메뉴 건너뛰기




Volumn 3, Issue 4, 2011, Pages 507-516

Current status and future applications of cellular therapies for cancer

Author keywords

ACT; adoptive therapy; cancer immunotherapy; dendritic cell vaccine; T cell

Indexed keywords

ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC AGENT; B7 ANTIGEN; BARDOXOLONE METHYL; CD86 ANTIGEN; CHEMOKINE RECEPTOR CCR7; CYCLOPHOSPHAMIDE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4 ANTIBODY; DACLIZUMAB; DCVAX; DENDRITIC CELL VACCINE; DENILEUKIN DIFTITOX; DEXAMETHASONE; FLUDARABINE; GEMCITABINE; INTERLEUKIN 12; INTERLEUKIN 2; IPLIMUMAB; LENALIDOMIDE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PLACEBO; POMALIDOMIDE; PROVENGE; TAMOXIFEN; UNCLASSIFIED DRUG; ZOLEDRONIC ACID;

EID: 79953834363     PISSN: 1750743X     EISSN: None     Source Type: Journal    
DOI: 10.2217/imt.11.18     Document Type: Review
Times cited : (22)

References (67)
  • 1
    • 54849437711 scopus 로고    scopus 로고
    • Review of clinical studies on dendritic cell-based vaccination of patients with malignant melanoma: Assessment of correlation between clinical response and vaccine parameters
    • Overview of dendritic cell (DC) vaccines in melanoma patients, demonstrating both the achievable clinical efficacy and the variability in outcome of vaccination
    • Engell-Noerregaard L, Hansen TH, Andersen MH, Thor Straten P, Svane IM: Review of clinical studies on dendritic cell-based vaccination of patients with malignant melanoma: assessment of correlation between clinical response and vaccine parameters. Cancer Immunol. Immunother. 58, 1-14 (2009). Overview of dendritic cell (DC) vaccines in melanoma patients, demonstrating both the achievable clinical efficacy and the variability in outcome of vaccination.
    • (2009) Cancer Immunol. Immunother. , vol.58 , pp. 1-14
    • Engell-Noerregaard, L.1    Hansen, T.H.2    Andersen, M.H.3    Thor Straten, P.4    Svane, I.M.5
  • 5
    • 77953265082 scopus 로고    scopus 로고
    • Dendritic cell preparation for immunotherapeutic interventions
    • Simon T, Fonteneau JF, Gregoire M: Dendritic cell preparation for immunotherapeutic interventions. Immunotherapy 1, 289-302 (2009).
    • (2009) Immunotherapy , vol.1 , pp. 289-302
    • Simon, T.1    Fonteneau, J.F.2    Gregoire, M.3
  • 7
    • 67349239049 scopus 로고    scopus 로고
    • T-regulatory cell modulation: The future of cancer immunotherapy?
    • Nizar S, Copier J, Meyer B et al.: T-regulatory cell modulation: the future of cancer immunotherapy? Br. J. Cancer 100, 1697-1703 (2009).
    • (2009) Br. J. Cancer , vol.100 , pp. 1697-1703
    • Nizar, S.1    Copier, J.2    Meyer, B.3
  • 8
    • 77958056009 scopus 로고    scopus 로고
    • Dendritic cell vaccination in combination with anti-CD25 monoclonal antibody treatment: A Phase I/II study in metastatic melanoma patients
    • Jacobs JF, Punt CJ, Lesterhuis WJ et al.: Dendritic cell vaccination in combination with anti-CD25 monoclonal antibody treatment: a Phase I/II study in metastatic melanoma patients. Clin. Cancer Res. 16, 5067-5078 (2010).
    • (2010) Clin. Cancer Res. , vol.16 , pp. 5067-5078
    • Jacobs, J.F.1    Punt, C.J.2    Lesterhuis, W.J.3
  • 9
    • 33847368549 scopus 로고    scopus 로고
    • + regulatory T cells and restores T and NK effector functions in end stage cancer patients
    • + regulatory T cells and restores T and NK effector functions in end stage cancer patients. Cancer Immunol. Immunother. 56, 641-648 (2007).
    • (2007) Cancer Immunol. Immunother. , vol.56 , pp. 641-648
    • Ghiringhelli, F.1    Menard, C.2    Puig, P.E.3
  • 10
    • 74349102406 scopus 로고    scopus 로고
    • Administration of cyclophosphamide changes the immune profile of tumor-bearing mice
    • Liu P, Jaffar J, Hellstrom I, Hellstrom KE: Administration of cyclophosphamide changes the immune profile of tumor-bearing mice. J. Immunother. 33, 53-59 (2010).
