-
1
-
-
0037374498
-
The price of innovation: New estimates of drug development costs
-
J. DiMasi, R. Hansen, H. Grabowski, "The price of innovation: new estimates of drug development costs" J Health Econ, Vol. 22(2), pp. 151-85, 2003.
-
(2003)
J Health Econ
, vol.22
, Issue.2
, pp. 151-185
-
-
DiMasi, J.1
Hansen, R.2
Grabowski, H.3
-
2
-
-
33644663961
-
Process analytical technologies in the pharmaceutical industry: The FDA's PAT initiative
-
D. Hinz, "Process analytical technologies in the pharmaceutical industry: the FDA's PAT initiative" Anal Bioanal Chem, Vol. 384, pp. 1036-1042, 2006.
-
(2006)
Anal Bioanal Chem
, vol.384
, pp. 1036-1042
-
-
Hinz, D.1
-
3
-
-
0036489213
-
The evolving role of information technology in the drug discovery process
-
J. Augen, "The evolving role of information technology in the drug discovery process" Drug Discovery Today, Vol. 7, no. 5, pp. 315-23. 2002.
-
(2002)
Drug Discovery Today
, vol.7
, Issue.5
, pp. 315-323
-
-
Augen, J.1
-
4
-
-
22544454480
-
Systems modeling: A pathway to drug discovery
-
P. Rajasethupathy, S.J. Vayttaden and U.S. Bhalla, "Systems modeling: a pathway to drug discovery" Current Opinion in Chemical Biology, Vol. 9, no. 4, pp. 400-406, 2005.
-
(2005)
Current Opinion in Chemical Biology
, vol.9
, Issue.4
, pp. 400-406
-
-
Rajasethupathy, P.1
Vayttaden, S.J.2
Bhalla, U.S.3
-
7
-
-
84879748714
-
-
Marvin 4.1.7, 2007, ChemAxon, available via http://www.chemaxon.com
-
(2007)
Marvin 4.1.7
-
-
-
8
-
-
0009142039
-
MOPAC, A semi-empirical molecular orbital program
-
J.J.P. Stewart, "MOPAC, A Semi-Empirical Molecular Orbital Program" QCPE, pp. 455, 1983.
-
(1983)
QCPE
, pp. 455
-
-
Stewart, J.J.P.1
-
10
-
-
6944226371
-
Evaluation of fresh and cryopreserved hepatocytes as in vitro drug metabolism tools for the prediction of metabolic clearance
-
D.F. McGinnity, M.G. Soars, R.A. Urbanowicz, and R.J. Riley, "Evaluation of Fresh and Cryopreserved Hepatocytes as In Vitro Drug Metabolism Tools for the Prediction of Metabolic Clearance" Drug Metabolism And Disposition, Vol. 32, no. 11, pp. 1247-53, 2004.
-
(2004)
Drug Metabolism and Disposition
, vol.32
, Issue.11
, pp. 1247-1253
-
-
McGinnity, D.F.1
Soars, M.G.2
Urbanowicz, R.A.3
Riley, R.J.4
-
11
-
-
0036893242
-
Development of a novel in vitro model to predict hepatic clearance using fresh, cryopreserved, and sandwich-cultured hepatocytes
-
Y.Y. Lau, E. Sapidou, X. Cui, R.E. White, K.C. Cheng, "Development of a novel in vitro model to predict hepatic clearance using fresh, cryopreserved, and sandwich-cultured hepatocytes." Drug Metab Dispos, Vol. 30(12), pp. 1446-54, 2002.
-
(2002)
Drug Metab Dispos
, vol.30
, Issue.12
, pp. 1446-1454
-
-
Lau, Y.Y.1
Sapidou, E.2
Cui, X.3
White, R.E.4
Cheng, K.C.5
-
12
-
-
0033576604
-
Combining in vitro and in vivo pharmacokinetic data for prediction of hepatic drug clearance in humans by artificial neural networks and multivariate statistical techniques
-
G. Schneider, P. Coassolo, T. Lavé, "Combining in vitro and in vivo pharmacokinetic data for prediction of hepatic drug clearance in humans by artificial neural networks and multivariate statistical techniques" J Med Chem, Vol. 42(25), pp. 5072-6, 1999.
