An evaluation of BMP-2 delivery from scaffolds with miniaturized dental implants in a novel rat mandible model

Journal of Biomedical Materials Research - Part B Applied Biomaterials

Volumn 97 B, Issue 2, 2011, Pages 315-326

  Wen, Bo ^a   Karl, Matthias ^b   Pendrys, David ^c   Shafer, David ^c   Freilich, Martin ^c   Kuhn, Liisa ^c  

^a NANJING UNIVERSITY   (China)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

animal model; bone; controlled release; dental implants; growth factor

Indexed keywords

ANIMAL MODEL; BONE MORPHOGENETIC PROTEIN-2; CONTROLLED RELEASE; DENTAL IMPLANTS; DOSE-RESPONSE STUDY; GLYCOSYLATED; GROWTH FACTOR; HYDROGEL SCAFFOLDS; HYDROXYAPATITE COMPOSITE; IN-VITRO; IN-VIVO; MANDIBULAR BONE; MECHANICAL STRENGTH; MICRO CT; RELEASE RATE; SMALL ANIMAL MODEL; THRESHOLD DOSE;

ANIMALS; BONE; COMPUTERIZED TOMOGRAPHY; HYDROGELS; HYDROXYAPATITE; PEPTIDES; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; SCAFFOLDS (BIOLOGY); TITANIUM;

DENTAL PROSTHESES;

BONE MORPHOGENETIC PROTEIN 2; COLLAGEN; GLYCOSYLATED PROTEIN; HYDROXYAPATITE; SCAFFOLD PROTEIN; TITANIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; IN VITRO STUDY; IN VIVO STUDY; MANDIBLE; NONHUMAN; RAT; TOOTH IMPLANTATION;

ANIMALS; BIOCOMPATIBLE MATERIALS; BONE MORPHOGENETIC PROTEIN 2; COLLAGEN; DENTAL IMPLANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CARRIERS; DURAPATITE; HUMANS; HYDROGEL; IMPLANTS, EXPERIMENTAL; MALE; MANDIBLE; MATERIALS TESTING; MODELS, ANIMAL; OSTEOGENESIS; POLYETHYLENE GLYCOLS; RATS; RATS, WISTAR; TISSUE SCAFFOLDS; TITANIUM;

EID: 79953802041     PISSN: 15524973     EISSN: 15524981     Source Type: Journal    
DOI: 10.1002/jbm.b.31817     Document Type: Article

References (37)