    • (2010) J. Immunother. , vol.33 , pp. 53-59
    • Liu, P.1    Jaffar, J.2    Hellstrom, I.3    Hellstrom, K.E.4
  • 11
    • 70249083099 scopus 로고    scopus 로고
    • What is the role of cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma?
    • Robert C, Ghiringhelli F: What is the role of cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma? Oncologist 14, 848-861 (2009).
    • (2009) Oncologist , vol.14 , pp. 848-861
    • Robert, C.1    Ghiringhelli, F.2
  • 12
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • Hodi FS, O'Day SJ, McDermott DF et al.: Improved survival with ipilimumab in patients with metastatic melanoma. N. Engl. J. Med. 363, 711-723 (2010).
    • (2010) N. Engl. J. Med. , vol.363 , pp. 711-723
    • Hodi, F.S.1    O'Day, S.J.2    McDermott, D.F.3
  • 13
    • 77951637543 scopus 로고    scopus 로고
    • Blockade of programmed death ligand 1 enhances the therapeutic efficacy of combination immunotherapy against melanoma
    • Pilon-Thomas S, Mackay A, Vohra N, Mule JJ: Blockade of programmed death ligand 1 enhances the therapeutic efficacy of combination immunotherapy against melanoma. J. Immunol. 184, 3442-3449 (2010).
    • (2010) J. Immunol. , vol.184 , pp. 3442-3449
    • Pilon-Thomas, S.1    Mackay, A.2    Vohra, N.3    Mule, J.J.4
  • 14
    • 77949718839 scopus 로고    scopus 로고
    • Anti-inflammatory triterpenoid blocks immune suppressive function of MDSCs and improves immune response in cancer
    • Nagaraj S, Youn JI, Weber H et al.: Anti-inflammatory triterpenoid blocks immune suppressive function of MDSCs and improves immune response in cancer. Clin. Cancer Res. 16, 1812-1823 (2010).
    • (2010) Clin. Cancer Res. , vol.16 , pp. 1812-1823
    • Nagaraj, S.1    Youn, J.I.2    Weber, H.3
  • 15
    • 74249120625 scopus 로고    scopus 로고
    • Pre-treatment with chemotherapy can enhance the antigenicity and immunogenicity of tumours by promoting adaptive immune responses
    • Liu WM, Fowler DW, Smith P, Dalgleish AG: Pre-treatment with chemotherapy can enhance the antigenicity and immunogenicity of tumours by promoting adaptive immune responses. Br. J. Cancer 102, 115-123 (2010).
    • (2010) Br. J. Cancer , vol.102 , pp. 115-123
    • Liu, W.M.1    Fowler, D.W.2    Smith, P.3    Dalgleish, A.G.4
  • 16
    • 43149098068 scopus 로고    scopus 로고
    • Anti-inflammatory pretreatment enables an efficient dendritic cell-based immunotherapy against established tumors
    • Chiarella P, Vulcano M, Bruzzo J et al.: Anti-inflammatory pretreatment enables an efficient dendritic cell-based immunotherapy against established tumors. Cancer Immunol. Immunother. 57, 701-718 (2008).
    • (2008) Cancer Immunol. Immunother. , vol.57 , pp. 701-718
    • Chiarella, P.1    Vulcano, M.2    Bruzzo, J.3
  • 17
    • 70349100093 scopus 로고    scopus 로고
    • Massive expansion of regulatory T-cells following interleukin 2 treatment during a Phase I-II dendritic cell-based immunotherapy of metastatic renal cancer
    • Lemoine FM, Cherai M, Giverne C et al.: Massive expansion of regulatory T-cells following interleukin 2 treatment during a Phase I-II dendritic cell-based immunotherapy of metastatic renal cancer. Int. J. Oncol. 35, 569-581 (2009).
