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Volumn , Issue , 2008, Pages 147-158

The MPTP Mouse Model of Parkinson's Disease: The True, the False, and the Unknown

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EID: 79953677529     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-374028-1.00011-7     Document Type: Chapter
Times cited : (5)

References (85)
  • 1
    • 0027230452 scopus 로고
    • Age-related susceptibility to MPTP-induced neurotoxicity in mice
    • Ali S.F., David S.N., Newport G.D. Age-related susceptibility to MPTP-induced neurotoxicity in mice. Neurotoxicology 1993, 14:29-34.
    • (1993) Neurotoxicology , vol.14 , pp. 29-34
    • Ali, S.F.1    David, S.N.2    Newport, G.D.3
  • 2
    • 0035968070 scopus 로고    scopus 로고
    • Neuroprotective effects of pramipexole in young and aged MPTP-treated mice
    • Anderson D.W., Neavin T., Smith J.A., Schneider J.S. Neuroprotective effects of pramipexole in young and aged MPTP-treated mice. Brain Res 2001, 905:44-53.
    • (2001) Brain Res , vol.905 , pp. 44-53
    • Anderson, D.W.1    Neavin, T.2    Smith, J.A.3    Schneider, J.S.4
  • 3
    • 0020956905 scopus 로고
    • Histochemical observations on rodent brain melanin
    • Barden H., Levine S. Histochemical observations on rodent brain melanin. Brain Res Bull 1983, 10:847-851.
    • (1983) Brain Res Bull , vol.10 , pp. 847-851
    • Barden, H.1    Levine, S.2
  • 5
    • 0031262187 scopus 로고    scopus 로고
    • Effects of different schedules of MPTP administration on dopaminergic neurodegeneration in mice
    • Bezard E., Dovero S., Bioulac B., Gross C. Effects of different schedules of MPTP administration on dopaminergic neurodegeneration in mice. Exp Neurol 1997, 148:288-292.
    • (1997) Exp Neurol , vol.148 , pp. 288-292
    • Bezard, E.1    Dovero, S.2    Bioulac, B.3    Gross, C.4
  • 6
    • 0032977408 scopus 로고    scopus 로고
    • Absence of MPTP-induced neuronal death in mice lacking the dopamine transporter
    • Bezard E., Gross C.E., Fournier M.C., Dovero S., Bloch B., Jaber M. Absence of MPTP-induced neuronal death in mice lacking the dopamine transporter. Exp Neurol 1999, 155:268-273.
    • (1999) Exp Neurol , vol.155 , pp. 268-273
    • Bezard, E.1    Gross, C.E.2    Fournier, M.C.3    Dovero, S.4    Bloch, B.5    Jaber, M.6
  • 7
    • 0034571915 scopus 로고    scopus 로고
    • Spontaneous long-term compensatory dopaminergic sprouting in MPTP-treated mice
    • Bezard E., Dovero S., Imbert C., Boraud T., Gross C.E. Spontaneous long-term compensatory dopaminergic sprouting in MPTP-treated mice. Synapse 2000, 38:363-368.
    • (2000) Synapse , vol.38 , pp. 363-368
    • Bezard, E.1    Dovero, S.2    Imbert, C.3    Boraud, T.4    Gross, C.E.5
  • 8
    • 0019428018 scopus 로고
    • A brainstem atlas of catecholaminergic neurons in man, using melanin as a natural marker
    • Bogerts B. A brainstem atlas of catecholaminergic neurons in man, using melanin as a natural marker. J Comp Neurol 1981, 197:63-80.
    • (1981) J Comp Neurol , vol.197 , pp. 63-80
    • Bogerts, B.1
  • 9
    • 0023225802 scopus 로고
    • Adrenal medulla grafts enhance recovery of striatal dopaminergic fibers
    • Bohn M.C., Cupit L., Marciano F., Gash D.M. Adrenal medulla grafts enhance recovery of striatal dopaminergic fibers. Science 1987, 237:913-916.
    • (1987) Science , vol.237 , pp. 913-916
    • Bohn, M.C.1    Cupit, L.2    Marciano, F.3    Gash, D.M.4
  • 11
    • 33749520640 scopus 로고    scopus 로고
    • The surface oxidation potential of human neuromelanin reveals a spherical architecture with a pheomelanin core and a eumelanin surface
    • Bush W.D., Garguilo J., Zucca F.A., Albertini A., Zecca L., Edwards G.S., Nemanich R.J., Simon J.D. The surface oxidation potential of human neuromelanin reveals a spherical architecture with a pheomelanin core and a eumelanin surface. Proc Natl Acad Sci USA 2006, 103:14785-14789.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 14785-14789
    • Bush, W.D.1    Garguilo, J.2    Zucca, F.A.3    Albertini, A.4    Zecca, L.5    Edwards, G.S.6    Nemanich, R.J.7    Simon, J.D.8
  • 12
    • 0021893797 scopus 로고
    • Potential bioactivation pathways for the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
    • Castagnoli N., Chiba K., Trevor A.J. Potential bioactivation pathways for the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Life Sci 1985, 36:225-230.
