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Volumn 30, Issue 14, 2011, Pages 1681-1692

Cx43 suppresses mammary tumor metastasis to the lung in a Cx43 mutant mouse model of human disease

Author keywords

connexin43; ErbB2; gap junctions; mammary gland tumor; metastasis

Indexed keywords

CONNEXIN 43; DIMETHYLBENZ[A]ANTHRACENE; EPIDERMAL GROWTH FACTOR RECEPTOR 2;

EID: 79953767134     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2010.551     Document Type: Article
Times cited : (82)

References (51)
  • 2
    • 50849102685 scopus 로고    scopus 로고
    • The relevance of mouse models to understanding the development and progression of human breast cancer
    • Allred DC, Medina D. (2008). The relevance of mouse models to understanding the development and progression of human breast cancer. J Mammary Gland Biol Neoplasia 13: 279-288.
    • (2008) J Mammary Gland Biol Neoplasia , vol.13 , pp. 279-288
    • Allred, D.C.1    Medina, D.2
  • 3
    • 33747144159 scopus 로고    scopus 로고
    • Myoepithelial cells: Autocrine and paracrine suppressors of breast cancer progression
    • Barsky SH, Karlin NJ. (2005). Myoepithelial cells: autocrine and paracrine suppressors of breast cancer progression. J Mammary Gland Biol Neoplasia 10: 249-260.
    • (2005) J Mammary Gland Biol Neoplasia , vol.10 , pp. 249-260
    • Barsky, S.H.1    Karlin, N.J.2
  • 4
    • 58149186945 scopus 로고    scopus 로고
    • Metastasis suppressors and the tumor microenvironment
    • Bodenstine TM, Welch DR. (2008). Metastasis suppressors and the tumor microenvironment. Cancer Microenviron 1: 1-11.
    • (2008) Cancer Microenviron , vol.1 , pp. 1-11
    • Bodenstine, T.M.1    Welch, D.R.2
  • 6
    • 33749367965 scopus 로고    scopus 로고
    • Induction by 7,12-dimethylbenz(a)anthracene of molecular and biochemical alterations in transformed human mammary epithelial stem cells, and protection by N-acetylcysteine
    • De Flora S, Scarfi S, Izzotti A, D'Agostini F, Chang CC, Bagnasco M et al. (2006). Induction by 7,12-dimethylbenz(a)anthracene of molecular and biochemical alterations in transformed human mammary epithelial stem cells, and protection by N-acetylcysteine. Int J Oncol 29: 521-529.
    • (2006) Int J Oncol , vol.29 , pp. 521-529
    • De Flora, S.1    Scarfi, S.2    Izzotti, A.3    D'Agostini, F.4    Chang, C.C.5    Bagnasco, M.6
  • 7
    • 4344565895 scopus 로고    scopus 로고
    • Developmental regulation of gap junctions and their role in mammary epithelial cell differentiation
    • DOI 10.1023/B:JOMG.0000017432.04930.76, Cell Adhesion in Mammary Gland Biology and Neoplasia
    • El-Sabban ME, Abi-Mosleh LF, Talhouk RS. (2003). Developmental regulation of gap junctions and their role in mammary epithelial cell differentiation. J Mammary Gland Biol Neoplasia 8: 463-473. (Pubitemid 39137507)
    • (2003) Journal of Mammary Gland Biology and Neoplasia , vol.8 , Issue.4 , pp. 463-473
    • El-Sabban, M.E.1    Abi-Mosleh, L.F.2    Talhouk, R.S.3
  • 10
    • 0031896163 scopus 로고    scopus 로고
