Noscapine induces mitochondria-mediated apoptosis in gastric cancer cells in vitro and in vivo

Cancer Chemotherapy and Pharmacology

Volumn 67, Issue 3, 2011, Pages 605-612

  Liu, Meng ^a   Luo, Xiao Juan ^b   Liao, Fei ^a   Lei, Xiao Fei ^a   Dong, Wei Guo ^a  

^a RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

^b HUBEI UNIVERSITY OF MEDICINE   (China)

Author keywords

Apoptosis; Gastric cancer; Mitochondria; Noscapine

Indexed keywords

CASPASE 3; CASPASE 9; CYTOCHROME C; NOSCAPINE; PROTEIN BAX; PROTEIN BCL 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CONTROLLED STUDY; DOSE RESPONSE; DRUG INHIBITION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; MALE; MITOCHONDRION; MOUSE; NICK END LABELING; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; STOMACH CANCER; TUMOR GROWTH; TUMOR XENOGRAFT; ANIMAL; BAGG ALBINO MOUSE; DOWN REGULATION; DRUG EFFECT; DRUG SCREENING; GENETICS; METABOLISM; NUDE MOUSE; PATHOLOGY; STOMACH TUMOR; TUMOR CELL LINE; UPREGULATION;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CASPASE 9; CELL LINE, TUMOR; CYTOCHROMES C; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; HUMANS; IN SITU NICK-END LABELING; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; MITOCHONDRIA; NOSCAPINE; PROTO-ONCOGENE PROTEINS C-BCL-2; STOMACH NEOPLASMS; UP-REGULATION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 79953792744     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-010-1356-3     Document Type: Article

References (30)

