The effect of H. pylori eradication on meal-associated changes in plasma ghrelin and leptin

BMC Gastroenterology

Volumn 11, Issue , 2011, Pages

  Francois, Fritz ^a,b   Roper, Jatin ^a   Joseph, Neal ^a   Pei, Zhiheng ^a,b   Chhada, Aditi ^a   Shak, Joshua R ^a   de Perez, Asalia Z O ^a   Perez Perez, Guillermo I ^a   Blaser, Martin J ^a,b  

^a NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLIN; GASTRIC INHIBITORY POLYPEPTIDE; GHRELIN; GLUCAGON LIKE PEPTIDE 1; INSULIN; LEPTIN; PANCREAS POLYPEPTIDE; PEPTIDE YY; AMOXICILLIN; ANTIINFECTIVE AGENT; CLARITHROMYCIN; PROTON PUMP INHIBITOR;

ADULT; AGED; ARTICLE; BACTERIAL CLEARANCE; BLOOD SAMPLING; BODY MASS; BODY WEIGHT; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ERADICATION THERAPY; FEMALE; GASTROINTESTINAL ENDOSCOPY; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HOMEOSTASIS; HORMONE BLOOD LEVEL; HUMAN; INFECTION CONTROL; MAJOR CLINICAL STUDY; MALE; MORPHOMETRICS; PROSPECTIVE STUDY; PROTEIN DIET; BLOOD; CLINICAL TRIAL; DRUG COMBINATION; DRUG EFFECT; FOOD; MICROBIOLOGY; MIDDLE AGED;

AGED; AMOXICILLIN; ANTI-BACTERIAL AGENTS; BODY MASS INDEX; CLARITHROMYCIN; DRUG THERAPY, COMBINATION; FEMALE; FOOD; GHRELIN; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; LEPTIN; MALE; MIDDLE AGED; PROTON PUMP INHIBITORS;

EID: 79953863373     PISSN: None     EISSN: 1471230X     Source Type: Journal    
DOI: 10.1186/1471-230X-11-37     Document Type: Article

References (46)