    • (1985) Life Sci , vol.36 , pp. 225-230
    • Castagnoli, N.1    Chiba, K.2    Trevor, A.J.3
  • 13
    • 0021276089 scopus 로고
    • Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase
    • Chiba K., Trevor A., Castagnoli N. Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase. Biochem Biophys Res Commun 1984, 120:574-578.
    • (1984) Biochem Biophys Res Commun , vol.120 , pp. 574-578
    • Chiba, K.1    Trevor, A.2    Castagnoli, N.3
  • 14
    • 0021800939 scopus 로고
    • Studies on the molecular mechanism of bioactivation of the selective nigrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
    • Chiba K., Peterson L.A., Castagnoli K.P., Trevor A.J., Castagnoli N. Studies on the molecular mechanism of bioactivation of the selective nigrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Drug Metab Dispos 1985, 13:342-347.
    • (1985) Drug Metab Dispos , vol.13 , pp. 342-347
    • Chiba, K.1    Peterson, L.A.2    Castagnoli, K.P.3    Trevor, A.J.4    Castagnoli, N.5
  • 15
    • 0021165054 scopus 로고
    • Oxy-radical toxicity in catecholamine neurons
    • Cohen G. Oxy-radical toxicity in catecholamine neurons. Neurotoxicology 1984, 5:77-82.
    • (1984) Neurotoxicology , vol.5 , pp. 77-82
    • Cohen, G.1
  • 19
    • 0023137046 scopus 로고
    • Characterization of the binding of N-methyl-4-phenylpyridine, the toxic metabolite of the parkinsonian neurotoxin N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, to neuromelanin
    • D'Amato R.J., Benham D.F., Snyder S.H. Characterization of the binding of N-methyl-4-phenylpyridine, the toxic metabolite of the parkinsonian neurotoxin N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, to neuromelanin. J Neurochem 1987, 48:653-658.
    • (1987) J Neurochem , vol.48 , pp. 653-658
    • D'Amato, R.J.1    Benham, D.F.2    Snyder, S.H.3
  • 20
    • 0023175628 scopus 로고
    • Ro 16-6491: A new reversible and highly selective MAO-B inhibitor protects mice from the dopaminergic neurotoxicity of MPTP
    • Da Prada M., Kettler R., Keller H.H., Bonetti E.P., Imhof R. Ro 16-6491: A new reversible and highly selective MAO-B inhibitor protects mice from the dopaminergic neurotoxicity of MPTP. Adv Neurol 1987, 45:175-178.
    • (1987) Adv Neurol , vol.45 , pp. 175-178
    • Da Prada, M.1    Kettler, R.2    Keller, H.H.3    Bonetti, E.P.4    Imhof, R.5
  • 21
    • 0141741347 scopus 로고    scopus 로고
    • Parkinson's disease: Mechanisms and models
    • Dauer W., Przedborski S. Parkinson's disease: Mechanisms and models. Neuron 2003, 39:889-909.
    • (2003) Neuron , vol.39 , pp. 889-909
    • Dauer, W.1    Przedborski, S.2
  • 22
    • 26444610840 scopus 로고    scopus 로고
    • Parkinsonism
    • Lippincott Williams & Wilkins, New York, L.P. Rowland (Ed.)
    • Fahn S., Przedborski S. Parkinsonism. Merritt's Neurology 2005, 828-846. Lippincott Williams & Wilkins, New York. 11th edn. L.P. Rowland (Ed.).
    • (2005) Merritt's Neurology , pp. 828-846
    • Fahn, S.1    Przedborski, S.2
  • 23
    • 15244339160 scopus 로고    scopus 로고
    • Neuromelanin in human dopamine neurons: Comparison with peripheral melanins and relevance to Parkinson's disease
    • Fedorow H., Tribl F., Halliday G., Gerlach M., Riederer P., Double K.L. Neuromelanin in human dopamine neurons: Comparison with peripheral melanins and relevance to Parkinson's disease. Prog Neurobiol 2005, 75:109-124.