    • (2009) Int. J. Oncol. , vol.35 , pp. 569-581
    • Lemoine, F.M.1    Cherai, M.2    Giverne, C.3
  • 18
    • 68049140780 scopus 로고    scopus 로고
    • Clinical and immunologic effects of intranodal autologous tumor lysate-dendritic cell vaccine with Aldesleukin (interleukin 2) and IFN-a2a therapy in metastatic renal cell carcinoma patients
    • Schwaab T, Schwarzer A, Wolf B et al.: Clinical and immunologic effects of intranodal autologous tumor lysate-dendritic cell vaccine with Aldesleukin (interleukin 2) and IFN-a2a therapy in metastatic renal cell carcinoma patients. Clin. Cancer Res. 15, 4986-4992 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , pp. 4986-4992
    • Schwaab, T.1    Schwarzer, A.2    Wolf, B.3
  • 19
    • 48649102654 scopus 로고    scopus 로고
    • Alterations in p53-specific T cells and other lymphocyte subsets in breast cancer patients during vaccination with p53-peptide loaded dendritic cells and low-dose interleukin-2
    • Svane IM, Pedersen AE, Nikolajsen K, Zocca MB: Alterations in p53-specific T cells and other lymphocyte subsets in breast cancer patients during vaccination with p53-peptide loaded dendritic cells and low-dose interleukin-2. Vaccine 26, 4716-4724 (2008).
    • (2008) Vaccine , vol.26 , pp. 4716-4724
    • Svane, I.M.1    Pedersen, A.E.2    Nikolajsen, K.3    Zocca, M.B.4
  • 20
    • 77957319524 scopus 로고    scopus 로고
    • Vaccination with autologous dendritic cells pulsed with multiple tumor antigens for treatment of patients with malignant melanoma: Results from a Phase I/II trial
    • Trepiakas R, Berntsen A, Hadrup SR et al.: Vaccination with autologous dendritic cells pulsed with multiple tumor antigens for treatment of patients with malignant melanoma: results from a Phase I/II trial. Cytotherapy 12, 721-734 (2010).
    • (2010) Cytotherapy , vol.12 , pp. 721-734
    • Trepiakas, R.1    Berntsen, A.2    Hadrup, S.R.3
  • 21
    • 68549135290 scopus 로고    scopus 로고
    • Integrated data from 2 randomized, double-blind, placebo-controlled, Phase 3 trials of active cellular immunotherapy with sipuleucel-T in advanced prostate cancer
    • Higano CS, Schellhammer PF, Small EJ et al.: Integrated data from 2 randomized, double-blind, placebo-controlled, Phase 3 trials of active cellular immunotherapy with sipuleucel-T in advanced prostate cancer. Cancer 115, 3670-3679 (2009).
    • (2009) Cancer , vol.115 , pp. 3670-3679
    • Higano, C.S.1    Schellhammer, P.F.2    Small, E.J.3
  • 22
    • 66549098937 scopus 로고    scopus 로고
    • Improving the efficacy of cancer immunotherapy
    • Copier J, Dalgleish AG, Britten CM et al.: Improving the efficacy of cancer immunotherapy. Eur. J. Cancer 45, 1424-1431 (2009).
    • (2009) Eur. J. Cancer , vol.45 , pp. 1424-1431
    • Copier, J.1    Dalgleish, A.G.2    Britten, C.M.3
  • 23
    • 33845993628 scopus 로고    scopus 로고
    • A clinical development paradigm for cancer vaccines and related biologics
    • Hoos A, Parmiani G, Hege K et al.: A clinical development paradigm for cancer vaccines and related biologics. J. Immunother. 30, 1-15 (2007).
    • (2007) J. Immunother. , vol.30 , pp. 1-15
    • Hoos, A.1    Parmiani, G.2    Hege, K.3
  • 24
    • 65249173447 scopus 로고    scopus 로고
    • Adoptive cell therapy for the treatment of patients with metastatic melanoma
    • Rosenberg SA, Dudley ME: Adoptive cell therapy for the treatment of patients with metastatic melanoma. Curr. Opin. Immunol. 21, 233-240 (2009).
    • (2009) Curr. Opin. Immunol. , vol.21 , pp. 233-240
    • Rosenberg, S.A.1    Dudley, M.E.2
  • 25
    • 0037174674 scopus 로고    scopus 로고
    • Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes
    • Dudley ME, Wunderlich JR, Robbins PF et al.: Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes. Science 298, 850-854 (2002).
    • (2002) Science , vol.298 , pp. 850-854
    • Dudley, M.E.1    Wunderlich, J.R.2    Robbins, P.F.3
  • 26
    • 77958064837 scopus 로고    scopus 로고
    • Tumor infiltrating lymphocyte therapy for metastatic melanoma: Analysis of tumors resected for TIL
    • Data from Phase III clinical trials of sipuleucel-T, an autologous DC vaccine, which has recently been awarded a licence in the USA for the treatment of advanced prostate cancer
    • Goff SL, Smith FO, Klapper JA et al.: Tumor infiltrating lymphocyte therapy for metastatic melanoma: analysis of tumors resected for TIL. J. Immunother. 33, 840-847 (2010). Data from Phase III clinical trials of sipuleucel-T, an autologous DC vaccine, which has recently been awarded a licence in the USA for the treatment of advanced prostate cancer.
