메뉴 건너뛰기




Volumn 3, Issue 1, 2011, Pages 61-78

Doxorubicin-loaded PEG-PCL-PEG micelle using xenograft model of nude mice: Effect of multiple administration of micelle on the suppression of human breast cancer

Author keywords

Antitumor activity; Biodistribution; Drug delivery system; Monomethoxy poly(ethylene glycol); Nanoparticles; Poly(e caprolactone); Safety evaluation

Indexed keywords

COPOLYMER; DOXORUBICIN; ETHYLENE GLYCOL EPSILON CAPROLACTONE ETHYLENE GLYCOL COPOLYMER; UNCLASSIFIED DRUG;

EID: 79953715989     PISSN: None     EISSN: 20726694     Source Type: Journal    
DOI: 10.3390/cancers3010061     Document Type: Article
Times cited : (74)

References (38)
  • 2
    • 74249123929 scopus 로고    scopus 로고
    • Role of combination bortezomib and pegylated liposomal doxorubicin in the management of relapsed and/or refractory multiple myeloma
    • Shah, J.J.; Orlowski, R.Z.; Thomas, S.K. Role of combination bortezomib and pegylated liposomal doxorubicin in the management of relapsed and/or refractory multiple myeloma. Therapeut. Clin. Risk Manag. 2009, 5, 151-159.
    • (2009) Therapeut. Clin. Risk Manag. , vol.5 , pp. 151-159
    • Shah, J.J.1    Orlowski, R.Z.2    Thomas, S.K.3
  • 3
    • 0037360873 scopus 로고    scopus 로고
    • Pharmacokinetics of doxorubicin administered i.v. As myocet (tlc d-99; liposome-encapsulated doxorubicin citrate) compared with conventional doxorubicin when given in combination with cyclophosphamide in patients with metastatic breast cancer
    • Swenson, C.E.; Bolcsak, L.E.; Batist, G.; Guthrie, T.H.J.; Tkaczuk, K.H.; Boxenbaum, H.; Welles, L.; Chow, S.C.; Bhamra, R.; Chaikin, P. Pharmacokinetics of doxorubicin administered i.v. As myocet (tlc d-99; liposome-encapsulated doxorubicin citrate) compared with conventional doxorubicin when given in combination with cyclophosphamide in patients with metastatic breast cancer. Anti-Cancer Drugs 2003, 14, 239-246.
    • (2003) Anti-Cancer Drugs , vol.14 , pp. 239-246
    • Swenson, C.E.1    Bolcsak, L.E.2    Batist, G.3    Guthrie, T.H.J.4    Tkaczuk, K.H.5    Boxenbaum, H.6    Welles, L.7    Chow, S.C.8    Bhamra, R.9    Chaikin, P.10
  • 4
    • 74249114385 scopus 로고    scopus 로고
    • Recent advances in pharmacokinetics of polymeric excipients used in nanosized anti-cancer drugs
    • Cuong, N.V.; Hsieh, M.F. Recent advances in pharmacokinetics of polymeric excipients used in nanosized anti-cancer drugs. Curr. Drug Metab. 2009, 10, 842-850.
    • (2009) Curr. Drug Metab. , vol.10 , pp. 842-850
    • Cuong, N.V.1    Hsieh, M.F.2
  • 5
    • 33646798446 scopus 로고    scopus 로고
    • A mechanistic study of enhanced doxorubicin uptake and retention in multidrug resistant breast cancer cells using a polymer-lipid hybrid nanoparticle system
    • Wong, H.L.; Bendayan, R.; Rauth, A.M.; Xue, H.Y.; Babakhanian, K.; Wu, X.Y. A mechanistic study of enhanced doxorubicin uptake and retention in multidrug resistant breast cancer cells using a polymer-lipid hybrid nanoparticle system. J. Pharmacol. Exp. Ther. 2006, 317, 1372-1381.
    • (2006) J. Pharmacol. Exp. Ther. , vol.317 , pp. 1372-1381
    • Wong, H.L.1    Bendayan, R.2    Rauth, A.M.3    Xue, H.Y.4    Babakhanian, K.5    Wu, X.Y.6
  • 6
    • 75549088350 scopus 로고    scopus 로고
    • The therapeutic response to multifunctional polymeric nano-conjugates in the targeted cellular and subcellular delivery of doxorubicin
    • Xiong, X.-B.; Ma, Z.; Lai, R.; Lavasanifar, A. The therapeutic response to multifunctional polymeric nano-conjugates in the targeted cellular and subcellular delivery of doxorubicin. Biomaterials 2010, 31, 757-768.
