Differential effects of endothelins on histological and ultrastructural changes and trypsinogen activation in the secretagogue-induced acute pancreatitis in rats

Experimental and Toxicologic Pathology

Volumn 63, Issue 4, 2011, Pages 371-378

  Andrzejewska, Anna ^a   Dlugosz, Jan W ^a  

^a MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

Author keywords

Acute pancreatitis; Caerulein; Endothelins; Rats; Trypsinogen; Ultrastructure

Indexed keywords

ENDOTHELIN 1; ENDOTHELIN 2; ENDOTHELIN 3; TRYPSINOGEN;

ACINAR CELL; ACUTE PANCREATITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL INFILTRATION; CELL VACUOLE; CONTROLLED STUDY; DISEASE COURSE; ELECTRON MICROSCOPY; ENZYME ACTIVATION; HISTOPATHOLOGY; MALE; NONHUMAN; PROTEIN FUNCTION; RAT; STRUCTURE ANALYSIS;

ANIMALS; CAERULEIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELINS; ENZYME ACTIVATION; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; PANCREATITIS; RATS; RATS, WISTAR; TRYPSINOGEN;

RATTUS;

EID: 79953736837     PISSN: 09402993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etp.2010.02.013     Document Type: Article

References (42)

1. Andrzejewska A., Dlugosz J., Augustynowicz A. Effect of endothelin-1 receptor antagonists on histological changes in the pancreas and trypsinogen activation in the early course of caerulein-induced acute pancreatitis in rats. World J Gastroenterol 2005, 11:1115-1121.
2. Andrzejewska A., Dlugosz J.W. The endothelin-1 receptor antagonists ameliorate histology and ultrastructural alterations in the pancreas and decrease trypsinogen activation in severe taurocholate pancreatitis in rats. Int J Exp Pathol 2003, 84:221-229.
3. Andrzejewska A., Jurkowska G. Nitric oxide protects the ultrastructure of pancreatic acinar cells in the course of caerulein-induced acute pancreatitis. Int J Exp Pathol 1999, 80:317-324.
4. Chen H.-M., Sunamura M., Shibuya K., Yamauchi J.-I., Sakai Y., Fukuyama S., et al. Early microcirculatory derangement in mild and severe pancreatitis models in mice. Surg Today 2001, 31:634-642.
5. Cuthbertson C.M., Christophi C. Disturbances of microcirculation in acute pancreatitis. Br J Surg 2006, 93:518-530.
6. DiMagno M.J., Williams J.A., Hao Y., Ernst S.A., Owyang C. Endothelial nitric oxide synthase is protective in the initiation of caerulein-induced acute pancreatitis in mice. Am J Physiol 2004, 287:G80-G87.
7. Dlugosz J.W., Andrzejewska A., Wroblewski E., Poplawski C., Wereszczynska-Siemiatkowska U. Beneficial effect of iloprost on the course of acute taurocholate pancreatitis in rats and its limitation by antecedent acute ethanol intake. Exp Toxic Pathol 2004, 55:401-409.
8. Dlugosz J.W., Wroblewski E., Poplawski C., Gabryelewicz A., Andrzejewska A. Does antecedent ethanol intake affect course of taurocholate pancreatitis in rats?. Dig Dis Sci 1997, 42:944-952.
9. Eibl G., Forgacs B., Hotz H.G., Buhr H.J., Foitzik T. Endothelin A but not endothelin B receptor blockade reduces capillary permeability in severe experimental pancreatitis. Pancreas 2002, 25:15-20.
10. Eibl G., Hotz H.G., Faulhaber J., Kirchengast M., Buhr H.J., Foitzik T. Effect of endothelin and endothelin receptor blockade on capillary permeability in experimental pancreatitis. Gut 2000, 46:390-394.