    • (2010) J. Immunother. , vol.33 , pp. 840-847
    • Goff, S.L.1    Smith, F.O.2    Klapper, J.A.3
  • 28
    • 0037829421 scopus 로고    scopus 로고
    • Generation of tumor-infiltrating lymphocyte cultures for use in adoptive transfer therapy for melanoma patients
    • Dudley ME, Wunderlich JR, Shelton TE, Even J, Rosenberg SA: Generation of tumor-infiltrating lymphocyte cultures for use in adoptive transfer therapy for melanoma patients. J. Immunother. 26, 332-342 (2003).
    • (2003) J. Immunother. , vol.26 , pp. 332-342
    • Dudley, M.E.1    Wunderlich, J.R.2    Shelton, T.E.3    Even, J.4    Rosenberg, S.A.5
  • 29
    • 12744253307 scopus 로고    scopus 로고
    • Sinks, suppressors and antigen presenters: How lymphodepletion enhances T cell-mediated tumor immunotherapy
    • Klebanoff CA, Khong HT, Antony PA, Palmer DC, Restifo NP: Sinks, suppressors and antigen presenters: how lymphodepletion enhances T cell-mediated tumor immunotherapy. Trends Immunol. 26, 111-117 (2005).
    • (2005) Trends Immunol. , vol.26 , pp. 111-117
    • Klebanoff, C.A.1    Khong, H.T.2    Antony, P.A.3    Palmer, D.C.4    Restifo, N.P.5
  • 30
    • 73349118752 scopus 로고    scopus 로고
    • Dendritic cell recovery post-lymphodepletion: A potential mechanism for anti-cancer adoptive T cell therapy and vaccination
    • Original study in melanoma patients showing that tumor-derived T cells could produce both clinical and immunological effects
    • Salem ML, Cole DJ: Dendritic cell recovery post-lymphodepletion: a potential mechanism for anti-cancer adoptive T cell therapy and vaccination. Cancer Immunol. Immunother. 59, 341-353 (2010). Original study in melanoma patients showing that tumor-derived T cells could produce both clinical and immunological effects.
    • (2010) Cancer Immunol. Immunother. , vol.59 , pp. 341-353
    • Salem, M.L.1    Cole, D.J.2
  • 31
    • 20244366111 scopus 로고    scopus 로고
    • Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma
    • Dudley ME, Wunderlich JR, Yang JC et al.: Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma. J. Clin. Oncol. 23, 2346-2357 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , pp. 2346-2357
    • Dudley, M.E.1    Wunderlich, J.R.2    Yang, J.C.3
  • 32
    • 74349084455 scopus 로고    scopus 로고
    • Increased intensity lymphodepletion enhances tumor treatment efficacy of adoptively transferred tumor-specific T cells
    • Wrzesinski C, Paulos CM, Kaiser A et al.: Increased intensity lymphodepletion enhances tumor treatment efficacy of adoptively transferred tumor-specific T cells. J. Immunother. 33, 1-7 (2010).
    • (2010) J. Immunother. , vol.33 , pp. 1-7
    • Wrzesinski, C.1    Paulos, C.M.2    Kaiser, A.3
  • 33
    • 55949125601 scopus 로고    scopus 로고
    • Adoptive cell therapy for patients with metastatic melanoma: Evaluation of intensive myeloablative chemoradiation preparative regimens
    • Dudley ME, Yang JC, Sherry R et al.: Adoptive cell therapy for patients with metastatic melanoma: evaluation of intensive myeloablative chemoradiation preparative regimens. J. Clin. Oncol. 26, 5233-5239 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , pp. 5233-5239
    • Dudley, M.E.1    Yang, J.C.2    Sherry, R.3
  • 34
    • 62749185585 scopus 로고    scopus 로고
    • Fludarabine modulates immune response and extends in vivo survival of adoptively transferred CD8 T cells in patients with metastatic melanoma
    • Wallen H, Thompson JA, Reilly JZ et al.: Fludarabine modulates immune response and extends in vivo survival of adoptively transferred CD8 T cells in patients with metastatic melanoma. PLoS One 4, E4749 (2009).
    • (2009) PLoS One , vol.4
    • Wallen, H.1    Thompson, J.A.2    Reilly, J.Z.3
  • 36
    • 38149117105 scopus 로고    scopus 로고
    • + T cells derived from central memory cells establishes persistent T cell memory in primates
    • + T cells derived from central memory cells establishes persistent T cell memory in primates. J. Clin. Invest. 118, 294-305 (2008).