    • (2005) Prog Neurobiol , vol.75 , pp. 109-124
    • Fedorow, H.1    Tribl, F.2    Halliday, G.3    Gerlach, M.4    Riederer, P.5    Double, K.L.6
  • 24
    • 0031005815 scopus 로고    scopus 로고
    • Systemic administration of rotenone produces selective damage in the striatum and globus pallidus, but not in the substantia nigra
    • Ferrante R.J., Schulz J.B., Kowall N.W., Beal M.F. Systemic administration of rotenone produces selective damage in the striatum and globus pallidus, but not in the substantia nigra. Brain Res 1997, 753:157-162.
    • (1997) Brain Res , vol.753 , pp. 157-162
    • Ferrante, R.J.1    Schulz, J.B.2    Kowall, N.W.3    Beal, M.F.4
  • 25
    • 33748323168 scopus 로고    scopus 로고
    • Behavioral phenotypes and pharmacology in genetic mouse models of Parkinsonism
    • Fleming S.M., Chesselet M.F. Behavioral phenotypes and pharmacology in genetic mouse models of Parkinsonism. Behav Pharmacol 2006, 17:383-391.
    • (2006) Behav Pharmacol , vol.17 , pp. 383-391
    • Fleming, S.M.1    Chesselet, M.F.2
  • 27
    • 0021864767 scopus 로고
    • Metabolism of the neurotoxin in MPTP by human liver monoamine oxidase B
    • Fritz R.R., Abell C.W., Patel N.T., Gessner W., Brossi A. Metabolism of the neurotoxin in MPTP by human liver monoamine oxidase B. FEBS Lett 1985, 186:224-228.
    • (1985) FEBS Lett , vol.186 , pp. 224-228
    • Fritz, R.R.1    Abell, C.W.2    Patel, N.T.3    Gessner, W.4    Brossi, A.5
  • 28
    • 0021285158 scopus 로고
    • Depletion of cardiac norepinephrine in rats and mice by 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
    • Fuller R.W., Hahn R.A., Snoddy H.D., Wikel J.H. Depletion of cardiac norepinephrine in rats and mice by 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Biochem Pharmacol 1984, 19:2957-2960.
    • (1984) Biochem Pharmacol , vol.19 , pp. 2957-2960
    • Fuller, R.W.1    Hahn, R.A.2    Snoddy, H.D.3    Wikel, J.H.4
  • 29
    • 33748264554 scopus 로고    scopus 로고
    • Corticosterone-sensitive monoamine transport in the rat dorsomedial hypothalamus: Potential role for organic cation transporter 3 in stress-induced modulation of monoam-inergic neurotransmission
    • Gasser P.J., Lowry C.A., Orchinik M. Corticosterone-sensitive monoamine transport in the rat dorsomedial hypothalamus: Potential role for organic cation transporter 3 in stress-induced modulation of monoam-inergic neurotransmission. J Neurosci 2006, 26:8758-8766.
    • (2006) J Neurosci , vol.26 , pp. 8758-8766
    • Gasser, P.J.1    Lowry, C.A.2    Orchinik, M.3
  • 30
    • 0025864532 scopus 로고
    • Correlation between the neostriatal content of the 1-methyl-4- phenylpyridinium species and dopaminergic neurotoxicity following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration to several strains of mice
    • Giovanni A., Sieber B.A., Heikkila R.E., Sonsalla P.K. Correlation between the neostriatal content of the 1-methyl-4- phenylpyridinium species and dopaminergic neurotoxicity following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration to several strains of mice. J Pharmacol Exp Ther 1991, 257:691-697.
    • (1991) J Pharmacol Exp Ther , vol.257 , pp. 691-697
    • Giovanni, A.1    Sieber, B.A.2    Heikkila, R.E.3    Sonsalla, P.K.4
  • 31
    • 0027972113 scopus 로고
    • Studies on species sensitivity to the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Part 1: Systemic administration
    • Giovanni A., Sieber B.-A., Heikkila R.E., Sonsalla P.K. Studies on species sensitivity to the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Part 1: Systemic administration. J Pharmacol Exp Ther 1994, 270:1000-1007.
    • (1994) J Pharmacol Exp Ther , vol.270 , pp. 1000-1007
    • Giovanni, A.1    Sieber, B.-A.2    Heikkila, R.E.3    Sonsalla, P.K.4
  • 32
    • 0027986482 scopus 로고
    • Studies on species sensitivity to the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Part 2: Central administration of 1-methyl-4-phenylpyridinium
    • Giovanni A., Sonsalla P.K., Heikkila R.E. Studies on species sensitivity to the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Part 2: Central administration of 1-methyl-4-phenylpyridinium. J Pharmacol Exp Ther 1994, 270:1008-1014.
