Development of a stigmatic mass microscope using laser desorptionionization and a multi-turn time-of-flight mass spectrometer

Journal of Biomedical Optics

Volumn 16, Issue 4, 2011, Pages

  Hazama, Hisanao ^a,e   Yoshimura, Hidetoshi ^a,e   Aoki, Jun ^a,e   Nagao, Hirofumi ^a,e   Toyoda, Michisato ^a,e   Masuda, Katsuyoshi ^b,e   Fujii, Kenichi ^c,e   Tashima, Toshio ^e   Naito, Yasuhide ^d,e   Awazu, Kunio ^a,e  

^a OSAKA UNIVERSITY   (Japan)

^b SUNTORY INSTITUTE FOR BIOORGANIC RESEARCH   (Japan)

^c OSAKA INSTITUTE OF TECHNOLOGY   (Japan)

^d GRADUATE SCHOOL FOR THE CREATION OF NEW PHOTONICS INDUSTRIES   (Japan)

^e JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

imaging mass spectrometry; matrix assisted laser desorptionionization; multi turn time of flight mass spectrometer; stigmatic mass microscope

Indexed keywords

CRYSTAL VIOLET; DOT DIAMETER; IMAGING MASS SPECTROMETRY; ION IMAGES; LINEAR MODES; MASS-TO-CHARGE RATIO; MATRIX-ASSISTED LASER DESORPTIONIONIZATION; METHYLENE BLUE; MICRODOT PATTERN; MOUSE BRAIN; MULTI-TURN; RHODAMINE B; SPATIAL RESOLUTION; SQUARE MESHES; STIGMATIC MASS MICROSCOPE; TIME OF FLIGHT; TIME-OF-FLIGHT MASS SPECTROMETERS;

DYES; IONS; MICROSCOPES; SECONDARY ION MASS SPECTROMETRY; SPECTROMETRY;

MASS SPECTROMETERS;

CRYSTAL VIOLET; RHODAMINE; RHODAMINE B;

ANIMAL; ARTICLE; C57BL MOUSE; CHEMISTRY; EQUIPMENT DESIGN; HIPPOCAMPUS; IMAGE PROCESSING; INSTRUMENTATION; MASS SPECTROMETRY; METHODOLOGY; MOLECULAR IMAGING; MOUSE;

ANIMALS; EQUIPMENT DESIGN; GENTIAN VIOLET; HIPPOCAMPUS; IMAGE PROCESSING, COMPUTER-ASSISTED; MICE; MICE, INBRED C57BL; MOLECULAR IMAGING; RHODAMINES; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 79953797729     PISSN: 10833668     EISSN: 15602281     Source Type: Journal    
DOI: 10.1117/1.3561091     Document Type: Article

References (24)