1. R Wesolowshi C Lee R Kim 2009 Is there a role for second-line chemotherapy in advanced gastric cancer? Lancet Oncol 10 903 912 10.1016/S1470-2045(09)70136-6
2. E Winer J Gralow L Dille, et al. 2008 Clinical cancer advances 2008: major research advances in cancer treatment, prevention, and screening-a report from the American Society of Clinical Oncology J Clin Oncol 27 812 826 10.1200/JCO.2008.21.2134 19103723
3. F Bozzetti E Marubini G Bonfanti, et al. 1999 Subtotal versus total gastrectomy for gastric cancer: five-year survival rates in a multicenter randomized Italian trial Ann Surg 230 170 178 1:STN:280:DyaK1Mznsl2guw%3D%3D 10.1097/00000658-199908000-00006 10450730 (Pubitemid 30191882)
4. E Uña 2009 Gastric cancer: predictors of recurrence when lymph-node dissection is inadequate World J Surg Oncol 7 69 10.1186/1477-7819-7-69 19761613
5. HC Joshi J Zhou 2000 Noscapine and analogues as potential chemotherapeutic agents Drug News Perspect 13 543 546 1:CAS:528: DC%2BD3MXht1SiurY%3D 10.1358/dnp.2000.13.9.858482 12879125 (Pubitemid 32120910)
6. K Ye Y Ke N Keshava J Shanks, et al. 1998 Opium alkaloid noscapine is an antitumor agent that arrests metaphase and induces apoptosis in dividing cells Proc Natl Acad Sci USA 95 1601 1606 1:CAS:528:DyaK1cXht1WqtLo%3D 10.1073/pnas.95.4.1601 9465062 (Pubitemid 28103439)
7. EW Newcomb Y Lukyanov T Schnee, et al. 2006 Noscapine inhibits hypoxia-mediated HIF-1α expression and angiogenesis in vitro: a novel function for an old drug Int J Noncol 28 1121 1130 1:CAS:528: DC%2BD28Xks1Cju7s%3D
8. J Zhou K Gupta S Aggarwal R Aneja, et al. 2003 Brominated derivatives of noscapine are potent microtubule-interfering agents that perturb mitosis and inhibit cell proliferation Mol Pharmacol 63 799 807 1:CAS:528: DC%2BD3sXisFeksL8%3D 10.1124/mol.63.4.799 12644580 (Pubitemid 36368986)
9. T Jackson MB Chougule N Ichite, et al. 2008 Antitumor activity of noscapine in human non-small cell lung cancer xenograft model Cancer Chemother Pharmacol 63 117 126 1:CAS:528:DC%2BD1cXhtF2kur7K 10.1007/s00280-008-0720-z 18338172
10. JW Landen R Lang SJ McMahon, et al. 2002 Noscapine alters microtubule dynamics in living cells and inhibits the progression of melanoma Cancer Res 62 4109 4114 1:CAS:528:DC%2BD38XlsV2ltr4%3D 12124349 (Pubitemid 34791082)
11. Y Ke K Ye HE Grossniklaus, et al. 2000 Noscapine inhibits tumor growth with little toxicity to normal tissues or inhibition of immune responses Cancer Immunol Immunother 49 217 225 1:CAS:528:DC%2BD3cXlvFymtr8%3D 10.1007/s002620000109 10941904 (Pubitemid 30484828)
12. BR Kim JW Shim DK Sung SS Kim, et al. 2008 Granulocyte stimulating factor attenuates hypoxic-ischemic brain injury by inhibiting apoptosis in neonatal rats Yonsei Med J 49 836 842 1:CAS:528:DC%2BD1cXhsVyltLfJ 10.3349/ymj.2008.49.5. 836 18972605
13. N Holler R Zaru O Micheau, et al. 2000 Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule Nat Immunol 1 489 495 1:CAS:528:DC%2BD3cXoslyru74%3D 10.1038/82732 11101870
14. H Suzuki E Iwasaki T Hibi 2009 Helicobacter pylori and gastric cancer Gastric Cancer 12 79 87 10.1007/s10120-009-0507-x 19562461
15. W Liu X Zhang W Sun 2008 Developments in treatment of esophageal/gastric cancer Curr Treat Options Oncol 9 375 387 10.1007/s11864-009-0097-1 19396633
16. S Fleming F Lucas M Schofield 2001 A therapeutic area review of oncology products and players Expert Opin Emerg Drugs 6 317 329 1:CAS:528: DC%2BD3MXotl2rtr4%3D 10.1517/14728214.6.2.317 15989529 (Pubitemid 34131409)
17. L van Zuylen J Verweij A Sparreboom 2001 Role of formulation vehicles in taxane pharmacology Invest New Drugs 19 125 141 10.1023/A:1010618632738 11392447 (Pubitemid 32423718)
18. M Markman 2003 Managing taxane toxicities Support Care Cancer 11 144 147 12618923 (Pubitemid 36733807)
19. R Aneja AM Ghaleb J Zhou, et al. 2007 p53 and p21 determine the sensitivity of noscapine-induced apoptosis in colon cancer cells Cancer Res 67 3826 3870 10.1158/0008-5472.CAN-06-4282 (Pubitemid 46762174)
20. DV Krysko T Vanden Berghe K D'Herde, et al. 2008 Apoptosis and necrosis: detection, discrimination and phagocytosis Methods 44 205 221 1:CAS:528:DC%2BD1cXislWnurk%3D 10.1016/j.ymeth.2007.12.001 18314051 (Pubitemid 351296447)
21. DV Krysko K D'Herde P Vandenabeele 2006 Clearance of apoptotic and necrotic cells and its immunological consequences Apoptosis 11 1709 1726 10.1007/s10495-006-9527-8 16951923 (Pubitemid 44371047)
22. Y Tsujimoto LR Finger J Yunis, et al. 1984 Cloning of the chromosome breakpoint of neoplastic B cells with the t (14;18) chromosome translocation Science 226 1097 1099 1:CAS:528:DyaL2MXhvVyjug%3D%3D 10.1126/science.6093263 6093263 (Pubitemid 15217831)
23. A Jourdain JC Martinou 2009 Mitochondrial outer-membrane permeabilization and remodelling in apoptosis Int J Biochem Cell Biol 41 1884 1889 1:CAS:528:DC%2BD1MXhtVentbvF 10.1016/j.biocel.2009.05.001 19439192
24. DL Vaux S Cory JM Adams 1988 Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells Nature 335 440 442 1:CAS:528:DyaL1MXlt1alsA%3D%3D 10.1038/335440a0 3262202
25. Y Muto H Moriwaki M Ninomiya, et al. 1996 Prevention of second primary tumors by an acyclic retinoid, polyprenoic acid, in patients with hepatocellular carcinoma. Hepatoma Prevention Study Group N Engl J Med 334 1561 1567 1:CAS:528:DyaK28XksVCgsLk%3D 10.1056/NEJM199606133342402 8628336 (Pubitemid 26177483)
26. WF Holmes DR Soprano KJ Soprano 2003 Early events in the induction of apoptosis in ovarian carcinoma cells by CD437: activation of the p38 MAP kinase signal pathway Oncogene 2 6377 6386 10.1038/sj.onc.1206694 (Pubitemid 37281686)
27. JM Adams S Cory 2007 The Bcl-2-regulated apoptosis: mechanism and therapeutic potential Curr Opin Immunol 19 488 496 1:CAS:528:DC%2BD2sXhtFSmu7vN 10.1016/j.coi.2007.05.004 17629468 (Pubitemid 47487452)
28. P Boya G Kroemer 2009 Beclin 1: a BH3-only protein that fails to induce apoptosis Oncogene 28 2128 2141 10.1038/onc.2009.83
29. RJ Youle A Strasser 2008 The BCL-2 protein family: opposing activities that mediate cell death Nat Rev Mol Cell Biol 9 47 59 1:CAS:528: DC%2BD2sXhsVKrsrrP 10.1038/nrm2308 18097445
30. G Varbiro B Veres F Gallyas Jr, et al. 2001 Direct effect of Taxol on free radical formation and mitochondrial permeability transition Free Radic Biol Med 31 548 558 1:CAS:528:DC%2BD3MXlslGnuro%3D 10.1016/S0891-5849(01)00616-5 11498288 (Pubitemid 32728442)