Proton radiography and fluoroscopy of lung tumors: A Monte Carlo study using patient-specific 4DCT phantoms

Medical Physics

Volumn 38, Issue 4, 2011, Pages 1903-1911

  Han, Bin ^a   Xu, X George ^a   Chen, George T Y ^b  

^a RENSSELAER POLYTECHNIC INSTITUTE   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL ORGANS; IMAGE ENHANCEMENT; IMAGE QUALITY; IMAGE RECONSTRUCTION; PATIENT MONITORING; PHANTOMS; RADIOGRAPHY; SCINTILLATION COUNTERS; TELESCOPES; TUMORS;

ELEMENTAL COMPOSITIONS; IMAGE RECONSTRUCTION ALGORITHM; MEASURED RESIDUALS; MONTE CARLO N PARTICLES; RECONSTRUCTION ALGORITHMS; SCINTILLATOR DETECTOR; SPATIAL DISCRIMINATION; TESTING PARAMETERS;

MONTE CARLO METHODS;

EID: 79953669037     PISSN: 00942405     EISSN: None     Source Type: Journal    
DOI: 10.1118/1.3555039     Document Type: Article

References (38)

1. D. Schulz-Ertner, O. J kel, and W. Schlegel, "Radiation therapy with charged particles," Semin. Radiat. Oncol. 16, 249-259 (2006).
2. D. Weber, R. Mirimanoff, and R. Miralbell, "Proton beam therapy: Clinical indications and summary of the Swiss experience," Bull. Cancer (Paris) 94, 807-815 (2007).
3. J. Castro, D. Char, P. Petti, I. Daftari, J. Quivey, R. Singh, E. Blakely, and T. Phillips, "15 years experience with helium ion radiotherapy for uveal melanoma," Int. J. Radiat. Oncol., Biol., Phys. 39, 989-996 (1997).
4. J. Munzenrider and N. Liebsch, "Proton therapy for tumors of the skull base," Strahlenther. Onkol. 175, 57-63 (1999).
5. W. H. St. Clair, J. A. Adams, M. Bues, B. C. Fullerton, S. La Shell, H. M. Kooy, J. S. Loeffler, and N. J. Tarbell, "Advantage of protons compared to conventional x-ray or IMRT in the treatment of a pediatric patient with medulloblastoma," Int. J. Radiat. Oncol., Biol., Phys. 58, 727-734 (2004).
6. A. Melancon, A. Lee, R. Kudchadker, U. Titt, S. Beddar, X. Zhu, and L. Dong, "SU-HH-BRB-11: Range adaptive proton therapy for prostate cancer," Med. Phys. 37, 3332 (2010).
7. H.-M. Lu, "A potential method for in vivo range verification in proton therapy treatment," Phys. Med. Biol. 53, 1413-1424 (2008).
8. K. Parodi, H. Paganetti, H. Shih, S. Michaud, J. Loeffler, T. DeLaney, N. Liebsch, J. Munzenrider, A. Fischman, and A. Knopf, "Patient study of in vivo verification of beam delivery and range, using positron emission tomography and computed tomography imaging after proton therapy," Int. J. Radiat. Oncol., Biol., Phys. 68, 920-934 (2007).
9. A. Knopf, K. Parodi, T. Bortfeld, H. A. Shih, and H. Paganetti, "Systematic analysis of biological and physical limitations of proton beam range verification with offline PET/CT scans," Phys. Med. Biol. 54, 4477 (2009).
10. R. Wilson, "Radiological use of fast protons," Radiology 47, 487-491 (1946).
11. A. Koehler, "Proton radiography," Science 160, 303-304 (1968).
12. V. W. Steward and A. M. Koehler, "Proton beam radiography in tumor detection," Science 179, 913-914 (1973).
13. S. Kramer, D. Moffett, R. Martin, E. Colton, and V. Steward, "Proton imaging for medical applications," Radiology 135, 485-494 (1980).
14. U. Schneider, "Proton radiography," Z. Med. Phys. 5, 187-194 (1996).
15. L. Johnson, B. Keeney, G. Ross, H. Sadrozinski, A. Seiden, D. Williams, L. Zhang, V. Bashkirov, R. Schulte, and K. Shahnazi, "Initial studies on proton computed tomography using a silicon strip detector telescope," Nucl. Instrum. Methods Phys. Res. A 514, 215-223 (2003).
16. H. Ryu, E. Song, J. Lee, and J. Kim, "Density and spatial resolutions of proton radiography using a range modulation technique," Phys. Med. Biol. 53, 5461-5468 (2008).
17. J. Seco and N. Depauw, "WE-E-201C-04: Development of the first MGH proton range telescope (PRaT) prototype using scintillating fibers," Med. Phys. 37, 3440 (2010).
