Human mammaglobin: A superior marker for reverse-transcriptase PCR in detecting circulating tumor cells in breast cancer patients

Biomarkers in Medicine

Volumn 5, Issue 2, 2011, Pages 249-260

  Li, Guangliang ^a   Zhang, Jing ^a   Jin, Ketao ^a,b   He, Kuifeng ^a   Wang, Haohao ^a   Lu, Haiqi ^c   Teng, Lisong ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b WENZHOU MEDICAL UNIVERSITY   (China)

^c ZHEJIANG UNIVERSITY   (China)

Author keywords

breast cancer; circulating tumor cell; human mammaglobin; reverse transcriptase PCR

Indexed keywords

BIOLOGICAL MARKER; CARCINOEMBRYONIC ANTIGEN; CHORIONIC GONADOTROPIN BETA SUBUNIT; CYTOKERATIN 19; CYTOKERATIN 20; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; MAMMAGLOBIN; MASPIN; MUCIN 1; PARATHYROID HORMONE RELATED PROTEIN;

AMINO ACID SEQUENCE; BREAST CANCER; CANCER DIAGNOSIS; CANCER GROWTH; CANCER PATIENT; CONTROLLED STUDY; GENE LOCATION; HUMAN; HUMAN CELL; HUMAN TISSUE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; SENSITIVITY AND SPECIFICITY; TUMOR BIOPSY; TUMOR CELL; TUMOR EMBOLISM;

BREAST NEOPLASMS; FEMALE; HUMANS; NEOPLASM PROTEINS; NEOPLASTIC CELLS, CIRCULATING; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR MARKERS, BIOLOGICAL; UTEROGLOBIN;

EID: 79953873115     PISSN: 17520363     EISSN: None     Source Type: Journal    
DOI: 10.2217/bmm.11.20     Document Type: Review

References (67)

