메뉴 건너뛰기




Volumn , Issue , 2010, Pages 355-359

Predicting human hepatic clearance using hypernet neural networks

Author keywords

[No Author keywords available]

Indexed keywords

ACCURATE PREDICTION; COMPLEX NATURE; FEATURE SPACE; HUMAN LIVER; PHYSICOCHEMICAL PROPERTY; PREDICTION PERFORMANCE; QUADRATIC DISCRIMINANTS; SIMPLE LEARNING ALGORITHMS;

EID: 79953887472     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: None     Document Type: Conference Paper
Times cited : (2)

References (19)
  • 1
    • 0037374498 scopus 로고    scopus 로고
    • The price of innovation: New estimates of drug development costs
    • J. DiMasi, R. Hansen, H. Grabowski, "The price of innovation: new estimates of drug development costs" J Health Econ, Vol. 22(2), pp. 151-85, 2003.
    • (2003) J Health Econ , vol.22 , Issue.2 , pp. 151-185
    • DiMasi, J.1    Hansen, R.2    Grabowski, H.3
  • 2
    • 33644663961 scopus 로고    scopus 로고
    • Process analytical technologies in the pharmaceutical industry: The FDA's PAT initiative
    • D. Hinz, "Process analytical technologies in the pharmaceutical industry: the FDA's PAT initiative" Anal Bioanal Chem, Vol. 384, pp. 1036-1042, 2006.
    • (2006) Anal Bioanal Chem , vol.384 , pp. 1036-1042
    • Hinz, D.1
  • 3
    • 0036489213 scopus 로고    scopus 로고
    • The evolving role of information technology in the drug discovery process
    • J. Augen, "The evolving role of information technology in the drug discovery process" Drug Discovery Today, Vol. 7, no. 5, pp. 315-23. 2002.
    • (2002) Drug Discovery Today , vol.7 , Issue.5 , pp. 315-323
    • Augen, J.1
  • 7
    • 84879748714 scopus 로고    scopus 로고
    • Marvin 4.1.7, 2007, ChemAxon, available via http://www.chemaxon.com
    • (2007) Marvin 4.1.7
  • 8
    • 0009142039 scopus 로고
    • MOPAC, A semi-empirical molecular orbital program
    • J.J.P. Stewart, "MOPAC, A Semi-Empirical Molecular Orbital Program" QCPE, pp. 455, 1983.
    • (1983) QCPE , pp. 455
    • Stewart, J.J.P.1
  • 10
    • 6944226371 scopus 로고    scopus 로고
    • Evaluation of fresh and cryopreserved hepatocytes as in vitro drug metabolism tools for the prediction of metabolic clearance
    • D.F. McGinnity, M.G. Soars, R.A. Urbanowicz, and R.J. Riley, "Evaluation of Fresh and Cryopreserved Hepatocytes as In Vitro Drug Metabolism Tools for the Prediction of Metabolic Clearance" Drug Metabolism And Disposition, Vol. 32, no. 11, pp. 1247-53, 2004.
    • (2004) Drug Metabolism and Disposition , vol.32 , Issue.11 , pp. 1247-1253
    • McGinnity, D.F.1    Soars, M.G.2    Urbanowicz, R.A.3    Riley, R.J.4
  • 11
    • 0036893242 scopus 로고    scopus 로고
    • Development of a novel in vitro model to predict hepatic clearance using fresh, cryopreserved, and sandwich-cultured hepatocytes
    • Y.Y. Lau, E. Sapidou, X. Cui, R.E. White, K.C. Cheng, "Development of a novel in vitro model to predict hepatic clearance using fresh, cryopreserved, and sandwich-cultured hepatocytes." Drug Metab Dispos, Vol. 30(12), pp. 1446-54, 2002.
    • (2002) Drug Metab Dispos , vol.30 , Issue.12 , pp. 1446-1454
    • Lau, Y.Y.1    Sapidou, E.2    Cui, X.3    White, R.E.4    Cheng, K.C.5
  • 12
    • 0033576604 scopus 로고    scopus 로고