    • (2008) J. Clin. Invest. , vol.118 , pp. 294-305
    • Berger, C.1    Jensen, M.C.2    Lansdorp, P.M.3
  • 37
    • 34249819361 scopus 로고    scopus 로고
    • Detection and long-term in vivo monitoring of individual tumor-specific T cell clones in patients with metastatic melanoma
    • Michalek J, Kocak I, Fait V, Zaloudik J, Hajek R: Detection and long-term in vivo monitoring of individual tumor-specific T cell clones in patients with metastatic melanoma. J. Immunol. 178, 6789-6795 (2007).
    • (2007) J. Immunol. , vol.178 , pp. 6789-6795
    • Michalek, J.1    Kocak, I.2    Fait, V.3    Zaloudik, J.4    Hajek, R.5
  • 38
    • 70149114880 scopus 로고    scopus 로고
    • Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen
    • Differences in clinical outcome achievable through alteration of host environment prior to adoptive therapy. This was related to intensity of lymphodepletion
    • Johnson LA, Morgan RA, Dudley ME et al.: Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen. Blood 114, 535-546 (2009). Differences in clinical outcome achievable through alteration of host environment prior to adoptive therapy. This was related to intensity of lymphodepletion.
    • (2009) Blood , vol.114 , pp. 535-546
    • Johnson, L.A.1    Morgan, R.A.2    Dudley, M.E.3
  • 40
    • 77957305114 scopus 로고    scopus 로고
    • The interplay between Epstein-Barr virus and the immune system: A rationale for adoptive cell therapy of EBV-related disorders
    • Merlo A, Turrini R, Dolcetti R et al.: The interplay between Epstein-Barr virus and the immune system: a rationale for adoptive cell therapy of EBV-related disorders. Haematologica 95, 1769-1777 (2010).
    • (2010) Haematologica , vol.95 , pp. 1769-1777
    • Merlo, A.1    Turrini, R.2    Dolcetti, R.3
  • 41
    • 77958014713 scopus 로고    scopus 로고
    • Adoptive therapy using antigen-specific T-cell clones
    • Yee C: Adoptive therapy using antigen-specific T-cell clones. Cancer J. 16, 367-373 (2010).
    • (2010) Cancer J. , vol.16 , pp. 367-373
    • Yee, C.1
  • 42
    • 79959351392 scopus 로고    scopus 로고
    • Treatment of metastatic melanoma with autologous Melan-A/MART-1-specific cytotoxic T lymphocyte clones
    • Khammari A, Labarriere N, Vignard V et al.: Treatment of metastatic melanoma with autologous Melan-A/MART-1-specific cytotoxic T lymphocyte clones. J. Invest. Dermatol. 129, 2835-2842 (2009).
    • (2009) J. Invest. Dermatol. , vol.129 , pp. 2835-2842
    • Khammari, A.1    Labarriere, N.2    Vignard, V.3
  • 43
    • 77951257237 scopus 로고    scopus 로고
    • Therapy of relapsed leukemia after allogeneic hematopoietic cell transplantation with T cells specific for minor histocompatibility antigens
    • Warren EH, Fujii N, Akatsuka Y et al.: Therapy of relapsed leukemia after allogeneic hematopoietic cell transplantation with T cells specific for minor histocompatibility antigens. Blood 115, 3869-3878 (2010).
    • (2010) Blood , vol.115 , pp. 3869-3878
    • Warren, E.H.1    Fujii, N.2    Akatsuka, Y.3
  • 44
    • 77953457564 scopus 로고    scopus 로고
    • Both CD4 and CD8 T cells mediate equally effective in vivo tumor treatment when engineered with a highly avid TCR targeting tyrosinase
    • Frankel TL, Burns WR, Peng PD et al.: Both CD4 and CD8 T cells mediate equally effective in vivo tumor treatment when engineered with a highly avid TCR targeting tyrosinase. J. Immunol. 184, 5988-5998 (2010).
    • (2010) J. Immunol. , vol.184 , pp. 5988-5998
    • Frankel, T.L.1    Burns, W.R.2    Peng, P.D.3
  • 45
    • 77955270629 scopus 로고    scopus 로고
    • + T cells exhibit multifunctional effector and helper responses, in vitro
    • + T cells exhibit multifunctional effector and helper responses, in vitro. Clin. Immunol. 136, 338-347 (2010).
