Integration of genotypic and phenotypic screening reveals molecular mediators of melanoma-stromal interaction

Cancer Research

Volumn 71, Issue 7, 2011, Pages 2433-2444

  Stine, Megan J ^a,b   Wang, C Joanne ^b,c   Moriarty, Whei F ^a,b   Ryu, Byungwoo ^a,d   Cheong, Raymond ^b,c   Westra, William H ^b   Levchenko, Andre ^b,c   Alani, Rhoda M ^a,b,e  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Johns Hopkins University   (United States)

^d NEVADA CANCER INSTITUTE   (United States)

^e BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROPILIN 2;

ARTICLE; CELL COMMUNICATION; CELL DIVISION; CELL GROWTH; CELL INTERACTION; CELL MIGRATION; CELL MOTION; CELL SURFACE; COCULTURE; CONTROLLED STUDY; ENDOTHELIUM CELL; GENOMICS; HUMAN; HUMAN CELL; MELANOMA CELL; MELANOMA STROMAL INTERACTION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; UMBILICAL VEIN ENDOTHELIAL CELL; UPREGULATION;

CELL COMMUNICATION; CELL GROWTH PROCESSES; CELL LINE, TUMOR; COCULTURE TECHNIQUES; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENOTYPE; HUMANS; LIGANDS; MELANOMA; NEUROPILIN-2; PHENOTYPE; STROMAL CELLS; UP-REGULATION;

EID: 79953326943     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-10-1875     Document Type: Article

References (50)

