Modelling asthma in macaques: Longitudinal changes in cellular and molecular markers

European Respiratory Journal

Volumn 37, Issue 3, 2011, Pages 541-552

  Ayanoglu, G ^a   Desai, B ^a   Fick Jr , R B ^a   Grein, J ^a   De Waal Malefyt, R ^a   Mattson, J ^a   McClanahan, T ^a   Olmstead, S ^b   Reece, S P ^b   Van Scott, M R ^b   Wardle, R L ^b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b EAST CAROLINA UNIVERSITY   (United States)

Author keywords

Asthma; Corticosteroid treatment; Natural killer T cell; Primate model

Indexed keywords

CORTICOSTEROID; EOTAXIN; HISTAMINE; HOUSE DUST ALLERGEN; IMMUNOGLOBULIN E; INTERLEUKIN 13; INTERLEUKIN 19; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6;

AIRWAY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASSAY; ASTHMA; BRONCHUS BIOPSY; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL FUNCTION; CONTROLLED STUDY; EOSINOPHILIA; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; GENE EXPRESSION PROFILING; HISTAMINE BLOOD LEVEL; IMMUNIZATION; LUNG LAVAGE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE SUBPOPULATION; MACACA; MALE; MOLECULAR BIOLOGY; NATURAL KILLER CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; SENSITIZATION; THYMUS;

ADRENAL CORTEX HORMONES; ALLERGENS; ANIMALS; ASTHMA; BIOLOGICAL MARKERS; BRONCHOALVEOLAR LAVAGE; DISEASE MODELS, ANIMAL; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HUMANS; IMMUNOGLOBULIN E; KILLER CELLS, NATURAL; LUNG; LYMPHOCYTES; MACACA; MITES; STEROIDS;

EID: 79953699940     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00047410     Document Type: Article

References (38)