    • Carcinomas of the breast showing myoepithelial cell differentiation
    • DOI 10.1007/s004280050170
    • Foschini MP, Eusebi V. (1998). Carcinomas of the breast showing myoepithelial cell differentiation. A review of the literature. Virchows Arch 432: 303-310. (Pubitemid 28171991)
    • (1998) Virchows Archiv , vol.432 , Issue.4 , pp. 303-310
    • Foschini, M.P.1    Eusebi, V.2
  • 12
    • 0026472124 scopus 로고
    • Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease
    • Guy CT, Webster MA, Schaller M, Parsons TJ, Cardiff RD, Muller WJ. (1992). Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease. Proc Natl Acad Sci USA 89: 10578-10582.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 10578-10582
    • Guy, C.T.1    Webster, M.A.2    Schaller, M.3    Parsons, T.J.4    Cardiff, R.D.5    Muller, W.J.6
  • 13
    • 34248994869 scopus 로고    scopus 로고
    • Gap junctional complexes: From partners to functions
    • DOI 10.1016/j.pbiomolbio.2007.03.010, PII S0079610707000089, Gap junction channels: from protein genes to diseases
    • Herve JC, Bourmeyster N, Sarrouilhe D, Duffy HS. (2007). Gap junctional complexes: from partners to functions. Prog Biophys Mol Biol 94: 29-65. (Pubitemid 46782980)
    • (2007) Progress in Biophysics and Molecular Biology , vol.94 , Issue.1-2 , pp. 29-65
    • Herve, J.-C.1    Bourmeyster, N.2    Sarrouilhe, D.3    Duffy, H.S.4
  • 14
    • 0037093223 scopus 로고    scopus 로고
    • Lack of ductal development in the absence of functional estrogen receptor α delays mammary tumor formation induced by transgenic expression of ErbB2/neu
    • Hewitt SC, Bocchinfuso WP, Zhai J, Harrell C, Koonce L, Clark J et al. (2002). Lack of ductal development in the absence of functional estrogen receptor alpha delays mammary tumor formation induced by transgenic expression of ErbB2/neu. Cancer Res 62: 2798-2805. (Pubitemid 34525763)
    • (2002) Cancer Research , vol.62 , Issue.10 , pp. 2798-2805
    • Hewitt, S.C.1    Bocchinfuso, W.P.2    Zhai, J.3    Harrell, C.4    Koonce, L.5    Clark, J.6    Myers, P.7    Korach, K.S.8
  • 15
    • 0029827827 scopus 로고    scopus 로고
    • Gap junction genes Cx26 and Cx43 individually suppress the cancer phenotype of human mammary carcinoma cells and restore differentiation potential
    • Hirschi KK, Xu CE, Tsukamoto T, Sager R. (1996). Gap junction genes Cx26 and Cx43 individually suppress the cancer phenotype of human mammary carcinoma cells and restore differentiation potential. Cell Growth Differ 7: 861-870. (Pubitemid 26360725)
    • (1996) Cell Growth and Differentiation , vol.7 , Issue.7 , pp. 861-870
    • Hirschi, K.K.1    Xu, C.-E.2    Tsukamoto, T.3    Sager, R.4
  • 17
    • 64549157275 scopus 로고    scopus 로고
    • Rassf3 is responsible in part for resistance to mammary tumor development in neu transgenic mice
    • Jacquemart IC, Springs AE, Chen WY. (2009). Rassf3 is responsible in part for resistance to mammary tumor development in neu transgenic mice. Int J Oncol 34: 517-528.
