Extracellular alkalinization stimulates calcium-activated chloride conductance in cystic fibrosis human airway epithelial cells

Cellular Physiology and Biochemistry

Volumn 27, Issue 3-4, 2011, Pages 401-410

  Dankó, Tamás ^a   Hargitai, Dóra ^a   Pataki, Ágnes ^a   Hakim, Hasif ^a   Molnár, Miklós ^a   Zsembery, Ákos ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

Extracellular pH; Sodium; Zinc

Indexed keywords

4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; CALCIUM; CALCIUM ACTIVATED CHLORIDE CHANNEL; CHLORIDE CHANNEL; FLUORESCENT DYE; NIFLUMIC ACID; SODIUM; UNCLASSIFIED DRUG; ZINC;

ALKALINIZATION; ARTICLE; CALCIUM CELL LEVEL; CELL STIMULATION; CELL VIABILITY; CHLORIDE CONDUCTANCE; CONTROLLED STUDY; CYSTIC FIBROSIS; EPITHELIUM CELL; EXTRACELLULAR CALCIUM; HUMAN; HUMAN CELL; ION CURRENT; PATCH CLAMP; PH; PRIORITY JOURNAL; RESPIRATORY EPITHELIUM; WHOLE CELL;

EID: 79953788275     PISSN: 10158987     EISSN: None     Source Type: Journal    
DOI: 10.1159/000327967     Document Type: Article

References (40)