    • (2010) Clin. Immunol. , vol.136 , pp. 338-347
    • Ray, S.1    Chhabra, A.2    Chakraborty, N.G.3
  • 46
    • 77956535599 scopus 로고    scopus 로고
    • Redirecting T-cell specificity by introducing a tumorspecific chimeric antigen receptor
    • Jena B, Dotti G, Cooper LJ: Redirecting T-cell specificity by introducing a tumorspecific chimeric antigen receptor. Blood 116, 1035-1044 (2010).
    • (2010) Blood , vol.116 , pp. 1035-1044
    • Jena, B.1    Dotti, G.2    Cooper, L.J.3
  • 47
    • 77951089216 scopus 로고    scopus 로고
    • A high molecular weight melanoma-associated antigen-specific chimeric antigen receptor redirects lymphocytes to target human melanomas
    • Burns WR, Zhao Y, Frankel TL et al.: A high molecular weight melanoma-associated antigen-specific chimeric antigen receptor redirects lymphocytes to target human melanomas. Cancer Res. 70, 3027-3033 (2010).
    • (2010) Cancer Res. , vol.70 , pp. 3027-3033
    • Burns, W.R.1    Zhao, Y.2    Frankel, T.L.3
  • 48
    • 77950475517 scopus 로고    scopus 로고
    • Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2
    • Morgan RA, Yang JC, Kitano M et al.: Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2. Mol. Ther. 18, 843-851 (2010).
    • (2010) Mol. Ther. , vol.18 , pp. 843-851
    • Morgan, R.A.1    Yang, J.C.2    Kitano, M.3
  • 49
    • 33749624177 scopus 로고    scopus 로고
    • Cancer regression in patients after transfer of genetically engineered lymphocytes
    • Morgan RA, Dudley ME, Wunderlich JR et al.: Cancer regression in patients after transfer of genetically engineered lymphocytes. Science 314, 126-129 (2006).
    • (2006) Science , vol.314 , pp. 126-129
    • Morgan, R.A.1    Dudley, M.E.2    Wunderlich, J.R.3
  • 50
    • 42649085033 scopus 로고    scopus 로고
    • Nonmyeloablative chemotherapy followed by T-cell adoptive transfer and dendritic cell-based vaccination results in rejection of established melanoma
    • Along with references [51] and [52] demonstrates the potential synergy between DC vaccination and T-cell therapy
    • Koike N, Pilon-Thomas S, Mule JJ: Nonmyeloablative chemotherapy followed by T-cell adoptive transfer and dendritic cell-based vaccination results in rejection of established melanoma. J. Immunother. 31, 402-412 (2008). Along with references [51] and [52] demonstrates the potential synergy between DC vaccination and T-cell therapy.
    • (2008) J. Immunother. , vol.31 , pp. 402-412
    • Koike, N.1    Pilon-Thomas, S.2    Mule, J.J.3
  • 51
    • 4644364500 scopus 로고    scopus 로고
    • Dendritic cells strongly boost the antitumor activity of adoptively transferred T cells in vivo
    • Along with references [50] and [52] demonstrates the potential synergy between DC vaccination and T-cell therapy
    • Lou Y, Wang G, Lizee G et al.: Dendritic cells strongly boost the antitumor activity of adoptively transferred T cells in vivo. Cancer Res. 64, 6783-6790 (2004). Along with references [50] and [52] demonstrates the potential synergy between DC vaccination and T-cell therapy.
    • (2004) Cancer Res. , vol.64 , pp. 6783-6790
    • Lou, Y.1    Wang, G.2    Lizee, G.3
  • 52
    • 77956500311 scopus 로고    scopus 로고
    • + T cell/regulatory T cells in tumour
    • Along with references [50] and [51] demonstrates the potential synergy between DC vaccination and T-cell therapy
    • + T cell/regulatory T cells in tumour. Clin. Exp. Immunol. 162, 75-83 (2010). Along with references [50] and [51] demonstrates the potential synergy between DC vaccination and T-cell therapy.
    • (2010) Clin. Exp. Immunol. , vol.162 , pp. 75-83
    • Song, S.1    Zhang, K.2    You, H.3
  • 53
    • 40549097760 scopus 로고    scopus 로고
    • Adoptive immunotherapy for pancreatic cancer using MUC1 peptide-pulsed dendritic cells and activated T lymphocytes
    • Kondo H, Hazama S, Kawaoka T et al.: Adoptive immunotherapy for pancreatic cancer using MUC1 peptide-pulsed dendritic cells and activated T lymphocytes. Anticancer Res. 28, 379-387 (2008).
