The CD4+ T-cell transcriptome and serum IgE in asthma: IL17RB and the role of sex

BMC Pulmonary Medicine

Volumn 11, Issue , 2011, Pages

  Hunninghake, Gary M ^a   Chu, Jen Hwa ^a   Sharma, Sunita S ^a   Cho, Michael H ^a   Himes, Blanca E ^a,b   Rogers, Angela J ^a   Murphy, Amy ^a   Carey, Vincent J ^a   Raby, Benjamin A ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN E; INTERLEUKIN 17 RECEPTOR; RNA; TRANSCRIPTOME;

ADULT; ARTICLE; ASTHMA; CANONICAL ANALYSIS; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; GENE CONTROL; GENE EXPRESSION; GENETIC ASSOCIATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOGLOBULIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; RNA ISOLATION; SEX; BIOSYNTHESIS; BLOOD; COHORT ANALYSIS; CROSS-SECTIONAL STUDY; DNA MICROARRAY; GENE EXPRESSION PROFILING; GENETICS; IMMUNOLOGY; INHALATION TEST; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEXUAL DEVELOPMENT; SPIROMETRY;

ASTHMA; BRONCHIAL PROVOCATION TESTS; CD4-POSITIVE T-LYMPHOCYTES; COHORT STUDIES; CROSS-SECTIONAL STUDIES; FEMALE; GENE EXPRESSION PROFILING; GENOME-WIDE ASSOCIATION STUDY; HUMANS; IMMUNOGLOBULIN E; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RECEPTORS, INTERLEUKIN-17; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEX CHARACTERISTICS; SPIROMETRY; YOUNG ADULT;

EID: 79953687977     PISSN: None     EISSN: 14712466     Source Type: Journal    
DOI: 10.1186/1471-2466-11-17     Document Type: Article

References (36)

