Tumor infiltrating lymphocyte therapy for metastatic melanoma: Analysis of tumors resected for TIL

Journal of Immunotherapy

Volumn 33, Issue 8, 2010, Pages 840-847

  Goff, Stephanie L ^a   Smith, Franz O ^a   Klapper, Jacob A ^a   Sherry, Richard ^a   Wunderlich, John R ^a   Steinberg, Seth M ^a   White, Donald ^a   Rosenberg, Steven A ^a   Dudley, Mark E ^a   Yang, James C ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

adoptive cell transfer; metastatic melanoma; tumor infiltrating lymphocytes

Indexed keywords

ADOPTIVE IMMUNOTHERAPY; ARTICLE; CANCER GROWTH; CANCER IMMUNOTHERAPY; CELL GROWTH; HUMAN; HUMAN CELL; LUNG METASTASIS; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MELANOMA; PRIORITY JOURNAL; PROGNOSIS; TUMOR ASSOCIATED LEUKOCYTE; TUMOR REGRESSION; TUMOR VOLUME; VISCERAL METASTASIS;

ADOLESCENT; ADULT; AGED; ANTIGENS, NEOPLASM; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; GASTROINTESTINAL NEOPLASMS; HLA-A ANTIGENS; HUMANS; IMMUNOTHERAPY, ADOPTIVE; INTERFERON-GAMMA; LUNG NEOPLASMS; LYMPHOCYTES, TUMOR-INFILTRATING; MALE; MELANOMA; MIDDLE AGED; REMISSION INDUCTION;

EID: 77958064837     PISSN: 15249557     EISSN: None     Source Type: Journal    
DOI: 10.1097/CJI.0b013e3181f05b91     Document Type: Article

References (15)

1. Balch CM, Atkins MB, Sober AJ. Cutaneous melanoma. In: DeVita VT Jr, Helman S, Rosenberg SA, eds. Cancer: Principles and Practice of Oncology. 7th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2005:1754-1808.
2. Smith FO, Downey SG, Klapper JA, et al. Treatment of metastatic melanoma using interleukin-2 alone or in conjunction with vaccines. Clin Cancer Res. 2008;14:5610-5618.
3. Atkins MB, Hsu J, Lee S, et al. Phase III trial comparing concurrent biochemotherapy with cisplatin, vinblastine, dacar-bazine, interleukin-2, and interferon alfa-2b with cisplatin, vinblastine, and dacarbazine alone in patients with metastatic malignant melanoma (E3695): a trial coordinated by the Eastern Cooperative Oncology Group. J Clin Oncol. 2008;26:5748-5754.
4. Dudley ME, Wunderlich JR, Yang JC, et al. Adoptive cell transfer therapy following non-myeloablative but lymphodeplet-ing chemotherapy for the treatment of patients with refractory metastatic melanoma. J Clin Oncol. 2005;23:2346-2357.
5. Dudley ME, Yang JC, Sherry R, et al. Adoptive cell therapy for patients with metastatic melanoma: evaluation of intensive myeloablative chemoradiation preparative regimens. J Clin Oncol. 2008;26:5233-5239.
6. Hughes MS, Yu YYL, Dudley ME, et al. Transfer of a TCR gene derived from a patient with a marked antitumor response conveys highly active T-cell effector functions. Hum Gene Ther. 2005;16:1-16.
7. Zhao Y, Zheng Z, Robbins PF, et al. Primary human lymphocytes transduced with NY-ESO-1 antigen specific TR genes recognize and kill diverse human tumor cell lines. J Immunol. 2005;174:4415-4423.
8. Roskowski JJ, Lyons GE, Kast WM, et al. Simultaneous generation of CD8+ and CD4+ melanoma-reactive T cells by retroviral-mediated transfer of a single T-cell receptor. Cancer Res. 2005;65:1570-1576.
9. Engles B, Noesnner E, Frankenberger B, et al. Redirecting human T lymphocytes toward renal cell carcinoma specificity by retroviral transfer of T cell receptor genes. Hum Gene Ther. 2005;16:799-810.
10. Cohen CJ, Zheng A, Bray R, et al. Recognition of fresh human tumor by human peripheral blood lymphocytes transduced with a bicistronic retroviral vector encoding a murine anti-p53 TCR. J Immunol. 2005;175:5799-5808.
11. Morgan RA, Dudley ME, Wunderlich JR, et al. Cancer regression in patients after transfer of genetically engineered lymphocytes. Science. 2006;314:126-129.
12. Johnson LA, Heemskerk B, Powell D, et al. Gene transfer of tumor-reactive TCR confers both high avidity and tumor reactivity to nonreactive peripheral blood mononuclear cells and tumor-infiltrating lymphocytes. J Immunol. 2006;177: 6548-6559.
13. Tran KQ, Zhou J, Durflinger KH, et al. Minimally cultured tumor-infiltrating lymphocytes display optimal characteristics for adoptive cell therapy. J Immunother. 2008;31: 742-751.
14. Dudley ME, Wunderlich JR, Shelton TE, et al. Generation of tumor-infiltrating lymphocyte cultures for use in adoptive transfer therapy for melanoma patients. J Immunother. 2003; 26:332-342.
15. Topalian SL, Solomon D, Rosenberg SA. Tumor-specific cytolysis by lymphocytes infiltrating human melanomas. J Immunol. 1989;142:3714-3725.