    • (2008) Anticancer Res. , vol.28 , pp. 379-387
    • Kondo, H.1    Hazama, S.2    Kawaoka, T.3
  • 54
    • 33846813974 scopus 로고    scopus 로고
    • Safety profile and anti-tumor effects of adoptive immunotherapy using γ-δ T cells against advanced renal cell carcinoma: A pilot study
    • Kobayashi H, Tanaka Y, Yagi J et al.: Safety profile and anti-tumor effects of adoptive immunotherapy using γ-δ T cells against advanced renal cell carcinoma: a pilot study. Cancer Immunol. Immunother. 56, 469-476 (2007).
    • (2007) Cancer Immunol. Immunother. , vol.56 , pp. 469-476
    • Kobayashi, H.1    Tanaka, Y.2    Yagi, J.3
  • 55
    • 50649102839 scopus 로고    scopus 로고
    • Phase-I study of Innacell γδ, an autologous cell-therapy product highly enriched in γ9δ2 T lymphocytes, in combination with IL-2, in patients with metastatic renal cell carcinoma
    • Bennouna J, Bompas E, Neidhardt EM et al.: Phase-I study of Innacell γδ, an autologous cell-therapy product highly enriched in γ9δ2 T lymphocytes, in combination with IL-2, in patients with metastatic renal cell carcinoma. Cancer Immunol. Immunother. 57, 1599-1609 (2008).
    • (2008) Cancer Immunol. Immunother. , vol.57 , pp. 1599-1609
    • Bennouna, J.1    Bompas, E.2    Neidhardt, E.M.3
  • 56
    • 77951296062 scopus 로고    scopus 로고
    • A Phase I study of adoptive immunotherapy for recurrent non-small-cell lung cancer patients with autologous γδ T cells
    • Nakajima J, Murakawa T, Fukami T et al.: A Phase I study of adoptive immunotherapy for recurrent non-small-cell lung cancer patients with autologous γδ T cells. Eur. J. Cardiothorac. Surg. 37, 1191-1197 (2010).
    • (2010) Eur. J. Cardiothorac. Surg. , vol.37 , pp. 1191-1197
    • Nakajima, J.1    Murakawa, T.2    Fukami, T.3
  • 57
    • 78650386896 scopus 로고    scopus 로고
    • Zoledronate-activated Vγ9γδ T cell-based immunotherapy is feasible and restores the impairment of γδ T cells in patients with solid tumors
    • Noguchi A, Kaneko T, Kamigaki T et al.: Zoledronate-activated Vγ9γδ T cell-based immunotherapy is feasible and restores the impairment of γδ T cells in patients with solid tumors. Cytotherapy 13(1), 92-97 (2010).
    • (2010) Cytotherapy , vol.13 , Issue.1 , pp. 92-97
    • Noguchi, A.1    Kaneko, T.2    Kamigaki, T.3
  • 58
    • 0037968274 scopus 로고    scopus 로고
    • γδ T cells for immune therapy of patients with lymphoid malignancies
    • Wilhelm M, Kunzmann V, Eckstein S et al.: γδ T cells for immune therapy of patients with lymphoid malignancies. Blood 102, 200-206 (2003).
    • (2003) Blood , vol.102 , pp. 200-206
    • Wilhelm, M.1    Kunzmann, V.2    Eckstein, S.3
  • 59
    • 34547638252 scopus 로고    scopus 로고
    • Targeting human γδ T cells with zoledronate and interleukin-2 for immunotherapy of hormone-refractory prostate cancer
    • Analysis of peripheral γδ T-cell activation and phenotype in patients treated with aminobisphosphonates. Demonstrates that it is possible to manipulate γδ T cells without the need for ex vivo culture
    • Dieli F, Vermijlen D, Fulfaro F et al.: Targeting human γδ T cells with zoledronate and interleukin-2 for immunotherapy of hormone-refractory prostate cancer. Cancer Res. 67, 7450-7457 (2007). Analysis of peripheral γδ T-cell activation and phenotype in patients treated with aminobisphosphonates. Demonstrates that it is possible to manipulate γδ T cells without the need for ex vivo culture.
