-166
    • Djerf, E.1    Trinks, C.2    Abdiu, A.3
  • 120
    • 70350110307 scopus 로고    scopus 로고
    • NRG1/ERBB3 signaling in melanocyte development and melanoma: Inhibition of differentiation and promotion of proliferation
    • Buac K, Xu M, Cronin JJ, et al.: NRG1/ERBB3 signaling in melanocyte development and melanoma: Inhibition of differentiation and promotion of proliferation. Pigment Cell Melanoma Res 2009; 22: 773-784.
    • (2009) Pigment Cell Melanoma Res , vol.22 , pp. 773-784
    • Buac, K.1    Xu, M.2    Cronin, J.J.3
  • 121
    • 70349556805 scopus 로고    scopus 로고
    • Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4
    • Prickett T, Agrawal N, Wei X, et al.: Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4. Nat Genet 2009; 41: 1127-1132.
    • (2009) Nat Genet , vol.41 , pp. 1127-1132
    • Prickett, T.1    Agrawal, N.2    Wei, X.3
  • 122
    • 38549115197 scopus 로고    scopus 로고
    • The Met tyrosine kinase receptor in development and cancer
    • Gentile A, Trusolino L, Comoglio P,: The Met tyrosine kinase receptor in development and cancer. Cancer Metastasis Rev 2008; 27: 85-94.
    • (2008) Cancer Metastasis Rev , vol.27 , pp. 85-94
    • Gentile, A.1    Trusolino, L.2    Comoglio, P.3
  • 123
    • 0036993573 scopus 로고    scopus 로고
    • Melanoma development and progression: A conspiracy between tumor and host
    • DOI 10.1046/j.1432-0436.2002.700906.x
    • Hsu MY, Meier F, Herlyn M,: Melanoma development and progression: A conspiracy between tumor and host. Differentiation 2002; 70: 522-536. (Pubitemid 36194317)
    • (2002) Differentiation , vol.70 , Issue.9-10 , pp. 522-536
    • Hsu, M.-Y.1    Meier, F.2    Herlyn, M.3
  • 124
    • 56849116168 scopus 로고    scopus 로고
    • Receptors for the liver synthesized growth factors IGF-1 and HGF/SF in uveal melanoma: Intercorrelation and prognostic implications
    • Economou M, All-Ericsson C, Bykov V, et al.: Receptors for the liver synthesized growth factors IGF-1 and HGF/SF in uveal melanoma: Intercorrelation and prognostic implications. Acta Ophthalmol 2008; 86: 20-25.
    • (2008) Acta Ophthalmol , vol.86 , pp. 20-25
    • Economou, M.1    All-Ericsson, C.2    Bykov, V.3
  • 125
    • 0024376173 scopus 로고
    • Ras Oncogenes in human cancer: A review
    • Bos JL,: Ras oncogenes in human cancer: A review. Cancer Res 1989; 49: 4682-4689. (Pubitemid 19213607)
    • (1989) Cancer Research , vol.49 , Issue.17 , pp. 4682-4689
    • Bos, J.L.1
  • 126
    • 0035908493 scopus 로고    scopus 로고
    • Blocking oncogenic Ras signaling for cancer therapy
    • Adjei AA,: Blocking oncogenic Ras signaling for cancer therapy. J Natl Cancer Inst 2001; 93: 1062-1074. (Pubitemid 32717538)
    • (2001) Journal of the National Cancer Institute , vol.93 , Issue.14 , pp. 1062-1074
    • Adjei, A.A.1
  • 128
    • 67649909568 scopus 로고    scopus 로고
    • Results of a phase III, randomized, placebo-controlled study of sorafenib in combination with carboplatin and paclitaxel as second-line treatment in patients with unresectable stage III or stage IV melanoma
    • Hauschild A, et al.: Results of a phase III, randomized, placebo-controlled study of sorafenib in combination with carboplatin and paclitaxel as second-line treatment in patients with unresectable stage III or stage IV melanoma. J Clin Oncol 2010; 27: 2823-2830.
    • (2010) J Clin Oncol , vol.27 , pp. 2823-2830
    • Hauschild, A.1
  • 129
    • 77956033802 scopus 로고    scopus 로고
    • Final results of E2603: A double-blind, randomized phase III trial comparing carboplatin (C)/paclitaxel (P) with or without sorafenib (S) in metastatic melanoma
    • Abstr 8511: 613s
    • Flaherty K, Lee S, Schuchter L, et al.: Final results of E2603: a double-blind, randomized phase III trial comparing carboplatin (C)/paclitaxel (P) with or without sorafenib (S) in metastatic melanoma. J Clin Oncol 2010; 28: 15S, Abstr 8511: 613s
    • (2010) J Clin Oncol , vol.28
    • Flaherty, K.1    Lee, S.2    Schuchter, L.3
  • 131
    • 77957350123 scopus 로고    scopus 로고
    • Phase I/II study of GSK2118436, a selective inhibitor of oncogenic mutant BRAF inase, in patients with metastatic melanoma and other solid tumors
    • Abstr 8503: 611s.
    • Kefford R, Arkenau H, Brown M, et al.: Phase I/II study of GSK2118436, a selective inhibitor of oncogenic mutant BRAF inase, in patients with metastatic melanoma and other solid tumors. J Clin Oncol 2010; 28: 15S, Abstr 8503: 611s.
    • (2010) J Clin Oncol , vol.28
    • Kefford, R.1    Arkenau, H.2    Brown, M.3
  • 132
    • 79251570621 scopus 로고    scopus 로고
    • Clinical responses to AZD6244 (ARRY-142886)-based combination therapy stratified by gene mutations in patients with metastatic melanoma
    • Abstr 8501: 611s
    • Patel S, Lazar A, Mahoney S, et al.: Clinical responses to AZD6244 (ARRY-142886)-based combination therapy stratified by gene mutations in patients with metastatic melanoma. J Clin Oncol 2010; 28: 15S, Abstr 8501: 611s
    • (2010) J Clin Oncol , vol.28
    • Patel, S.1    Lazar, A.2    Mahoney, S.3
  • 133
    • 41049114747 scopus 로고    scopus 로고
    • How to make a melanoma: What do we know of the primary clonal events?
    • Review.
    • Bennett D,: How to make a melanoma: What do we know of the primary clonal events? Pigment Cell Melanoma Res 2008; 21: 27-238. Review.
    • (2008) Pigment Cell Melanoma Res , vol.21 , pp. 27-238
    • Bennett, D.1
  • 137
    • 58149260596 scopus 로고    scopus 로고
    • KIT gene mutations and copy number in melanoma subtypes
    • Beadling C, et al. KIT gene mutations and copy number in melanoma subtypes. Clin Cancer Res 2008; 14: 6821-6828.
    • (2008) Clin Cancer Res , vol.14 , pp. 6821-6828
    • Beadling, C.1
  • 138
    • 42949128595 scopus 로고    scopus 로고
    • Major response to imatinib mesylate in KIT-mutated melanoma
    • Hodi FS, et al. Major response to imatinib mesylate in KIT-mutated melanoma. J Clin Oncol 2008; 26: 2046-2051.
    • (2008) J Clin Oncol , vol.26 , pp. 2046-2051
    • Hodi, F.S.1


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