    • (1994) J Pharmacol Exp Ther , vol.270 , pp. 1008-1014
    • Giovanni, A.1    Sonsalla, P.K.2    Heikkila, R.E.3
  • 34
    • 0021672697 scopus 로고
    • MPTP alters central catecholamine neurons in addition to the nigrostriatal system
    • Gupta M., Felten D.L., Gash D.M. MPTP alters central catecholamine neurons in addition to the nigrostriatal system. Brain Res Bull 1984, 13:737-742.
    • (1984) Brain Res Bull , vol.13 , pp. 737-742
    • Gupta, M.1    Felten, D.L.2    Gash, D.M.3
  • 35
    • 0022501692 scopus 로고
    • Aged mice are more sensitive to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment than young adults
    • Gupta M., Gupta B.K., Thomas R., Bruemmer V., Sladek J.R., Felten D.L. Aged mice are more sensitive to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment than young adults. Neurosci Lett 1986, 70:326-331.
    • (1986) Neurosci Lett , vol.70 , pp. 326-331
    • Gupta, M.1    Gupta, B.K.2    Thomas, R.3    Bruemmer, V.4    Sladek, J.R.5    Felten, D.L.6
  • 36
    • 0033562891 scopus 로고    scopus 로고
    • Differential strain susceptibility following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration acts in an autosomal dominant fashion: Quantitative analysis in seven strains of Mus musculus
    • Hamre K., Tharp R., Poon K., Xiong X., Smeyne R.J. Differential strain susceptibility following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration acts in an autosomal dominant fashion: Quantitative analysis in seven strains of Mus musculus. Brain Res 1999, 828:91-103.
    • (1999) Brain Res , vol.828 , pp. 91-103
    • Hamre, K.1    Tharp, R.2    Poon, K.3    Xiong, X.4    Smeyne, R.J.5
  • 37
    • 0021224694 scopus 로고
    • Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by monoamine oxidase inhibitors
    • Heikkila R.E., Manzino L., Cabbat F.S., Duvoisin R.C. Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by monoamine oxidase inhibitors. Nature 1984, 311:467-469.
    • (1984) Nature , vol.311 , pp. 467-469
    • Heikkila, R.E.1    Manzino, L.2    Cabbat, F.S.3    Duvoisin, R.C.4
  • 38
    • 0022363325 scopus 로고
    • Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and several of its analogues on the dopaminergic nigrostriatal pathway in mice
    • Heikkila R.E., Manzino L., Cabbat F.S., Duvoisin R.C. Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and several of its analogues on the dopaminergic nigrostriatal pathway in mice. Neurosci Lett 1985, 58:133-137.
    • (1985) Neurosci Lett , vol.58 , pp. 133-137
    • Heikkila, R.E.1    Manzino, L.2    Cabbat, F.S.3    Duvoisin, R.C.4
  • 39
    • 0022403289 scopus 로고
    • Dopaminergic toxicity of rotenone and the 1-methyl-4- phenylpyridinium ion after their stereotaxic administration to rats: Implication for the mechanism of 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine toxicity
    • Heikkila R.E., Nicklas W.J., Vyas I., Duvoisin R.C. Dopaminergic toxicity of rotenone and the 1-methyl-4- phenylpyridinium ion after their stereotaxic administration to rats: Implication for the mechanism of 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine toxicity. Neurosci Lett 1985, 62:389-394.
    • (1985) Neurosci Lett , vol.62 , pp. 389-394
    • Heikkila, R.E.1    Nicklas, W.J.2    Vyas, I.3    Duvoisin, R.C.4
  • 40
    • 0024381035 scopus 로고
    • Some features of the nigrostriatal dopaminergic neurotoxin 1- methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the mouse
    • Heikkila R.E., Sieber B.A., Manzino L., Sonsalla P.K. Some features of the nigrostriatal dopaminergic neurotoxin 1- methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the mouse. Mol Chemic Neuropathol 1989, 10:171-183.
    • (1989) Mol Chemic Neuropathol , vol.10 , pp. 171-183
    • Heikkila, R.E.1    Sieber, B.A.2    Manzino, L.3    Sonsalla, P.K.4
  • 41
    • 0023740954 scopus 로고
    • Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease
    • Hirsch E., Graybiel A.M., Agid Y.A. Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease. Nature 1988, 334:345-348.
    • (1988) Nature , vol.334 , pp. 345-348
    • Hirsch, E.1    Graybiel, A.M.2    Agid, Y.A.3
  • 42
    • 0023263919 scopus 로고
    • Biochemical pathophysiology of Parkinson's disease
    • Raven Press, M. Yahr, K.J. Bergmann (Eds.)
    • Hornykiewicz, Kish Biochemical pathophysiology of Parkinson's disease. Parkinson's Disease 1987, 19-34. Raven Press. M. Yahr, K.J. Bergmann (Eds.).
