Interferences with urine drug screens

Journal of Pharmacy Practice

Volumn 24, Issue 1, 2011, Pages 102-108

  Herring, Charles ^a   Muzyk, Andrew J ^a,b   Johnston, Cynthia ^a  

^a CAMPBELL UNIVERSITY   (United States)

^b NONE   (United States)

Author keywords

Drug information; Internal medicine; Substance abuse

Indexed keywords

3,4 METHYLENEDIOXYAMPHETAMINE; 3,4 METHYLENEDIOXYMETHAMPHETAMINE; BUPHENINE; CYCLAMATE SODIUM; METHYLPHENIDATE; OFLOXACIN; PERAZINE; PHENMETRAZINE; PHENOTHIAZINE; PHENTERMINE; PHENYLEPHRINE; PHENYLPROPANOLAMINE; PIPOTIAZINE; PRO FAST; PROMETHAZINE; PROPYLHEXEDRINE; PSEUDOEPHEDRINE; RANITIDINE; RITODRINE; SELEGILINE; TOLMETIN; TRAZODONE; TRIMETHOBENZAMIDE; UNCLASSIFIED DRUG;

ARTICLE; CLONED ENZYME DONOR IMMUNOASSAY; DRUG DETERMINATION; DRUG SCREENING; DRUG URINE LEVEL; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME MULTIPLIED IMMUNOASSAY TECHNIQUE; FALSE NEGATIVE RESULT; FALSE POSITIVE RESULT; FLUORESCENCE POLARIZATION IMMUNOASSAY; HUMAN; IMMUNOASSAY; KINETIC INTERACTION OF MICROPARTICLES IN SOLUTION; MASS FRAGMENTOGRAPHY; PROBLEM IDENTIFICATION; RADIOIMMUNOASSAY;

EID: 79953863867     PISSN: 08971900     EISSN: 15311937     Source Type: Journal    
DOI: 10.1177/0897190010380463     Document Type: Article

References (70)

