Multigram synthesis of 1-(difluoromethyl)imidazoles and -benzimidazoles

Synthesis

Volumn , Issue 8, 2011, Pages 1243-1248

  Levterov, Vadym ^a   Grygorenko, Oleksandr O ^a,b   Mykhailiuk, Pavel K ^a,b   Tolmachev, Andrey A ^a,b  

^a ENAMINE LTD   (Ukraine)

^b TARAS SHEVCHENKO NATIONAL UNIVERSITY OF KYIV   (Ukraine)

Author keywords

benzimidazoles; difluoromethylation; Fluorine compounds; heterocycles; imidazoles

Indexed keywords

BENZIMIDAZOLES; CHLORODIFLUOROMETHANE; DIFLUOROMETHYLATION; FUNCTIONALIZED SUBSTRATES; GRAM SCALE; HETEROCYCLES; IMIDAZOLES; KEY FEATURE; MULTIGRAM SYNTHESIS; REACTION MIXTURE;

CHLOROFLUOROCARBONS; FLUORINE; FLUORINE COMPOUNDS;

SYNTHESIS (CHEMICAL);

1 (DIFLUOROMETHYL) 1,3 DIHYDRO 2H BENZIMIDAZOLE 2 THIONE; 1 (DIFLUOROMETHYL) 1H IMIDAZOLE; 1 (DIFLUOROMETHYL) 2 (4 METHYLPHENYL) 1H BENZIMIDAZOLE; 1 (DIFLUOROMETHYL) 2 [(DIFLUOROMETHYL)SULFANYL] 1H BENZIMIDAZOLE; 1 (DIFLUOROMETHYL) 2 METHYL 1H BENZIMIDAZOLE; 1 (DIFLUOROMETHYL)(BENZ)IMIDAZOLE; 1 (DIFLUOROMETHYL)BENZIMIDAZOLE DERIVATIVE; 1 (DIFLUOROMETHYL)IMIDAZOLE DERIVATIVE; 1 [1 (DIFLUOROMETHYL) 1H BENZIMIDAZOLE 2 YL] 1 PHENYLETHANONE OXIME; 1 [1 (DIFLUOROMETHYL) 1H BENZIMIDAZOLE 2 YL]ACETONITRILE; 1 [1 (DIFLUOROMETHYL) 1H BENZIMIDAZOLE 2 YL]ETHANOL; 1 [1 (DIFLUOROMETHYL) 1H BENZIMIDAZOLE 2 YL]ETHANONE; 2 (CHLOROMETHYL) 1 (DIFLUOROMETHYL) 1H IMIDAZOLE; 2 (CHLOROMETHYL) 1 (DIFLUOROMETHYL)(BENZ)IMIDAZOLE; [1 (DIFLUOROMETHYL) 1H BENZIMIDAZOLE 2 YL]METHANOL; [1 (DIFLUOROMETHYL) 1H IMIDAZOLE 2 YL]ACETONITRILE; [1 (DIFLUOROMETHYL) 1H IMIDAZOLE 2 YL]METHANOL; BENZIMIDAZOLE DERIVATIVE; IMIDAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ADDITION REACTION; ARTICLE; CHEMICAL INTERACTION; CHEMICAL REACTION KINETICS; DIFLUOROMETHYLATION; DRUG STRUCTURE; DRUG SYNTHESIS; METHYLATION;

EID: 79953778584     PISSN: 00397881     EISSN: 1437210X     Source Type: Journal    
DOI: 10.1055/s-0030-1258470     Document Type: Article

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