    • (2010) Biomaterials , vol.31 , pp. 757-768
    • Xiong, X.-B.1    Ma, Z.2    Lai, R.3    Lavasanifar, A.4
  • 8
    • 33846410672 scopus 로고    scopus 로고
    • Folate-decorated poly(lactide-co-glycolide)-vitamine tpgs nanoparticles for targeted drug delivery
    • Zhang, Z.; Huey Lee, S.; Feng, S.S. Folate-decorated poly(lactide-co-glycolide)-vitamine tpgs nanoparticles for targeted drug delivery. Biomaterials 2007, 28, 1889-1899.
    • (2007) Biomaterials , vol.28 , pp. 1889-1899
    • Zhang, Z.1    Huey Lee, S.2    Feng, S.S.3
  • 10
    • 55849090997 scopus 로고    scopus 로고
    • Doxorubicin-loaded polymeric micelle overcomes multidrug resistance of cancer by double-targeting folate receptor and early endosomal ph
    • Kim, D.; Lee, E.S.; Oh, K.T.; Gao, Z.G.; Bae, Y.H. Doxorubicin-loaded polymeric micelle overcomes multidrug resistance of cancer by double-targeting folate receptor and early endosomal ph. Small 2008, 4, 2043-2050.
    • (2008) Small , vol.4 , pp. 2043-2050
    • Kim, D.1    Lee, E.S.2    Oh, K.T.3    Gao, Z.G.4    Bae, Y.H.5
  • 12
    • 60549091179 scopus 로고    scopus 로고
    • Multifunctional micellar nanomedicine for cancer therapy
    • Blanco, E.; Kessinger, C.W.; Sumer, B.D.; Gao, J. Multifunctional micellar nanomedicine for cancer therapy. Exp. Biol. Med. 2009, 234, 123-131.
    • (2009) Exp. Biol. Med. , vol.234 , pp. 123-131
    • Blanco, E.1    Kessinger, C.W.2    Sumer, B.D.3    Gao, J.4
  • 13
    • 34249820576 scopus 로고    scopus 로고
    • Multifunctional nanocarriers
    • Torchilin, V.P. Multifunctional nanocarriers. Adv. Drug Deliv. Rev. 2006, 58, 1532-1555.
    • (2006) Adv. Drug Deliv. Rev. , vol.58 , pp. 1532-1555
    • Torchilin, V.P.1
  • 14
    • 0034000453 scopus 로고    scopus 로고
    • Tumor vascular permeability and the epr effect in macromolecular therapeutics: A review
    • Maeda, H.; Wu, J.; Sawa, T.; Matsumura, Y.; Hori, K. Tumor vascular permeability and the epr effect in macromolecular therapeutics: A review. J. Contr. Release 2000, 65, 271-284.
    • (2000) J. Contr. Release , vol.65 , pp. 271-284
    • Maeda, H.1    Wu, J.2    Sawa, T.3    Matsumura, Y.4    Hori, K.5
  • 15
    • 33747762229 scopus 로고    scopus 로고
    • Exploiting the enhanced permeability and retention effect for tumor targeting
    • Arun, K.I.; Khaled, G.; Fang, J.; Maeda, H. Exploiting the enhanced permeability and retention effect for tumor targeting. Drug Discov. Today 2006, 11, 812-818.
    • (2006) Drug Discov. Today , vol.11 , pp. 812-818
    • Arun, K.I.1    Khaled, G.2    Fang, J.3    Maeda, H.4
  • 16
    • 48049091570 scopus 로고    scopus 로고
    • Doxorubicin conjugated to d-D-tocopheryl polyethylene glycol 1000 succinate (tpgs): Conjugation chemistry, characterization, in vitro and in vivo evaluation
    • Cao, N.; Feng, S.S. Doxorubicin conjugated to d-D-tocopheryl polyethylene glycol 1000 succinate (tpgs): Conjugation chemistry, characterization, in vitro and in vivo evaluation. Biomaterials 2008, 29, 3856-3865.