1. Leonhart MM. Clarification of existing requirements under the Controlled Substances Act for Prescribing Schedule II controlled substances. Federal Register 2005;70(165):50408-50409. http://a257.g.akamaitech.net/7/257/2422/ 01jan20051800/edocket.access.gpo.gov/2005/pdf/05-16954.pdf. Accessed July 3, 2006.
2. Leonhart MM. Issuance of Multiple Prescriptions for Schedule II Controlled Substances. Federal Register 2006;71(172): 52724-52726. http://frwebgate4.access.gpo.gov/cgi-bin/waisgate.cgi?WAISdocID= 9282146952+4+0+0&WAISaction=retrieve. Accessed March 26, 2007.
3. Campbell J, Peoples CR. North Carolina Board of Pharmacy: controlled substance rules & regulations pocket card. North Carolina Board of Pharmacy, Chapel Hill, NC, 2003, 2006. http://www.ncbop.org/about/Student%20Projects/ CSPocketCardRev06.06.pdf. Accessed July 3, 2006.
4. Eskridge KD, Guthrie SK. Clinical issues associated with urine testing of substances of abuse. Pharmacotherapy. 1997;17(3): 497-510. (Pubitemid 27227555)
5. Lee M, ed. Basic Skills in Interpreting Laboratory Data. 3rd ed. Bethesda, MD: American Society of Health-System Pharmacists Inc; 2004:2004:91-116.
6. Ateshkadi A, Carter BL, Farkas P, et al. Basic Skills in Interpreting Laboratory Data. 2nd ed. Bethesda, MD: American Society of Health-System Pharmacists Inc; 1996:1996:50-54.
7. Merigian KS, Browning RG. Desipramine and amantadine causing false-positive urine test for amphetamine. Ann Emerg Med. 1993;22(12):1927-1928. (Pubitemid 23346178)
8. Wagener RE, Linder MW, Valdes R. Decreased signal in emit assays of drugs of abuse in urine after ingestion of aspirin: potential for false-negative results. Clin Chem. 1994;40(4):608-612. (Pubitemid 24116112)
9. Linder MW, Valdes R. Mechanism and elimination of aspirininduced interference in Emit II d.a.u. assays. Clin Chem. 1994;40(8):1512-1516. (Pubitemid 24241130)
10. Berthier M, Bonneau D, Mura P, et al. Benzathine as a cause for a false-positive test result for amphetamines. J Pediatr. 1995; 127(4):669-670.
11. Olsen KM, Gulliksen M, Christophersen AS. Metabolites of chlorpromazine and brompheniramine may cause false-positive urine amphetamine results with monoclonal EMIT d.a.u. immunoassay. Clin Chem. 1992;38(4):611-612.
12. Nixon AL, Long WH, Puopolo PR, et al. Bupropion metabolites produce false-positive urine amphetamine results. Clin Chem. 1995;41(6):955-956.
13. Lora-Tamayo C, Tena T, Rodriguez A, et al. High concentration of chloroquine in urine gives positive result with amphetamine CEDIA reagent. J Anal Toxicol. 2002;26:58. (Pubitemid 34074129)
14. Kielland AS, Olsen KM, Christophersen AS. False-positive results with Emit II amphetamine/methamphetamine assay in users of common psychotropic drugs. Clin Chem. 1995;41(6):951-952.
15. Crane T, Dawson CM, Tickner TR. False-positive results from the Syva EMIT d.a.u. monoclonal amphetamine assay as a result of antipsychotic drug therapy. Clin Chem. 1993;39(3):549. (Pubitemid 23099032)
16. Merigian KS, Browning R, Kellerman A. Doxepin causing false-positive urine test for amphetamine. Ann Emerg Med. 1993;22(8):1370. (Pubitemid 23221491)
17. Stout PR, Klette KL, Horn CK. Evaluation of ephedrine, pseudoephedrine and phenylpropanolamine concentrations in human urine samples and a comparison of the specificity of DRI amphetamines and Abuscreen Online (KIMS) amphetamines screening immunoassays. J Forensic Sci. 2004;49(1):160-164. (Pubitemid 38063802)
18. Young DS. Effects of Drugs on Clinical Laboratory Tests. 5th ed. Washington, DC: AACC Press; 2004:113-116, 159-160, 293-294, 542-543, 552-553, 562-563, 588-589.
19. Markowitz JS, Donovan JL, DeVane CL, et al. Common herbal supplements did not produce false-positive results on urine drug screens analyzed by enzyme immunoassay. J Anal Toxicol. 2004;28(4):272-273. (Pubitemid 38581583)