    • (2007) Cancer Res. , vol.67 , pp. 7450-7457
    • Dieli, F.1    Vermijlen, D.2    Fulfaro, F.3
  • 60
    • 79953819157 scopus 로고    scopus 로고
    • Adjuvant ovarian suppression combined with tamoxifen or anastrozole, alone or in combination with zoledronic acid, in premenopausal women with hormomeresponsive, stage I and II breast cancer: First efficacy results from ABCSG-12
    • Presented at
    • Gnant M, Mlineritsch B, Schippinger W et al.: Adjuvant ovarian suppression combined with tamoxifen or anastrozole, alone or in combination with zoledronic acid, in premenopausal women with hormomeresponsive, stage I and II breast cancer: first efficacy results from ABCSG-12. Presented at: ASCO Annual Meeting Chicago, IL, USA 30 May-3 June 2008.
    • ASCO Annual Meeting Chicago, IL, USA 30 May-3 June 2008
    • Gnant, M.1    Mlineritsch, B.2    Schippinger, W.3
  • 61
    • 54849441655 scopus 로고    scopus 로고
    • In vivo effects of zoledronic acid on peripheral γδ T lymphocytes in early breast cancer patients
    • Santini D, Martini F, Fratto ME et al.: In vivo effects of zoledronic acid on peripheral γδ T lymphocytes in early breast cancer patients. Cancer Immunol. Immunother. 58, 31-38 (2009).
    • (2009) Cancer Immunol. Immunother. , vol.58 , pp. 31-38
    • Santini, D.1    Martini, F.2    Fratto, M.E.3
  • 62
    • 77954652637 scopus 로고    scopus 로고
    • In vivo manipulation of Vγ9Vδ2 T cells with zoledronate and low-dose interleukin-2 for immunotherapy of advanced breast cancer patients
    • Meraviglia S, Eberl M, Vermijlen D et al.: In vivo manipulation of Vγ9Vδ2 T cells with zoledronate and low-dose interleukin-2 for immunotherapy of advanced breast cancer patients. Clin. Exp. Immunol. 161, 290-297 (2010).
    • (2010) Clin. Exp. Immunol. , vol.161 , pp. 290-297
    • Meraviglia, S.1    Eberl, M.2    Vermijlen, D.3
  • 63
    • 67349188865 scopus 로고    scopus 로고
    • Regression of melanoma metastases following treatment with the N-bisphosphonate zoledronate and localised radiotherapy
    • Laggner U, Lopez JS, Perera G et al.: Regression of melanoma metastases following treatment with the N-bisphosphonate zoledronate and localised radiotherapy. Clin. Immunol. 131, 367-373 (2009).
    • (2009) Clin. Immunol. , vol.131 , pp. 367-373
    • Laggner, U.1    Lopez, J.S.2    Perera, G.3
  • 64
    • 77957958698 scopus 로고    scopus 로고
    • The potential of immunomodulatory drugs in the treatment of solid tumors
    • Dalgleish A, Galustian C: The potential of immunomodulatory drugs in the treatment of solid tumors. Future Oncol. 6, 1479-1484 (2010).
    • (2010) Future Oncol. , vol.6 , pp. 1479-1484
    • Dalgleish, A.1    Galustian, C.2
  • 65
    • 67349107194 scopus 로고    scopus 로고
    • The anti-cancer agents lenalidomide and pomalidomide inhibit the proliferation and function of T regulatory cells
    • Galustian C, Meyer B, Labarthe MC et al.: The anti-cancer agents lenalidomide and pomalidomide inhibit the proliferation and function of T regulatory cells. Cancer Immunol. Immunother. 58, 1033-1045 (2009).
    • (2009) Cancer Immunol. Immunother. , vol.58 , pp. 1033-1045
    • Galustian, C.1    Meyer, B.2    Labarthe, M.C.3
  • 66
    • 68749095218 scopus 로고    scopus 로고
    • Immunotherapy for malignant melanoma - Tracing Ariadne's thread through the labyrinth
    • Grange JM, Krone B, Stanford JL: Immunotherapy for malignant melanoma - tracing Ariadne's thread through the labyrinth. Eur. J. Cancer 45, 2266-2273 (2009).
    • (2009) Eur. J. Cancer , vol.45 , pp. 2266-2273
    • Grange, J.M.1    Krone, B.2    Stanford, J.L.3
  • 67
    • 38149032470 scopus 로고    scopus 로고
    • Successful immunotherapy with Mycobacterium vaccae in the treatment of adenocarcinoma of the lung
    • Stanford JL, Stanford CA, O'Brien ME, Grange JM: Successful immunotherapy with Mycobacterium vaccae in the treatment of adenocarcinoma of the lung. Eur. J. Cancer 44, 224-227 (2008).
    • (2008) Eur. J. Cancer , vol.44 , pp. 224-227
    • Stanford, J.L.1    Stanford, C.A.2    O'Brien, M.E.3    Grange, J.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.