1. Bernstein S, Cooke J, Fotek P, Wang HL,. Vertical bone augmentation: Where are we now? Implant Dent 2006; 15: 219-228. (Pubitemid 44395214)
2. Chiapasco M, Zaniboni M, Boisco M,. Augmentation procedures for the rehabilitation of deficient edentulous ridges with oral implants. Clin Oral Implants Res 2006; 17: 136-159. (Pubitemid 44327705)
3. Bessho K, Konishi Y, Kaihara S, Fujimura K, Okubo Y, Iizuka T,. Bone induction by Escherichia coli-derived recombinant human bone morphogenetic protein-2 compared with Chinese hamster ovary cell-derived recombinant human bone morphogenetic protein-2. Br J Oral Maxillofac Surg 2000; 38: 645-649. (Pubitemid 32051101)
4. Kubler NR, Reuther JF, Faller G, Kirchner T, Ruppert R, Sebald W,. Inductive properties of recombinant human BMP-2 produced in a bacterial expression system. Int J Oral Maxillofac Surg 1998; 27: 305-309. (Pubitemid 128364308)
5. Sachse A, Wagner A, Keller M, Wagner O, Wetzel WD, Layher F, Venbrocks RA, Hortschansky P, Pietraszczyk M, Wiederanders B, Hempel HJ, Bossert J, Horn J, Schmuck K, Mollenhauer J,. Osteointegration of hydroxyapatite-titanium implants coated with nonglycosylated recombinant human bone morphogenetic protein-2 (BMP-2) in aged sheep. Bone 2005; 37: 699-710. (Pubitemid 41476393)
6. Wikesjö UM, Qahash M, Polimeni G, Susin C, Shanaman RH, Rohrer MD, Wozney JM, Hall J,. Alveolar ridge augmentation using implants coated with recombinant human bone morphogenetic protein-2: Histologic observations. J Clin Periodontol 2008; 35: 1001-1010.
7. Schmoekel H, Schense JC, Weber FE, Grätz KW, Gnägi D, Müller R, Hubbell JA,. Bone healing in the rat and dog with nonglycosylated BMP-2 demonstrating low solubility in fibrin matrices. J Orthop Res 2004; 22: 376-381. (Pubitemid 38155295)
8. Schimandle JH, Boden SD, Hutton WC,. Experimental spinal fusion with recombinant human bone morphogenetic protein-2. Spine 1995; 20: 1326-1337.
9. Winn SR, Uludag H, Hollinger JO,. Carrier systems for bone morphogenetic proteins. Clin Orthop Relat Res 1999;(367 Suppl): S95-S106. (Pubitemid 29501490)
10. Hollinger JO, Uludag H, Winn SR,. Sustained release emphasizing recombinant human bone morphogenetic protein-2. Adv Drug Deliv Rev 1998; 31: 303-318. (Pubitemid 28191871)
11. Leknes KN, Yang J, Qahash M, Polimeni G, Susin C, Wikesjö UM,. Alveolar ridge augmentation using implants coated with recombinant human bone morphogenetic protein-2: Radiographic observations. Clin Oral Implants Res 2008; 19: 1027-1033.
12. Fischgrund JS, James SB, Chabot MC, Hankin R, Herkowitz HN, Wozney JM, Shirkhoda A,. Augmentation of autograft using rhBMP-2 and different carrier media in the canine spinal fusion model. J Spinal Disord 1997; 10: 467-472. (Pubitemid 28012003)
13. Geiger M, Li RH, Friess W,. Collagen sponges for bone regeneration with rhBMP-2. Adv Drug Deliv Rev 2003; 55: 1613-1629. (Pubitemid 37420006)
14. Takaoka K, Koezuka M, Nakahara H,. Telopeptide-depleted bovine skin collagen as a carrier for bone morphogenetic protein. J Orthop Res 1991; 9: 902-907.
15. Boyne PJ,. Animal studies of application of rhBMP-2 in maxillofacial reconstruction. Bone 1996; 19 (Suppl 1): 83S-92S. (Pubitemid 26254478)
16. Gao T, Lindholm TS, Marttinen A, Urist MR,. Composites of bone morphogenetic protein (BMP) and type IV collagen, coral-derived coral hydroxyapatite, and tricalcium phosphate ceramics. Int Orthop 1996; 20: 321-325. (Pubitemid 26377293)
17. Tsuruga E, Takita H, Itoh H, Wakisaka Y, Kuboki Y,. Pore size of porous hydroxyapatite as the cell-substratum controls BMP-induced osteogenesis. J Biochem 1997; 121: 317-324. (Pubitemid 27096208)
18. Koempel JA, Patt BS, O'Grady K, Wozney J, Toriumi DM,. The effect of recombinant human bone morphogenetic protein-2 on the integration of porous hydroxyapatite implants with bone. J Biomed Mater Res 1998; 41: 359-363. (Pubitemid 28300098)
19. Lutolf MP, Weber FE, Schmoekel HG, Schense JC, Kohler T, Müller R, Hubbell JA,. Repair of bone defects using synthetic mimetics of collagenous extracellular matrices. Nat Biotechnol 2003; 21: 513-518. (Pubitemid 36532015)
