Unlike esophageal squamous cells, barrett's epithelial cells resist apoptosis by activating the nuclear factor-κB pathway

Cancer Research

Volumn 69, Issue 2, 2009, Pages 672-677

  Hormi Carver, Kathy ^a   Zhang, Xi ^a   Hui, Ying Zhang ^a   Whitehead, Robert H ^c   Terada, Lance S ^a   Spechler, Stuart J ^a   Souza, Rhonda F ^a,b,d  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c VANDERBILT UNIVERSITY   (United States)

^d VA NORTH TEXAS HEALTH CARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4 TERT BUTYLPHENYLSULFONYL) 2 PROPENENITRILE; CIAP 1 PROTEIN; GENE PRODUCT; HISTONE H2AX; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN BCL 2; SMALL INTERFERING RNA; SURVIVIN; TELOMERASE; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS;

APOPTOSIS; ARTICLE; BARRETT ESOPHAGUS; CANCER SUSCEPTIBILITY; CELL IMMORTALIZATION; CELL PROLIFERATION; CONTROLLED STUDY; DNA DAMAGE; EPITHELIUM CELL; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; GENE MUTATION; GENOTOXICITY; HOMEOSTASIS; HUMAN; HUMAN CELL; LOW ENERGY RADIATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; ULTRAVIOLET B RADIATION;

APOPTOSIS; BARRETT ESOPHAGUS; CELL LINE; DNA DAMAGE; EPITHELIAL CELLS; GASTROESOPHAGEAL REFLUX; HUMANS; NF-KAPPA B; PHENOTYPE; PROTO-ONCOGENE PROTEINS C-BCL-2; ULTRAVIOLET RAYS;

EID: 58349118248     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-08-3703     Document Type: Article

References (29)