    • (1987) Parkinson's Disease , pp. 19-34
    • Hornykiewicz1    Kish2
  • 43
    • 0026543770 scopus 로고
    • The relationships between aging, monoamine oxidase, striatal dopamine and the effects of MPTP in C57BL/6 mice: A critical reassessment
    • Irwin I., Finnegan K.T., DeLanney L.E., Di Monte D., Langston J.W. The relationships between aging, monoamine oxidase, striatal dopamine and the effects of MPTP in C57BL/6 mice: A critical reassessment. Brain Res 1992, 572:224-231.
    • (1992) Brain Res , vol.572 , pp. 224-231
    • Irwin, I.1    Finnegan, K.T.2    DeLanney, L.E.3    Di Monte, D.4    Langston, J.W.5
  • 44
    • 34347259269 scopus 로고    scopus 로고
    • Protocol for the MPTP mouse model of Parkinson's disease
    • Jackson-Lewis V., Przedborski S. Protocol for the MPTP mouse model of Parkinson's disease. Nat Protocols 2007, 2:141-151.
    • (2007) Nat Protocols , vol.2 , pp. 141-151
    • Jackson-Lewis, V.1    Przedborski, S.2
  • 45
    • 0028784523 scopus 로고
    • Time course and morphology of dopaminergic neuronal death caused by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
    • Jackson-Lewis V., Jakowec M., Burke R.E., Przedborski S. Time course and morphology of dopaminergic neuronal death caused by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Neurodegeneration 1995, 4:257-269.
    • (1995) Neurodegeneration , vol.4 , pp. 257-269
    • Jackson-Lewis, V.1    Jakowec, M.2    Burke, R.E.3    Przedborski, S.4
  • 46
    • 0022259396 scopus 로고
    • Age-dependent effects of 1-methyl-4-phenyl-1,2,3,4-tetrahydropyridine (MPTP)
    • Jarvis M.F., Wagner G.C. Age-dependent effects of 1-methyl-4-phenyl-1,2,3,4-tetrahydropyridine (MPTP). Neuropharmacology 1985, 24:581-583.
    • (1985) Neuropharmacology , vol.24 , pp. 581-583
    • Jarvis, M.F.1    Wagner, G.C.2
  • 47
    • 0021680307 scopus 로고
    • + by dopamine neurons explains selectivity of parkinsonism-inducing neurotoxin, MPTP
    • + by dopamine neurons explains selectivity of parkinsonism-inducing neurotoxin, MPTP. Eur J Pharmacol 1984, 106:455-456.
    • (1984) Eur J Pharmacol , vol.106 , pp. 455-456
    • Javitch, J.A.1    Snyder, S.H.2
  • 48
    • 0000340348 scopus 로고
    • Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: Uptake of the metabolite N-methyl-4-phenylpyridinium by dopamine neurons explain selective toxicity
    • Javitch J.A., D'Amato R.J., Strittmatter S.M., Snyder S.H. Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: Uptake of the metabolite N-methyl-4-phenylpyridinium by dopamine neurons explain selective toxicity. Proc Natl Acad Sci USA 1985, 82:2173-2177.
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 2173-2177
    • Javitch, J.A.1    D'Amato, R.J.2    Strittmatter, S.M.3    Snyder, S.H.4
  • 49
    • 0002715641 scopus 로고
    • Relationship of the in vivo metabolism of MPTP to toxicity
    • Academic Press, Orlando, S.P. Markey, N. Castagnoli., A.J. Trevor, I.J. Kopin (Eds.)
    • Johannessen J.N., Chiueh C.C., Herkenham M., Markey C.J. Relationship of the in vivo metabolism of MPTP to toxicity. MPTP: A Neurotoxin Producing a Parkinsonian Syndrome 1986, 173-190. Academic Press, Orlando. S.P. Markey, N. Castagnoli., A.J. Trevor, I.J. Kopin (Eds.).
    • (1986) MPTP: A Neurotoxin Producing a Parkinsonian Syndrome , pp. 173-190
    • Johannessen, J.N.1    Chiueh, C.C.2    Herkenham, M.3    Markey, C.J.4
  • 50
    • 0023852436 scopus 로고
    • Role for monoamine oxidase-A (MAO-A) in the bioactivation and nigrostriatal dopaminergic neurotoxicity of the MPTP analog, 2'Me- MPTP
    • Kindt M.V., Youngster S.K., Sonsalla P.K., Duvoisin R.C., Heikkila R.E. Role for monoamine oxidase-A (MAO-A) in the bioactivation and nigrostriatal dopaminergic neurotoxicity of the MPTP analog, 2'Me- MPTP. Eur J Pharmacol 1988, 146:313-318.