1. World Health Organization. WHO Fact Sheet: Bronchial Asthma. Geneva, WHO, 2000.
2. Patterson R, Harris KE. IgE-mediated rhesus monkey asthma: natural history and individual animal variation. Int Arch Allergy Immunol 1992; 97: 154-159.
3. Plopper CG, Hyde DM. The non-human primate as a model for studying COPD and asthma. Pulm Pharmacol Ther 2008; 21: 755-766.
4. Coffman RL, Hessel EM. Nonhuman primate models of asthma. J Exp Med 2005; 201: 1875-1879. (Pubitemid 41002922)
5. Bice DE, Seagrave JC, Green FHY. Animal models of asthma. Inhal Tox 2000; 12: 829-862.
6. Van Scott MR, Aycock D, Cozzi E, et al. Separation of bronchoconstriction from increased ventilatory drive in a nonhuman primate model of chronic allergic asthma. J Appl Physiol 2005; 99: 2080-2086. (Pubitemid 41691623)
7. Turner CR, Spannhake EW. Acute topical steroid administration blocks mast cell increase and the late asthmatic response of the canine peripheral airways. Am Rev Respir Dis 1990; 141: 421-427. (Pubitemid 20068885)
8. Pritchard DI, Eady RP, Harper ST, et al. Laboratory infection of primates with Ascaris suum to provide a model of allergic bronchoconstriction. Clin Exp Immunol 1983; 54: 469-476. (Pubitemid 13018195)
9. Gundel RH, Gerritsen ME, Gleich GJ, et al. Repeated antigen inhalation results in a prolonged airway eosinophilia and airway hyperresponsiveness in primates. J Appl Physiol 1990; 68: 779-786. (Pubitemid 20088918)
10. Young SS, Ritacco G, Skeans S, et al. Eotaxin and nitric oxide production as markers of inflammation in allergic cynomolgus monkeys. Int Arch Allergy Immunol 1999; 120: 209-217.
11. Renz H, Enssle K, Lauffer L, et al. Inhibition of allergen-induced IgE and IgG1 production by soluble IL-4 receptor. Int Arch Allergy Immunol 1995; 106: 46-54.
12. Yasue M, Nakamura S, Yokota T, et al. Experimental monkey model sensitized with mite antigen. Int Arch Allergy Immunol 1998; 115: 303-311. (Pubitemid 28143032)
13. Schelegle ES, Gershwin LJ, Miller LA, et al. Allergic asthma induced in rhesus monkeys by house dust mite (Dermatophagoides farinae). Am J Pathol 2001; 158: 333-41. (Pubitemid 32096500)
14. Zou J, Young S, Zhu F, et al. Microarray profile of differentially expressed genes in a monkey model of allergic asthma. Genome Biol 2002; 3: research0020.
15. US Department of Agriculture. National Research Council Guide for the Care and Use of Laboratory Animals. Washington, National Academy Press, 1996.
16. Van Scott MR, Hooker JL, Ehrmann D, et al. Dust miteinduced asthma in cynomolgus monkeys. J Appl Physiol 2004; 96: 1433-1444. (Pubitemid 38392681)
17. WorldHealth Organization.WHOInternational Biological Reference Preparations. www.who.int/bloodproducts/catalogue/AlphJan10. pdf Date last accessed: December 3, 2010. Date last updated: January 4, 2010.
18. Wilson JH, Boniface K, Chan JR, et al. Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nat Immunol 2007; 8: 950-957. (Pubitemid 47300009)
19. Naidenko OV, Maher JK, Ernst WA, et al. Binding and antigen presentation of ceramide-containing glycolipids by soluble mouse and human CD1d molecules. J Exp Med 1999; 190: 1069-1080.
20. Stone SF, Cotterell C, Isbister GK, et al. Elevated serum cytokines during human anaphylaxis: identification of potential mediators of acute allergic reactions. J Allergy Clin Immunol 2009; 124: 786-792.
21. De Amici M, Puggioni F, Casali L, et al. Variations in serum levels of interleukin (IL)-1b, IL-2, IL-6, and tumor necrosis factor-α during specific immunotherapy. Ann Allergy Asthma Immunol 2001; 86: 311-313. (Pubitemid 32240216)
22. Lommatzsch M, Julius P, Kuepper M, et al. The course of allergeninduced leukocyte infiltration in human and experimental asthma. J Allergy Clin Immunol 2006; 118: 91-97. (Pubitemid 43946466)
23. + natural killer T cells in bronchial asthma. N Engl J Med 2006; 354: 1117-1129.
24. Lisbonne M, Diem S, de Castro Keller A, et al. Cutting edge: invariant V alpha 14 NKT cells are required for allergen-induced airway inflammation and hyperreactivity in an experimental asthma model. J Immunol 2003; 171: 1637-1641. (Pubitemid 36966444)
25. Vijayanand P, Seumois G, Pickard C, et al. Invariant natural killer T cells in asthma and chronic obstructive pulmonary disease. N Engl J Med 2007; 356: 1410-1422. (Pubitemid 46556326)
26. Arnold V, Balkow S, Staats R, et al. Increase in perforin-positive peripheral blood lymphocytes in extrinsic and intrinsic asthma. Am Respir Crit Care Med 2000; 161: 182-186. (Pubitemid 30055923)
27. Walker C, Bode E, Boer L, et al. Allergic and nonallergic asthmatics have distinct patterns of T-cell activation and cytokine production in peripheral blood and bronchoalveolar lavage. Am Rev Respir Dis 1992; 146: 109-115.
28. Wahlstrom J, Dahlen B, Ihre E, et al. Selective CD8+ T cells accumulate in the lungs of patients with allergic asthma after allergen bronchoprovocation. Clin Exp Immunol 1998; 112: 1-9. (Pubitemid 28157091)
29. H2-type cytokine mRNA expression, and eosinophil recruitment in bronchoalveolar lavage after allergen inhalation challenge in patients with atopic asthma. J Allergy Clin Immunol 1993; 92: 313-324.
30. Bakakos P, Pickard C, Smith JL, et al. TCR usage and cytokine expression in peripheral blood and BAL T cells. Clin Exp Immunol 2002; 128: 295-301. (Pubitemid 34534043)
31. Corry DB. Emerging immune targets for the therapy of allergic asthma. Nat Rev Drug Discov 2002; 1: 55-64. (Pubitemid 37361404)
32. Corrigan CJ, Kay AB. Asthma. Role of T-lymphocytes and lymphokines. British Med Bulletin 1992; 48: 72-84.
33. Romagnani S. Cytokines and chemoattractants in allergic inflammation. Mol Immunol 2002; 38: 881-885. (Pubitemid 34496945)
34. Yanai M, Sato K, Aoki N, et al. The role of CCL22/macrophagederived chemokine in allergic rhinitis. Clin Immunol 2007; 125: 291-298. (Pubitemid 350116711)
35. Ying S, O'Connor B, Ratoff J, et al. Expression and cellular provenance of thymic stromal lymphopoietin and chemokines in patients with severe asthma and chronic obstructive pulmonary disease. J Immunol 2008; 181: 2790-2798.
36. Ko FW, Lau CY, Leung TF, et al. Exhaled breath condensate levels of eotaxin and macrophage-derived chemokine in stable adult asthma patients. Clin Exp Allergy 2006; 36: 44-51.
37. Stock P, Akbari O, DeKruyff RH, et al. Respiratory tolerance is inhibited by the administration of corticosteroids. J Immunol 2005; 175: 7380-7387. (Pubitemid 41713435)
38. Spinozzi F, Agea E, Bistoni O, et al. Increased allergenspecific, steroid-sensitive gamma delta T cells in bronchoalveolar lavage fluid from patients with asthma. Ann Int Med 1996; 124: 223-228.