11. Fiedler F., Ayasse D., Rohmeiss P., Gretz N., Rehbein C., Keim V. The endothelin antagonist bosentan does not improve survival in severe experimental pancreatitis in rats. Int J Pancreatol 1999, 26:147-154.
12. Foitzik T., Eibl G., Hotz H., Faulhaber J., Kirchengast M., Buhr H.J. Endothelin receptor blockade in severe acute pancreatitis leads to systemic enhancement of microcirculation, stabilization of capillary permeability, and improved survival rates. Surgery 2000, 127:399-407.
13. Foitzik T., Faulhaber J., Hotz H., Kirchengast M., Buhr H.J. Endothelin mediates local and systemic disease sequelae in severe experimental pancreatitis. Pancreas 2001, 22:248-254.
14. Garcia M., Hernandez-Barbachano E., Hernandez Lorenzo M.P., Calvo J.J., Lopez Novoa J.M., San Roman J.I. Cardiovascular homeostasis in hypotension associated with initial stages of severe acute pancreatitis. Pancreas 2008, 37:432-439.
15. Griesbacher T., Rainer I., Tiran B., Fink E., Lembeck F., Peskar B.A. Mechanism of kinin release during experimental acute pancreatitis in rats: evidence for pro- as well as anti-inflammatory roles of oedema formation. Br J Pharmacol 2003, 139:299-308.
16. Gukovskaya A.S., Vaquero E., Zaninovic V., Gorelick F.S., Lusis A.J., Brennan M-L, et al. Neutrophils and NADPH oxidase mediate intrapancreatic trypsin activation in murine experimental acute pancreatitis. Gastroenterology 2002, 122:974-984.
17. Hietaranta A.J., Saluja A.K., Bhagat C., Singh V.P., Song A.M., Steer M.L. Relationship between NF-κB and trypsinogen activation in rat pancreas after supramaximal caerulein stimulation. Biochem Biophys Res Commun 2001, 280:388-395.
18. Hildebrand P., Mrozinski J.E., Mantey S.A., Patto R.J., Jensen R.T. Pancreatic acini possess endothelin receptors whose internalization is regulated by PLC-activating agents. Am J Physiol 1993, 264:G984-993.
19. Imrie CW, McKay CJ. Incidence, mortality rate and underdiagnosis of acute pancreatitis. Pancreatic disease 1999, 57-64. Springer Verlag, London, Tokyo. C.D. Johnson, C.W. Imrie (Eds.).
20. Inoue A., Yanagisawa M., Kimura S., Kasuya Y., Miyauchi T., Goto K., et al. The human endothelin family: Three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proc Natl Acad Sci USA 1989, 86:2863-2867.
21. Inoue K., Hirota M., Kimura Y., Kuwata, Ohmuraya M., Ogawa M. Further evidence for endothelin as an important mediator of pancreatic and intestinal ischemia. Pancreas 2003, 26:218-223.
22. Keck T., Friebe V., Warshaw A.L., Antonin B.A., Waneck G., Benz S., et al. Pancreatic proteases in serum induce leukocyte - endothelial adhesion and pancreatic microcirculatory failure. Pancreatology 2005, 5:241-250.
23. Kogire M., Inoue K., Higashide S.-I., Takaori K., Echigo Y., Gu Y.-J., et al. Protective effects of endothelin-1 on acute pancreatitis in rats. Dig Dis Sci 1995, 40:1207-1212.
24. Kruse P., Lasson A., Hage E. Proteases and protease inhibitors in cerulein-induced acute pancreatitis in rats. J Surg Res 1999, 85:294-300.
25. Kyogoku T., Manabe T., Tobe T. Role of ischemia in acute pancreatitis. Hemorrhagic shock converts edematous pancreatitis to hemorrhagic pancreatitis in rats. Dig Dis Sci 1992, 37:1409-1417.