18. V. Sipala, M. Bruzzi, M. Bucciolini, G. Candiano, and L. Capineri, "A proton imaging device: Design and status of realization," Nucl. Instrum. Methods Phys. Res. A 612, 566-570 (2010).
19. U. Schneider and E. Pedroni, "Proton radiography as a tool for quality control in proton therapy," Med. Phys. 22, 353-363 (1995).
20. P. Pemler, J. Besserer, J. de Boer, M. Dellert, C. Gahn, M. Moosburger, U. Schneider, E. Pedroni, and H. Stuble, "A detector system for proton radiography on the gantry of the Paul-Scherrer-Institute* 1," Nucl. Instrum. Methods Phys. Res. A 432, 483-495 (1999).
21. U. Schneider, M. Dellert, E. Pedroni, P. Pemler, J. Besserer, M. Moosburger, P. Theiler, and B. Kaser-Hotz, "Quantitative proton radiography of an animal patient," Proc. SPIE 5030, 585-592 (2003).
22. U. Schneider, J. Besserer, P. Pemler, M. Dellert, M. Moosburger, E. Pedroni, and B. Kaser-Hotz, "First proton radiography of an animal patient," Med. Phys. 31, 1046-1051 (2004).
23. F. Sauli, Advanced quality assurance: Proton range radiography, http://project-aqua.web.cern.ch/project-aqua/prr.html (last access 2010).
24. M. Mumot, C. Algranati, M. Hartmann, J. M. Schippers, E. Hug, and A. J. Lomax, "Proton range verification using a range probe: Definition of concept and initial analysis," Phys. Med. Biol. 55, 4771-4782 (2010).
25. L. A. Dawson and D. A. Jaffray, "Advances in image-guided radiation therapy," J. Clin. Oncol. 25, 938-946 (2007).
26. D. Pelowitz, MCNPX user's manual, version 2.5. 0 (Los Alamos National Laboratory, 2005).
27. B. Bednarz, G. T. Chen, H. Paganetti, B. Han, A. Ding, and X. G. Xu, "Comparison of particle tracking features in Geant4 and MCNPX codes for applications in mapping of proton range uncertainty," American Nuclear Society (ANS) 2010 Joint Topical Meeting of the Radiation Protection and Shielding Division/Isotopes and Radiation Division/Biology and Medicine Division, 2010 (unpublished).
28. Geant4-Team, "Geant4 - A simulation tool," Nucl. Instrum. Methods Phys. Res. A 506, 250-303 (2003).
29. P. V. Vavilov, "Ionization losses of high-energy heavy particles," Sov. Phys. JETP 5, 749-751 (1957).
30. H. Bertini, "Low-energy intranuclear cascade calculation," Phys. Rev. 131, 1801-1821 (1963).
31. W. Schneider, T. Bortfeld, and W. Schlegel, "Correlation between CT numbers and tissue parameters needed for Monte Carlo simulations of clinical dose distributions," Phys. Med. Biol. 45, 459-478 (2000).
32. F. Sauli, in AQUA: Advance Quality Assurance for Hadron Therapy, IEEE Nuclear Science Symposium and Medical Imaging Conference (Dresden, Germany, 2008), pp. 25.
33. T. Li, Z. Liang, J. V. Singanallur, T. J. Satogata, D. C. Williams, and R. W. Schulte, "Reconstruction for proton computed tomography by tracing proton trajectories: A Monte Carlo study," Med. Phys. 33, 699-706 (2006).
34. D. Wang, T. Rockwell Mackie, and W. A. Tome, "On the use of a proton path probability map for proton computed tomography reconstruction," Med. Phys. 37, 4138-4145 (2010).
35. I. Evseev, M. Klock, S. Paschuk, H. Schelin, J. Setti, R. Lopes, R. Schulte, and D. Williams, "Computerized tomography with high-energy proton beams: Tomographic image reconstruction from computersimulated data," Braz. J. Phys. 34, 804-807 (2004).
36. S. Mori, J. Wolfgang, H.-M. Lu, R. Schneider, N. C. Choi, and G. T. Y. Chen, "Quantification assessment of range fluctuations in charged particle lung irradiation," Int. J. Radiat. Oncol., Biol., Phys. 70, 253-261 (2008).
37. U. Schneider and E. Pedroni, "Multiple Coulomb scattering and spatial resolution in proton radiography," Med. Phys. 21, 1657-1664 (1994).
38. J. Zhang, Y. H. Na, P. F. Caracappa, and X. G. Xu, "RPI-AM and RPI-AF, a pair of mesh-based, size-adjustable adult male and female computational phantoms using ICRP-89 parameters and their calculations for organ doses from monoenergetic photon beams," Phys. Med. Biol. 54, 5885-5908 (2009).