1. Spechler SJ. Clinical practice. Barrett's Esophagus. N Engl J Med 2002;346:836-42.
2. Pohl H, Welch HG. The role of overdiagnosis and reclassification in the marked increase of esophageal adenocarcinoma incidence. J Natl Cancer Inst 2005;97:142-6.
3. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100:57-70.
4. Perkins ND. Integrating cell-signalling pathways with NF-κB and IKK function. Nat Rev Mol Cell Biol 2007;8:49-62.
5. Jovov B, Van Itallie CM, Shaheen NJ, et al. Claudin-18: a dominant tight junction protein in Barrett's esophagus and likely contributor to its acid resistance. Am J Physiol Gastrointest Liver Physiol 2007;293:G1106-13.
6. Dvorakova K, Payne CM, Ramsey L, et al. Apoptosis resistance in Barrett's esophagus: ex vivo bioassay of live stressed tissues. Am J Gastroenterol 2005;100:424-31.
7. van der Woude CJ, Jansen PL, Tiebosch AT, et al. Expression of apoptosis-related proteins in Barrett's metaplasia-dysplasia-carcinoma sequence: a switch to a more resistant phenotype. Hum Pathol 2002;33:686-92.
8. Raouf AA, Evoy DA, Carton E, Mulligan E, Griffin MM, Reynolds JV. Loss of Bcl-2 expression in Barrett's dysplasia and adenocarcinoma is associated with tumor progression and worse survival but not with response to neoadjuvant chemoradiation. Dis Esophagus 2003;16:17-23.
9. Katada N, Hinder RA, Smyrk TC, et al. Apoptosis is inhibited early in the dysplasia-carcinoma sequence of Barrett esophagus. Arch Surg 1997;132:728-33.
10. Iravani S, Zhang HQ, Yuan ZQ, et al. Modification of insulin-like growth factor 1 receptor, c-Src, and Bcl-XL protein expression during the progression of Barrett's neoplasia. Hum Pathol 2003;34:975-82.
11. Baldwin AS, Jr. The NF-κB and IκB proteins: new discoveries and insights. Annu Rev Immunol 1996;14:649-83.
12. O'Riordan JM, Abdel-latif MM, Ravi N, et al. Proinflammatory cytokine and nuclear factor κ-B expression along the inflammation-metaplasia- dysplasia-adenocarcinoma sequence in the esophagus. Am J Gastroenterol 2005;100:1257-64.
13. Abdel-latif MM, O'Riordan J, Windle HJ, et al. NF-κB activation in esophageal adenocarcinoma: relationship to Barrett's metaplasia, survival, and response to neoadjuvant chemoradiotherapy. Ann Surg 2004;239:491-500.
14. Jaiswal KR, Morales CP, Feagins LA, et al. Characterization of telomerase-immortalized, non-neoplastic, human Barrett's cell line (BAR-T). Dis Esophagus 2007;20:256-64.
15. Zhang HY, Zhang X, Chen X, et al. Differences in activity and phosphorylation of MAPK enzymes in esophageal squamous cells of GERD patients with and without Barrett's esophagus. Am J Physiol Gastrointest Liver Physiol 2008;295:G470-8.
16. Zhang HY, Zhang X, Hormi-Carver K, Feagins LA, Spechler SJ, Souza RF. In non-neoplastic Barrett's epithelial cells, acid exerts early antiproliferative effects through activation of the chk2 pathway. Cancer Res 2007;67:8580-7.
17. Quaroni A, Wands J, Trelstad RL, Isselbacher KJ. Epithelioid cell cultures from rat small intestine. Characterization by morphologic and immunologic criteria. J Cell Biol 1979;80:248-65.
18. Whitehead RH, VanEeden PE, Noble MD, Ataliotis P, Jat PS. Establishment of conditionally immortalized epithelial cell lines from both colon and small intestine of adult H-2Kb-tsA58 transgenic mice. Proc Natl Acad Sci U S A 1993;90:587-91.
19. Jat PS, Noble MD, Ataliotis P, et al. Direct derivation of conditionally immortal cell lines from an H-2Kb-tsA58 transgenic mouse. Proc Natl Acad Sci U S A 1991;88:5096-100.
20. Ramirez RD, Morales CP, Herbert BS, et al. Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions. Genes Dev 2001;15:398-403.
21. Cotton J, Spandau DF. Ultraviolet B-radiation dose influences the induction of apoptosis and p53 in human keratinocytes. Radiat Res 1997;147:148-55.
22. Hormi-Carver K, Feagins LA, Spechler SJ, Souza RF. All trans-retinoic acid induces apoptosis via p38 and caspase pathways in metaplastic Barrett's cells. Am J Physiol Gastrointest Liver Physiol 2007;292:G18-27.
23. Huerta-Yepez S, Vega M, Jazirehi A, et al. Nitric oxide sensitizes prostate carcinoma cell lines to TRAIL-mediated apoptosis via inactivation of NF-κ B and inhibition of Bcl-xl expression. Oncogene 2004;23:4993-5003.
24. Rioux-Leclercq N, Turlin B, Sutherland F, et al. Analysis of Ki-67, p53 and Bcl-2 expression in the dysplasia-carcinoma sequence of Barrett's esophagus. Oncol Rep 1999;6:877-82.
25. Latonen L, Laiho M. Cellular UV damage responses-functions of tumor suppressor p53. Biochim Biophys Acta 2005;1755:71-89.
26. Chu ZL, McKinsey TA, Liu L, Gentry JJ, Malim MH, Ballard DW. Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-κB control. Proc Natl Acad Sci U S A 1997;94:10057-62.
27. Shiraki K, Takase K, Nakano T. The emerging role of caspase inhibitors in gastrointestinal cancers. J Gastroenterol 2002;37:323-31.
28. Souza RF, Shewmake KL, Shen Y, et al. Differences in ERK activation in Squamous mucosa in patients who have gastroesophageal reflux disease with and without Barrett's esophagus. Am J Gastroenterol 2005;100:551-9.
29. Ali I, Rafiee P, Hogan WJ, et al. Dickkopf homologs in squamous mucosa of esophagitis patients are overexpressed compared with Barrett's patients and healthy controls. Am J Gastroenterol 2006;101:1437-48.