Sterol carrier protein-2: Structure reveals function

Cellular and Molecular Life Sciences

Volumn 59, Issue 2, 2002, Pages 193-212

  Stolowich, N J ^a   Petrescu, A D ^b   Huang, H ^b   Martin, G G ^b   Scott, A I ^c   Schroeder, F ^b  

^a UNIVERSITY OF LOUISVILLE   (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

^c TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Binding site; Fatty acid; NMR; Sterol carrier protein 2

Indexed keywords

ACETYL COENZYME A ACYLTRANSFERASE; ACYL COENZYME A; AMINO ACID; APOPROTEIN; CHOLESTEROL; CHOLESTEROL ESTER; COMPLEMENTARY DNA; MEMBRANE LIPID; OLEIC ACID; PHOSPHATIDIC ACID; PHOSPHOLIPID; STEROL CARRIER PROTEIN 2;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; CARBOXY TERMINAL SEQUENCE; CIRCULAR DICHROISM; ENZYME ACTIVATION; ENZYME ACTIVITY; FUSION GENE; GENE STRUCTURE; GENETIC TRANSFECTION; LIPID METABOLISM; MEMBRANE BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; REVIEW;

ACETYL-COA C-ACETYLTRANSFERASE; ANIMALS; BINDING SITES; CARRIER PROTEINS; CRYSTALLOGRAPHY, X-RAY; FLUORESCENCE; LIGANDS; LIPID METABOLISM; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PLANT PROTEINS; PROTEIN CONFORMATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RNA, MESSENGER; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 0036179980     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00018-002-8416-8     Document Type: Review

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10. 1H-NMR data
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12. Cholesterol interactions with recombinant human sterol carrier protein-2
13. Identification of two lipid binding proteins from liver of Gallus domesticus
14. 13C-NMR investigation of cholesterol and fatty acid binding sites
15. Defective peroxisomal catabolism of branched fatty acyl coenzyme A in mice lacking the sterol carrier protein-2/sterol carrier protein-x gene function
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21. Sterol carrier protein-2 is involved in cholesterol transfer from the endoplasmic reticulum to the plasma membrane in human fibroblasts
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28. Modulation of intrahepatic cholesterol trafficking: Evidence by in vivo antisense treatment for the involvement of sterol carrier protein-2 in newly synthesized cholesterol transfer into bile
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34. Lipid specificity and location of the sterol carrier protein-2 fatty acid binding site: A fluorescence displacement and energy transfer study
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39. Differential expression of hepatic sterol carrier proteins in the streptozotocin-treated diabetic rat
40. Altered ovarian sterol carrier protein-2 expression in pregnant streptozotocin treated diabetic rat
41. Reduced hepatic LDL-receptor, 3-hydroxy-3-methylglutaryl CoA reductase and sterol carrier protein-2 is associated with pregnancy loss in the diabetic rat
42. Phospholipid transfer proteins revisited
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47. Thiolase involved in bile acid formation
48. Peroxisomal fatty acid oxidation disorders and 58 kDa sterol carrier protein-x (SCP=x): Activity measurements in liver and fibroblasts using a newly developed method
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53. The structure of the human sterol carrier protein X/sterol carrier protein 2 gene (SCP2)
54. Human sterol carrier protein x/sterol carrier protein 2 gene has two promoters
55. Cloning, expression and nucleotide sequence of rat liver sterol carrier protein-2 cDNAs
56. Amino acid sequence of rat liver non-specific lipid transfer protein (sterol carrier protein-2) is present in a high molecular weight protein: Evidence from cDNA Analysis
57. cDNA sequence and bacterial expression of mouse liver sterol carrier protein-2
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59. Cloning, expression and sequence of SCP-X encoding cDNAs and a related pseudogene
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61. Characterization of a cDNA encoding rat sterol carrier protein-2
62. Identification of the cDNA clone which encodes the 58-kDa protein containing the amino acid sequence of rat liver non-specific lipid-transfer protein (sterol-carrier protein 2): Homology with rat peroxisomal and mitochondrial 3-oxacyl-CoA thiolases
63. Intrinsic sterol- and phosphatidylcholine transfer activities of 17 beta-hydroxysteroid dehydrogenase type IV
64. Sterol carrier protein-2 overexpression enhances sterol cycling and inhibits cholesterol ester synthesis and high density lipoprotein cholesterol secretion
65. NMR determination of the secondary structure and the three-dimensional polypeptide backbone fold of the human sterol carrier protein 2
66. NMR structure of the sterol carrier protein-2: Implications for the biological role
67. In pre-sterol carrier protein 2 (SCP2) in solution the leader peptide is flexibly disordered, and residues 21-143 adopt the same globular fold as in mature SCP-2
68. Crystallization and initial X-ray analysis of rabbit mature sterol carrier protein 2
69. Structure of sterol carrier protein 2 at 1.8 Å resolution reveals a hydrophobic tunnel suitable for lipid binding
70. The sterol carrier protein-2 amino terminus: A membrane interaction domain
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73. Stability and binding properties of wild-type and c17s mutated human sterol carrier protein 2
74. Regulation of membrane cholesterol domains by sterol carrier protein-2
75. Interactions of oleic acid with liver fatty acid binding protein: A carbon-13 NMR study
76. Expression of the mature and the pro-form of human sterol carrier protein 2 in Escherichia coli alters bacterial lipids
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82. Lipid binding to sterol carrier protein-2 is inhibited by ethanol
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84. Cytoplasmic fatty acid binding proteins: Significance for intracellular transport of fatty acids and putative role on signal transduction pathways
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