    • (2009) Int J Oncol , vol.34 , pp. 517-528
    • Jacquemart, I.C.1    Springs, A.E.2    Chen, W.Y.3
  • 18
    • 0031908039 scopus 로고    scopus 로고
    • Expression of gap junction proteins connexin 26 and connexin 43 in normal human breast and in breast tumours
    • DOI 10.1002/(SICI)1096-9896(199801)184:1<37::AID-PATH966>3.0.CO;2-D
    • Jamieson S, Going JJ, D'Arcy R, George WD. (1998). Expression of gap junction proteins connexin 26 and connexin 43 in normal human breast and in breast tumours. J Pathol 184: 37-43. (Pubitemid 28086151)
    • (1998) Journal of Pathology , vol.184 , Issue.1 , pp. 37-43
    • Jamieson, S.1    Going, J.J.2    D'Arcy, R.3    George, W.D.4
  • 19
    • 33750536492 scopus 로고    scopus 로고
    • Cx26 inhibits breast MDA-MB-435 cell tumorigenic properties by a gap junctional intercellular communication-independent mechanism
    • DOI 10.1093/carcin/bgl110
    • Kalra J, Shao Q, Qin H, Thomas T, Alaoui-Jamali MA, Laird DW. (2006). Cx26 inhibits breast MDA-MB-435 cell tumorigenic properties by a gap junctional intercellular communication-independent mechanism. Carcinogenesis 27: 2528-2537. (Pubitemid 44884112)
    • (2006) Carcinogenesis , vol.27 , Issue.12 , pp. 2528-2537
    • Kalra, J.1    Shao, Q.2    Qin, H.3    Thomas, T.4    Alaoui-Jamali, M.A.5    Laird, D.W.6
  • 21
    • 33645002735 scopus 로고    scopus 로고
    • Life cycle of connexins in health and disease
    • Laird DW. (2006). Life cycle of connexins in health and disease. Biochem J 394: 527-543.
    • (2006) Biochem J , vol.394 , pp. 527-543
    • Laird, D.W.1
  • 23
    • 0026646956 scopus 로고
    • Transcriptional downregulation of gap-junction proteins blocks junctional communication in human mammary tumor cell lines
    • Lee SW, Tomasetto C, Paul D, Keyomarsi K, Sager R. (1992). Transcriptional downregulation of gap-junction proteins blocks junctional communication in human mammary tumor cell lines. J Cell Biol 118: 1213-1221.
    • (1992) J Cell Biol , vol.118 , pp. 1213-1221
    • Lee, S.W.1    Tomasetto, C.2    Paul, D.3    Keyomarsi, K.4    Sager, R.5
  • 25
    • 56549116154 scopus 로고    scopus 로고
    • Fate of connexin43 in cardiac tissue harbouring a disease-linked connexin43 mutant
    • Manias JL, Plante I, Gong XQ, Shao Q, Churko J, Bai D et al. (2008). Fate of connexin43 in cardiac tissue harbouring a disease-linked connexin43 mutant. Cardiovas Res 80: 385-395.
    • (2008) Cardiovas Res , vol.80 , pp. 385-395
    • Manias, J.L.1    Plante, I.2    Gong, X.Q.3    Shao, Q.4    Churko, J.5    Bai, D.6
  • 27
    • 36249001676 scopus 로고    scopus 로고
    • Connexins and gap junctions in mammary gland development and breast cancer progression
    • DOI 10.1007/s00232-007-9052-x
    • McLachlan E, Shao Q, Laird DW. (2007). Connexins and gap junctions in mammary gland development and breast cancer progression. J Membr Biol 218: 107-121. (Pubitemid 350132123)
    • (2007) Journal of Membrane Biology , vol.218 , Issue.1-3 , pp. 107-121
    • McLachlan, E.1    Shao, Q.2    Laird, D.W.3
  • 28
    • 36549034908 scopus 로고    scopus 로고
    • Chemical carcinogenesis of rat and mouse mammary glands
    • Comparative Pathobiology of Breat Cancer
    • Medina D. (2007). Chemical carcinogenesis of rat and mouse mammary glands. Breast Dis 28: 63-68. (Pubitemid 350187026)
    • (2007) Breast Disease , vol.28 , pp. 63-68