20. Magit DP, Maak T, Trioano N, Raphael B, Hamouria Q, Polzhofer G, Drespe I, Albert TJ, Grauer JN,. Healos/recombinant human growth and differentiation factor-5 induces posterolateral lumbar fusion in a New Zealand white rabbit model. Spine 2006; 31: 2180-2188. (Pubitemid 44337853)
21. Jahng TA, Fu TS, Cunningham BW, Dmitriev AE, Kim DH,. Endoscopic instrumented posterolateral lumbar fusion with Healos and recombinant human growth/differentiation factor-5. Neurosurgery 2004; 54: 171-180.
22. Neen D, Noyes D, Shaw M, Gwilym S, Fairlie N, Birch N,. Healos and bone marrow aspirate used for lumbar spine fusion: A case controlled study comparing Healos with autograft. Spine 2006; 31: E636-E640.
23. Lutolf MP, Lauer-Fields JL, Schmoekel HG, Metters AT, Weber FE, Fields GB, Hubbell JA,. Synthetic matrix metalloproteinase-sensitive hydrogels for the conduction of tissue regeneration: Engineering cell-invasion characteristics. Proc Natl Acad Sci USA 2003; 100: 5413-5418. (Pubitemid 36542719)
24. Miranda DA, Blumenthal NM, Sorensen RG, Wozney JM, Wikesjö UM,. Evaluation of recombinant human bone morphogenetic protein-2 on the repair of alveolar ridge defects in baboons. J Periodontol 2005; 76: 210-220. (Pubitemid 40542248)
25. Jung RE, Glauser R, Schärer P, Hämmerle CH, Sailer HF, Weber FE,. Effect of rhBMP-2 on guided bone regeneration in humans. Clin Oral Implants Res 2003; 14: 556-568.
26. Jung RE, Windisch SI, Eggenschwiler AM, Thoma DS, Weber FE, Hämmerle CH,. A randomized-controlled clinical trial evaluating clinical and radiological outcomes after 3 and 5 years of dental implants placed in bone regenerated by means of GBR techniques with or without the addition of BMP-2. Clin Oral Implants Res 2009; 20: 660-666.
27. Matin K, Nakamura H, Irie K, Ozawa H, Ejiri S,. Impact of recombinant human bone morphogenetic protein-2 on residual ridge resorption after tooth extraction: An experimental study in the rat. Int J Oral Maxillofac Implants 2001; 16: 400-411. (Pubitemid 33673143)
28. Matin K, Senpuku H, Hanada N, Ozawa H, Ejiri S,. Bone regeneration by recombinant human bone morphogenetic protein-2 around immediate implants: A pilot study in rats. Int J Oral Maxillofac Implants 2003; 18: 211-217. (Pubitemid 37162403)
29. Donath K, Breuner G,. A method for the study of undecalcified bones and teeth with attached soft tissues. The Säge-Schliff (sawing and grinding) technique. J Oral Pathol 1982; 11: 318-326. (Pubitemid 12092572)
30. Sciadini MF, Johnson KD,. Evaluation of recombinant human bone morphogenetic protein-2 as a bone-graft substitute in a canine segmental defect model. J Orthop Res 2000; 2: 289-302. (Pubitemid 30304759)
31. Woo BH, Fink BF, Page R, Schrier JA, Jo YW, Jiang G, DeLuca M, Vasconez HC, DeLuca PP,. Enhancement of bone growth by sustained delivery of recombinant human bone morphogenetic protein-2 in a polymeric matrix. Pharm Res 2001; 18: 1747-1753. (Pubitemid 34020432)
32. Seeherman H, Wozney J, Li R,. Bone morphogenetic protein delivery systems. Spine 2002; 27 (Suppl): s16-s23.
33. Seeherman H, Wozney J,. Delivery of bone morphogenetic proteins for orthopedic tissue regeneration. Cytokine Growth Factor Rev 2005; 16: 329-345. (Pubitemid 40910322)
34. Arosarena O, Collins W,. Comparison of BMP-2 and -4 for rat mandibular bone regeneration at various doses. Orthod Craniofac Res 2005; 8: 267-276.
35. Cowan CM, Aghaloo T, Chou YF, Walder B, Zhang X, Soo C, Ting K, Wu B,. MicroCT evaluation of three-dimensional mineralization in response to BMP-2 doses in vitro and in critical sized rat calvarial defects. Tissue Eng 2007; 13: 501-312.
36. Freilich M, Shafer D, Wei M, Adams D, Kuhn L,. Implant system for guiding a new layer of bone-computed microtomography and histomorphometric analysis in the rabbit mandible. Clin Oral Implants Res 2009; 20: 201-207.
37. Freilich M, Patel C, Wei M, Shafer D, Schleier P, Hortschansky P, Kompali R, Kuhn L,. Growth of new bone guided by implants in a murine calvarial model. Bone 2008; 43: 781-788.