    • (1988) Eur J Pharmacol , vol.146 , pp. 313-318
    • Kindt, M.V.1    Youngster, S.K.2    Sonsalla, P.K.3    Duvoisin, R.C.4    Heikkila, R.E.5
  • 51
    • 0025780967 scopus 로고
    • Distribution of type B monoamine oxidase immunoreactivity in the cat brain with reference to enzyme histochemistry
    • Kitahama K., Denney R.M., Maeda T., Jouvet M. Distribution of type B monoamine oxidase immunoreactivity in the cat brain with reference to enzyme histochemistry. Neuroscience 1991, 44:185-204.
    • (1991) Neuroscience , vol.44 , pp. 185-204
    • Kitahama, K.1    Denney, R.M.2    Maeda, T.3    Jouvet, M.4
  • 52
    • 0037101913 scopus 로고    scopus 로고
    • Organic cation transporter mRNA and function in the rat superior cervical ganglion
    • Kristufek D., Rudorfer W., Pifl C., Huck S. Organic cation transporter mRNA and function in the rat superior cervical ganglion. J Physiol 2002, 543:117-134.
    • (2002) J Physiol , vol.543 , pp. 117-134
    • Kristufek, D.1    Rudorfer, W.2    Pifl, C.3    Huck, S.4
  • 53
    • 0020680904 scopus 로고
    • Chronic parkinsonism in humans due to a product of meperidine-analog synthesis
    • Langston J.W., Ballard P., Irwin I. Chronic parkinsonism in humans due to a product of meperidine-analog synthesis. Science 1983, 219:979-980.
    • (1983) Science , vol.219 , pp. 979-980
    • Langston, J.W.1    Ballard, P.2    Irwin, I.3
  • 54
    • 0032829070 scopus 로고    scopus 로고
    • Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure
    • Langston J.W., Forno L.S., Tetrud J., Reeves A.G., Kaplan J.A., Karluk D. Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure. Ann Neurol 1999, 46:598-605.
    • (1999) Ann Neurol , vol.46 , pp. 598-605
    • Langston, J.W.1    Forno, L.S.2    Tetrud, J.3    Reeves, A.G.4    Kaplan, J.A.5    Karluk, D.6
  • 55
    • 0031456051 scopus 로고    scopus 로고
    • Midbrain injection of recombinant adeno-associated virus encoding rat glial cell line-derived neurotrophic factor protects nigral neurons in a progressive 6-hydroxydopamine-induced degeneration model of Parkinson's disease in rats
    • Mandel R.J., Spratt S.K., Snyder R.O., Leff S.E. Midbrain injection of recombinant adeno-associated virus encoding rat glial cell line-derived neurotrophic factor protects nigral neurons in a progressive 6-hydroxydopamine-induced degeneration model of Parkinson's disease in rats. Proc Natl Acad Sci USA 1997, 94:14083-14088.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 14083-14088
    • Mandel, R.J.1    Spratt, S.K.2    Snyder, R.O.3    Leff, S.E.4
  • 56
    • 0021137683 scopus 로고
    • Intraneuronal generation of a pyridinium metabolite may cause drug-induced parkinsonism
    • Markey S.P., Johannessen J.N., Chiueh C.C., Burns R.S., Herkenham M.A. Intraneuronal generation of a pyridinium metabolite may cause drug-induced parkinsonism. Nature 1984, 311:464-467.
    • (1984) Nature , vol.311 , pp. 464-467
    • Markey, S.P.1    Johannessen, J.N.2    Chiueh, C.C.3    Burns, R.S.4    Herkenham, M.A.5
  • 57
    • 0000902524 scopus 로고
    • Pigmentation in the nucleus substantiae nigrae of mammals
    • Marsden C.D. Pigmentation in the nucleus substantiae nigrae of mammals. J Anat 1961, 95:256-261.
    • (1961) J Anat , vol.95 , pp. 256-261
    • Marsden, C.D.1
  • 58
    • 0037159608 scopus 로고    scopus 로고
    • Lysosomal malfunction accompanies alpha-synuclein aggregation in a progressive mouse model of Parkinson's disease
    • Meredith G.E., Totterdell S., Petroske E., Santa C.K., Callison R.C., Lau Y.S. Lysosomal malfunction accompanies alpha-synuclein aggregation in a progressive mouse model of Parkinson's disease. Brain Res 2002, 956:156-165.
    • (2002) Brain Res , vol.956 , pp. 156-165
    • Meredith, G.E.1    Totterdell, S.2    Petroske, E.3    Santa, C.K.4    Callison, R.C.5    Lau, Y.S.6
  • 59
    • 0031868194 scopus 로고    scopus 로고
    • The impact of gender and estrogen on striatal dopaminergic neurotoxicity
    • Miller D.B., Ali S.F., O'Callaghan J.P., Laws S.C. The impact of gender and estrogen on striatal dopaminergic neurotoxicity. Ann NY Acad Sci 1998, 844:153-165.