1. M. Karas and F. Hillenkamp, Laser desorption ionization of proteins with molecular masses exceeding 10000 daltons., Anal. Chem. 60 (20), 2299-2301 (1988). 10.1021/ac00171a028
2. M. Mann, R. C. Hendrickson, and A. Randy, Analysis of proteins and proteomes by mass spectrometry., Annu. Rev. Biochem. 70, 437-473 (2001). 10.1146/annurev.biochem.70.1.437 (Pubitemid 32662217)
3. S. S. Rubakhin, J. C. Jurchen, E. B. Monroe, and J. V. Sweedler, Imaging mass spectrometry: fundamentals and applications to drug discovery., Drug Discovery Today 10 (12), 823-837 (2005). 10.1016/S1359-6446(05)03458-6 (Pubitemid 40824737)
4. S. Khatib-Shahidi, M. Andersson, J. L. Herman, T. A. Gillespie, and R. M. Caprioli, Direct molecular analysis of whole-body animal tissue sections by imaging MALDI mass spectrometry., Anal. Chem. 78 (18), 6448-6456 (2006). 10.1021/ac060788p (Pubitemid 44418954)
5. M. Andersson, M. R. Groseclose, A. Y. Deutch, and R. M. Caprioli, Imaging mass spectrometry of proteins and peptides: 3D volume reconstruction., Nat. Methods 5 (1), 101-108 (2008). 10.1038/nmeth1145
6. T. Harada, A. Yuba-Kubo, Y. Sugiura, N. Zaima, T. Hayasaka, N. Goto-Inoue, M. Wakui, M. Suematsu, K. Takeshita, K. Ogawa, Y. Yoshida, and M. Setou, Visualization of volatile substances in different organelles with an atmospheric-pressure mass microscope., Anal. Chem. 81 (21), 9153-9157 (2009). 10.1021/ac901872n
7. H. Hazama, J. Aoki, H. Nagao, R. Suzuki, T. Tashima, K. Fujii, K. Masuda, K. Awazu, M. Toyoda, and Y. Naito, Construction of a novel stigmatic MALDI imaging mass spectrometer., Appl. Surf. Sci. 255 (4), 1257-1263 (2008). 10.1016/j.apsusc.2008.05.058
8. S. L. Luxemburg, T. H. Mize, L. A. McDonnell, and R. M. A. Heeren, High-spatial resolution mass spectrometric imaging of peptide and protein distributions on a surface., Anal. Chem. 76 (18), 5339-5344 (2004). 10.1021/ac049692q (Pubitemid 39249414)
9. A. F. M. Altelaar, I. Klinkert, K. Jalink, R. P. J. de Lange, R. A. H. Adan, R. M. A. Heeren, and S. R. Piersma, Gold-enhanced biomolecular surface imaging of cells and tissue by SIMS and MALDI mass spectrometry., Anal. Chem. 78 (3), 734-742 (2006). 10.1021/ac0513111 (Pubitemid 43228580)
10. L. A. McDonnell and R. M. A. Heeren, Imaging mass spectrometry., Mass Spectrom. Rev. 26 (4), 606-643 (2007). 10.1002/mas.20124 (Pubitemid 47169781)
11. K. Chughtai and R. M. A. Heeren, Mass spectrometric imaging for biomedical tissue analysis., Chem. Rev. 110 (5), 3237-3277 (2010). 10.1021/cr100012c
12. M. Toyoda, D. Okumura, M. Ishihara, and I. Katakuse, Multi-turn time-of-flight mass spectrometers with electrostatic sectors., J. Mass Spectrom. 38 (11), 1125-1142 (2003). 10.1002/jms.546 (Pubitemid 37508680)
13. M. Toyoda, Development of multi-turn time-of-flight mass spectrometers and their applications., Eur. J. Mass Spectrom. 16 (3), 397-406 (2010). 10.1255/ejms.1076
14. H. Matsuda and Y. Fujita, Potential distribution in a cylindrical condenser terminated by Matsuda plates., Int. J. Mass Spectrom. Ion Phys. 16 (4), 395-404 (1975). 10.1016/0020-7381(75)85028-5
15. O. Yogi, T. Kawakami, M. Yamauchi, J. Y. Ye, and M. Ishikawa, On-demand droplet spotter for preparing pico- to femtoliter droplets on surfaces., Anal. Chem. 73 (8), 1896-1902 (2001). 10.1021/ac0012039 (Pubitemid 32862459)
16. O. Yogi, T. Kawakami, and A. Mizuno, Properties of droplet formation made by cone jet using a novel capillary with an external electrode., J. Electrost. 64 (7-9), 634-638 (2006). 10.1016/j.elstat.2005.10.016
17. T. Tashima, M. Toyoda, H. Hazama, K. Fujii, J. Aoki, K. Masuda, K. Awazu, and Y. Naito, Preparation of micro-dot patterns used to evaluate spatial resolution of stigmatic mass spectrometric microscope with multi-turn TOF., Abstracts 57th Annu. Conf. Mass Spectrom. Jpn., 176-177 (2009).
18. H. Inoue, M. Kaga, H. Minami, S. Sugaya, Y. Sato, K. Sasajima, S. Hamatani, A. Shiokawa, and S. Kudo, Ultra-high magnifying endoscopy; from endomicroscopy to endocytoscopy (in Japanese)., Gastroenterol. Endosc. 49 (11), 2811-2818 (2007). (Pubitemid 350306642)
19. T. L. Colliver, C. L. Brummel, M. L. Pacholski, F. D. Swanek, A. G. Ewing, and N. Winograd, Atomic and molecular imaging at the single-cell level with TOF-SIMS., Anal. Chem. 69 (13), 2225-2231 (1997). 10.1021/ac9701748
20. J. Aoki, A. Kubo, M. Ishihara, and M. Toyoda, Simulation of ion trajectories using the surface-charge method on a special purpose computer., Nucl. Instrum. Methods Phys. Res. A 600 (2), 466-470 (2009). 10.1016/j.nima.2008.11.095
21. A. Oelsner, O. Schmidt, M. Schicketanz, M. Klais, G. Schnhense, V. Mergel, O. Jagutzki, and H. Schmidt-Bcking, Microspectroscopy and imaging using a delay line detector in time-of-flight photoemission microscopy., Rev. Sci. Instrum. 72 (10), 3968-3974 (2001). 10.1063/1.1405781
22. O. Jagutzki, A. Cerezo, A. Czasch, R. Drner, M. Hatta, M. Huang, V. Mergel, U. Spillmann, K. Ullmann-Pfleger, T. Weber, H. Schmidt-Bcking, and G. D. W. Smith, Multiple hit readout of a microchannel plate detector with a three-layer delay-line anode., IEEE Trans. Nucl. Sci. 49 (5), 2477-2483 (2002). 10.1109/TNS.2002.803889 (Pubitemid 35443037)
23. G. D. Costa, F. Vurpillot, A. Bostel, M. Bouet, and B. Deconihout, Design of a delay-line position-sensitive detector with improved performance., Rev. Sci. Instrum. 76 (1), 013304 (2005). 10.1063/1.1829975
24. A. Czasch, J. Milnes, N. Hay, W. Wicking, and O. Jagutzki, Position- and time-sensitive single photon detector with delay-line readout., Nucl. Instrum. Methods Phys. Res. A 580 (2), 1066-1070 (2007). 10.1016/j.nima.2007.06.063 (Pubitemid 47381550)