    • (2008) Biomaterials , vol.29 , pp. 3856-3865
    • Cao, N.1    Feng, S.S.2
  • 18
    • 0037462992 scopus 로고    scopus 로고
    • Pegylated nanoparticles for biological and pharmaceutical applications
    • Otsuka, H.; Nagasaki, Y.; Kataoka, K. Pegylated nanoparticles for biological and pharmaceutical applications. Adv. Drug Deliv. Rev. 2003, 55, 403-419.
    • (2003) Adv. Drug Deliv. Rev. , vol.55 , pp. 403-419
    • Otsuka, H.1    Nagasaki, Y.2    Kataoka, K.3
  • 19
    • 0041701404 scopus 로고    scopus 로고
    • Novel biodegradable ternary copolymers hy-pei-g-pcl-b-peg: Synthesis, characterization, and potential as efficient nonviral gene delivery vectors
    • Shuai, X.; Merdan, T.; Unger, F.; Wittmar, M.; Kissel, T. Novel biodegradable ternary copolymers hy-pei-g-pcl-b-peg: Synthesis, characterization, and potential as efficient nonviral gene delivery vectors. Macromolecules 2003, 36, 5751-5759.
    • (2003) Macromolecules , vol.36 , pp. 5751-5759
    • Shuai, X.1    Merdan, T.2    Unger, F.3    Wittmar, M.4    Kissel, T.5
  • 20
    • 33748797672 scopus 로고    scopus 로고
    • Macrophage uptake of core-shell nanoparticles surface modified with poly(ethylene glycol)
    • Zahr, A.S.; Davis, C.A.; Pishko, M.V. Macrophage uptake of core-shell nanoparticles surface modified with poly(ethylene glycol). Langmuir 2006, 22, 8178-8185.
    • (2006) Langmuir , vol.22 , pp. 8178-8185
    • Zahr, A.S.1    Davis, C.A.2    Pishko, M.V.3
  • 21
    • 22544471541 scopus 로고    scopus 로고
    • Synthesis and in vitro drug release behavior of amphiphilic triblock copolymer nanoparticles based on poly (ethylene glycol) and polycaprolactone
    • Zhang, Y.; Zhuo, R.X. Synthesis and in vitro drug release behavior of amphiphilic triblock copolymer nanoparticles based on poly (ethylene glycol) and polycaprolactone. Biomaterials 2005, 26, 6736-6742.
    • (2005) Biomaterials , vol.26 , pp. 6736-6742
    • Zhang, Y.1    Zhuo, R.X.2
  • 22
    • 77951835943 scopus 로고    scopus 로고
    • Biodegradable self-assembled peg-pcl-peg micelles for hydrophobic honokiol delivery: I. Preparation and characterization
    • Gong, C.; We, X.; Wang, X.; Wang, Y.; Guo, G.; Mao, Y.; Luo, F.; Qian, Z. Biodegradable self-assembled peg-pcl-peg micelles for hydrophobic honokiol delivery: I. Preparation and characterization. Nanotechnology 2010, 21, 215103.
    • (2010) Nanotechnology , vol.21 , pp. 215103
    • Gong, C.1    We, X.2    Wang, X.3    Wang, Y.4    Guo, G.5    Mao, Y.6    Luo, F.7    Qian, Z.8
  • 23
    • 77951498216 scopus 로고    scopus 로고
    • Amphiphilic biodegradable poly(ε-caprolactone)-poly(ethyl ene glycol)-poly(ε-caprol actone) triblock copolymers: Synthesis, characterization and their use as drug carriers for foli c acid
    • Xu, B.; Yuan, J.; Ding, T.; Gao, Q. Amphiphilic biodegradable poly(ε-caprolactone)-poly(ethyl ene glycol)-poly(ε-caprol actone) triblock copolymers: Synthesis, characterization and their use as drug carriers for foli c acid. Polym. Bull. 2010, 64, 537-551.
    • (2010) Polym. Bull. , vol.64 , pp. 537-551
    • Xu, B.1    Yuan, J.2    Ding, T.3    Gao, Q.4
  • 24
    • 0036285644 scopus 로고    scopus 로고
    • Preparation, characterization, and drug release behaviors of drug nimodipine-loaded poly(Hcaprolactone)-poly(ethylene oxide)-poly(Hcaprolactone) amphiphilic triblock copolymer micelles
    • Ge, H.; Hu, Y.; Jiang, X.; Cheng, D.; Yuan, Y.; Bi, H.; Yang, C. Preparation, characterization, and drug release behaviors of drug nimodipine-loaded poly(Hcaprolactone)-poly(ethylene oxide)-poly(Hcaprolactone) amphiphilic triblock copolymer micelles. J. Pharm. Sci. 2002, 91, 1463-1473.