    • Medina, D.1
  • 29
    • 35348891428 scopus 로고    scopus 로고
    • Gap junctions: Basic structure and function
    • DOI 10.1038/sj.jid.5700770, PII 5700770
    • Mese G, Richard G, White TW. (2007). Gap junctions: basic structure and function. J Invest Dermatol 127: 2516-2524. (Pubitemid 47585051)
    • (2007) Journal of Investigative Dermatology , vol.127 , Issue.11 , pp. 2516-2524
    • Mese, G.1    Richard, G.2    White, T.W.3
  • 32
    • 34848858289 scopus 로고    scopus 로고
    • Connexin26 expression is associated with lymphatic vessel invasion and poor prognosis in human breast cancer
    • DOI 10.1007/s10549-006-9465-8
    • Naoi Y, Miyoshi Y, Taguchi T, Kim SJ, Arai T, Tamaki Y et al. (2007). Connexin26 expression is associated with lymphatic vessel invasion and poor prognosis in human breast cancer. Breast Cancer Res Treat 106: 11-17. (Pubitemid 47498083)
    • (2007) Breast Cancer Research and Treatment , vol.106 , Issue.1 , pp. 11-17
    • Naoi, Y.1    Miyoshi, Y.2    Taguchi, T.3    Kim, S.J.4    Arai, T.5    Tamaki, Y.6    Noguchi, S.7
  • 33
    • 77952929243 scopus 로고    scopus 로고
    • Implications and challenges of connexin connections to cancer
    • Naus CC, Laird DW. (2010). Implications and challenges of connexin connections to cancer. Nat Rev Cancer 10: 435-441.
    • (2010) Nat Rev Cancer , vol.10 , pp. 435-441
    • Naus, C.C.1    Laird, D.W.2
  • 34
    • 66749106316 scopus 로고    scopus 로고
    • GJA1 mutations, variants, and connexin 43 dysfunction as it relates to the oculodentodigital dysplasia phenotype
    • Paznekas WA, Karczeski B, Vermeer S, Lowry RB, Delatycki M, Laurence F et al. (2009). GJA1 mutations, variants, and connexin 43 dysfunction as it relates to the oculodentodigital dysplasia phenotype. Hum Mutat 30: 724-733.
    • (2009) Hum Mutat , vol.30 , pp. 724-733
    • Paznekas, W.A.1    Karczeski, B.2    Vermeer, S.3    Lowry, R.B.4    Delatycki, M.5    Laurence, F.6
  • 35
    • 0015589798 scopus 로고
    • Cell contacts in the mouse mammary gland. I. Normal gland in postnatal development and the secretory cycle
    • Pitelka DR, Hamamoto ST, Duafala JG, Nemanic MK. (1973). Cell contacts in the mouse mammary gland. I. Normal gland in postnatal development and the secretory cycle. J Cell Biol 56: 797-818.
    • (1973) J Cell Biol , vol.56 , pp. 797-818
    • Pitelka, D.R.1    Hamamoto, S.T.2    Duafala, J.G.3    Nemanic, M.K.4
  • 36
    • 44349184836 scopus 로고    scopus 로고
    • Decreased levels of connexin43 result in impaired development of the mammary gland in a mouse model of oculodentodigital dysplasia
    • Plante I, Laird DW. (2008). Decreased levels of connexin43 result in impaired development of the mammary gland in a mouse model of oculodentodigital dysplasia. Dev Biol 318: 312-322.
    • (2008) Dev Biol , vol.318 , pp. 312-322
    • Plante, I.1    Laird, D.W.2
  • 37
    • 77953818935 scopus 로고    scopus 로고
    • Milk Secretion and Ejection Are Impaired in the Mammary Gland of Mice Harboring a Cx43 Mutant while Expression and Localization of Tight and Adherens Junction Proteins Remain Unchanged
    • Plante I, Wallis A, Shao Q, Laird DW. (2010). Milk Secretion and Ejection Are Impaired in the Mammary Gland of Mice Harboring a Cx43 Mutant While Expression and Localization of Tight and Adherens Junction Proteins Remain Unchanged. Biol Reprod 28: 837-847.