1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ: Cancer statistics, 2009. CA Cancer J. Clin. 59(4), 225-249 (2009).
2. Diel IJ, Kaufmann M, Costa SD et al.: Micrometastatic breast cancer cells in bone marrow at primary surgery: prognostic value in comparison with nodal status. J. Natl Cancer Inst. 88(22), 1652-1658 (1996). (Pubitemid 26384811)
3. Cristofanilli M, Budd GT, Ellis MJ et al.: Circulating tumor cells, disease progression, and survival in metastatic breast cancer. N. Engl. J. Med. 351(8), 781-791 (2004). (Pubitemid 39095313)
4. Cristofanilli M, Hayes DF, Budd GT et al.: Circulating tumor cells: a novel prognostic factor for newly diagnosed metastatic breast cancer. J. Clin. Oncol. 23(7), 1420-1430 (2005).
5. Hayes DF, Cristofanilli M, Budd GT et al.: Circulating tumor cells at each follow-up time point during therapy of metastatic breast cancer patients predict progression-free and overall survival. Clin. Cancer Res. 12(14 Pt 1), 4218-4224 (2006).
6. Budd GT, Cristofanilli M, Ellis MJ et al.: Circulating tumor cells versus imaging-predicting overall survival in metastatic breast cancer. Clin. Cancer Res. 12(21), 6403-6409 (2006). (Pubitemid 44799711)
7. Ashworth TR: A case of cancer in which cells similar to those in the tumours were seen in the blood after death. Australian Med. J. 14, 146 (1869).
8. Lacroix M: Signifcance, detection and markers of disseminated breast cancer cells. Endocr. Relat. Cancer 13(4), 1033-1067 (2006). (Pubitemid 46212562)
9. Grünewald K, Haun M, Urbanek M et al.: Mammaglobin gene expression: a superior marker of breast cancer cells in peripheral blood in comparison to epidermal-growth-factor receptor and cytokeratin-19. Lab. Invest. 80(7), 1071-1077 (2000). (Pubitemid 30483225)
10. Ntoulia M, Stathopoulou A, Ignatiadis M et al.: Detection of mammaglobin A-mRNA-positive circulating tumor cells in peripheral blood of patients with operable breast cancer with nested RT-PCR. Clin. Biochem. 39(9), 879-887 (2006). (Pubitemid 44363084)
11. Watson MA, Fleming TP: Mammaglobin, a mammary-specifc member of the uteroglobin gene family, is overexpressed in human breast cancer. Cancer Res. 56(4), 860-865 (1996). (Pubitemid 26055478)
12. Watson MA, Darrow C, Zimonjic DB, Popescu NC, Fleming TP: Structure and transcriptional regulation of the human mammaglobin gene, a breast cancer associated member of the uteroglobin gene family localized to chromosome 11q13. Oncogene 16(6), 817-824 (1998). (Pubitemid 28076094)
13. Ni J, Kalff-Suske M, Gentz R, Schageman J, Beato M, Klug J: All human genes of the uteroglobin family are localized on chromosome 11q12.2 and form a dense cluster. Ann. NY Acad. Sci. 923, 25-42 (2000). (Pubitemid 32050853)
14. Leygue E, Snell L, Dotzlaw H et al.: Mammaglobin, a potential marker of breast cancer nodal metastasis. J. Pathol. 189(1), 28-33 (1999). (Pubitemid 29406815)
15. Zach O, Kasparu H, Krieger O, Hehenwarter W, Girschikofsky M, Lutz D: Detection of circulating mammary carcinoma cells in the peripheral blood of breast cancer patients via a nested reverse transcriptase polymerase chain reaction assay for mammaglobin mRNA. J. Clin. Oncol. 17(7), 2015-2019 (1999). (Pubitemid 29318829)
16. Gargano G, Agnese V, Calò V et al.: Detection and quantifcation of mammaglobin in the blood of breast cancer patients: can it be useful as a potential clinical marker? Preliminary results of a GOIM (Gruppo Oncologico dell'Italia Meridionale) prospective study. Ann. Oncol. 17(Suppl. 7), 741-745 (2006).
17. Roncella S, Ferro P, Bacigalupo B et al.: Human mammaglobin mRNA is a reliable molecular marker for detecting occult breast cancer cells in peripheral blood. J. Exp. Clin. Cancer Res. 24(2), 265-271 (2005). (Pubitemid 41039611)
18. Silva AL, Tomé MJ, Correia AE, Passos-Coelho JL: Human mammaglobin RT-PCR assay for detection of occult breast cancer cells in hematopoietic products. Ann. Oncol. 13(3), 422-429 (2002). (Pubitemid 34705004)
