Identification of a thiolase gene essential for β-oxidation of the acyl side chain of the steroid compound cholate in Pseudomonas sp. strain Chol1

FEMS Microbiology Letters

Volumn 318, Issue 2, 2011, Pages 123-130

  Birkenmaier, Antoinette ^a   Möller, Heiko M ^a   Philipp, Bodo ^a  

^a UNIVERSITY OF KONSTANZ   (Germany)

Author keywords

ketothiolase; Bile salts; Cholate; Steroid degradation

Indexed keywords

7ALPHA,12ALPHA DIHYDROXY 3 OXOCHOLA 1,4,22 TRIENE 24 OATE; 7ALPHA,12ALPHA,22 TRIHYDROXY 3 OXOCHOLA 1,4 DIENE 24 OATE; ACETYL COENZYME A ACYLTRANSFERASE; BACTERIAL PROTEIN; CARRIER PROTEIN; CHOLIC ACID; CHOLIC ACID DERIVATIVE; PROTEIN SCP X; PROTEIN SKT; STEROID; UNCLASSIFIED DRUG;

BACTERIAL GROWTH; COMAMONAS TESTOSTERONI; CONTROLLED STUDY; ENZYME ACTIVITY; FATTY ACID OXIDATION; GENE DOSAGE; GENE IDENTIFICATION; GENE MUTATION; GENETIC CODE; GENETIC DIFFERENCE; LIPID DEGRADATION; MOLECULAR MODEL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DOMAIN; PSEUDOMONAS; REVIEW; STEROID METABOLISM; STRUCTURE ANALYSIS; SUPERNATANT; TRANSPOSON;

ACETYL-COA C-ACYLTRANSFERASE; AMINO ACID SEQUENCE; BACTERIAL PROTEINS; CHOLATES; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; PSEUDOMONAS; SEQUENCE ALIGNMENT;

ANIMALIA; BACTERIA (MICROORGANISMS); COMAMONAS TESTOSTERONI; EUKARYOTA; PSEUDOMONAS SP.;

EID: 79953731327     PISSN: 03781097     EISSN: 15746968     Source Type: Journal    
DOI: 10.1111/j.1574-6968.2011.02250.x     Document Type: Review

References (26)

1. Birkenmaier A, Holert J, Erdbrink H, Möller HM, Friemel A, Schoenenberger R, Suter MJ, Klebensberger J & Philipp B (2007) Biochemical and genetic investigation of initial reactions in aerobic degradation of the bile acid cholate in Pseudomonas sp. strain Chol1. J Bacteriol 189: 7165-7173.
2. Bortolini O, Medici A & Poli S (1997) Biotransformations on steroid nucleus of bile acids. Steroids 62: 564-577.
3. Carson JD, Jenkins RL, Wilson EM, Howell W & Moore R (2008) Naturally occurring progesterone in loblolly pine (Pinus taeda L.): a major steroid precursor of environmental androgens. Environ Toxicol Chem 27: 1273-1278.
4. Combalbert S & Hernandez-Raquet G (2010) Occurrence, fate, and biodegradation of estrogens in sewage and manure. Appl Microbiol Biot 86: 1671-1692.
5. Hofmann AF & Mysels KJ (1988) Bile salts as biological surfactants. Colloids surface 30: 145-173.
6. Horinouchi M, Hayashi T & Kudo T (2010a) Steroid degradation in Comamonas testosteroni. J Steroid Biochem DOI: DOI: 10.1016/j.jsbmb.2010.10.008.
7. Horinouchi M, Kurita T, Hayashi T & Kudo T (2010b) Steroid degradation genes in Comamonas testosteroni TA441: isolation of genes encoding aΔ4(5)-isomerase and 3α- and 3β-dehydrogenases and evidence for a 100kb steroid degradation gene hot spot. J Steroid Biochem 122: 253-263.
8. Hu Y, van der Geize R, Besra GS, Gurcha SS, Liu A, Rohde M, Singh M & Coates A (2010) 3-Ketosteroid 9alpha-hydroxylase is an essential factor in the pathogenesis of Mycobacterium tuberculosis. Mol Microbiol 75: 107-121.
9. Jagmann N, Brachvogel HP & Philipp B (2010) Parasitic growth of Pseudomonas aeruginosa in co-culture with the chitinolytic bacterium Aeromonas hydrophila. Environ Microbiol 12: 1787-1802.
10. Kannenberg F, Ellinghaus P, Assmann G & Seedorf U (1999) Aberrant oxidation of the cholesterol side chain in bile acid synthesis of sterol carrier protein-2/sterol carrier protein-x knockout mice. J Biol Chem 274: 35455-35460.
11. Kovach ME, Elzer PH, Hill SD, Robertson GT, Farris MA, Roop RM & Peterson KM (1995) Four new derivatives of the broad-host-range cloning vector pBBR1MCS, carrying different antibiotic-resistance cassettes. Gene 166: 175-176.
12. Kunau WH, Dommes V & Schulz H (1995) β-Oxidation of fatty acids in mitochondria, peroxisomes, and bacteria: a century of continued progress. Prog Lipid Res 34: 267-342.
13. Leppik RA (1983) Deoxycholic acid degradation by a Pseudomonas sp. acidic intermediates with A-ring unsaturation. Biochem J 210: 829-836.
14. Mahato SB & Garai S (1997) Advances in microbial steroid biotransformation. Steroids 62: 332-345.
15. Marchler-Bauer A, Anderson JB, Chitsaz F et al. (2009) CDD: specific functional annotation with the Conserved Domain Database. Nucleic Acids Res 37: D205-D210.
16. Nesbitt NM, Yang X, Fontan P, Kolesnikova I, Smith I, Sampson NS & Dubnau E (2010) A thiolase of Mycobacterium tuberculosis is required for virulence and production of androstenedione and androstadienedione from cholesterol. Infect Immun 78: 275-282.
17. Pandey AK & Sassetti CM (2008) Mycobacterial persistence requires the utilization of host cholesterol. P Natl Acad Sci USA 105: 4376-4380.
18. Peretó J, Lopez-Garcia P & Moreira D (2005) Phylogenetic analysis of eukaryotic thiolases suggests multiple proteobacterial origins. J Mol Evol 61: 65-74.
19. Philipp B (2011) Bacterial degradation of bile salts. Appl Microbiol Biot 89: 903-915.
20. Philipp B, Erdbrink H, Suter MJ & Schink B (2006) Degradation of and sensitivity to cholate in Pseudomonas sp. strain Chol1. Arch Microbiol 185: 192-201.
21. Ridlon JM, Kang DJ & Hylemon PB (2006) Bile salt transformations by human intestinal bacteria. J Lipid Res 47: 241-259.
22. Rösch V, Denger K, Schleheck D, Smits THM & Cook AM (2008) Different bacterial strategies to degrade taurocholate. Arch Microbiol 190: 11-18.
23. Russell DW (2003) The enzymes, regulation, and genetics of bile acid synthesis. Annu Rev Biochem 72: 137-174.
24. Shimizu T, Jikumaru Y, Okada A et al. (2008) Effects of a bile acid elicitor, cholic acid, on the biosynthesis of diterpenoid phytoalexins in suspension-cultured rice. Phytochemistry 69: 973-981.
25. Stolowich NJ, Petrescu AD, Huang H, Martin GG, Scott AI & Schroeder F (2002) Sterol carrier protein-2: structure reveals function. Cell Mol Life Sci 59: 193-212.
26. Windgassen M, Urban A & Jaeger KE (2000) Rapid gene inactivation in Pseudomonas aeruginosa. FEMS Microbiol Lett 193: 201-205.