Noscapine and analogues as potential chemotherapeutic agents

Drug News and Perspectives

Volumn 13, Issue 9, 2000, Pages 543-546

  Joshi, H C ^a   Zhou, J ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHOXY 5 (2,3,4 TRIMETHOXYPHENYL)TROPONE; ANTINEOPLASTIC AGENT; BENZENE DERIVATIVE; CELL PROTEIN; COLCHICINE; NOSCAPINE; PODOPHYLLOTOXIN; TUBULIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; CANCER CELL; CANCER GROWTH; CELL DIVISION; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; CYTOTOXICITY; DRUG EFFICACY; MICROTUBULE; MITOSIS; MITOSIS INHIBITION; MITOSIS SPINDLE; MOUSE; NONHUMAN; REVIEW;

EID: 0034491250     PISSN: 02140934     EISSN: None     Source Type: Journal    
DOI: 10.1358/dnp.2000.13.9.858482     Document Type: Review

References (27)

1. Opium alkaloid noscapine is an anti-tumor agent that arrests metaphase and induces apoptosis in dividing cells
2. Comparison of the antitussive effects of codeine phosphate 20 mg, dextromethorphan 30 mg and noscapine 30 mg using citric acid-induced cough in normal subjects
3. Pharmacokinetic properties of noscapine
4. Pharmacokinetics of oral noscapine
5. Microtubule dynamics in living cells
6. Dynamic instability of microtubule growth
7. Some new aspects of mitotic poisoning
8. Desacetylamino-colchicine: A derivative of colchicine with increased cytotoxic activity in mammalian cell cultures
9. Taxol stabilizes microtubules in mouse fibroblast cells
10. The clinical pharmacology and use of antimicrotubule agents in cancer chemotherapeutics
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12. Systemic therapy for gynecologic cancer
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14. Kinetics of mitotic arrest and apoptosis in murine mammary and ovarian tumors treated with Taxol
15. Loss of normal p53 function confers sensitization to Taxol by increasing G2/M arrest and apoptosis
16. cdc25+ functions as an inducer in mitotic control of fission yeast
17. Negative regulation of mitosis by weel +, a gene encoding a protein kinase homologue
18. Human weel maintains mitotic timing by protecting the nucleus from cytoplasmically activated cdc2 kinase
19. Taxol induces internucleosomal DNA fragmentation associated with programmed cell death in human myeloid leukemia cells
20. Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations
21. Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death
22. Colchicine induces apoptosis in cerebellar granule cells
23. Taxol-induced mitotic block triggers rapid onset of a p53-independent apoptotic pathway
24. Modulation of vinblastine cytotoxicity by dilantin (phenytoin) or the protein phosphatase inhibitor okadaic acid involves the potentiation of anti-mitotic effects and induction of apoptosis in human tumor cells
25. Overexpression of ErbB2 blocks Taxol induced apoptosis by upregulation of p21Cip1, which inhibits p34 cdc2 kinase
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