19. Suchy B, Austrup F, Driesel G et al.: Detection of mammaglobin expressing cells in blood of breast cancer patients. Cancer Lett. 158(2), 171-178 (2000).
20. Cerveira N, Torres L, Rocha P et al.: Highly sensitive detection of the MGB1 transcript (mammaglobin) in the peripheral blood of breast cancer patients. Int. J. Cancer 108(4), 592-595 (2004). (Pubitemid 38036661)
21. Reinholz MM, Nibbe A, Jonart LM et al.: Evaluation of a panel of tumor markers for molecular detection of circulating cancer cells in women with suspected breastcancer. Clin. Cancer Res. 11(10), 3722-3732 (2005). (Pubitemid 40685589)
22. Watson MA, Dintzis S, Darrow CM et al.: Mammaglobin expression in primary, metastatic, and occult breast cancer. Cancer Res. 59(13), 3028-3031 (1999). (Pubitemid 29315994)
23. Ferrucci PF, Rabascio C, Mazzetta C et al.: Mammaglobin expression in leukapheresis products is a predictive marker of poor prognosis in women with high-risk breast cancer. Clin. Cancer Res. 10(18 Pt 1), 6039-6046 (2004). (Pubitemid 39287508)
24. Silva JM, Dominguez G, Silva J et al.: Detection of epithelial messenger RNA in the plasma of breast cancer patients is associated with poor prognosis tumor characteristics. Clin. Cancer Res. 7(9), 2821-2825 (2001). (Pubitemid 32911391)
25. Went PT, Lugli A, Meier S et al.: Frequent EpCam protein expression in human carcinomas. Hum. Pathol. 35, 122-128 (2004). (Pubitemid 38133932)
26. Willipinski-Stapelfeldt B, Riethdorf S, Assmann V et al.: Changes in cytoskeletal protein composition indicative of an epithelial-mesenchymal transition in human micrometastatic and primary breast carcinoma cells. Clin. Cancer Res. 11, 8006-8014 (2005). (Pubitemid 41698741)
27. Rack B, Schindlbeck C, Hofmann S et al.: Circulating tumor cells (CTCs) in peripheral blood of primary breast cancer patients. Proc Am. Soc Clin. Oncol. 25, 10595 (2007) (Abstract 10595).
28. Xenidis N, PerrakiM, Kafousi M et al.: Predictive and prognostic value of peripheral blood cytokeratin-19 mRNA-positive cells detected by real-time polymerase chain reaction in node-negative breast cancer patients. J. Clin. Oncol. 24, 3756-3762 (2006). (Pubitemid 46622314)
29. Ignatiadis M, Xenidis N, Perraki M et al.: Different prognostic value of cytokeratin-19 mRNA-positive circulating tumor cells according to estrogen receptor and HER2 status in early breast cancer. J. Clin. Oncol. 25, 5194-5202 (2007). (Pubitemid 350232250)
30. Van der Auwera I, Peeters D, Benoy IH et al.: Circulating tumour cell detection: a direct comparison between the CellSearch System, the AdnaTest and CK-19/mammaglobin RT-PCR in patients with metastatic breast cancer. Br. J. Cancer 102(2), 276-284(2010).
31. Min CJ, Tafra L, Verbanac KM: Identifcation of superior markers for polymerase chain reaction detection of breast cancer metastases in sentinel lymph nodes. Cancer Res. 58(20), 4581-4584 (1998). (Pubitemid 28480618)
32. Corradini P, Voena C, Astolf M et al.: Maspin and mammaglobin genes are specifc markers for RT-PCR detection of minimal residual disease in patients with breast cancer. Ann. Oncol. 12(12), 1693-1698 (2001). (Pubitemid 34105658)
33. Fabisiewicz A, Kulik J, Kober P, Brewczynska E, Pienkowski T, Siedlecki JA: Detection of circulating breast cancer cells in peripheral blood by a two-marker reverse transcriptase-polymerase chain reaction assay. Acta Biochim. Pol. 51(3), 747-755 (2004). (Pubitemid 39296928)
34. Lin YC, Wu Chou YH, Liao IC, Cheng AJ: The expression of mammaglobin mRNA in peripheral blood of metastatic breast cancer patients as an adjunct to serum tumor markers. Cancer Lett. 191(1), 93-99 (2003).
35. de Cremoux P, Extra JM, Denis MG et al.: Detection of MUC1-expressing mammary carcinoma cells in the peripheral blood of breast cancer patients by real-time polymerase chain reaction. Clin. Cancer Res. 6(8), 3117-3122 (2000). (Pubitemid 30637736)