1. Shintani M, Ogawa Y, Ebihara K, Aizawa-Abe M, Miyanaga F, Takaya K, Hayashi T, Inoue G, Hosoda K, Kojima M, et al. Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway. Diabetes 2001, 50(2):227-232. 10.2337/diabetes.50.2.227, 11272130.
2. Schwartz MW, Seeley RJ, Campfield LA, Burn P, Baskin DG. Identification of targets of leptin action in rat hypothalamus. J Clin Invest 1996, 98(5):1101-1106. 10.1172/JCI118891, 507530, 8787671.
3. Cummings DE, Purnell JQ, Frayo RS, Schmidova K, Wisse BE, Weigle DS. A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 2001, 50(8):1714-1719. 10.2337/diabetes.50.8.1714, 11473029.
4. Tschop M, Smiley DL, Heiman ML. Ghrelin induces adiposity in rodents. Nature 2000, 407(6806):908-913. 10.1038/35038090, 11057670.
5. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 1995, 269(5223):543-546. 10.1126/science.7624777, 7624777.
6. Mix H, Widjaja A, Jandl O, Cornberg M, Kaul A, Goke M, Beil W, Kuske M, Brabant G, Manns MP, et al. Expression of leptin and leptin receptor isoforms in the human stomach. Gut 2000, 47(4):481-486. 10.1136/gut.47.4.481, 1728089, 10986207.
7. Gnanapavan S, Kola B, Bustin SA, Morris DG, McGee P, Fairclough P, Bhattacharya S, Carpenter R, Grossman AB, Korbonits M. The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans. J Clin Endocrinol Metab 2002, 87(6):2988. 10.1210/jc.87.6.2988, 12050285.
8. Liew PL, Lee WJ, Lee YC, Chen WY. Gastric ghrelin expression associated with Helicobacter pylori infection and chronic gastritis in obese patients. Obes Surg 2006, 16(5):612-619. 10.1381/096089206776945002, 16687031.
9. Roper J, Francois F, Shue PL, Mourad MS, Pei Z, Olivares de Perez AZ, Perez-Perez GI, Tseng CH, Blaser MJ. Leptin and ghrelin in relation to Helicobacter pylori status in adult males. J Clin Endocrinol Metab 2008, 93(6):2350-2357. 10.1210/jc.2007-2057, 2435636, 18397989.
10. Atherton JC, Blaser MJ. Coadaptation of Helicobacter pylori and humans: ancient history, modern implications. J Clin Invest 2009, 119(9):2475-2487. 10.1172/JCI38605, 2735910, 19729845.
11. Pacifico L, Anania C, Osborn JF, Ferrara E, Schiavo E, Bonamico M, Chiesa C. Long-term effects of Helicobacter pylori eradication on circulating ghrelin and leptin concentrations and body composition in prepubertal children. Eur J Endocrinol 2008, 158(3):323-332. 10.1530/EJE-07-0438, 18299465.
12. Azuma T, Suto H, Ito Y, Muramatsu A, Ohtani M, Dojo M, Yamazaki Y, Kuriyama M, Kato T. Eradication of Helicobacter pylori infection induces an increase in body mass index. Aliment Pharmacol Ther 2002, 16(Suppl 2):240-244. 10.1046/j.1365-2036.16.s2.31.x, 11966548.
13. Nwokolo CU, Freshwater DA, O'Hare P, Randeva HS. Plasma ghrelin following cure of Helicobacter pylori. Gut 2003, 52(5):637-640. 10.1136/gut.52.5.637, 1773634, 12692045.
14. Francois F, Roper J, Goodman AJ, Pei Z, Ghumman M, Mourad M, de Perez AZ, Perez-Perez GI, Tseng CH, Blaser MJ. The association of gastric leptin with oesophageal inflammation and metaplasia. Gut 2008, 57(1):16-24. 10.1136/gut.2007.131672, 17761783.
15. Tytgat GN. The Sydney System: endoscopic division. Endoscopic appearances in gastritis/duodenitis. J Gastroenterol Hepatol 1991, 6(3):223-234. 10.1111/j.1440-1746.1991.tb01469.x, 1912432.
16. Dixon MF, Genta RM, Yardley JH, Correa P. Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994. Am J Surg Pathol 1996, 20(10):1161-1181. 10.1097/00000478-199610000-00001, 8827022.
17. Goggin N, Rowland M, Imrie C, Walsh D, Clyne M, Drumm B. Effect of Helicobacter pylori eradication on the natural history of duodenal ulcer disease. Arch Dis Child 1998, 79(6):502-505. 10.1136/adc.79.6.502, 1717771, 10210995.
18. Tummuru MK, Cover TL, Blaser MJ. Cloning and expression of a high-molecular-mass major antigen of Helicobacter pylori: evidence of linkage to cytotoxin production. Infect Immun 1993, 61(5):1799-1809. 280768, 8478069.
19. Perez-Perez GI, Dworkin BM, Chodos JE, Blaser MJ. Campylobacter pylori antibodies in humans. Ann Intern Med 1988, 109(1):11-17.
20. Blaser MJ, Perez-Perez GI, Kleanthous H, Cover TL, Peek RM, Chyou PH, Stemmermann GN, Nomura A. Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach. Cancer Res 1995, 55(10):2111-2115.
21. Egan BJ, Marzio L, O'Connor H, O'Morain C. Treatment of Helicobacter pylori infection. Helicobacter 2008, 13(Suppl 1):35-40. 10.1111/j.1523-5378.2008.00639.x, 18783520.
22. Malfertheiner P, Megraud F, O'Morain C, Bazzoli F, El-Omar E, Graham D, Hunt R, Rokkas T, Vakil N, Kuipers EJ. Current concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus Report. Gut 2007, 56(6):772-781. 10.1136/gut.2006.101634, 1954853, 17170018.
23. Zhang F, Chen Y, Heiman M, Dimarchi R. Leptin: structure, function and biology. Vitam Horm 2005, 71:345-372. full_text, 16112274.
