An outbreak of hepatitis A associated with green onions

New England Journal of Medicine

Volumn 353, Issue 9, 2005, Pages 890-897

  Wheeler, Charlotte ^a,b   Vogt, Tara M ^a,b   Armstrong, Gregory L ^b   Vaughan, Gilberto ^b   Weltman, Andre ^c   Nainan, Omana V ^b   Dato, Virginia ^c   Xia, Guoliang ^b   Waller, Kirsten ^c   Amon, Joseph ^a,b   Lee, Teresa M ^b   Highbaugh Battle, Angela ^a   Hembree, Cambria ^a   Evenson, Stephanie ^a   Ruta, Michael A ^d   Williams, Ian T ^b   Fiore, Anthony E ^a,b   Bell, Beth P ^b  

^a CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^b NATL CENTER FOR INFECTIOUS DISEASES   (United States)

^c PENNSYLVANIA DEPARTMENT OF HEALTH   (United States)

^d OHIO DEPARTMENT OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS RNA;

ADOLESCENT; ADULT; AGED; ARTICLE; CATERING SERVICE; CHILD; CONFIDENCE INTERVAL; FEMALE; FOOD CONTAMINATION; FOOD INTAKE; HEPATITIS A; HEPATITIS A VIRUS; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; ONION; OUTCOMES RESEARCH; PRIORITY JOURNAL; RNA EXTRACTION; SEQUENCE ANALYSIS; SERUM; VIRAL CONTAMINATION; WORKER; CASE CONTROL STUDY; EPIDEMIC; FOOD CONTROL; FOOD HANDLING; FOOD POISONING; GENETICS; ISOLATION AND PURIFICATION; MEXICO; MIDDLE AGED; MORTALITY; PRESCHOOL CHILD; UNITED STATES; VIROLOGY;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; DISEASE OUTBREAKS; FEMALE; FOOD HANDLING; FOOD MICROBIOLOGY; FOOD POISONING; HEPATITIS A; HEPATITIS A VIRUS; HUMANS; INFANT; MALE; MEXICO; MIDDLE AGED; ONIONS; PENNSYLVANIA; RESTAURANTS; RNA, VIRAL;

EID: 24044484768     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMoa050855     Document Type: Article

References (28)

