Systematic analysis of biological and physical limitations of proton beam range verification with offline PET/CT scans

Physics in Medicine and Biology

Volumn 54, Issue 14, 2009, Pages 4477-4495

  Knopf, A ^a,b   Parodi, K ^c   Bortfeld, T ^a   Shih, H A ^a   Paganetti, H ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c Heidelberg Ion Beam Therapy Center HIT   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ABSOLUTE VALUES; ACTIVITY DISTRIBUTION; BIOLOGICAL PARAMETER; BONY STRUCTURES; CLINICAL ROUTINE; CLINICAL USE; COREGISTRATION; HEAD AND NECK; HOUNSFIELD UNITS; IRRADIATED TISSUE; MASSACHUSETTS; MONTE CARLO; OFFLINE; ORGAN MOVEMENTS; PATIENT MOTIONS; PET SCANNER; PHYSICAL LIMITATIONS; POSITRON EMISSION TOMOGRAPHY/COMPUTED TOMOGRAPHIES; REPRODUCIBILITIES; SIMULATED DISTRIBUTION; SOFT TISSUE; SPATIAL ACCURACY; SPATIAL DEVIATION; SYSTEMATIC ANALYSIS; TISSUE CLASSIFICATION; TUMOR LOCATION; TUMOR SITE; VERIFICATION METHOD;

POSITRON EMISSION TOMOGRAPHY; PROTON BEAMS; PROTON IRRADIATION; TUMORS;

PROTONS;

ARTICLE; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; HUMAN; MONTE CARLO METHOD; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTON RADIATION; RADIATION DOSE DISTRIBUTION; RADIATION DOSE FRACTIONATION; SENSITIVITY ANALYSIS; TREATMENT PLANNING; TUMOR LOCALIZATION; VALIDATION PROCESS; BIOLOGICAL MODEL; COMPUTER ASSISTED RADIOTHERAPY; COMPUTER SIMULATION; EVALUATION; IMAGE SUBTRACTION; MEGAVOLTAGE RADIOTHERAPY; METHODOLOGY; RADIATION DOSE; RADIOMETRY; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; VALIDATION STUDY;

PROTON;

COMPUTER SIMULATION; MODELS, BIOLOGICAL; POSITRON-EMISSION TOMOGRAPHY; PROTONS; RADIOMETRY; RADIOTHERAPY DOSAGE; RADIOTHERAPY PLANNING, COMPUTER-ASSISTED; RADIOTHERAPY, HIGH-ENERGY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SUBTRACTION TECHNIQUE; TOMOGRAPHY, X-RAY COMPUTED;

EID: 70349582700     PISSN: 00319155     EISSN: 13616560     Source Type: Journal    
DOI: 10.1088/0031-9155/54/14/008     Document Type: Article

References (20)

1. Crespo P, Shakirin G and Enghardt W 2006 On the detector arrangement for in-beam PET for hadron therapy monitoring Phys. Med. Biol. 51 2143-63
2. Enghardt W, Debus J, Haberer T, Hasch B G, Hinz R, Jäkel O, Krämer M, Lauckner K, Pawelke J and Pönisch F 1999 Positron emission tomography for quality assurance of cancer therapy with light ion beams Nucl. Phys A 654 1047-50c
3. Enghardt W, Parodi K, Crespo P, Fiedler F, Pawelke J and Pönisch F 2004 Dose quantification from in-beam positron emission tomography Radiother. Oncol. 73 (Suppl. 2) 96-8
4. Fasso A et al 2003 The physics models of FLUKA: status and recent developments Proc. Computing in High Energy and Nuclear Physics 2003 Conf. (La Jolla) paper MOMT005 eConf C0303241
5. Ferrari A et al 2005 FLUKA: a multi-particle transport code CERN 2005-10; INFN/TC[lowm]05/11; SLAC-R-773
6. Knopf A, Parodi K, Paganetti H, Cascio E, Bonab A and Bortfeld T 2008 Quantitative assessment of the physical-potential of proton beam range verification with PET/CT Phys. Med. Biol. 53 4137-51
7. Knopf A, Zhu X, Parodi K, Paganetti H, Bortfeld T and El Fakhri G 2009 In-room proton range verification using mobile NeuroPET-feasibility study 51st Ann. AAPM Meeting Abstract #10393
8. Mizuno H, Tomitami T and Kanazawa M 2003 Washout measurements of radioisotope implanted by radioactive beams in the rabbit Phys. Med. Biol. 48 2269-81 (Pubitemid 37020977)
9. Paganetti H et al 2004 Accurate Monte Carlo simulations for nozzle design, commissioning and quality assurance in proton radiation therapy Med. Phys. 31 2107-18
10. Parodi K 2004 On the feasibility of dose quantification with in-beam PET data in radiotherapy with 12C and proton beams Wiss.-Tech. Ber. FZR415
11. Parodi K and Bortfeld T 2006 A filtering approach based on Gaussian-powerlaw convolutions for local PET verification of proton radiotherapy Phys. Med. Biol. 51 1991-2009
12. Parodi K, Bortfeld T and Haberer T 2008 Comparison between in-beam and offline positron emission tomography imaging of proton and carbon ion therapeutic irradiation at synchrotron- and cyclotron-based facilities Int. J. Radiat. Oncol. Biol. Phys. 71 945-56
13. +-radioactivity induced by proton beams Phys. Med. Biol. 47 21-36
14. Parodi K et al 2007b Patient study on in-vivo verification of beam delivery and range using PET/CT imaging after proton therapy Int. J. Radiat. Oncol. Biol. Phys. 68 920-34
15. Parodi K, Ferrari A, Sommer F and Paganetti H 2007c Clinical CT-based calculations of dose and positron emitter distributions in proton therapy using the FLUKA Monte Carlo code Phys. Med. Biol. 52 3369-87
16. Parodi K, Paganetti H, Cascio E, Flanz J B, Bonab A, Alpert N M, Lohmann K and Bortfeld T 2007a PET/CT imaging for treatment verification after proton therapy-a study with plastic phantoms and metallic implants Med. Phys. 34 319-435
17. Parodi K, Pönisch F and Enghardt W 2005 Experimental study on the feasibility of in-beam PET for accurate monitoring of proton therapy IEEE Trans. Nucl. Sci. 52 778-86
18. Pönisch F, Parodi K, Hasch B G and Enghardt W 2004 The modeling of positron emitter production and PET imaging during carbon ion therapy Phys. Med. Biol. 49 5217-32
19. PSD 2008 http://www.photodetection.com
20. Schneider W, Bortfeld T and Schlegel W 2000 Correlation between CT numbers and tissue parameters needed for Monte Carlo simulations of clinical dose distributions Phys. Med. Biol. 45 459-78