Expression of C4.4A, a structural uPAR homolog, reflects squamous epithelial differentiation in the adult mouse and during embryogenesis

Journal of Histochemistry and Cytochemistry

Volumn 59, Issue 2, 2011, Pages 188-201

  Kriegbaum, Mette C ^a   Jacobsen, Benedikte ^a   Hald, Andreas ^b   Ploug, Michael ^a,c  

^a FINSEN LABORATORY   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c Danish Chinese Centre for Proteases and Cancer   (Denmark)

Author keywords

Biomarker; Immunohistochemistry; LYPD3; Mouse; NSCLC; Squamo columnar junctions; Squamous epithelium differentiation; Stratum spinosum; uPAR

Indexed keywords

C4.4A PROTEIN; PARAFFIN; TUMOR MARKER; UNCLASSIFIED DRUG; UROKINASE RECEPTOR; CELL ADHESION MOLECULE; GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORED PROTEIN; LYPD3 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; CORNEA; EMBRYO DEVELOPMENT; ESOPHAGUS; FEMALE; MALE; MOUTH CAVITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STRUCTURE; RAT; SKIN; SQUAMOUS EPITHELIUM; STOMACH; VAGINA; ANIMAL; CHEMISTRY; CYTOLOGY; EPITHELIUM CELL; GENE EXPRESSION REGULATION; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLISM; MOUSE; PHENOTYPE; PROTEIN TRANSPORT; REPRODUCTION; SEQUENCE HOMOLOGY;

ORYCTOLAGUS CUNICULUS; RATTUS; RODENTIA;

ANIMALS; CELL ADHESION MOLECULES; CELL DIFFERENTIATION; EMBRYONIC DEVELOPMENT; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GPI-LINKED PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICE; PHENOTYPE; PROTEIN TRANSPORT; RATS; RECEPTORS, UROKINASE PLASMINOGEN ACTIVATOR; REPRODUCTION; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 79953780037     PISSN: 00221554     EISSN: None     Source Type: Journal    
DOI: 10.1369/0022155410394859     Document Type: Article

References (43)