    • (2010) Biol Reprod , vol.28 , pp. 837-847
    • Plante, I.1    Wallis, A.2    Shao, Q.3    Laird, D.W.4
  • 38
    • 0032526073 scopus 로고    scopus 로고
    • Genetic modulation of neu proto-oncogene-induced mammary tumorigenesis
    • Rowse GJ, Ritland SR, Gendler SJ. (1998). Genetic modulation of neu proto-oncogene-induced mammary tumorigenesis. Cancer Res 58: 2675-2679. (Pubitemid 28275443)
    • (1998) Cancer Research , vol.58 , Issue.12 , pp. 2675-2679
    • Rowse, G.J.1    Ritland, S.R.2    Gendler, S.J.3
  • 39
    • 0035266149 scopus 로고    scopus 로고
    • Breast cancer metastatic potential correlates with a breakdown in homospecific and heterospecific gap junctional intercellular communication
    • Saunders MM, Seraj MJ, Li Z, Zhou Z, Winter CR, Welch DR et al. (2001). Breast cancer metastatic potential correlates with a breakdown in homospecific and heterospecific gap junctional intercellular communication. Cancer Res 61: 1765-1767. (Pubitemid 32691980)
    • (2001) Cancer Research , vol.61 , Issue.5 , pp. 1765-1767
    • Saunders, M.M.1    Seraj, M.J.2    Li, Z.3    Zhou, Z.4    Winter, C.R.5    Welch, D.R.6    Donahue, H.J.7
  • 40
    • 16844375853 scopus 로고    scopus 로고
    • Down-regulation of Cx43 by retroviral delivery of small interfering RNA promotes an aggressive breast cancer cell phenotype
    • DOI 10.1158/0008-5472.CAN-04-2367
    • Shao Q, Wang H, McLachlan E, Veitch GI, Laird DW. (2005). Down-regulation of Cx43 by retroviral delivery of small interfering RNA promotes an aggressive breast cancer cell phenotype. Cancer Res 65: 2705-2711. (Pubitemid 40490071)
    • (2005) Cancer Research , vol.65 , Issue.7 , pp. 2705-2711
    • Shao, Q.1    Wang, H.2    McLachlan, E.3    Veitch, G.I.L.4    Laird, D.W.5
  • 41
    • 20444411484 scopus 로고    scopus 로고
    • Connexin phosphorylation as a regulatory event linked to gap junction channel assembly
    • DOI 10.1016/j.bbamem.2004.09.013, PII S0005273604002445
    • Solan JL, Lampe PD. (2005). Connexin phosphorylation as a regulatory event linked to gap junction channel assembly. Biochim Biophys Acta 1711: 154-163. (Pubitemid 40799290)
    • (2005) Biochimica et Biophysica Acta - Biomembranes , vol.1711 , Issue.2 SPEC. ISS. , pp. 154-163
    • Solan, J.L.1    Lampe, P.D.2
  • 42
    • 36349007570 scopus 로고    scopus 로고
    • Key connexin 43 phosphorylation events regulate the gap junction life cycle
    • DOI 10.1007/s00232-007-9035-y
    • Solan JL, Lampe PD. (2007). Key connexin 43 phosphorylation events regulate the gap junction life cycle. J Membr Biol 217: 35-41. (Pubitemid 350160003)
    • (2007) Journal of Membrane Biology , vol.217 , Issue.1-3 , pp. 35-41
    • Solan, J.L.1    Lampe, P.D.2
  • 44
    • 69849084075 scopus 로고    scopus 로고
    • Key stages in mammary gland development: The cues that regulate ductal branching morphogenesis
    • Sternlicht MD. (2006). Key stages in mammary gland development: the cues that regulate ductal branching morphogenesis. Breast Cancer Res 8: 201.