20. Kraemer T, Wennig R, Maurer HH. The antispasmodic drug mebeverine leads to positive amphetamine results by fluorescence polarization immunoassay (FPIA)-studies on the toxicological analysis of urine by FPIA and GC-MS. J Anal Toxicol. 2001;25(5):333-338. (Pubitemid 32660386)
21. ADVIA 1650 AMPHET [package insert]. Pittsburgh, PA: Bayer HealthCare; 2005.
22. Manzi S, Law T, Shannon MW. Methylphenidate produces a false-positive urine amphetamine screen. Pediatr Emerg Care. 2002;18(5):401. (Pubitemid 35176435)
23. Nomier MA, Al-Huseini HK. False-positive TDxFLx urine amphetamine/methamphetamine II assay from ofloxacin. Saudi Pharm J. 2004;12:42-46. (Pubitemid 38478469)
24. Schmolke M, Hallbach J, Guder WG. False-positive results for urine amphetamine and opiate immunoassays in a patient intoxicated with perazine. Clin Chem. 1996;42(10):1725-1726. (Pubitemid 26354762)
25. Grinstead GF. Ranitidine and high concentrations of phenypropanolamine cross react in the EMIT monoclonal amphetamine/methamphetamine assay. Clin Chem. 1989;35(9):1998-1999.
26. Kelly KL. Ranitidine cross-reactivity in theEMIT d.a.u. monoclonal amphetamine/methamphetamine assay. Clin Chem. 1990;36(7): 1391-1392. (Pubitemid 20251964)
27. Martz W, Schutz HW. Synthetic sweetner cyclamate as a potential source of false-positive amphetamine results in the TDx system. Clin Chem. 1991;37(11):2016-2017.
28. Roberge RJ, Luellen JR, Reed S. False-positive amphetamine screen following a trazodone overdose. J Toxicol Clin Toxicol. 2001;39(2):181-182. (Pubitemid 32523797)
29. Jones R, Klette K, Kuhlman JJ, et al. Trimethobenzamide crossreacts in immunoassays of amphetamine/methamphetamine. Clin Chem. 1993;39(4):699-700.
30. Solomon MD, Wright JA. False-positive for (D)-methamphetamine. Clin Chem. 1977;23(8):1504.
31. Poklis A, Moore KA. Response of EMIT amphetamine immunoassays to urinary desoxyephedrine following Vicks inhaler use. Ther Drug Monit. 1995;17(1):89-94.
32. Rollins DE, Jennison TA, Jones G. Investigation of interference by nonsteroidal anti-inflammatory drugs in urine tests for abused drugs. Clin Chem. 1990;36(4):602-606.
33. Siff KS, Finkler AE. False-positive barbiturate test in urine owing to pheytoin and 5-(p-hydroxyphenyl)-5-phenylhydantoin. Clin Chem. 1988;34(6):1359-1360.
34. ADVIA 1650 BARB [package insert]. Pittsburgh, PA: Bayer HealthCare; 2005.
35. Pulini M. False-positive benzodiazepine urine test due to oxaprozin. JAMA. 1995;273(24):1905.
36. Gear JL. False-positive toxicology screens. J Am Acad Child Adolesc Psychiatry. 1996;35(12):1571-1572.
37. ADVIA 1650 THC [package insert]. Pittsburgh, PA: Bayer HealthCare; 2005.
38. Gottesman L. Sustiva may cause false positive on marijuana test. WORLD. 1999;96:7.
39. Kelner MJ. Positive diphenhydramine interference in the EMITd. a.u. assay. Clin Chem. 1984;30(8):1430.
40. Hausmann E, Kohl B, von Boehmer H, et al. False-positive EMIT indication of opiates and methadone in a doxylamine intoxication. J Clin Chem Clin Biochem. 1983;21(10):599-600. (Pubitemid 14201657)
41. Lichtenwalner MR, Mencken T, Tully R, et al. False-positive immunochemical screen for methadone attributable to metabolites of verapamil. Clin Chem. 1998;44(5):1039-1041. (Pubitemid 28213145)
42. Zacher JL, Givone DM. False-positive urine opiate screening associated with fluoroquinolone use. Ann Pharmacother. 2004;38(9):1525-1528. (Pubitemid 39100210)
43. Meatherall R, Dai J. False-positive EMIT II opiates from ofloxacin. Ther Drug Monit. 1997;19(1):98-99. (Pubitemid 28069005)
44. Baden LR, Horowitz G, Jacoby H, et al. Quinolones and falsepositive urine screening for opiates by immunoassay technology. JAMA. 2001;286(24):3115-3119. (Pubitemid 34016526)
45. Thevis M, Opfermann G, Schanzer W. Urinary concentrations of morphine and codeine after consumption of poppy seeds. J Anal Toxicol. 2003;27(1):53-56. (Pubitemid 36139427)
46. Salerno C, Wisniewski HM, Rudelli RD. Effect of poppy seed ingestion on the TxD opiates assay. Ther Drug Monit. 1990;12(2):210-211. (Pubitemid 20078606)