    • Combining in vitro and in vivo pharmacokinetic data for prediction of hepatic drug clearance in humans by artificial neural networks and multivariate statistical techniques
    • G. Schneider, P. Coassolo, T. Lavé, "Combining in vitro and in vivo pharmacokinetic data for prediction of hepatic drug clearance in humans by artificial neural networks and multivariate statistical techniques" J Med Chem, Vol. 42(25), pp. 5072-6, 1999.
    • (1999) J Med Chem , vol.42 , Issue.25 , pp. 5072-5076
    • Schneider, G.1    Coassolo, P.2    Lavé, T.3
  • 13
    • 33947125972 scopus 로고    scopus 로고
    • A new method for predicting human hepatic clearance from in vitro experimental data using molecular descriptors
    • S. Lee, D. Kim, "A new method for predicting human hepatic clearance from in vitro experimental data using molecular descriptors" Arch Pharm Res, Vol. 30(2):182-90, 2007.
    • (2007) Arch Pharm Res , vol.30 , Issue.2 , pp. 182-190
    • Lee, S.1    Kim, D.2
  • 14
    • 0028342648 scopus 로고
    • Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance
    • J.B. Houston, "Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance" Biochem Pharmacol, Vol. 47(9), pp. 1469-79, 1994.
    • (1994) Biochem Pharmacol , vol.47 , Issue.9 , pp. 1469-1479
    • Houston, J.B.1
  • 15
    • 0344333422 scopus 로고    scopus 로고
    • Prediction of hepatic clearance from microsomes, hepatocytes, and liver slices
    • J.B. Houston, D.J. Carlile, "Prediction of hepatic clearance from microsomes, hepatocytes, and liver slices" Drug Metab Rev, Vol. 29(4), pp. 891-922, 1997.
    • (1997) Drug Metab Rev , vol.29 , Issue.4 , pp. 891-922
    • Houston, J.B.1    Carlile, D.J.2
  • 16
    • 0030918716 scopus 로고    scopus 로고
    • Integration of in vitro data into allometric scaling to predict hepatic metabolic clearance in man: Application to 10 extensively metabolized drugs
    • T. Lave, S. Dupin, C. Schmitt, R.C. Chou, D. Jaeck, P. Coassolo, "Integration of in vitro data into allometric scaling to predict hepatic metabolic clearance in man: application to 10 extensively metabolized drugs" J Pharm Sci, Vol. 86(5), pp. 584-90, 1997.
    • (1997) J Pharm Sci , vol.86 , Issue.5 , pp. 584-590
    • Lave, T.1    Dupin, S.2    Schmitt, C.3    Chou, R.C.4    Jaeck, D.5    Coassolo, P.6
  • 17
    • 0034897160 scopus 로고    scopus 로고
    • Prediction of hepatic metabolic clearance: Comparison and assessment of prediction models
    • J. Zuegge, G. Schneider, P. Coassolo, T. Lavé, "Prediction of hepatic metabolic clearance: comparison and assessment of prediction models" Clin Pharmacokinet, Vol. 40(7), pp. 553-63, 2001.
    • (2001) Clin Pharmacokinet , vol.40 , Issue.7 , pp. 553-563
    • Zuegge, J.1    Schneider, G.2    Coassolo, P.3    Lavé, T.4
  • 18
    • 3543026365 scopus 로고    scopus 로고
    • Comparison of the use of liver models for predicting drug clearance using in vitro kinetic data from hepatic microsomes and isolated hepatocytes
    • K. Ito, J.B. Houston, "Comparison of the use of liver models for predicting drug clearance using in vitro kinetic data from hepatic microsomes and isolated hepatocytes" Pharm Res, Vol. 21(5), pp. 785-92, 2004.
    • (2004) Pharm Res , vol.21 , Issue.5 , pp. 785-792
    • Ito, K.1    Houston, J.B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.