The tyrosine kinase p56(lck) is essential in coxsackievirus B3-mediated heart disease

Nature Medicine

Volumn 6, Issue 4, 2000, Pages 429-434

  Liu, Peter ^a   Aitken, Karen ^a   Kong, Young Yun ^a   Opavsky, Mary Anne ^a   Martino, Tammy ^a   Dawood, Fayez ^a   Wen, Wen Hu ^a   Kozeiradzki, Ivona ^a   Bachmaier, Kurt ^a   Straus, David ^b   Mak, Tak W ^a   Penninger, Josef M ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; MESSENGER RNA; PROTEIN TYROSINE KINASE; PROTEIN KINASE LCK;

ANIMAL MODEL; ARTICLE; CARDIOMYOPATHY; CARDIOVASCULAR DISEASE; COXSACKIE VIRUS; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; VIRUS INFECTION; VIRUS MYOCARDITIS; VIRUS REPLICATION; ANIMAL; CHRONIC DISEASE; CONGESTIVE CARDIOMYOPATHY; COXSACKIE VIRUS INFECTION; ENCEPHALOMYOCARDITIS VIRUS; ENTEROVIRUS; GENETICS; HELA CELL; LEUKEMIA CELL LINE; METABOLISM; MOUSE; MOUSE MUTANT; PATHOGENICITY; PATHOLOGY; PHYSIOLOGY; VIROLOGY;

ANIMALIA; COXSACKIEVIRUS;

ANIMALS; CARDIOMYOPATHY, DILATED; CHRONIC DISEASE; COXSACKIEVIRUS INFECTIONS; ENCEPHALOMYOCARDITIS VIRUS; ENTEROVIRUS B, HUMAN; HELA CELLS; HUMANS; JURKAT CELLS; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); MICE; MICE, KNOCKOUT; SRC-FAMILY KINASES; VIRUS REPLICATION;

EID: 0033622010     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/74689     Document Type: Article

References (27)

1. Bachmaier, K. et al. Chlamydia infections and heart disease linked through antigenic mimicry. Science 283, 1335-1339 (1999).
2. Martino, T.A., Liu, P. & Sole, M.J. Viral infection and the pathogenesis of dilated cardiomyopathy. Circ. Res. 74, 182-188 (1994).
3. Friman, G. et al. The epidemiology of infectious myocarditis, lymphocytic myocarditis and dilated cardiomyopathy. Eur. Heart J. 16, 36-41 (1995).
4. Horwitz, M.S. et al. Diabetes induced by Coxsackie virus: Initiation by bystander damage and not molecular mimicry. Nature Med. 4, 781-785 (1998).
5. Archard, L.C. et al. Characterization of Coxsackie B virus RNA in myocardium from patients with dilated cardiomyopathy by nucleotide sequencing of reverse transcription-nested polymerase chain reaction products. Human Path. 29, 578-584 (1998).
6. Martino, T.A. et al. Quantitation of enteroviral RNA by competitive polymerase chain reaction. J. Clin. Microbiol. 31, 2634-2640 (1993).
7. Woodruff, J.F. Viral myocarditis A review. Am. J. Path. 101, 425-484 (1980).
8. Huber, S.A. Coxsackievirus-induced myocarditis is dependent on distinct immunopathogenic responses in different strains of mice. Lab. Invest. 76, 691-701 (1997).
9. Wolfgram, L.J. et al. Variations in the susceptibility to Coxsackievirus B3-induced myocarditis among different strains of mice. J. Immunol. 136, 1846-1852 (1986).
10. Klingel, K. et al. Pathogenesis of murine enterovirus myocarditis: virus dissemination and immune cell targets. J. Virol. 70, 8888-8895 (1996).
11. Anderson, D.R. et al. Direct interactions of coxsackievirus B3 with immune cells in the splenic compartment of mice susceptible or resistant to myocarditis. J. Virol. 70, 4632-4645 (1996).
12. Shafren, D.R., Viral cell entry induced by cross-linked decay-accelerating factor. J. Virol. 72, 9407-9412 (1998).
13. Bergelson, J.M. et al. Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5. Science 275, 1320-1323 (1997).
14. Wang, X. & Bergelson, J.M. Coxsackievirus and adenovirus receptor cytoplasmic and transmembrane domains are not essential for coxsackievirus and adenovirus infection. J. Virol. 73, 2559-2562 (1999).
15. Shenoy-Scaria, A.M. et al. Signal transduction through decay-accelerating factor Interaction of glycosyl-phosphatidylinositol anchor and protein tyrosine kinases p56lck and p59fyn 1. J. Immunol. 149, 3535-3541 (1992).
16. Straus, D.B. & Weiss, A. Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor. Cell 70, 585-593 (1992).
17. Koretzky, G.A. et al. Tyrosine phosphatase CD45 is required for T-cell antigen receptor and CD2-mediated activation of a protein tyrosine kinase and interleukin 2 production. Proc. Natl. Acad. Sci. USA 88, 2037-2041 (1991).
18. Molina, T.J. et al. Profound block in thymocyte development in mice lacking p56lck. Nature 357, 161-164 (1992).
19. Gauntt, C. J. et al. Coxsackievirus-induced chronic myocarditis in murine models. Eur. Heart J. 16, 56-58 (1995).
20. Rahemtulla, A. et al. CD4 negative mice as a model for immunodeficiency. Nature 353, 180-184 (1993).
21. Fung-Leung, W.P. et al. CD8 is needed for development of cytotoxic T cells but not helper T cells. Cell 65, 443-449 (1991).
22. Shahinian, A. et al. Differential T cell costimulatory requirements in CD28-deficient mice. Science 261, 609-612 (1993).
23. Mombaerts, P. et al. RAG-1-deficient mice have no mature B and T lymphocytes. Cell 68, 869-877 (1992).
24. Molina, T.J. et al. Peripheral T cells in mice lacking p56lck do not express significant antiviral effector functions. J. Immunol. 151, 699-706 (1993).
25. Matsumori, A. & Kawai, C. An experimental model for congestive heart failure after encephalomyocarditis virus myocarditis in mice. Circulation 65, 1230-1235 (1982).
26. Huber, S.A. & Lodge, P. A. Coxsackievirus B-3 myocarditis in Balb/c mice. Evidence for autoimmunity to myocyte antigens. Am. J. Pathol. 116, 21-29 (1984).
27. Rose, N.R. et al. Autoimmune myocarditis: a paradigm of post-infection autoimmune disease. Immunol. Today 9, 117-120 (1988).