1. Burrows B, Martinez FD, Halonen M, Barbee RA, Cline MG. Association of asthma with serum IgE levels and skin-test reactivity to allergens. N Engl J Med 1989, 320:271-277. 10.1056/NEJM198902023200502, 2911321.
2. Sears MR, Burrows B, Flannery EM, Herbison GP, Hewitt CJ, Holdaway MD. Relation between airway responsiveness and serum IgE in children with asthma and in apparently normal children. N Engl J Med 1991, 325:1067-1071. 10.1056/NEJM199110103251504, 1891008.
3. Geha RS, Jabara HH, Brodeur SR. The regulation of immunoglobulin E class-switch recombination. Nat Rev Immunol 2003, 3:721-732. 10.1038/nri1181, 12949496.
4. Guilbert TW, Morgan WJ, Zeiger RS, Bacharier LB, Boehmer SJ, Krawiec M, Larsen G, Lemanske RF, Liu A, Mauger DT, et al. Atopic characteristics of children with recurrent wheezing at high risk for the development of childhood asthma. J Allergy Clin Immunol 2004, 114:1282-1287. 10.1016/j.jaci.2004.09.020, 15577824.
5. Uekert SJ, Akan G, Evans MD, Li Z, Roberg K, Tisler C, Dasilva D, Anderson E, Gangnon R, Allen DB, et al. Sex-related differences in immune development and the expression of atopy in early childhood. J Allergy Clin Immunol 2006, 118:1375-1381. 10.1016/j.jaci.2006.09.008, 17157669.
6. Kerkhof M, Droste JH, de Monchy JG, Schouten JP, Rijcken B. Distribution of total serum IgE and specific IgE to common aeroallergens by sex and age, and their relationship to each other in a random sample of the Dutch general population aged 20-70 years. Dutch ECRHS Group, European Community Respiratory Health Study. Allergy 1996, 51:770-776.
7. Raby BA, Soto-Quiros ME, Avila L, Lake SL, Murphy A, Liang C, Fournier E, Spesny M, Sylvia JS, Verner A, et al. Sex-specific linkage to total serum immunoglobulin E in families of children with asthma in Costa Rica. Hum Mol Genet 2007, 16:243-253. 10.1093/hmg/ddl447, 17142250.
8. Weiss LA, Pan L, Abney M, Ober C. The sex-specific genetic architecture of quantitative traits in humans. Nat Genet 2006, 38:218-222. 10.1038/ng1726, 16429159.
9. The Childhood Asthma Management Program (CAMP): design, rationale, and methods. Childhood Asthma Management Program Research Group. Control Clin Trials 1999, 20:91-120. 10.1016/S0197-2456(98)00044-0, 10027502.
10. Jonuleit H, Schmitt E, Schuler G, Knop J, Enk AH. Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J Exp Med 2000, 192:1213-1222. 10.1084/jem.192.9.1213, 2193357, 11067871.
11. Gonzalez P, Zigler JS, Epstein DL, Borras T. Identification and isolation of differentially expressed genes from very small tissue samples. Biotechniques 1999, 26:884-886. 888-892.
12. Barnes M, Freudenberg J, Thompson S, Aronow B, Pavlidis P. Experimental comparison and cross-validation of the Affymetrix and Illumina gene expression analysis platforms. Nucleic Acids Res 2005, 33:5914-5923. 10.1093/nar/gki890, 1258170, 16237126.
13. Du P, Kibbe WA, Lin SM. lumi: a pipeline for processing Illumina microarray. Bioinformatics 2008, 24:1547-1548. 10.1093/bioinformatics/btn224, 18467348.
14. Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, Scherf U, Speed TP. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 2003, 4:249-264. 10.1093/biostatistics/4.2.249, 12925520.
15. Smyth GK. Bioinformatics and Computational Biology Solutions using R and Bioconductor 2005, New York: Springer.
16. R Development Core Team R: A Language and Environment for Statistical Computing. 2009, Vienna, Austria, R Development Core Team.
17. Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S, Ellis B, Gautier L, Ge Y, Gentry J, et al. Bioconductor: open software development for computational biology and bioinformatics. Genome Biol 2004, 5:R80. 10.1186/gb-2004-5-10-r80, 545600, 15461798.
18. Smyth GK. Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 2004, 3. Article3.
19. Benjamini Y, Drai D, Elmer G, Kafkafi N, Golani I. Controlling the false discovery rate in behavior genetics research. Behav Brain Res 2001, 125:279-284. 10.1016/S0166-4328(01)00297-2, 11682119.
20. Tibshirani R. Regression shrinkage and selection via the lasso. Journal of the Royal Statistical Society Series B 1995,
21. Tibshirani R. The lasso method for variable selection in the Cox model. Stat Med 1997, 16:385-395. 10.1002/(SICI)1097-0258(19970228)16:4<385::AID-SIM380>3.0.CO;2-3, 9044528.
22. Weidinger S, Gieger C, Rodriguez E, Baurecht H, Mempel M, Klopp N, Gohlke H, Wagenpfeil S, Ollert M, Ring J, et al. Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus. PLoS Genet 2008, 4:e1000166. 10.1371/journal.pgen.1000166, 2565692, 18846228.
23. Tian E, Sawyer JR, Largaespada DA, Jenkins NA, Copeland NG, Shaughnessy JD. Evi27 encodes a novel membrane protein with homology to the IL17 receptor. Oncogene 2000, 19:2098-2109. 10.1038/sj.onc.1203577, 10815801.
24. Wang YH, Liu YJ. The IL-17 cytokine family and their role in allergic inflammation. Curr Opin Immunol 2008, 20:697-702. 10.1016/j.coi.2008.09.004, 18832032.
25. Angkasekwinai P, Park H, Wang YH, Chang SH, Corry DB, Liu YJ, Zhu Z, Dong C. Interleukin 25 promotes the initiation of proallergic type 2 responses. J Exp Med 2007, 204:1509-1517. 10.1084/jem.20061675, 2118650, 17562814.
26. Lajoie-Kadoch S, Joubert P, Letuve S, Halayko AJ, Martin JG, Soussi-Gounni A, Hamid Q. TNF-alpha and IFN-gamma inversely modulate expression of the IL-17E receptor in airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 2006, 290:L1238-1246. 10.1152/ajplung.00301.2005, 16428271.
27. Wang YH, Angkasekwinai P, Lu N, Voo KS, Arima K, Hanabuchi S, Hippe A, Corrigan CJ, Dong C, Homey B, et al. IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells. J Exp Med 2007, 204:1837-1847. 10.1084/jem.20070406, 2118667, 17635955.
28. Wang H, Mobini R, Fang Y, Barrenas F, Zhang H, Xiang Z, Benson M. Allergen challenge of peripheral blood mononuclear cells from patients with seasonal allergic rhinitis increases IL-17RB, which regulates basophil apoptosis and degranulation. Clin Exp Allergy 40:1194-1202. 10.1111/j.1365-2222.2010.03542.x, 20545698.
29. Fort MM, Cheung J, Yen D, Li J, Zurawski SM, Lo S, Menon S, Clifford T, Hunte B, Lesley R, et al. IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo. Immunity 2001, 15:985-995. 10.1016/S1074-7613(01)00243-6, 11754819.
30. Ballantyne SJ, Barlow JL, Jolin HE, Nath P, Williams AS, Chung KF, Sturton G, Wong SH, McKenzie AN. Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma. J Allergy Clin Immunol 2007, 120:1324-1331. 10.1016/j.jaci.2007.07.051, 17889290.
31. Whitacre CC, Reingold SC, O'Looney PA. A gender gap in autoimmunity. Science 1999, 283:1277-1278. 10.1126/science.283.5406.1277, 10084932.
32. Jerevall PL, Brommesson S, Strand C, Gruvberger-Saal S, Malmstrom P, Nordenskjold B, Wingren S, Soderkvist P, Ferno M, Stal O. Exploring the two-gene ratio in breast cancer--independent roles for HOXB13 and IL17BR in prediction of clinical outcome. Breast Cancer Res Treat 2008, 107:225-234. 10.1007/s10549-007-9541-8, 17453342.
33. Hunninghake GM, Lasky-Su J, Soto-Quiros ME, Avila L, Liang C, Lake SL, Hudson TJ, Spesny M, Fournier E, Sylvia JS, et al. Sex-stratified linkage analysis identifies a female-specific locus for IgE to cockroach in Costa Ricans. Am J Respir Crit Care Med 2008, 177:830-836. 10.1164/rccm.200711-1697OC, 2292826, 18244952.
34. Weinstein Y, Ran S, Segal S. Sex-associated differences in the regulation of immune responses controlled by the MHC of the mouse. J Immunol 1984, 132:656-661.
35. Gourdy P, Araujo LM, Zhu R, Garmy-Susini B, Diem S, Laurell H, Leite-de-Moraes M, Dy M, Arnal JF, Bayard F, Herbelin A. Relevance of sexual dimorphism to regulatory T cells: estradiol promotes IFN-gamma production by invariant natural killer T cells. Blood 2005, 105:2415-2420. 10.1182/blood-2004-07-2819, 15383462.
36. Hewagama A, Patel D, Yarlagadda S, Strickland FM, Richardson BC. Stronger inflammatory/cytotoxic T-cell response in women identified by microarray analysis. Genes Immun 2009, 10:509-516. 10.1038/gene.2009.12, 2735332, 19279650.