Astragalosides reduce cisplatin ototoxicity in guinea pigs

ORL

Volumn 73, Issue 3, 2011, Pages 131-136

  Xiong, Min ^a   He, Qinglian ^b   Wang, Jian ^a   Lai, Huangwen ^a  

^a GUANGZHOU GENERAL HOSPITAL OF GUANGZHOU MILITARY COMMAND   (China)

^b CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Astragalosides; Cisplatin; Malondialdehyde; Nitric oxide; Ototoxicity

Indexed keywords

ANTIOXIDANT; ASTRAGALOSIDE; CISPLATIN; MALONALDEHYDE; NITRIC OXIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COCHLEA; DRUG ANTAGONISM; DRUG EFFECT; DRUG EFFICACY; EVOKED BRAIN STEM AUDITORY RESPONSE; GUINEA PIG; HISTOPATHOLOGY; NONHUMAN; OTOTOXICITY; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; ASTRAGALUS PLANT; AUDITORY THRESHOLD; CISPLATIN; DISEASE MODELS, ANIMAL; DRUG INTERACTIONS; DRUGS, CHINESE HERBAL; GUINEA PIGS; HAIR CELLS, AUDITORY, OUTER; HEARING LOSS, SENSORINEURAL; MALONDIALDEHYDE; NITRIC OXIDE; OXIDATIVE STRESS;

EID: 79953860203     PISSN: 03011569     EISSN: 14230275     Source Type: Journal    
DOI: 10.1159/000326240     Document Type: Article

References (21)

1. Deravajan P, Savoca M, Castaneda MP, et al: Cisplatin induced apoptosis in auditory cells: role of death receptor and mitochon-drial pathways. Hear Res 2002; 174:45-54. (Pubitemid 35305031)
2. Ravi R, Somani S, Rybak LP: Mechanism of cisplatin ototoxicity: antioxidant system. Pharmacol Toxicol 1995; 76:386-394.
3. Rybak LP, Husain K, Morris C, et al: Effect of protective agents against cisplatin ototoxic-ity. Am J Otol 2000; 21: 513-520. (Pubitemid 30432460)
4. Rybak LP, Somani S: Ototoxicity: ameliora-tion by protective agents. Ann NY Acad Sci 1999; 884: 143-151.
5. Husain K, Scott B, Whitworth C, et al: Time response of carboplatin-induced hearing loss in rat. Hear Res 2004; 191:110-118. (Pubitemid 38510516)
6. Watanabe K, Hess A, Bloch W, et al: Nitric oxide synthase inhibitor suppresses the oto-toxic side effect of cisplatin in guinea pigs. Anticancer Drugs 2000; 11:401-406. (Pubitemid 30459476)
7. Tada S, Yase Y, Shirataki Y: Inhibitory effects of astragali radix, crude drug in oriental medicines on lipid peroxidation and protein oxidative modification of mouse brain ho-mogenates by copper. Phytother Res 2000; 14:294-296. (Pubitemid 30410063)
8. Hei ZQ, Huang HQ, Zhang JJ, et al: Protec-tive effects of Astragalus membranaceus on intestinal mucosa reperfusion injury after hemorrhagic shock in rats. World J Gastro-enterol 2005; 11:4986-4991.
9. Jia RZ, Jiang L, Qiao LX: Study on effect of radix astragali on injury of cerebral cortex in neonatal rats after hypoxia/ischemia brain damage. Zhongguo Zhong Xi Yi Jie He Za Zhi 2005; 25:54-57.
10. Wang D, Shen W, Tian Y, et al: Protective effect of active components extracted from ra-dix astragali on human erythrocyte mem-brane damage caused by reactive oxygen species. Zhongguo Zhong Yao Za Zhi 1996; 21:746-748.
11. Lei H, Wang B, Li WP, et al: Anti-aging effect of astragaloside and its mechanism of action. Acta Pharmacol Sin 2003; 24: 230-234. (Pubitemid 36286009)
12. 2+ ATPase of viral myocarditis mice. Zhongguo Zhong Xi Yi Jie He Za Zhi 1999; 19: 672-674.
13. Meng D, Chen XJ, Bian YY, et al: Effect of astragaloside on intracellular calcium over-load in cultured cardiac myocytes of neona-tal rats. Am J Chin Med 2005; 33:11-20. (Pubitemid 40468299)
14. Husain K, Whitworth C, Somani S, et al: Carboplatin-induced oxidative stress in rat cochlea. Hear Res 2001; 158:14-22. (Pubitemid 32743314)
15. Read SM, Northcole DH: Minimization of variation in the response to different pro-tein of the Coomassie blue G dye-binding assay for protein. Anal Biochem 1981; 116: 53-64. (Pubitemid 12176725)
16. Hess A, Bloch W, Huverstuhl J, et al: Expres-sion of inducible nitric oxide synthase (iNOS/NOS II) in the cochlea of guinea pigs after intratympanical endotoxin treatment. Brain Res 1999; 830: 113-122. (Pubitemid 29251718)
17. Shi X, Nuttall AL: Upregulated iNOS and oxidative damage to the cochlear stria vascu-laris due to noise stress. Brain Res 2003; 967: 1-10. (Pubitemid 36324283)
18. Watanabe K, Hess A, Bloch W, Michel O: In-hibition of inducible nitric oxide synthase lowers the cochlear damage by lipopolysac-charide in guinea pigs. Free Radic Res 2000; 32:363-370. (Pubitemid 30167482)
19. Watanabe KI, Hess A, Bloch W, Michel O: Nitric oxide synthase inhibitor suppresses the ototoxic side effect of cisplatin in guinea pigs. Anticancer Drugs 2000; 11:401-406. (Pubitemid 30459476)
20. Zhou JY, Fan Y, Kong JL, et al: Effects of com-ponents isolated from Astragalus membra-naceus Bunge on cardiac function injured by myocardial ischemia reperfusion in rats. Zhongguo Zhong Yao Za Zhi 2000; 25: 300-302.
21. Duan P, Wang ZM: Clinical study on effect of Astragalus in efficacy enhancing and toxicity reducing of chemotherapy in patients with malignant tumor. Zhongguo Zhong Xi Yi Jie He Za Zhi 2002; 22:515-517.