-
(1999)
J Med Chem
, vol.42
, Issue.25
, pp. 5072-5076
-
-
Schneider, G.1
Coassolo, P.2
Lavé, T.3
-
13
-
-
33947125972
-
A new method for predicting human hepatic clearance from in vitro experimental data using molecular descriptors
-
S. Lee, D. Kim, "A new method for predicting human hepatic clearance from in vitro experimental data using molecular descriptors" Arch Pharm Res, Vol. 30(2):182-90, 2007.
-
(2007)
Arch Pharm Res
, vol.30
, Issue.2
, pp. 182-190
-
-
Lee, S.1
Kim, D.2
-
14
-
-
0028342648
-
Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance
-
J.B. Houston, "Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance" Biochem Pharmacol, Vol. 47(9), pp. 1469-79, 1994.
-
(1994)
Biochem Pharmacol
, vol.47
, Issue.9
, pp. 1469-1479
-
-
Houston, J.B.1
-
15
-
-
0344333422
-
Prediction of hepatic clearance from microsomes, hepatocytes, and liver slices
-
J.B. Houston, D.J. Carlile, "Prediction of hepatic clearance from microsomes, hepatocytes, and liver slices" Drug Metab Rev, Vol. 29(4), pp. 891-922, 1997.
-
(1997)
Drug Metab Rev
, vol.29
, Issue.4
, pp. 891-922
-
-
Houston, J.B.1
Carlile, D.J.2
-
16
-
-
0030918716
-
Integration of in vitro data into allometric scaling to predict hepatic metabolic clearance in man: Application to 10 extensively metabolized drugs
-
T. Lave, S. Dupin, C. Schmitt, R.C. Chou, D. Jaeck, P. Coassolo, "Integration of in vitro data into allometric scaling to predict hepatic metabolic clearance in man: application to 10 extensively metabolized drugs" J Pharm Sci, Vol. 86(5), pp. 584-90, 1997.
-
(1997)
J Pharm Sci
, vol.86
, Issue.5
, pp. 584-590
-
-
Lave, T.1
Dupin, S.2
Schmitt, C.3
Chou, R.C.4
Jaeck, D.5
Coassolo, P.6
-
17
-
-
0034897160
-
Prediction of hepatic metabolic clearance: Comparison and assessment of prediction models
-
J. Zuegge, G. Schneider, P. Coassolo, T. Lavé, "Prediction of hepatic metabolic clearance: comparison and assessment of prediction models" Clin Pharmacokinet, Vol. 40(7), pp. 553-63, 2001.
-
(2001)
Clin Pharmacokinet
, vol.40
, Issue.7
, pp. 553-563
-
-
Zuegge, J.1
Schneider, G.2
Coassolo, P.3
Lavé, T.4
-
18
-
-
3543026365
-
Comparison of the use of liver models for predicting drug clearance using in vitro kinetic data from hepatic microsomes and isolated hepatocytes
-
K. Ito, J.B. Houston, "Comparison of the use of liver models for predicting drug clearance using in vitro kinetic data from hepatic microsomes and isolated hepatocytes" Pharm Res, Vol. 21(5), pp. 785-92, 2004.
-
(2004)
Pharm Res
, vol.21
, Issue.5
, pp. 785-792
-
-
Ito, K.1
Houston, J.B.2
-
19
-
-
70350215756
-
At the biological modeling and simulation frontier
-
C. A. Hunt, G. E. Ropella, T. N. Lam, J. Tang, S. H. Kim, J. A. Engelberg, S. Sheikh-Bahaei, "At the biological modeling and simulation frontier" Pharm Res, Vol. 26(11), pp. 2369-400, 2009.
-
(2009)
Pharm Res
, vol.26
, Issue.11
, pp. 2369-2400
-
-
Hunt, C.A.1
Ropella, G.E.2
Lam, T.N.3
Tang, J.4
Kim, S.H.5
Engelberg, J.A.6
Sheikh-Bahaei, S.7
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