36. Gradilone A, Gazzaniga P, Silvestri I et al.: Detection of CK19, CK20 and EGFR mRNAs in peripheral blood of carcinoma patients: correlation with clinical stage of disease. Oncol. Rep. 10(1), 217-222 (2003).
37. De Luca A, Pignata S, Casamassimi A et al.: Detection of circulating tumor cells in carcinoma patients by a novel epidermal growth factor receptor reverse transcription-PCR assay. Clin. Cancer Res. 6(4), 1439-1444 (2000). (Pubitemid 30226232)
38. Wulf GG, Jürgens B, Liersch T et al.: Reverse transcriptase/ polymerase chain reaction analysis of parathyroid hormone-related protein for the detection of tumor cell dissemination in the peripheral blood and bone marrow of patients with breast cancer. J. Cancer Res. Clin. Oncol. 123(9), 514-521 (1997). (Pubitemid 27436012)
39. Ignatiadis M, Kallergi G, Ntoulia M et al.: Prognostic value of the molecular detection of circulating tumor cells using a multimarker reverse transcription-PCR assay for cytokeratin 19, mammaglobin A, and HER2 in early breast cancer. Clin. Cancer Res. 14(9), 2593-2600 (2008).
40. Sasaki E, Tsunoda N, Hatanaka Y, Mori N, Iwata H, Yatabe Y: Breast-specifc expression of MGB1/mammaglobin: an examination of 480 tumors from various organs and clinicopathological analysis of MGB1-positive breast cancers. Mod. Pathol. 20(2), 208-214 (2007). (Pubitemid 46422175)
41. Benoy IH, Elst H, Van Dam P et al.: Detection of circulating tumour cells in blood by quantitative real-time RT-PCR: effect of pre-analytical time. Clin. Chem. Lab. Med. 44(9), 1082-1087 (2006). (Pubitemid 44370926)
42. Mitas M, Mikhitarian K, Walters C et al.: Quantitative real-time RT-PCR detection of breast cancer micrometastasis using a multigene marker panel. Int. J. Cancer 93(2), 162-171 (2001). (Pubitemid 32574270)
43. Fortunato L, Mascaro A, Baldi A et al.: Positive bone marrow biopsy is associated with a decreased disease-free survival in patients with operable breast cancer. Ann. Surg. Oncol. 16(11), 3010-3019 (2009).
44. Ballestrero A, Garuti A, Bertolotto M et al.: Effect of different cytokines on mammaglobin and maspin gene expression in normal leukocytes: possible relevance to the assays for the detection of micrometastatic breast cancer. Br. J. Cancer 92(10), 1948-1952 (2005). (Pubitemid 40826146)
45. Houghton RL, Dillon DC, Molesh DA et al.: Transcriptional complementarity in breast cancer: application to detection of circulating tumor cells. Mol. Diagn. 6(2), 79-91 (2001). (Pubitemid 32622693)
46. Zehentner BK, Dillon DC, Jiang Y et al.: Application of a multigene reverse transcription-PCR assay for detection of mammaglobin and complementary transcribed genes in breast cancer lymph nodes. Clin. Chem. 48(8), 1225-1231 (2002). (Pubitemid 34809830)
47. Zehentner BK, Dillon DC, Jiang Y et al.: Expression of Mammaglobin, B305D, GABAII and B726P and elevation of mammaglobin protein in the peripheral blood of women with untreated breast cancers. Clin. Chem. 50(11), 2069-2076 (2004).
48. Zehentner BK, Secrist H, Hayes DC et al.: Detection of circulating tumor cells in peripheral blood of breast cancer patients during or after therapy using a multigene real-time RT-PCR assay. Mol. Diagn. Ther. 10(1), 41-47 (2006).
49. Chen CC, Hou MF, Wang JY et al.: Simultaneous detection of multiple mRNA markers CK19, CEA, c-Met, Her2/neu and hMAM with membrane array, an innovative technique with a great potential for breast cancer diagnosis. Cancer Lett. 240(2), 279-288 (2006).
50. Chen Y, Zou TN, Wu ZP et al.: Detection of cytokeratin 19, human mammaglobin, and carcinoembryonic antigen-positive circulating tumor cells by three-marker reverse transcription-PCR assay and its relation to clinical outcome in early breast cancer. Int. J. Biol. Markers 25(2), 59-68 (2010).