    • (2002) J. Pharm. Sci. , vol.91 , pp. 1463-1473
    • Ge, H.1    Hu, Y.2    Jiang, X.3    Cheng, D.4    Yuan, Y.5    Bi, H.6    Yang, C.7
  • 25
    • 70349480763 scopus 로고    scopus 로고
    • Poly(H-caprolactone)/poly(ethylene glycol)/poly(H-caprolactone) nanoparticles: Preparation, characterization, and application in doxorubicin delivery
    • Gou, M.; Zheng, X.; Men, K.; Zhang, J.; Zheng, L.; Wang, X.; Luo, F.; Zhao, Y.; Zhao, X.; Wei, Y.; Qian, Z. Poly(H-caprolactone)/poly(ethylene glycol)/poly(H-caprolactone) nanoparticles: Preparation, characterization, and application in doxorubicin delivery. J. Phys. Chem. B 2009, 113, 12928-12933.
    • (2009) J. Phys. Chem. B , vol.113 , pp. 12928-12933
    • Gou, M.1    Zheng, X.2    Men, K.3    Zhang, J.4    Zheng, L.5    Wang, X.6    Luo, F.7    Zhao, Y.8    Zhao, X.9    Wei, Y.10    Qian, Z.11
  • 26
    • 79953691612 scopus 로고    scopus 로고
    • Doxorubicin-loaded nanosized micelles of a star-shaped poly(H-caprolactone)-polyphosphoester block co-polymer for treatment of human breast cancer
    • doi:10.1163/092050610X510533
    • Cuong, N.V.; Hsieh, M.F.; Chen, Y.T.; Liau, I. Doxorubicin-loaded nanosized micelles of a star-shaped poly(H-caprolactone)-polyphosphoester block co-polymer for treatment of human breast cancer. J. Biomater. Sci. Polym. Ed. 2010, doi:10.1163/092050610X510533.
    • (2010) J. Biomater. Sci. Polym. Ed.
    • Cuong, N.V.1    Hsieh, M.F.2    Chen, Y.T.3    Liau, I.4
  • 27
    • 77955942377 scopus 로고    scopus 로고
    • Synthesis and characterization of peg-pcl-peg triblock copolymers as carriers of doxorubicin for the treatment of breast cancer
    • Cuong, N.V.; Hsieh, M.F.; Chen, Y.T.; Liau, I. Synthesis and characterization of peg-pcl-peg triblock copolymers as carriers of doxorubicin for the treatment of breast cancer. J. Appl. Polym. Sci. 2010, 117, 3694-3703.
    • (2010) J. Appl. Polym. Sci. , vol.117 , pp. 3694-3703
    • Cuong, N.V.1    Hsieh, M.F.2    Chen, Y.T.3    Liau, I.4
  • 28
    • 70349394917 scopus 로고    scopus 로고
    • Oxidative stress of silica nanoparticles in human bronchial epithelial cell, beas-2b
    • Eom, H.J.; Choi, J. Oxidative stress of silica nanoparticles in human bronchial epithelial cell, beas-2b. Toxicol. Vitro 2009, 23, 1326-1332.
    • (2009) Toxicol. Vitro , vol.23 , pp. 1326-1332
    • Eom, H.J.1    Choi, J.2
  • 29
    • 1642475114 scopus 로고    scopus 로고
    • Determination and modeling of kinetics of cancer cell killing by doxorubicin and doxorubicin encapsulated in targeted liposomes
    • Eliaz, R.E.; Nir, S.; Marty, C.; Szoka, F.C. Determination and modeling of kinetics of cancer cell killing by doxorubicin and doxorubicin encapsulated in targeted liposomes. Cancer Res. 2004, 64, 711-718.
    • (2004) Cancer Res. , vol.64 , pp. 711-718
    • Eliaz, R.E.1    Nir, S.2    Marty, C.3    Szoka, F.C.4
  • 31
    • 33845791448 scopus 로고    scopus 로고
    • Bio-functional micelles self-assembled from a folate-conjugated block copolymer for targeted intracellular delivery of anti cancer drugs
    • Liu, S.Q.; Wiradharma, N.; Gao, S.J.; Tong, Y.W.; Yang, Y.Y. Bio-functional micelles self-assembled from a folate-conjugated block copolymer for targeted intracellular delivery of anti cancer drugs. Biomaterials 2007, 28, 1423-1433.