26. Liu S., Premont R.T., Kontos C.D., Huang J., Rockey D.C. Endothelin-1 activates endothelial cell nitric-oxide synthase via heterotrimeric G-protein betagamma subunit signaling to protein jinase B/Akt. J Biol Chem 2003, 278:49929-49935.
27. Liu X.-H., Kimura T., Ishikawa H., Yamagouchi H., Furokawa M., Nakano I., et al. Effect of endothelin-1 on the development of hemorrhagic pancreatitis in rats. Scand J Gastroenterol 1995, 30:276-282.
28. Liu X.-H., Nakano I., Ito T., Kimura T., Nawata H. Is endothelin an aggravating factor in the development of acute pancreatitis?. Chin Med J 1999, 12:603-607.
29. Martignoni M.E., Ceyhan G.O., Ayuni E., Kondo Y., Zimmermann A., Büchler M.W., et al. Endothelin receptor antagonists are not beneficial in the therapy of acute experimental pancreatitis. Langenbeckỳs Arch Surg 2004, 389:184-192.
30. Mithöfer K., Fernández-Del Castillo C., Rattner D., Warsaw A. Subcellular kinetics of early trypsinogen activation in acute rodent pancreatitis. Am J Physiol 1998, 274:G71-79.
31. Müller M.W., McNeil P.L., Büchler P., Ceyhan G.O., Wolf-Hieber E, Adler G, et al. Acinar membrane disruption is an early event in experimental pancreatitis in rats. Pancreas 2007, 35:e30-40.
32. Paulino E.C., Souza L.J., Molan N.A., Machado M.C., Jancar S. Neutrophils from acute pancreatitis patients cause more severe in vitro endothelial damage compared with neutrophils from healthy donors and are differently regulated by endothelins. Pancreas 2007, 35:37-41.
33. Plusczyk T., Bersal B., Menger M., Feifel G. Differential effects of ET-1, ET-2, and ET-3 on pancreatic microcirculation, tissue integrity, and inflammation. Dig Dis Sci 2001, 46:1343-1351.
34. Plusczyk T., Bersal B., Westermann S., Menger M., Feifel G. ET-1 induces pancreatitis-like microvascular deterioration and acinar cell injury. J Surg Res 1999, 85:301-310.
35. Plusczyk T., Witzel B., Menger M., Schilling M. ETA and ETB receptor function in pancreatitis - associated microcirculatory failure, inflammation and parenchymal injury. Am J Physiol 2003, 285:G145-153.
36. Rossi G.P., Seccia T.M., Albertin G., Pessina A. Measurement of endothelin: clinical and research use. Ann Clin Biochem 2000, 37:608-626.
37. Saluja A.K., Bhagat L., Lee H.S., Bhatia M., Frossard J.L., Steer M.L. Secretagogue-induced digestive enzyme activation and cell injury in rat pancreatic acini. Am J Physiol 1999, 276:G835-842.
38. Schmidt J., Ebeling D., Ryschich E., Werner J., Gebhard M.M., Klar E. Pancreatic capillary blood flow in an improved model of necrotizing pancreatitis in the rat. J Surg Res 2002, 106:335-341.
39. Sherwood M.W., Prior I.A., Voronina S.G., Barrow S.L., Woodsmith J.D., Gerasimenko O., et al. Activation of trypsinogen in large endocytic vacuoles of pancreatic acinar cell. Proc Natl Acad Sci. 27,104 2007, 5674-5679.
40. Sunamura M., Yamauchi J.-I., Shibuya K., Chen H.-M., Ding L., Takeda K., et al. Pancreatic microcirculation in acute pancreatitis. J Hepato-Biliary-Pancreatic Surg 1998, 5:62-68.
41. Takaori K., Inoue K., Kogire M., Higashide S-I., Tun T., Aung T., et al. Effects of endothelin on microcirculation of the pancreas. Life Sci 1992, 51:615-622.
42. Yamaguchi H., Kimura T., Mimura K., Nawata H. Activation of proteases in cerulein-induced pancreatitis. Pancreas 1989, 4:565-571.