1. + conductance in cystic fibrosis. Pflugers Arch 1995;431:1-9.
2. Knowles MR, Boucher RC: Mucus clearance as a primary innate defense mechanism for mammalian airways. J Clin Invest 2002;109:571-577. (Pubitemid 34204834)
3. -/- mice. Proc Natl Acad Sci USA 1994;91:479-483.
4. Grubb BR, Pickles RJ, Ye H, Yankaskas JR, Vick RN, Engelhardt JF, Wilson JM, Johnson LG, Boucher RC: Inefficient gene transfer by adenovirus vector to cystic fibrosis airway epithelia of mice and humans. Nature 1994;371:802-806. (Pubitemid 24333869)
5. Tarran R, Button B, Picher M, Paradiso AM, Ribeiro CM, Lazarowski ER, Zhang L, Collins PL, Pickles RJ, Fredberg JJ, Boucher RC: Normal and cystic fibrosis airway surface liquid homeostasis. The effects of phasic shear stress and viral infections. J Biol Chem 2005;280:35751-35759. (Pubitemid 41532768)
6. Knowles MR, Clarke LL, Boucher RC: Activation by extracellular nucleotides of chloride secretion in the airway epithelia of patients with cystic fibrosis. N Engl J Med 1991;325:533-538.
7. - channels with different functions. Cell Calcium 2009;46:233-241.
8. 2+ -regulated cl- secretory channel in mouse airways. J Biol Chem 2009;284:14875-14880.
9. Hartzell C, Putzier I, Arreola J: Calcium-activated chloride channels. Annu Rev Physiol 2005;67:719-758. (Pubitemid 40404508)
10. Kellerman D, Evans R, Mathews D, Shaffer C: Inhaled p2y2 receptor agonists as a treatment for patients with cystic fibrosis lung disease. Adv Drug Deliv Rev 2002;54:1463-1474. (Pubitemid 35375770)
11. Zsembery A, Boyce AT, Liang L, Peti-Peterdi J, Bell PD, Schwiebert EM: Sustained calcium entry through p2x nucleotide receptor channels in human airway epithelial cells. J Biol Chem 2003;278:13398-13408. (Pubitemid 36800113)
12. Zsembery A, Fortenberry JA, Liang L, Bebok Z, Tucker TA, Boyce AT, Braunstein GM, Welty E, Bell PD, Sorscher EJ, Clancy JP, Schwiebert EM: Extracellular zinc and atp restore chloride secretion across cystic fibrosis airway epithelia by triggering calcium entry. J Biol Chem 2004;279:10720-10729. (Pubitemid 38372685)
13. Adamson IY, Prieditis H, Hedgecock C, Vincent R: Zinc is the toxic factor in the lung response to an atmospheric particulate sample. Toxicol Appl Pharmacol 2000;166:111-119. (Pubitemid 30497434)
14. Barceloux DG: Zinc. J Toxicol Clin Toxicol 1999;37:279-292.
15. Blanc PD, Boushey HA, Wong H, Wintermeyer SF, Bernstein MS: Cytokines in metal fume fever. Am Rev Respir Dis 1993;147:134-138. (Pubitemid 23025928)
16. Davidson TM, Smith WM: The bradford hill criteria and zinc-induced anosmia: A causality analysis. Arch Otolaryngol Head Neck Surg 2010;136:673-676.
17. Kuschner WG, D'Alessandro A, Wong H, Blanc PD: Early pulmonary cytokine responses to zinc oxide fume inhalation. Environ Res 1997;75:7-11. (Pubitemid 27446790)
18. Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ: Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch 1981;391:85-100. (Pubitemid 11012976)
19. Mall M, Grubb BR, Harkema JR, O'Neal WK, Boucher RC: Increased airway epithelial na+ absorption produces cystic fibrosis-like lung disease in mice. Nat Med 2004;10:487-493. (Pubitemid 38667907)
20. + channel in the pathogenesis and as a therapeutic target for cystic fibrosis lung disease. Exp Physiol 2009;94:171-174.
21. Kellerman D, Rossi Mospan A, Engels J, Schaberg A, Gorden J, Smiley L: Denufosol: A review of studies with inhaled p2y(2) agonists that led to phase 3. Pulm Pharmacol Ther 2008;21:600-607.
22. Clunes MT, Boucher RC: Front-runners for pharmacotherapeutic correction of the airway ion transport defect in cystic fibrosis. Curr Opin Pharmacol 2008;8:292-299.
23. Liang L, MacDonald K, Schwiebert EM, Zeitlin PL, Guggino WB: Spiperone, identified through compound screening, activates calcium-dependent chloride secretion in the airway. Am J Physiol Cell Physiol 2009;296:C131-141.
24. 2+ signals. J Gen Physiol 2000;115:59-80.
25. Machaca K, HC Hartzell: Reversible ca gradients between the subplasmalemma and cytosol differentially activate ca-dependent cl currents. J Gen Physiol 1999;113:249-266. (Pubitemid 29219798)
26. Chen XH, Bezprozvanny I, Tsien RW: Molecular basis of proton block of l-type Ca2+ channels. J Gen Physiol 1996;108:363-374. (Pubitemid 26374747)
27. 2+ entry in isolated rat cortical collecting duct is pH- and voltage sensitive. Cell Physiol Biochem 1997;7:333-344.
28. Sutton RA, Wong NL, Dirks JH: Effects of metabolic acidosis and alkalosis on sodium and calcium transport in the dog kidney. Kidney Int 1979;15:520-533. (Pubitemid 9256747)
29. Dipolo R, Beaugé L: The effect of ph on ca2+ extrusion mechanisms in dialyzed squid axons. Biochim Biophys Acta 1982;688:237-245.
30. Krafte DS, Kass RS: Hydrogen ion modulation of ca channel current in cardiac ventricular cells. Evidence for multiple mechanisms. J Gen Physiol 1988;91:641-657.
31. Polo-Parada L, Korn SJ: Block of n-type calcium channels in chick sensory neurons by external sodium. J Gen Physiol 1997;109:693-702. (Pubitemid 27255935)
32. Ma W, Korngreen A, Weil S, Cohen EB, Priel A, Kuzin L, Silberberg SD: Pore properties and pharmacological features of the p2x receptor channel in airway ciliated cells. J Physiol 2006;571:503-517. (Pubitemid 43329544)
33. Iijima T, Ciani S, Hagiwara S: Effects of the external ph on ca channels: Experimental studies and theoretical considerations using a two-site, two-ion model. Proc Natl Acad Sci USA 1986;83:654-658. (Pubitemid 16035533)
34. Paoletti P, Ascher P, Neyton J: High-affinity zinc inhibition of nmda nr1-nr2a receptors. J Neurosci 1997;17:5711-5725. (Pubitemid 27310487)
35. Hosie AM, Dunne EL, Harvey RJ, Smart TG: Zinc-mediated inhibition of gaba(a) receptors: Discrete binding sites underlie subtype specificity. Nat Neurosci 2003;6:362-369. (Pubitemid 36373981)
36. Huidobro-Toro JP, Lorca RA, Coddou C: Trace metals in the brain: Allosteric modulators of ligand-gated receptor channels, the case of atp-gated p2x receptors. Eur Biophys J 2008;37:301-314.
37. 2+ channels by zinc. J Biol Chem 2004;279:11106-11111.
38. 2+ in relation to extracellular ionic environment in human airway epithelial cells. Respir Physiol Neurobiol 2010;170:67-75.
39. Linley JE, Simmons NL, Gray MA: Extracellular zinc stimulates a calcium-activated chloride conductance through mobilisation of intracellular calcium in renal inner medullary collecting duct cells. Pflugers Arch 2007;453:487-495. (Pubitemid 46011169)
40. Inagaki A, Yamaguchi S, Takahashi-Iwanaga H, Iwanaga T, Ishikawa T: Functional characterization of a ClC-2-like Cl- conductance in surface epithelial cells of rat rectal colon. J Membr Biol 2010;235:27-41.