    • (2007) Biomaterials , vol.28 , pp. 1423-1433
    • Liu, S.Q.1    Wiradharma, N.2    Gao, S.J.3    Tong, Y.W.4    Yang, Y.Y.5
  • 32
    • 37349053715 scopus 로고    scopus 로고
    • Selectivity of folate conjugated polymer micelles against different tumor cells
    • Zhao, H.; Yung, L.Y.L. Selectivity of folate conjugated polymer micelles against different tumor cells. Int. J. Pharm. 2008, 349, 256-268.
    • (2008) Int. J. Pharm. , vol.349 , pp. 256-268
    • Zhao, H.1    Yung, L.Y.L.2
  • 33
    • 77953412389 scopus 로고    scopus 로고
    • Understanding and overcoming major barriers in cancer nanomedicine
    • Nie, S. Understanding and overcoming major barriers in cancer nanomedicine. Nanomedicine 2010, 5, 523-528.
    • (2010) Nanomedicine , vol.5 , pp. 523-528
    • Nie, S.1
  • 34
    • 47149103300 scopus 로고    scopus 로고
    • Nano-sized micelles of block copolymers of methoxy poly(ethylene glycol)-poly(H-caprolactone)-graft-2-hydroxyethyl cellulose for doxorubi ci n delivery
    • Hsieh, M.F.; Cuong, N.V.; Chen, C.H.; Chen, Y.T.; Yeh, J.M. Nano-sized micelles of block copolymers of methoxy poly(ethylene glycol)-poly(H-caprolactone)-graft-2-hydroxyethyl cellulose for doxorubi ci n delivery. J. Nanosci. Nanotechnol. 2008, 8, 2362-2368.
    • (2008) J. Nanosci. Nanotechnol. , vol.8 , pp. 2362-2368
    • Hsieh, M.F.1    Cuong, N.V.2    Chen, C.H.3    Chen, Y.T.4    Yeh, J.M.5
  • 35
    • 19444375866 scopus 로고    scopus 로고
    • Micelles of methoxy poly(ethylene oxide)-b-poly(H-caprolactone) as vehicles for the solubilization and controlled delivery of cyclospori ne a
    • Aliabadi, H.M.; Mahmud, A.; Sharifabadi, A.D.; Lavasanifar, A. Micelles of methoxy poly(ethylene oxide)-b-poly(H-caprolactone) as vehicles for the solubilization and controlled delivery of cyclospori ne a. J. Contr. Release 2005, 104, 301-311.
    • (2005) J. Contr. Release , vol.104 , pp. 301-311
    • Aliabadi, H.M.1    Mahmud, A.2    Sharifabadi, A.D.3    Lavasanifar, A.4
  • 36
    • 32344453463 scopus 로고    scopus 로고
    • Biodegradable polymeric nanoparticles bearing stealth peg shell and lipophilic polyester core
    • Hsieh, M.F.; Lin, T.Y.; Gau, R.J.; Chang, H.T.; Lo, Y.L.; Lai, C.H. Biodegradable polymeric nanoparticles bearing stealth peg shell and lipophilic polyester core. J. Chin. Inst. Chem. Engrs. 2005, 36, 609-615.
    • (2005) J. Chin. Inst. Chem. Engrs. , vol.36 , pp. 609-615
    • Hsieh, M.F.1    Lin, T.Y.2    Gau, R.J.3    Chang, H.T.4    Lo, Y.L.5    Lai, C.H.6
  • 38
    • 65949101227 scopus 로고    scopus 로고
    • Improved hplc method for doxorubicin quantification in rat plasma to study the pharmacokinetics of micelle-encapsulated and liposome-encapsulated doxorubicin formulations
    • Wei, G.; Xiao, S.; Si, D.; Liu, C. Improved hplc method for doxorubicin quantification in rat plasma to study the pharmacokinetics of micelle-encapsulated and liposome-encapsulated doxorubicin formulations. Biomed. Chromatogr. 2008, 22, 1252-1258.
    • (2008) Biomed. Chromatogr. , vol.22 , pp. 1252-1258
    • Wei, G.1    Xiao, S.2    Si, D.3    Liu, C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.