Rescue of the early vascular defects in Tek/Tie2 null mice reveals an essential survival function

EMBO Reports

Volumn 2, Issue 5, 2001, Pages 438-445

  Jones, Nina ^a,b   Voskas, Daniel ^a,b   Master, Zubin ^a,b   Sarao, Renu ^c   Jones, Jamie ^b   Dumont, Daniel J ^a,b,d  

^a UNIVERSITY OF TORONTO   (Canada)

^b SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^c AMGEN INSTITUTE   (Canada)

^d DEPARTMENT OF RADIATION ONCOLOGY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN RECEPTOR; PROTEIN TYROSINE KINASE; TEK PROTEIN; TETRACYCLINE; UNCLASSIFIED DRUG;

ALLELE; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLEEDING; BLOOD VESSEL; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; CORRELATION FUNCTION; EMBRYO; EMBRYO DEVELOPMENT; ENDOTHELIUM CELL; GENE EXPRESSION; GROWTH CURVE; IN VIVO STUDY; LETHALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SURVIVAL; TRANSGENIC MOUSE; VASCULAR ENDOTHELIUM; VASCULARIZATION;

ANIMALIA; MAMMALIA; MUS MUSCULUS;

EID: 0034984712     PISSN: 1469221X     EISSN: None     Source Type: Journal    
DOI: 10.1093/embo-reports/kve093     Document Type: Article

References (20)

1. Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning
2. Tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors
3. Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo
4. Vascularization of the mouse embryo: A study of flk-1, tek, tie, and vascular endothelial growth factor expression during development
5. Blood vessel formation: What is its molecular basis?
6. Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation
7. Transcriptional activation by tetracyclines in mammalian cells
8. Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration
9. Angiopoietin-1 regulates endothelial cell survival through the phosphatidylinositol 3-kinase/Akt signal transduction pathway
10. Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice
11. Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and Akt
12. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis
13. TIE1 and TIE2 receptor tyrosine kinases inversely regulate embryonic angiogenesis by the mechanism of intussusceptive microvascular growth
14. Interaction of the TEK and TIE receptor tyrosine kinases during cardiovascular development
15. Conditional transgene expression in endothelial cells
16. Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation
17. Uniform vascular-endothelial-cell-specific gene expression in both embryonic and adult transgenic mice
18. Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis
19. Tie2 expression and phosphorylation in angiogenic and quiescent adult tissues
20. Expression and function of murine receptor tyrosine kinases, TIE and TEK, in hematopoietic stem cells