Genetic analysis of "leucine-rich repeat (LRR) and immunoglobulin (Ig) domain-containing, Nogo receptor-interacting protein-1 (LINGO1)" in two independent Chinese parkinson's disease populations

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Volumn 156, Issue 1, 2011, Pages 99-103

  Wu, Yih Ru ^a   Tan, Eng King ^b,c   Chen, Chiung Mei ^a   Kumar, Prakash M ^b   Lee Chen, Guey Jen ^d   Chen, Sien Tsong ^a  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^b SINGAPORE GENERAL HOSPITAL   (Singapore)

^c DUKE NUS MEDICAL SCHOOL   (Singapore)

^d NATIONAL TAIWAN NORMAL UNIVERSITY   (Taiwan)

Author keywords

Disease association; LINGO1; Parkinson's disease; SNP

Indexed keywords

LEUCINE RICH REPEAT AND IMMUNOGLOBULIN DOMAIN CONTAINING NOGO RECEPTOR INTERACTING PROTEIN 1; PEPTIDES AND PROTEINS; UNCLASSIFIED DRUG; LINGO1 PROTEIN, HUMAN; MEMBRANE PROTEIN; NERVE PROTEIN;

ADULT; AGED; ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC VARIABILITY; GENOTYPING TECHNIQUE; HUMAN; MAJOR CLINICAL STUDY; MALE; ONSET AGE; PARKINSON DISEASE; PRIORITY JOURNAL; SINGAPORE; TAIWAN; ASIAN; DEMOGRAPHY; GENETICS; GENOTYPE; META ANALYSIS (TOPIC); MIDDLE AGED; POPULATION GENETICS; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AGED; AGED, 80 AND OVER; ASIAN CONTINENTAL ANCESTRY GROUP; CASE-CONTROL STUDIES; DEMOGRAPHY; FEMALE; GENE FREQUENCY; GENETICS, POPULATION; GENOTYPE; HUMANS; MALE; MEMBRANE PROTEINS; META-ANALYSIS AS TOPIC; MIDDLE AGED; NERVE TISSUE PROTEINS; PARKINSON DISEASE; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 79953671128     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.31124     Document Type: Article

References (21)

1. Bialecka M, Kurzawski M, Tan EK, Drozdzik M. 2010. Analysis of LINGO1 (rs9652490) polymorphism in sporadic Parkinson's disease in a Polish population, and a meta-analysis. Neurosci Lett 472: 53-55.
2. Carim-Todd L, Escarceller M, Estivill X, Sumoy L. 2003. LRRN6A/LERN1 (leucine-rich repeat neuronal protein 1), a novel gene with enriched expression in limbic system and neocortex. Eur J Neurosci 18: 3167-3182.
3. Clark LN, Park N, Kisselev S, Rios E, Lee JH, Louis ED. 2010. Replication of the LINGO1 gene association with essential tremor in a North American population. Eur J Hum Genet 18: 838-843.
4. Gibb WR, Lees AJ. 1989. The significance of the Lewy body in the diagnosis of idiopathic Parkinson's disease. Neuropathol Appl Neurobiol 15: 27-44.
5. Gupta A, Dawson VL, Dawson TM. 2008. What causes cell death in Parkinson's disease? Ann Neurol 64: S3-S15.
6. Hardy J, Lewis P, Revesz T, Lees A, Paisan-Ruiz C. 2009. The genetics of Parkinson's syndromes: A critical review. Curr Opin Genet Dev 19: 254-265.
7. Haubenberger D, Hotzy C, Pirker W, Katzenschlager R, Brucke T, Zimprich F, Auff E, Zimprich A. 2009. Role of LINGO1 polymorphisms in Parkinson's disease. Mov Disord 24: 2404-2407.
8. Hughes AJ, Daniel SE, Kilford L, Lees AJ. 1992. Accuracy of clinical diagnosis of idiopathic Parkinson's disease: A clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 55: 181-184.
9. Inoue H, Lin L, Lee X, Shao Z, Mendes S, Snodgrass-Belt P, Sweigard H, Engber T, Pepinsky B, Yang L, Beal MF, Mi S, Isacson O. 2007. Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models. Proc Natl Acad Sci USA 104: 14430-14435.
10. Klebe S, Thier S, Lorenz D, Nothnagel M, Schreiber S, Klein C, Hagenah J, Kasten M, Berg D, Srulijes K, Gasser T, Deuschl G, Kuhlenbäumer G. 2010. LINGO1 is not associated with Parkinson's disease in German patients. Am J Med Genet B Neuropsychiatr Genet 153B: 1173-1178.
11. Lin PI, Vance JM, Pericak-Vance MA, Martin ER. 2007. No gene is an island: The flip-flop phenomenon. Am J Hum Genet 80: 531-538.
12. Mi S, Lee X, Shao Z, Thill G, Ji B, Relton J, Levesque M, Allaire N, Perrin S, Sands B, Crowell T, Cate RL, McCoy JM, Pepinsky RB. 2004. LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex. Nat Neurosci 7: 221-228.
13. Satake W, Nakabayashi Y, Mizuta I, Hirota Y, et al. 2009. Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease. Nat Genet 41: 1303-1307.
14. Simón-Sánchez J, Schulte C, Bras JM, Sharma M., et al. 2009. Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nat Genet 41: 1308-1312.
15. Stefansson H, Steinberg S, Petursson H, Gustafsson O, Gudjonsdottir IH, Jonsdottir GA, et al. 2009. Variant in the sequence of the LINGO1 gene confers risk of essential tremor. Nat Genet 41: 277-279.
16. Tan EK, Teo YY, Prakash KM, Li R, Lim HQ, Angeles D, Tan LC, Au WL, Yih Y, Zhao Y. 2009. LINGO1 variant increases risk of familial essential tremor. Neurology 73: 1161-1162.
17. Thier S, Lorenz D, Nothnagel M, Stevanin G, Dürr A, Nebel A, Schreiber S, Kuhlenbäumer G, Deuschl G, Klebe S. 2010. LINGO1 polymorphisms are associated with essential tremor in Europeans. Mov Disord 25: 709-715.
18. Vilariño-Güell C, Ross OA, Wider C, Jasinska-Myga B, Cobb SA, Soto-Ortolaza AI, Kachergus JM, Keeling BH, Dachsel JC, Melrose HL, Behrouz B, Wszolek ZK, Uitti RJ, Aasly JO, Rajput A, Farrer MJ. 2010a. LINGO1 rs9652490 is associated with essential tremor and Parkinson disease. Parkinsonism Relat Disord 16: 109-111.
19. Vilariño-Güell C, Wider C, Ross OA, Jasinska-Myga B, Kachergus J, Cobb SA, Soto-Ortolaza AI, Behrouz B, Heckman MG, Diehl NN, Testa CM, Wszolek ZK, Uitti RJ, Jankovic J, Louis ED, Clark LN, Rajput A, Farrer MJ. 2010b. LINGO1 and LINGO2 variants are associated with essential tremor and Parkinson disease. Neurogenetics 11: 401-408.
20. Webber PJ, West AB. 2009. LRRK2 in Parkinson's disease: Function in cells and neurodegeneration. FEBS J 276: 6436-6444.
21. Zhang Z, Xu X, Zhang Y, Zhou J, Yu Z, He C. 2009. LINGO-1 interacts with WNK1 to regulate nogo-induced inhibition of neurite extension. J Biol Chem 284: 15717-15728.