    • (2006) Breast Cancer Res , vol.8 , pp. 201
    • Sternlicht, M.D.1
  • 45
    • 0031025487 scopus 로고    scopus 로고
    • The myoepithelial defense: A host defense against cancer
    • DOI 10.1016/S0306-9877(97)90022-0
    • Sternlicht MD, Barsky SH. (1997). The myoepithelial defense: a host defense against cancer. Med Hypotheses 48: 37-46. (Pubitemid 27072863)
    • (1997) Medical Hypotheses , vol.48 , Issue.1 , pp. 37-46
    • Sternlicht, M.D.1    Barsky, S.H.2
  • 47
    • 54149110523 scopus 로고    scopus 로고
    • Heterocellular interaction enhances recruitment of alpha and beta-catenins and ZO-2 into functional gap-junction complexes and induces gap junction-dependant differentiation of mammary epithelial cells
    • Talhouk RS, Mroue R, Mokalled M, Abi-Mosleh L, Nehme R, Ismail A et al. (2008). Heterocellular interaction enhances recruitment of alpha and beta-catenins and ZO-2 into functional gap-junction complexes and induces gap junction-dependant differentiation of mammary epithelial cells. Exp Cell Res 314: 3275-3291.
    • (2008) Exp Cell Res , vol.314 , pp. 3275-3291
    • Talhouk, R.S.1    Mroue, R.2    Mokalled, M.3    Abi-Mosleh, L.4    Nehme, R.5    Ismail, A.6
  • 48
    • 27644547807 scopus 로고    scopus 로고
    • Mechanism of Cx43 and Cx26 transport to the plasma membrane and gap junction regeneration
    • DOI 10.1242/jcs.02569
    • Thomas T, Jordan K, Simek J, Shao Q, Jedeszko C, Walton P et al. (2005). Mechanisms of Cx43 and Cx26 transport to the plasma membrane and gap junction regeneration. J Cell Sci 118: 4451-4462. (Pubitemid 41556343)
    • (2005) Journal of Cell Science , vol.118 , Issue.19 , pp. 4451-4462
    • Thomas, T.1    Jordan, K.2    Simek, J.3    Shao, Q.4    Jedeszko, C.5    Walton, P.6    Laird, D.W.7
  • 49
    • 33947528274 scopus 로고    scopus 로고
    • Multistep mouse mammary tumorigenesis through preneoplasia to neoplasia and acquisition of metastatic potential
    • DOI 10.1007/s00795-006-0351-6
    • Tsubura A, Yoshizawa K, Uehara N, Yuri T, Matsuoka Y. (2007). Multistep mouse mammary tumorigenesis through pre-neoplasia to neoplasia and acquisition of metastatic potential. Med Mol Morphol 40: 9-17. (Pubitemid 46475024)
    • (2007) Medical Molecular Morphology , vol.40 , Issue.1 , pp. 9-17
    • Tsubura, A.1    Yoshizawa, K.2    Uehara, N.3    Yuri, T.4    Matsuoka, Y.5
  • 50
    • 0037294510 scopus 로고    scopus 로고
    • The unknown biology of the unknown primary tumour: A literature review
    • DOI 10.1093/annonc/mdg068
    • Van de Wouw AJ, Jansen RL, Speel EJ, Hillen HF. (2003). The unknown biology of the unknown primary tumour: a literature review. Ann Oncol 14: 191-196. (Pubitemid 36305428)
    • (2003) Annals of Oncology , vol.14 , Issue.2 , pp. 191-196
    • Van De Wouw, A.J.1    Jansen, R.L.H.2    Speel, E.J.M.3    Hillen, H.F.P.4
  • 51
    • 77952011329 scopus 로고    scopus 로고
    • A study of immunohistochemical differential expression in pulmonary and mammary carcinomas
    • Yang M, Nonaka D. (2010). A study of immunohistochemical differential expression in pulmonary and mammary carcinomas. Mod Pathol 23: 654-661.
    • (2010) Mod Pathol , vol.23 , pp. 654-661
    • Yang, M.1    Nonaka, D.2


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