1. Bickenbach JR, Greer JM, Bundman DS, Rothnagel JA, Roop DR. 1995. Loricrin expression is coordinated with other epidermal proteins and the appearance of lipid lamellar granules in development. J Invest Dermatol. 104:405-410.
2. Bos PD, Nguyen DX, Massague J. 2010. Modeling metastasis in the mouse. Curr Opin Pharmacol. 10:1-7.
3. Byrne C, Tainsky M, Fuchs E. 1994. Programming gene expression in developing epidermis. Development. 120:2369-2383.
4. Chisamore MJ, Wilkinson HA, Flores O, Chen JD. 2009. Estrogen-related receptor-alpha antagonist inhibits both estrogen receptor-positive and estrogen receptor-negative breast tumor growth in mouse xenografts. Mol Cancer Ther. 8:672-681.
5. Claas C, Herrmann K, Matzku S, Moller P, Zoller M. 1996. Developmentally regulated expression of metastasis-associated antigens in the rat. Cell Growth Differ. 7:663-678.
6. Connolly BM, Choi EY, Gardsvoll H, Bey AL, Currie BM, Chavakis T, Liu S, Molinolo A, Ploug M, Leppla SH, et al. 2010. Selective abrogation of the uPA-uPAR interaction in vivo reveals a novel role in suppression of fibrin-associated inflammation. Blood. 116:1593-1603.
7. Davidson P, Hardy MH. 1952. The development of mouse vibrissae in vivo and in vitro. J Anat. 86:342-356.
8. DuPage M, Dooley AL, Jacks T. 2009. Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase. Nat Protoc. 4:1064-1072.
9. Fries F, Nazarenko I, Hess J, Claas A, Angel P, Zoller M. 2007. CEBPbeta, JunD and c-Jun contribute to the transcriptional activation of the metastasis-associated C4.4A gene. Int J Cancer. 120:2135-2147.
10. Fukamachi H, Mizuno T, Takayama S. 1979. Epithelialmesenchymal interactions in differentiation of stomach epithelium in fetal mice. Anat Embryol (Berl). 157:151-160.
11. Gardsvoll H, Hansen LV, Jorgensen TJ, Ploug M. 2007. A new tagging system for production of recombinant proteins in Drosophila S2 cells using the third domain of the urokinase receptor. Protein Expr Purif. 52:384-394.
12. Hansen LV, Gardsvoll H, Nielsen BS, Lund LR, Dano K, Jensen ON, Ploug M. 2004. Structural analysis and tissue localization of human C4.4A: a protein homologue of the urokinase receptor. Biochem J. 380:845-857.
13. Hansen LV, Larum OD, Illemann M, Nielsen BS, Ploug M. 2008. Altered expression of the urokinase receptor homologue, C4.4A, in invasive areas of human esophageal squamous cell carcinoma. Int J Cancer. 122:734-741.
14. Hansen LV, Skov BG, Ploug M, Pappot H. 2007. Tumour cell expression of C4.4A, a structural homologue of the urokinase receptor, correlates with poor prognosis in non-small cell lung cancer. Lung Cancer. 58:260-266.
15. Hanson J. 1947. The histogenesis of the epidermis in the rat and mouse. J Anat. 81:174-197.
16. Hardman MJ, Ashcroft GS. 2008. Estrogen, not intrinsic aging, is the major regulator of delayed human wound healing in the elderly. Genome Biol. 9:R80.
17. Helvering LM, Adrian MD, Geiser AG, Estrem ST, Wei T, Huang S, Chen P, Dow ER, Calley JN, Dodge JA, et al. 2005. Differential effects of estrogen and raloxifene on messenger RNA and matrix metalloproteinase 2 activity in the rat uterus. Biol Reprod. 72:830-841.
18. Hijazi A, Masson W, Auge B, Waltzer L, Haenlin M, Roch F. 2009. Boudin is required for septate junction organisation in Drosophila and codes for a diffusible protein of the Ly6 superfamily. Development. 136:2199-2209.
19. Holt DR, Kirk SJ, Regan MC, Hurson M, Lindblad WJ, Barbul A. 1992. Effect of age on wound healing in healthy human beings. Surgery. 112:293-297; discussion 297-298.
20. Hoyer-Hansen G, Lund IK. 2007. Urokinase receptor variants in tissue and body fluids. Adv Clin Chem. 44:65-102.
21. Huai Q, Mazar AP, Kuo A, Parry GC, Shaw DE, Callahan J, Li Y, Yuan C, Bian C, Chen L, et al. 2006. Structure of human urokinase plasminogen activator in complex with its receptor. Science. 311:656-659.
22. Ito M. 1986. The innermost cell layer of the outer root sheath in anagen hair follicle: light and electron microscopic study. Arch Dermatol Res. 279:112-119.
23. Jacobsen B, Ploug M. 2008. The urokinase receptor and its structural homologue C4.4A in human cancer: expression, prognosis and pharmacological inhibition. Curr Med Chem. 15:2559-2573.
24. Jacobsen B, Santoni-Rugiu E, Illemann M, Larum OD, Ploug M. 2011. Expression of C4.4A in precursor lesions of non-small cell lung cancer. Int J Cancer. Manuscript submitted.
25. Kjaergaard M, Hansen LV, Jacobsen B, Gardsvoll H, Ploug M. 2008. Structure and ligand interactions of the urokinase receptor (uPAR). Front Biosci. 13:5441-5461.
26. Lin L, Gardsvoll H, Huai Q, Huang M, Ploug M. 2010. Structurebased engineering of species selectivity in the interaction between urokinase and its receptor: implication for preclinical cancer therapy. J Biol Chem. 285:10982-10992.
27. Llinas P, Le Du MH, Gardsvoll H, Dano K, Ploug M, Gilquin B, Stura EA, Menez A. 2005. Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide. EMBO J 24:1655-1663.
28. Meuwissen R, Berns A. 2005. Mouse models for human lung cancer. Genes Dev. 19:643-664.
29. Nilton A, Oshima K, Zare F, Byri S, Nannmark U, Nyberg KG, Fehon RG, Uv AE. 2010. Crooked, coiled and crimpled are three Ly6-like proteins required for proper localization of septate junction components. Development. 137:2427-2437.
30. Parakkal PF. 1967. An electron microscopic study of esophageal epithelium in the newborn and adult mouse. Am J Anat. 121:175-195.
31. Paret C, Bourouba M, Beer A, Miyazaki K, Schnolzer M, Fiedler S, Zoller M. 2005. Ly6 family member C4.4A binds laminins 1 and 5, associates with galectin-3 and supports cell migration. Int J Cancer. 115:724-733.
32. Paret C, Hildebrand D, Weitz J, Kopp-Schneider A, Kuhn A, Beer A, Hautmann R, Zoller M. 2007. C4.4A as a candidate marker in the diagnosis of colorectal cancer. Br J Cancer. 97:1146-1156.
33. Ploug M. 2003. Structure-function relationships in the interaction between the urokinase-type plasminogen activator and its receptor. Curr Pharm Des. 9:1499-1528.
34. Raymond C, Anne V, Millane G. 1991. Development of esophageal epithelium in the fetal and neonatal mouse. Anat Rec. 230:225-234.
35. Rosel M, Claas C, Seiter S, Herlevsen M, Zoller M. 1998. Cloning and functional characterization of a new phosphatidyl-inositol anchored molecule of a metastasizing rat pancreatic tumor. Oncogene. 17:1989-2002.
36. Seiter S, Stassar M, Rappl G, Reinhold U, Tilgen W, Zoller M. 2001. Upregulation of C4.4A expression during progression of melanoma. J Invest Dermatol. 116:344-347.
37. Shezen E, Okon E, Ben-Hur H, Abramsky O. 1995. Cytokeratin expression in human thymus: immunohistochemical mapping. Cell Tissue Res. 279:221-231.
38. Smith BA, Kennedy WJ, Harnden P, Selby PJ, Trejdosiewicz LK, Southgate J. 2001. Identification of genes involved in human urothelial cell-matrix interactions: implications for the progression pathways of malignant urothelium. Cancer Res. 61:1678-1685.
39. Ullah MF, Aatif M. 2009. The footprints of cancer development: cancer biomarkers. Cancer Treat Rev. 35:193-200.
40. Westwood FR. 2008. The female rat reproductive cycle: a practical histological guide to staging. Toxicol Pathol. 36:375-384.
41. Wistuba II, Gazdar AF. 2006. Lung cancer preneoplasia. Annu Rev Pathol. 1:331-348.
42. Wurfel J, Seiter S, Stassar M, Claas A, Klas R, Rosel M, Marhaba R, Savelyeva L, Schwab M, Matzku S, et al. 2001. Cloning of the human homologue of the metastasis-associated rat C4.4A. Gene. 262:35-41.
43. Yu WY, Slack JM, Tosh D. 2005. Conversion of columnar to stratified squamous epithelium in the developing mouse oesophagus. Dev Biol. 284:157-170.