1. Prevention of hepatitis A through active or passive immunization: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 1999;48(RR-12):1-37.
2. Wasley A, Samandari T, Bell BP. Incidence of hepatitis A in the United States in the era of vaccination. JAMA 2005;294:194-201.
3. Fiore AE. Hepatitis A transmitted by food. Clin Infect Dis 2004;38:705-15.
4. McCaustland KA, Bond WW, Bradley DW, Ebert JW, Maynard JE. Survival of hepatitis A virus in feces after drying and storage for 1 month. J Clin Microbiol 1982;16:957-8.
5. Reid TM, Robinson HG. Frozen raspberries and hepatitis A. Epidemiol Infect 1987;98:109-12.
6. Rosenblum LS, Mirkin IR, Allen DT, Safford S, Hadler SC. A multifocal outbreak of hepatitis A traced to commercially distributed lettuce. Am J Public Health 1990;80:1075-9.
7. Niu MT, Polish LB, Robertson BH, et al. Multistate outbreak of hepatitis A associated with frozen strawberries. J Infect Dis 1992;166:518-24.
8. Hutin YJ, Pool V, Cramer EH, et al. A multistate, foodborne outbreak of hepatitis A. N Engl J Med 1999;340:595-602.
9. Dentinger CM, Bower WA, Nainan OV, et al. An outbreak of hepatitis A associated with green onions. J Infect Dis 2001;183:1273-6.
10. Datta SD, Traeger MS, Nainan OV, et al. Identification of a multi-state outbreak of hepatitis A associated with green onions using a novel molecular epidemiologic technique. In: Program and abstracts of the 39th Annual Meeting of the Infectious Diseases Society of America, San Francisco, October 27, 2001. abstract.
11. Nainan OV, Armstrong GL, Han X-H, Williams I, Bell BP, Margolis HS. Hepatitis A molecular epidemiology in the United States, 1996-1997: sources of infection and implications of vaccination policy. J Infect Dis 2005;191:957-63.
12. Armstrong GA, Nainan OV, Xia GL, et al. Trends in hepatitis A virus (HAV) molecular epidemiology, United States 2001-2003. In: Program and abstracts of the 41st Annual Meeting of the Infectious Diseases Society of America, San Diego, Calif., October 11, 2003. abstract.
13. Amon J, Devasia R, Xia G, et al. Molecular epidemiologic investigation of hepatitis A outbreaks, 2003. Presented at the 4th International Conference on Emerging Infectious Diseases, Atlanta, March 2, 2004. abstract.
14. Food and Drug Administration. Import alert #25-20: detention without physical examination of green onions (scallions) from specific firms in Mexico. (Accessed August 4, 2005, at http://www.fda.gov/ora/fiars/ora_ import_ia2520.html.)
15. Idem. Consumers advised that recent hepatitis A outbreaks have been associated with green onions. (Accessed August 4, 2005, at http://www.fda.gov/ bbs/topics/ANSWERS/2003/ANS01262.html.)
16. Halliday ML, Kang L-Y, Zhou T-K, et al. An epidemic of hepatitis A attributable to the ingestion of raw clams in Shanghai, China. J Infect Dis 1991;164:852-9.
17. Public Health Service. Food Code 2001. (Accessed August 4, 2005, at http://www.cfsan.fda.gov/~dms/fc01-3.html.)
18. Food and Drug Administration. Guidance for industry: guide to minimize microbial food safety hazards for fresh fruits and vegetables. (Accessed August 4, 2005, at http://www.foodsafety.gov/~dms/prodguid.html.)
19. Jean J, Vachon JF, Moroni O, Darveau A, Kukavica-Ibrulj I, Fliss I. Effectiveness of commercial disinfectants for inactivating hepatitis A virus on agri-food surfaces. J Food Prot 2003;66:115-9.
20. Ticehurst JR, Feinstone SM, Chestnut T, Tassopolous NC, Popper H, Purcell RH. Detection of hepatitis A virus by extraction of viral RNA and molecular hybridization. J Clin Microbiol 1987;25:1822-9.
21. Tauxe RV. Emerging foodborne diseases: an evolving public health challenge. Emerg Infect Dis 1997;3:425-34.
22. Calvin L, Avendaño B, Schwentesius R. The economics of food safety: the case of green onions and hepatitis A outbreaks. (Accessed August 4, 2005, at http://www.ers.usda.gov/publications/vgs/nov04/VGS30501/.)
23. Croci L, De Medici D, Scalfaro C, Fiore A, Toti L. The survival of hepatitis A virus in fresh produce. Int J Food Microbiol 2002;73:29-34.
24. Multistate outbreaks of Salmonella serotype Poona infections associated with eating cantaloupe from Mexico - United States and Canada, 2000-2002. MMWR Morb Mortal Wkly Rep 2002;51:1044-7.
25. Cummings K, Barrett E, Mohle-Boetani JC, et al. A multistate outbreak of Salmonella enterica serotype Baildon associated with domestic raw tomatoes. Emerg Infect Dis 2001;7:1046-8.
26. Sivapalasingam S, Barrett E, Kimura A, et al. A multistate outbreak of Salmonella enterica serotype Newport infection linked to mango consumption: impact of water-dip disinfestation technology. Clin Infect Dis 2003;37:1585-90.
27. Sivapalasingam S, Friedman CR, Cohen L, Tauxe RV. Fresh produce: a growing cause of outbreaks of foodborne illness in the United States, 1973 through 1997. J Food Prot 2004;67:2342-53.
28. Tanaka J. Hepatitis A shifting epidemiology in Latin America. Vaccine 2000;18:Suppl 1:S57-S60.