    • (1998) Ann NY Acad Sci , vol.844 , pp. 153-165
    • Miller, D.B.1    Ali, S.F.2    O'Callaghan, J.P.3    Laws, S.C.4
  • 60
    • 0031469040 scopus 로고    scopus 로고
    • Divergent expression of regional metabolic topographies in Parkinson's disease and normal ageing
    • Moeller J.R., Eidelberg D. Divergent expression of regional metabolic topographies in Parkinson's disease and normal ageing. Brain 1997, 120:2197-2206.
    • (1997) Brain , vol.120 , pp. 2197-2206
    • Moeller, J.R.1    Eidelberg, D.2
  • 64
    • 0026583465 scopus 로고
    • Transgenic mice with increased Cu/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity
    • Przedborski S., Kostic V., Jackson-Lewis V., Naini A.B., Simonetti S., Fahn S., Carlson E., Epstein C.J., Cadet J.L. Transgenic mice with increased Cu/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity. J Neurosci 1992, 12:1658-1667.
    • (1992) J Neurosci , vol.12 , pp. 1658-1667
    • Przedborski, S.1    Kostic, V.2    Jackson-Lewis, V.3    Naini, A.B.4    Simonetti, S.5    Fahn, S.6    Carlson, E.7    Epstein, C.J.8    Cadet, J.L.9
  • 65
    • 0035091767 scopus 로고    scopus 로고
    • The parkinsonian toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): A technical review of its utility and safety
    • Przedborski S., Jackson-Lewis V., Naini A., Jakowec M., Petzinger G., Miller R., Akram M. The parkinsonian toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): A technical review of its utility and safety. J Neurochem 2001, 76:1265-1274.
    • (2001) J Neurochem , vol.76 , pp. 1265-1274
    • Przedborski, S.1    Jackson-Lewis, V.2    Naini, A.3    Jakowec, M.4    Petzinger, G.5    Miller, R.6    Akram, M.7
  • 66
    • 0024409628 scopus 로고
    • Entry of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine into the rat brain
    • Riachi N.J., LaManna J.C., Harik S.I. Entry of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine into the rat brain. J Pharmacol Exp Ther 1989, 249:744-748.
    • (1989) J Pharmacol Exp Ther , vol.249 , pp. 744-748
    • Riachi, N.J.1    LaManna, J.C.2    Harik, S.I.3
  • 67
    • 0020264291 scopus 로고
    • Correspondence of melanin-pigmented neurons in human brain with A1-A14 catecholamine cell groups
    • Saper C.B., Petito C.K. Correspondence of melanin-pigmented neurons in human brain with A1-A14 catecholamine cell groups. Brain 1982, 105:87-101.
    • (1982) Brain , vol.105 , pp. 87-101
    • Saper, C.B.1    Petito, C.K.2
  • 68
    • 0028220834 scopus 로고
    • Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine: A combined retrograde tracing and immunocytochemical study in the rat
    • Sauer H., Oertel W.H. Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine: A combined retrograde tracing and immunocytochemical study in the rat. Neuroscience 1994, 59:401-415.
    • (1994) Neuroscience , vol.59 , pp. 401-415
    • Sauer, H.1    Oertel, W.H.2
  • 69
    • 0033950543 scopus 로고    scopus 로고
    • Fluoro-Jade: Novel fluorochromes for detecting toxicant-induced neuronal degeneration
    • Schmued L.C., Hopkins K.J. Fluoro-Jade: Novel fluorochromes for detecting toxicant-induced neuronal degeneration. Toxicol Pathol 2000, 28:91-99.
    • (2000) Toxicol Pathol , vol.28 , pp. 91-99
    • Schmued, L.C.1    Hopkins, K.J.2
  • 70
    • 0030901162 scopus 로고    scopus 로고
    • Fluoro-Jade: A novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration
    • Schmued L.C., Albertson C., Slikker W. Fluoro-Jade: A novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration. Brain Res 1997, 751:37-46.
    • (1997) Brain Res , vol.751 , pp. 37-46
    • Schmued, L.C.1    Albertson, C.2    Slikker, W.3
  • 71
    • 0035829368 scopus 로고    scopus 로고
    • Behavioral phenotyping of the MPTP mouse model of Parkinson's disease
    • Sedelis M., Schwarting R.K., Huston J.P. Behavioral phenotyping of the MPTP mouse model of Parkinson's disease. Behav Brain Res 2001, 125:109-125.
