A novel anti-fibrotic agent, baicalein, for the treatment of myocardial fibrosis in spontaneously hypertensive rats

European Journal of Pharmacology

Volumn 658, Issue 2-3, 2011, Pages 175-181

  Kong, Ebenezer K C ^a,b   Yu, Shan ^a,b   Sanderson, John E ^a,b   Chen, Kar Bik ^b   Huang, Yu ^a,c   Yu, Cheuk Man ^a,b  

^a Li Ka Shing Institute of Health Sciences   (Hong Kong)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^c CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Baicalein; Cardiac fibrosis; Collagen; Hypertension; Rat

Indexed keywords

ARACHIDONATE 12 LIPOXYGENASE; BAICALEIN; BRAIN NATRIURETIC PEPTIDE; GELATINASE B; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PROCOLLAGEN; PROCOLLAGEN TYPE 1; PROCOLLAGEN TYPE 3; UNCLASSIFIED DRUG; VALSARTAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIFIBROTIC EFFECT; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MEGADOSE; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME REPRESSION; ESSENTIAL HYPERTENSION; GENE EXPRESSION; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE FIBROSIS; HEART VENTRICLE SEPTUM; HEART WEIGHT; LOW DRUG DOSE; MALE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; SYSTOLIC BLOOD PRESSURE;

ANIMALS; ARACHIDONATE 12-LIPOXYGENASE; BLOOD PRESSURE; BODY WEIGHT; COLLAGEN TYPE I; COLLAGEN TYPE III; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROSIS; FLAVANONES; GENE EXPRESSION REGULATION; HEART VENTRICLES; MALE; MATRIX METALLOPROTEINASE 9; MYOCARDIUM; NATRIURETIC PEPTIDE, BRAIN; ORGAN SIZE; PHOSPHOPROTEINS; PROCOLLAGEN; RATS; RATS, INBRED SHR; RNA, MESSENGER; VENTRICULAR SEPTUM;

EID: 79953800506     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.02.033     Document Type: Article

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