47. elSohly HN, elSohly MA, Stanford DF. Poppy seed ingestion and opiates urinalysis: a closer look. J Anal Toxicol. 1990;14(5): 308-310. (Pubitemid 20324452)
48. Beck O, Vitols S, Stensio M. Positive urine screening for opiates after consumption of sandwich bread with poppy seed flavoring. Ther Drug Monit. 1990;12(6):585-586.
49. ADVIA 1650 Opiate [package insert]. Pittsburgh, PA: Bayer HealthCare; 2005.
50. DePaula M, Saiz LC, Gonzalez-Revalderia J, et al. Rifampicin causes false-positive immunoassay results for urine opiates. Clin Chem Lab Med. 1998;36(4):241-243. (Pubitemid 28246279)
51. Daher R, Haidar JH, Al-Amin H. Rifampin interference with opiate immunoassays. Clin Chem. 2002;48(1):203-204.
52. Dasgupta A. Urinary adulterants and drugs-of-abuse testing. Med Lab Observ. 2003;35(2):26-28, 30-31.
53. Wu AH, Forte E, Casella G, et al. CEDIA for screening drugs of abuse in urine and the effect of adulterants. J Forensic Sci. 1995;40(4):614-618.
54. Paul BD, Jacobs A. Effects of oxidizing adulterants on detection of 11-nor-D9-THC-9-carboxylic acid in urine. J Anal Toxicol. 2002;26(7):460-463. (Pubitemid 36206780)
55. Kin HJ, Cerceo E. Interference by NaCl with the emit method of analysis for drugs of abuse. Clin Chem. 1976;22(11): 1935-1936.
56. Pearson SD, Ash KO, Urry FM. Mechanism of false-negative urine cannabinoid immunoassay screens by Visine eyedrops. Clin Chem. 1989;35(4):636-638. (Pubitemid 19111081)
57. Mikkelsen Sl, Ash KO. Adulterants causing false negatives in illicit drug testing. Clin Chem. 1998;34(11):2333-2336.
58. Dasgupta A, Wahed A, Wells A. Rapid spot tests for detecting the presence of adulterants in urine specimens submitted for drug testing. Am J Clin Pathol. 2002;117(2):325-329. (Pubitemid 34823675)
59. Urry FM, Komaromy-Hiller G, Staley B, et al. Nitrite adulteration of workplace urine drug-testing specimens: sources and associated concentrations of nitrite in urine and distinction between natural sources and adulteration. J Anal Toxicol. 1998;22(2):89-95. (Pubitemid 28128955)
60. Wu AH, Bristol B, Sexton K, et al. Adulteration of urine by "Urine Luck." Clin Chem. 1999;45(7):1051-1057.
61. Wenk RE. False-negative urine immunoassay after lorazepam overdose. Arch Pathol Lab Med. 2006;130(11):1600-1601. (Pubitemid 44683784)
62. Mazor SS, Mycyk MB, Wills BK, et al. Coca consumption causes positive urine cocaine assay. Eur J Emerg Med. 2006;13(6): 340-341. (Pubitemid 44715270)
63. Straley CM, Cecil EJ, Herriman MP. Gatifloxacin interference with opiate urine drug screen. Pharmacotherapy. 2006;26(3): 435-439. (Pubitemid 43334685)
64. Lancelin F, Kraoul L, Flatischler N, et al. False-positive results in the detection of methadone in urines of patients treated with psychotropic substances. Clin Chem. 2005;51(11):2176-2177. (Pubitemid 41532641)
65. la Porte CJ, Droste JA, Burger DM. False-positive results in urine drug screening in healthy volunteers participating in phase 1 studies with efavirenz and rifampin. Ther Drug Monit. 2006;28(2):286. (Pubitemid 44314965)
66. Burrows DL, Nicolaides A, Rice PJ, et al. Papain: a novel urine adulterant. J Anal Toxicol. 2005;29(5):275-295. (Pubitemid 41191695)
67. Widschwendter CG, Zernig G, Hofer A. Quetiapine cross reactivity with urine methadone immunoassays. Am J Psychiatry. 2007;164(1):172. (Pubitemid 46154804)
68. Vincent EC, Zebelman A, Goodwin C. Clinical inquiries. What common substances can cause false positives on urine screens for drugs of abuse? J Fam Pract. 2006;55(10):893-894, 897.
69. Rossi S, Yaksh T, Bentley H, et al. Characterization of interference with 6 commercial delta9-tetrahydrocannabinol immunoassays by efavirenz (glucuronide) in urine. Clin Chem. 2006;52(5): 896-897. (Pubitemid 43673273)
70. Lee HK, Lewis LD, Tsongalis GJ, et al. Case presentation from negative urine opioid screening caused by rifampin-mediated induction of oxycodone hepatic metabolism. Clinica Chimica Acta. 2006;367(1-2):196-200.