51. Mikhitarian K, Martin RH, Ruppel MB et al.: Detection of mammaglobin mRNA in peripheral blood is associated with high grade breast cancer: interim results of a prospective cohort study. BMC Cancer 8, 55 (2008).
52. Ferro P, Franceschini MC, Bacigalupo B et al.: Detection of circulating tumour cells in breast cancer patients using human mammaglobin RT-PCR: association with clinical prognostic factors. Anticancer Res. 30(6), 2377-2382 (2010).
53. Bossolasco P, Ricci C, Farina G et al.: Detection of micrometastatic cells in breast cancer by RT-PCR for the mammaglobin gene. Cancer Detect. Prev. 26(1), 60-63 (2002). (Pubitemid 36087183)
54. Marques AR, Teixeira E, Diamond J et al.: Detection of human mammaglobin mRNA in serial peripheral blood samples from patients with non-metastatic breast cancer is not predictive of disease recurrence. Breast Cancer Res. Treat. 114(2), 223-232 (2009).
55. Span PN, Waanders E, Manders P et al.: Mammaglobin is associated with low-grade, steroid receptor-positive breast tumors from postmenopausal patients, and has independent prognostic value for relapse-free survival time. J. Clin. Oncol. 22(4), 691-698 (2004). (Pubitemid 41095073)
56. O'Brien N, Maguire TM, O'Donovan N et al.: Mammaglobin a: a promising marker for breast cancer. Clin. Chem. 48(8), 1362-1364 (2002). (Pubitemid 34809847)
57. Melo JV, Yan XH, Diamond J, Lin F, Cross NC, Goldman JM: Reverse transcription/polymerase chain reaction (RT/PCR) amplifcation of very small numbers of transcripts: the risk in misinterpreting negative results. Leukemia 10(7), 1217-1221 (1996). (Pubitemid 26254029)
58. Sklar JL, Costa JC: In: Cancer: Principles and Practice of Oncology (5th Edition). Devita VT Jr, Hellman S, Rosenberg SA (Eds). Lippincott-Raven Publishers, PA, USA, 279-281 (1997).
59. Traystman MD, Cochran GT, Hake SJ et al.: Comparison of molecular cytokeratin 19 reverse transcriptase polymerase chain reaction (CK19 RT-PCR) and immunocytochemical detection of micrometastatic breast cancer cells in hematopoietic harvests. J. Hematother. 6(6), 551-561 (1997).
60. Bitisik O, Saip P, Saglam S, Derin D, Dalay N: Mammaglobin and maspin transcripts in blood may refect disease progression and the effect of therapy in breast cancer. Genet. Mol. Res. 9(1), 97-106 (2010).
61. Racila E, Euhus D, Weiss AJ et al.: Detection and characterization of carcinoma cells in the blood. Proc Natl Acad. Sci. USA 95(8), 4589-4594 (1998). (Pubitemid 28207957)
62. Ghossein RA, Osman I, Bhattacharya S et al.: Detection of prostatic specifc membrane antigen messenger RNA using immunobead reverse transcriptase polymerase chain reaction. Diagn. Mol. Pathol. 8(2), 59-65 (1999). (Pubitemid 29399034)
63. Benoy IH, Elst H, Philips M et al.: Real-time RT-PCR detection of disseminated tumour cells in bone marrow has superior prognostic signifcance in comparison with circulating tumour cells in patients with breast cancer. Br. J. Cancer 94(5), 672-680 (2006). (Pubitemid 43361898)
64. Zach O, Wagner H, Kasparu H, Krieger O, Lutz D: Statistical validation of the mammaglobin-nested RT-PCR assay for tumor cell detection in blood of breast cancer patients. Biotechniques 31(6), 1358-1362 (2001). (Pubitemid 33131220)
65. Lankiewicz S, Rivero BG, Bócher O: Quantitative real-time RT-PCR of disseminated tumor cells in combination with immunomagnetic cell enrichment. Mol. Biotechnol. 34(1), 15-27 (2006). (Pubitemid 44337216)
66. Wang Z, Zhang X, Shen P et al.: Identifcation, cloning, and expression of human estrogen receptor-a 36, a novel variant of human estrogen receptor-a66. Biochem. Biophys. Res. Commun. 336(4), 1023-1027 (2005). (Pubitemid 41383424)
67. Wang Z, Zhang X, Shen P et al.: A variant of estrogen receptor-a, hER-a36: transduction of estrogen-and antiestrogen-dependent membrane-initiated mitogenic signaling. Proc Natl Acad. Sci. USA 103(24), 9063-9068 (2006). (Pubitemid 43902533)