    • (2001) Behav Brain Res , vol.125 , pp. 109-125
    • Sedelis, M.1    Schwarting, R.K.2    Huston, J.P.3
  • 72
    • 0025074518 scopus 로고
    • Dose-dependent destruction of the coeruleus-cortical and nigral- striatal projections by MPTP
    • Seniuk N.A., Tatton W.G., Greenwood C.E. Dose-dependent destruction of the coeruleus-cortical and nigral- striatal projections by MPTP. Brain Res 1990, 527:7-20.
    • (1990) Brain Res , vol.527 , pp. 7-20
    • Seniuk, N.A.1    Tatton, W.G.2    Greenwood, C.E.3
  • 73
    • 0344406174 scopus 로고    scopus 로고
    • 1-Methyl-4-phenylpyridinium accumulates in cerebellar granule neurons via organic cation transporter 3
    • Shang T., Uihlein A.V., Van A.J., Kalyanaraman B., Hillard C.J. 1-Methyl-4-phenylpyridinium accumulates in cerebellar granule neurons via organic cation transporter 3. J Neurochem 2003, 85:358-367.
    • (2003) J Neurochem , vol.85 , pp. 358-367
    • Shang, T.1    Uihlein, A.V.2    Van, A.J.3    Kalyanaraman, B.4    Hillard, C.J.5
  • 76
    • 0015803674 scopus 로고
    • Injection of 6-hydroxydopamine in the substantia nigra of the rat. I. Morphological study
    • Sotelo C., Javoy F., Agid Y., Glowinski J. Injection of 6-hydroxydopamine in the substantia nigra of the rat. I. Morphological study. Brain Res 1973, 58:269-290.
    • (1973) Brain Res , vol.58 , pp. 269-290
    • Sotelo, C.1    Javoy, F.2    Agid, Y.3    Glowinski, J.4
  • 77
    • 0034108225 scopus 로고    scopus 로고
    • Inhibition of brain vesicular monoamine transporter (VMAT2) enhances 1-methyl-4-phenylpyridinium neurotoxicity in vivo in rat striata
    • Staal R.G., Sonsalla P.K. Inhibition of brain vesicular monoamine transporter (VMAT2) enhances 1-methyl-4-phenylpyridinium neurotoxicity in vivo in rat striata. J Pharmacol Exp Ther 2000, 293:336-342.
    • (2000) J Pharmacol Exp Ther , vol.293 , pp. 336-342
    • Staal, R.G.1    Sonsalla, P.K.2
  • 79
    • 0036099890 scopus 로고    scopus 로고
    • Significant reduction of 125 I-meta-iodobenzylguanidine accumulation directly caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydroxypyridine, a toxic agent for inducing experimental Parkinson's disease
    • Takatsu H., Wada H., Maekawa N., Takemura M., Saito K., Fujiwara H. Significant reduction of 125 I-meta-iodobenzylguanidine accumulation directly caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydroxypyridine, a toxic agent for inducing experimental Parkinson's disease. Nucl Med Commun 2002, 23:161-166.
    • (2002) Nucl Med Commun , vol.23 , pp. 161-166
    • Takatsu, H.1    Wada, H.2    Maekawa, N.3    Takemura, M.4    Saito, K.5    Fujiwara, H.6
  • 80
    • 0026555866 scopus 로고
    • Interactions between MPTP-induced and age-related neuronal death in a murine model of Parkinson's disease
    • Tatton W.G., Greenwood C.E., Seniuk N.A., Salo P.T. Interactions between MPTP-induced and age-related neuronal death in a murine model of Parkinson's disease. Can J Neurol Sci 1992, 19:124-133.
    • (1992) Can J Neurol Sci , vol.19 , pp. 124-133
    • Tatton, W.G.1    Greenwood, C.E.2    Seniuk, N.A.3    Salo, P.T.4
  • 81
    • 3142523288 scopus 로고    scopus 로고
    • Genetic clues to the pathogenesis of Parkinson's disease
    • Vila M., Przedborski S. Genetic clues to the pathogenesis of Parkinson's disease. Nat Med 2004, 10(Suppl):S58-sS62.
    • (2004) Nat Med , vol.10 , Issue.SUPPL.
    • Vila, M.1    Przedborski, S.2
  • 83
    • 0023942459 scopus 로고
    • Localization of distinct monoamine oxidase B cell populations in human brainstem
    • Westlund K.N., Denney R.M., Rose R.M., Abell C.W. Localization of distinct monoamine oxidase B cell populations in human brainstem. Neuroscience 1988, 25:439-456.
    • (1988) Neuroscience , vol.25 , pp. 439-456
    • Westlund, K.N.1    Denney, R.M.2    Rose, R.M.3    Abell, C.W.4


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