Does the peritumoral stroma of basal cell carcinoma recapitulate the follicular connective tissue sheath? A comparative analysis of nestin expression in basal cell carcinoma, trichoepithelioma, trichoblastoma and the hair follicle

Journal of Cutaneous Pathology

Volumn 38, Issue 7, 2011, Pages 551-559

  Sellheyer, Klaus ^a,b   Krahl, Dieter ^c  

^a LERNER RESEARCH INSTITUTE   (United States)

^b Nelson Dermatopathology Associates   (United States)

^c Institut fur Dermatohistologie   (Germany)

Author keywords

adnexal tumors; basal cell carcinoma; follicular connective tissue sheath; nestin; tumor stroma

Indexed keywords

INTERMEDIATE FILAMENT PROTEIN; NERVE PROTEIN; NESTIN; TUMOR MARKER;

ARTICLE; BASAL CELL CARCINOMA; BIOSYNTHESIS; CONNECTIVE TISSUE; HAIR FOLLICLE; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLISM; PATHOLOGY; SKIN TUMOR; SWEAT GLAND TUMOR; TUMOR MICROENVIRONMENT;

CARCINOMA, BASAL CELL; CONNECTIVE TISSUE; HAIR FOLLICLE; HUMANS; IMMUNOHISTOCHEMISTRY; INTERMEDIATE FILAMENT PROTEINS; NEOPLASMS, ADNEXAL AND SKIN APPENDAGE; NERVE TISSUE PROTEINS; SKIN NEOPLASMS; TUMOR MARKERS, BIOLOGICAL; TUMOR MICROENVIRONMENT;

EID: 79953673721     PISSN: 03036987     EISSN: 16000560     Source Type: Journal    
DOI: 10.1111/j.1600-0560.2011.01686.x     Document Type: Article

References (24)

1. Tlsty TD, Coussens LM., Tumor stroma and regulation of cancer development. Annu Rev Pathol 2006; 1: 119.
2. West RB, van de Rijn M., Experimental approaches to the study of cancer-stroma interactions: recent findings suggest a pivotal role for stroma in carcinogenesis. Lab Invest 2007; 87: 967.
3. Pietras K, Ostman A., Hallmarks of cancer: interactions with the tumor stroma. Exp Cell Res 2010; 316: 1324.
4. Lacina L, Smetana K Jr, Dvoránková B, et al., Stromal fibroblasts from basal cell carcinoma affect phenotype of normal keratinocytes. Br J Dermatol 2007; 156: 819.
5. Hardy MH., The secret life of the hair follicle. Trends Genet 1992; 8: 55.
6. Stenn KS, Paus R., Controls of hair follicle cycling. Physiol Rev 2001; 81: 449.
7. Tobin DJ, Gunin A, Magerl M, Handijski B, Paus R., Plasticity and cytokinetic dynamics of the hair follicle mesenchyme: implications for hair growth control. J Invest Dermatol 2003; 120: 895.
8. McCalmont TH., A call for logic in the classification of adnexal neoplasms. Am J Dermatopathol 1996; 18: 103.
9. Brooke JD, Fitzpatrick JE, Golitz LE., Papillary mesenchymal bodies: a histologic finding useful in differentiating trichoepitheliomas from basal cell carcinomas. J Am Acad Dermatol 1989; 21: 523.
10. Sellheyer K, Krahl D., Basal cell (trichoblastic) carcinoma. Common expression pattern for epithelial cell adhesion molecule links basal cell carcinoma to early follicular embryogenesis, secondary hair germ, and outer root sheath of the vellus hair follicle: a clue to the adnexal nature of basal cell carcinoma? J Am Acad Dermatol 2008; 58: 158.
11. Yang SH, Andl T, Grachtchouk V, et al., Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/beta3-catenin signaling. Nat Genet 2008; 40: 1130.
12. Krahl D, Sellheyer K., Basal cell carcinoma and pilomatrixoma mirror human follicular embryogenesis as reflected by their differential expression patterns of SOX9 and beta-catenin. Br J Dermatol 2010; 162: 1294.
13. Krahl D, Sellheyer K., p75 Neurotrophin receptor differentiates between morphoeic basal cell carcinoma and desmoplastic trichoepithelioma: insights into the histogenesis of adnexal tumours based on embryology and hair follicle biology. Br J Dermatol 2010; 163: 138.
14. Tiede S, Kloepper JE, Ernst N, Poeggeler B, Kruse C, Paus R., Nestin in human skin: exclusive expression in intramesenchymal skin compartments and regulation by leptin. J Invest Dermatol 2009; 129: 2711.
15. Sellheyer K, Krahl D., Spatiotemporal expression pattern of neuroepithelial stem cell marker nestin suggests a role in dermal homeostasis, neovasculogenesis, and tumor stroma development: a study on embryonic and adult human skin. J Am Acad Dermatol 2010; 63: 93.
16. Sellheyer K, Krahl D., Cutaneous mesenchymal stem cells: status of current knowledge, implications for dermatopathology. J Cutan Pathol 2010; 37: 624.
17. Misago N, Mori T, Narisawa Y., Nestin expression in stromal cells of trichoblastoma and basal cell carcinoma. J Eur Acad Dermatol Venereol 2010; 24: 1354.
18. Schulz T, Hartschuh W., The trichofolliculoma undergoes changes corresponding to the regressing normal hair follicle in its cycle. J Cutan Pathol 1998; 25: 341.
19. Ackerman AB, Reddy VB, Soyer HP., Neoplasms with follicular differentiation, 2nd ed. New York: Arbor Scribendi, 2001; 405.
20. Asada M, Schaart FM, de Almeida HL Jr, et al., Solid basal cell epithelioma (BCE) possibly originates from the outer root sheath of the hair follicle. Acta Derm Venereol 1993; 73: 286.
21. Krüger K, Blume-Peytavi U, Orfanos CE., Basal cell carcinoma possibly originates from the outer root sheath and/or the bulge region of the vellus hair follicle. Arch Dermatol Res 1999; 291: 253.
22. Florell SR, Zone JJ, Gerwels JW., Basal cell carcinomas are populated by melanocytes and Langerhans cells. Am J Dermatopathol 2001; 23: 24.
23. Schubert B, Rudolph P., Basal cell carcinoma: a natural milieu for melanocytes? Am J Dermatopathol 2001; 23: 558.
24. Bissell MJ, Radisky D., Putting tumours in context. Nat Rev Cancer 2001; 1: 46.