Exploiting morph-DAST mediated ring-expansion of substituted cyclic β-amino alcohols for the preparation of cyclic fluorinated amino acids. Synthesis of 5-fluoromethylproline and 5-fluoropipecolic acid

Tetrahedron

Volumn 67, Issue 17, 2011, Pages 3091-3097

  Mykhailiuk, Pavel K ^a,b   Shishkina, Svetlana V ^c   Shishkin, Oleg V ^c   Zaporozhets, Olga A ^b   Komarov, Igor V ^a,b  

^a ENAMINE LTD   (Ukraine)

^b TARAS SHEVCHENKO NATIONAL UNIVERSITY OF KYIV   (Ukraine)

^c INSTITUTE FOR SINGLE CRYSTALS   (Ukraine)

Author keywords

Amino acids; Fluorine; Morph DAST; Pipecolic acid; Proline

Indexed keywords

5 FLUOROMETHYLPROLINE; 5 FLUOROPIPECOLIC ACID; AMINO ACID; AMINO ACID DERIVATIVE; AMINOALCOHOL; FLUORINE DERIVATIVE; MORPHOLINOSULFUR TRIFLUORIDE; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

AMINO ACID SYNTHESIS; ARTICLE; CIS ISOMER; DRUG SYNTHESIS; FLUORINATION; PRIORITY JOURNAL; SUBSTITUTION REACTION; TRANS ISOMER;

EID: 79953725104     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2011.02.082     Document Type: Article

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