Hepatitis A virus vaccine escape variants and potential new serotype emergence

Emerging Infectious Diseases

Volumn 17, Issue 4, 2011, Pages 734-737

  Pérez Sautu, Unai ^a   Costafreda, M Isabel ^a   Caylà, Joan ^b   Tortajada, Cecilia ^b   Lite, Josep ^c   Bosch, Albert ^a   Pintó, Rosa M ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b AGÈNCIA DE SALUT PÚBLICA DE BARCELONA   (Spain)

^c Catlab   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

HEPATITIS A VACCINE; VIRUS PROTEIN;

AMINO ACID SUBSTITUTION; ANTIGENIC VARIATION; ARTICLE; EPIDEMIC; GENE SEQUENCE; HEPATITIS A; HEPATITIS A VIRUS; HUMAN; MALE HOMOSEXUAL; NUCLEOTIDE SEQUENCE; OUTCOME ASSESSMENT; SEROTYPE; VACCINATION; VIRUS REPLICATION;

EID: 79953715146     PISSN: 10806040     EISSN: 10806059     Source Type: Journal    
DOI: 10.3201/eid1704.101169     Document Type: Article

References (15)

1. Pintó RM, Costafreda MI, Bosch A. Risk assessment in shellfi sh-borne outbreaks of hepatitis A. Appl Environ Microbiol. 2009;75:7350-5. DOI:10.1128/AEM.01177-09
2. Wheeler C, Vogt TM, Armstrong GL, Vaughan G, Weltman A, Nainan OV, et al. An outbreak of hepatitis A associated with green onions. N Engl J Med. 2005;353:890-7. DOI:10.1056/NEJMoa050855
3. Faber MS, Stark K, Behnke SC, Schreier E, Frank C. Epidemiology of hepatitis A virus infections, Germany, 2007-2008. Emerg Infect Dis. 2009;15:1760-8.
4. Stene-Johansen K, Tjon G, Schreier E, Bremer V, Bruisten S, Ngui SL, et al. Molecular epidemiological studies show that hepatitis A virus is endemic among active homosexual men in Europe. J Med Virol. 2007;79:356-65. DOI: 10.1002/jmv.20781
5. Costa-Mattioli M, Napoli AD, Ferre V, Billaudel S, Perez-Bercoff R, Cristina J. Genetic variability of hepatitis A virus. J Gen Virol. 2003;84:3191-201. DOI: 10.1099/vir.0.19532-0
6. Robertson BH, Jansen RW, Khanna B, Totsuka A, Nainan OV, Siegl G, et al. Genetic relatedness of hepatitis A virus strains recovered from different geographical regions. J Gen Virol. 1992;73:1365-77.DOI: 10.1099/0022-1317-73-6-1365
7. Sánchez G, Bosch A, Pintó RM. Genome variability and capsid structural constraints of hepatitis A virus. J Virol. 2003;77:452-9.DOI: 10.1128/JVI.77.1.452-459.2003
8. Sánchez G, Bosch A, Gomez-Mariano G, Domingo E, Pintó RM. Evidence for quasispecies distributions in the human hepatitis A virus genome. Virology. 2003;315:34-42. DOI:10.1016/S0042-6822(03)00483-5
9. Aragonès L, Bosch A, Pintó RM, Hepatitis A. Virus mutant spectra under the selective pressure of monoclonal antibodies: codon usage constraints limit capsid variability. J Virol. 2008;82:1688-700. DOI:10.1128/JVI.01842-07
10. Aragonès L, Guix S, Ribes E, Bosch A, Pintó RM. Fine-tuning translation kinetics selection as the driving force of codon usage bias in the hepatitis A virus capsid. PLoS Pathog. 2010;6:e1000797. DOI:10.1371/journal.ppat.1000797
11. Luo M, Rossmann MG, Palmenberg AC. Prediction of three-dimensional models for foot-and-mouth disease virus and hepatitis a virus. Virology. 1988;166:503-14. DOI:10.1016/0042-6822(88)90521-1
12. Ping LH, Lemon SM. Antigenic structure of human hepatitis A virus defi ned by analysis of escape mutants selected against murine monoclonal antibodies. J Virol. 1992;66:2208-16.
13. Sánchez G, Aragonès L, Costafreda MI, Ribes E, Bosch A, Pintó RM. Capsid region involved in hepatitis a virus binding to glycophorin A of the erythrocyte membrane. J Virol. 2004;78:9807-13. DOI:10.1128/JVI.78.18.9807-9813.2004
14. Weissman S, Feucht C, Moore BA. Response to hepatitis A vaccine in HIV-positive patients. J Viral Hepat. 2006;13:81-6. DOI:10.1111/j.1365-2893.2005.00658.x
15. Neilsen GA, Bodsworth NJ, Watts N. Response to hepatitis A vaccination in human immunodefi ciency virus-infected and -uninfected homosexual men. J Infect Dis. 1997;176:1064-7. DOI:10.1086/516512