24. Zhou H, Yamada Y, Tsukiyama K, Miyawaki K, Hosokawa M, Nagashima K, Toyoda K, Naitoh R, Mizunoya W, Fushiki T, et al. Gastric inhibitory polypeptide modulates adiposity and fat oxidation under diminished insulin action. Biochem Biophys Res Commun 2005, 335(3):937-942. 10.1016/j.bbrc.2005.07.164, 16105663.
25. Aaboe K, Krarup T, Madsbad S, Holst JJ. GLP-1: physiological effects and potential therapeutic applications. Diabetes Obes Metab 2008, 10(11):994-1003. 10.1111/j.1463-1326.2008.00853.x, 18435775.
26. Lutz TA. Amylinergic control of food intake. Physiol Behav 2006, 89(4):465-471. 10.1016/j.physbeh.2006.04.001, 16697020.
27. Kim BW, Lee BI, Kim HK, Cho YS, Chae HS, Lee HK, Kim HJ, Han SW. [Influence of long-term gastric acid suppression therapy on the expression of serum gastrin, chromogranin A, and ghrelin]. Korean J Gastroenterol 2009, 53(2):84-89.
28. Yamamoto T, Sanaka M, Anjiki H, Hattori K, Ishii T, Kuyama Y. No relationship between plasma desacyl-ghrelin levels and rabeprazole-related delay in gastric emptying: controlled study in healthy volunteers. Drugs R D 2008, 9(5):345-348. 10.2165/00126839-200809050-00005, 18721003.
29. Osawa H, Kita H, Ohnishi H, Nakazato M, Date Y, Bowlus CL, Ishino Y, Watanabe E, Shiiya T, Ueno H, et al. Changes in plasma ghrelin levels, gastric ghrelin production, and body weight after Helicobacter pylori cure. J Gastroenterol 2006, 41(10):954-961. 10.1007/s00535-006-1880-4, 17096064.
30. Kawashima J, Ohno S, Sakurada T, Takabayashi H, Kudo M, Ro S, Kato S, Yakabi K. Circulating acylated ghrelin level decreases in accordance with the extent of atrophic gastritis. J Gastroenterol 2009, 44(10):1046-1054. 10.1007/s00535-009-0120-0, 19701601.
31. Rabeneck L, Cook KF, Wristers K, Souchek J, Menke T, Wray NP. SODA (severity of dyspepsia assessment): a new effective outcome measure for dyspepsia-related health. J Clin Epidemiol 2001, 54(8):755-765. 10.1016/S0895-4356(00)00365-6, 11470383.
32. Batterham RL, Cowley MA, Small CJ, Herzog H, Cohen MA, Dakin CL, Wren AM, Brynes AE, Low MJ, Ghatei MA, et al. Gut hormone PYY(3-36) physiologically inhibits food intake. Nature 2002, 418(6898):650-654. 10.1038/nature00887, 12167864.
33. Lassmann V, Vague P, Vialettes B, Simon MC. Low plasma levels of pancreatic polypeptide in obesity. Diabetes 1980, 29(6):428-430. 10.2337/diabetes.29.6.428, 7380112.
34. Wren AM, Seal LJ, Cohen MA, Brynes AE, Frost GS, Murphy KG, Dhillo WS, Ghatei MA, Bloom SR. Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab 2001, 86(12):5992. 10.1210/jc.86.12.5992, 11739476.
35. Baggio LL, Drucker DJ. Biology of incretins: GLP-1 and GIP. Gastroenterology 2007, 132(6):2131-2157. 10.1053/j.gastro.2007.03.054, 17498508.
36. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999, 402(6762):656-660. 10.1038/45230, 10604470.
37. Isomoto H, Ueno H, Nishi Y, Wen CY, Nakazato M, Kohno S. Impact of Helicobacter pylori infection on ghrelin and various neuroendocrine hormones in plasma. World J Gastroenterol 2005, 11(11):1644-1648.
38. Gunji T, Matsuhashi N, Sato H, Fujibayashi K, Okumura M, Sasabe N, Urabe A. Helicobacter pylori infection is significantly associated with metabolic syndrome in the Japanese population. Am J Gastroenterol 2008, 103(12):3005-3010. 10.1111/j.1572-0241.2008.02151.x, 19086952.
39. Tschop M, Wawarta R, Riepl RL, Friedrich S, Bidlingmaier M, Landgraf R, Folwaczny C. Post-prandial decrease of circulating human ghrelin levels. J Endocrinol Invest 2001, 24(6):RC19-21.
40. Blaser MJ, Kirschner D. The equilibria that allow bacterial persistence in human hosts. Nature 2007, 449(7164):843-849. 10.1038/nature06198, 17943121.
41. Adrian TE, Ferri GL, Bacarese-Hamilton AJ, Fuessl HS, Polak JM, Bloom SR. Human distribution and release of a putative new gut hormone, peptide YY. Gastroenterology 1985, 89(5):1070-1077.
42. Feillet CA. Food for thoughts: feeding time and hormonal secretion. J Neuroendocrinol 2010, 22(6):620-628. 10.1111/j.1365-2826.2010.01998.x, 20345747.
43. Stock S, Leichner P, Wong AC, Ghatei MA, Kieffer TJ, Bloom SR, Chanoine JP. Ghrelin, peptide YY, glucose-dependent insulinotropic polypeptide, and hunger responses to a mixed meal in anorexic, obese, and control female adolescents. J Clin Endocrinol Metab 2005, 90(4):2161-2168. 10.1210/jc.2004-1251, 15657373.
44. Moayyedi P, Soo S, Deeks J, Delaney B, Harris A, Innes M, Oakes R, Wilson S, Roalfe A, Bennett C, et al. Eradication of Helicobacter pylori for non-ulcer dyspepsia. Cochrane Database Syst Rev 2005, (1):CD002096.
45. Chandarana K, Drew ME, Emmanuel J, Karra E, Gelegen C, Chan P, Cron NJ, Batterham RL. Subject standardization, acclimatization, and sample processing affect gut hormone levels and appetite in humans. Gastroenterology 2009, 136(7):2115-2126. 10.1053/j.gastro.2009.02.047, 19233179.
46. Cutler AF, Havstad S, Ma CK, Blaser MJ, Perez-Perez GI, Schubert TT. Accuracy of invasive and noninvasive tests to diagnose Helicobacter pylori infection. Gastroenterology 1995, 109(1):136-141. 10.1016/0016-5085(95)90278-3, 7540995.