1. Gupta GP, Massague J. Cancer metastasis: building a framework. Cell 2006;127:679-95. (Pubitemid 44781029)
2. Balch CM, Buzaid AC, Soong SJ, Atkins MB, Cascinelli N, Coit DG, et al. Final version of the American Joint Committee on Cancer staging system for cutaneous melanoma. J Clin Oncol 2001;19:3635-48. (Pubitemid 32786276)
3. Fidler IJ. The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Nat Rev Cancer 2003;3:453-8.
4. Nguyen DX, Massague J. Genetic determinants of cancer metastasis. Nat Rev Genet 2007;8:341-52. (Pubitemid 46625811)
5. Liotta LA, Kohn EC. The microenvironment of the tumour-host interface. Nature 2001;411:375-379.
6. Chambers AF, Groom AC, MacDonald IC. Dissemination and growth of cancer cells in metastatic sites. Nat Rev Cancer 2002;2:563-72.
7. Kalluri R, Zeisberg M. Fibroblasts in cancer. Nat Rev Cancer 2006;6:392-401.
8. Shioda T, Munn LL, Fenner MH, Jain RK, Isselbacher KJ. Early events of metastasis in the microcirculation involve changes in gene expression of cancer cells. Tracking mRNA levels of metastasizing cancer cells in the chick embryo chorioallantoic membrane. Am J Pathol 1997;150:2099-112. (Pubitemid 27233081)
9. Anderson AR, Weaver AM, Cummings PT, Quaranta V. Tumor morphology and phenotypic evolution driven by selective pressure from the microenvironment. Cell 2006;127:905-15. (Pubitemid 44792251)
10. Bockhorn M, Jain RK, Munn LL. Active versus passive mechanisms in metastasis: do cancer cells crawl into vessels, or are they pushed? Lancet Oncol 2007;8:444-8. (Pubitemid 46621773)
11. Fecher LA, Cummings SD, Keefe MJ, Alani RM. Toward a molecular classification of melanoma. J Clin Oncol 2007;25:1606-20. (Pubitemid 46733089)
12. Yin Z, Noren D, Wang CJ, Hang R, Levchenko A. Analysis of pairwise cell interactions using an integrated dielectrophoretic-microfluidic system. Mol Syst Biol 2008;4:232.
13. Albrecht DR, Underhill GH, Wassermann TB, Sah RL, Bhatia SN. Probing the role of multicellular organization in three-dimensional microenvironments. Nat Methods 2006;3:369-75.
14. Hui EE, Bhatia SN. Micromechanical control of cell-cell interactions. Proc Natl Acad Sci U S A 2007;104:5722-6. (Pubitemid 47175601)
15. Khetani SR, Bhatia SN. Microscale culture of human liver cells for drug development. Nat Biotechnol 2008;26:120-.
16. Satyamoorthy K, DeJesus E, Linnenbach AJ, Kraj B, Kornreich DL, Rendle S, et al. Melanoma cell lines from different stages of progression and their biological and molecular analyses. Melanoma Res 1997;7Suppl 2:S35-42.
17. Ryu B, Kim DS, Deluca AM, Alani RM. Comprehensive expression profiling of tumor cell lines identifies molecular signatures of melanoma progression. PLoS One 2007;2:e594.
18. Dunlap S, Yu X, Cheng L, Civin CI, Alani RM. High-efficiency stable gene transduction in primary human melanocytes using a lentiviral expression system. J Invest Dermatol 2004;122:549-51. (Pubitemid 38281082)
19. Haga H, Irahara C, Kobayashi R, Nakagaki T, Kawabata K. Collective movement of epithelial cells on a collagen gel substrate. Biophys J 2005;88:2250-6. (Pubitemid 40976231)
20. Asaishi K, Endrich B, Gotz A, Messmer K. Quantitative analysis of microvascular structure and function in the amelanotic melanoma A-Mel-3. Cancer Res 1981;41:1898-1904. (Pubitemid 11114593)
21. Endrich B, Hammersen F, Gotz A, Messmer K. Microcirculatory blood flow, capillary morphology and local oxygen pressure of the hamster amelanotic melanoma A-Mel-3. J Natl Cancer Inst 1982;68:475-85. (Pubitemid 12156687)
22. Clark EA, Golub TR, Lander ES, Hynes RO. Genomic analysis of metastasis reveals an essential role for RhoC. Nature 2000;406:532-5. (Pubitemid 30625739)
23. Ridley A. Molecular switches in metastasis. Nature 2000;406:466-467. (Pubitemid 30625715)
24. Cha HJ, Jeong MJ, Kleinman HK. Role of thymosin beta4 in tumor metastasis and angiogenesis. J Natl Cancer Inst 2003;95:1674-80. (Pubitemid 37509076)
25. Adam F, Zheng S, Joshi N, Kelton DS, Sandhu A, Suehiro Y, et al. Analyses of cellular multimerin 1 receptors: in vitro evidence of binding mediated by alphaIIbbeta3 and alphavbeta3. Thromb Haemost 2005;94:1004-11. (Pubitemid 41645942)
26. Bielenberg DR, Pettaway CA, Takashima S, Klagsbrun M. Neuropilins in neoplasms: expression, regulation, and function. Exp Cell Res 2006;312:584-93. (Pubitemid 43290335)
27. Favier B, Alam A, Barron P, Bonnin J, Laboudie P, Fons P, et al. Neuropilin-2 interacts with VEGFR-2 and VEGFR-3 and promotes human endothelial cell survival and migration. Blood 2006;108:1243-50. (Pubitemid 44232021)
28. Staton CA, Kumar I, Reed MW, Brown NJ. Neuropilins in physiological and pathological angiogenesis. J Pathol 2007;212:237-48. (Pubitemid 47010058)
29. Caunt M, Mak J, Liang WC, Stawicki S, Pan Q, Tong RK, et al. Blocking neuropilin-2 function inhibits tumor cell metastasis. Cancer Cell 2008;13:331-342. (Pubitemid 351446192)
30. Klagsbrun M, Takashima S, Mamluk R. The role of neuropilin in vascular and tumor biology. Adv Exp Med Biol 2002;515:33-48. (Pubitemid 36324180)
31. Bielenberg DR, Hida Y, Shimizu A, Kaipainen A, Kreuter M, Kim CC, et al. Semaphorin 3F, a chemorepulsant for endothelial cells, induces a poorly vascularized, encapsulated, nonmetastatic tumor phenotype. J Clin Invest 2004;114:1260-71. (Pubitemid 40385297)
32. Chen C, Li M, Chai H, Yang H, Fisher WE, Yao Q. Roles of neuropilins in neuronal development, angiogenesis, and cancers. World J Surg 2005;29:271-275. (Pubitemid 40768036)
33. Chabbert-de Ponnat I, Buffard V, Leroy K, Bagot M, Bensussan A, Wolkenstein P, et al. Antiproliferative effect of semaphorin 3F on human melanoma cell lines. J Invest Dermatol 2006;126:2343-5. (Pubitemid 44413185)
34. Ellis LM. The role of neuropilins in cancer. Mol Cancer Ther 2006;5:1099-107. (Pubitemid 43881301)
35. Guttmann-Raviv N, Kessler O, Shraga-Heled N, Lange T, Herzog Y, Neufeld G. The neuropilins and their role in tumorigenesis and tumor progression. Cancer Lett 2006;231:1-11. (Pubitemid 41779447)
36. Bielenberg DR, Klagsbrun M. Targeting endothelial and tumor cells with semaphorins. Cancer Metastasis Rev 2007;26:421-31. (Pubitemid 350115126)
37. Nasarre P, Constantin B, Rouhaud L, Harnois T, Raymond G, Drabkin HA, et al. Semaphorin SEMA3F and VEGF have opposing effects on cell attachment and spreading. Neoplasia 2003;5:83-92. (Pubitemid 36151061)
38. Nasarre P, Kusy S, Constantin B, Castellani V, Drabkin HA, Bagnard D, et al. Semaphorin SEMA3F has a repulsing activity on breast cancer cells and inhibits E-cadherin-mediated cell adhesion. Neoplasia 2005;7:180-9. (Pubitemid 40315995)
39. Mac Gabhann F, Popel AS. Targeting neuropilin-1 to inhibit VEGF signaling in cancer: Comparison of therapeutic approaches. PLoS Comput Biol 2006;2:e180.
40. Graells J, Vinyals A, Figueras A, Llorens A, Moreno A, Marcoval J, et al. Overproduction of VEGF concomitantly expressed with its receptors promotes growth and survival of melanoma cells through MAPK and PI3K signaling. J Invest Dermatol 2004;123:1151-61. (Pubitemid 39586840)
41. Hendrix MJ, Seftor EA, Hess AR, Seftor RE. Vasculogenic mimicry and tumour-cell plasticity: lessons from melanoma. Nat Rev Cancer 2003;3:411-21. (Pubitemid 37328845)
42. Velazquez OC, Herlyn M. The vascular phenotype of melanoma metastasis. Clin Exp Metastasis 2003;20:229-35. (Pubitemid 36513227)
43. Dome B, Hendrix MJ, Paku S, Tovari J, Timar J. Alternative vascularization mechanisms in cancer: Pathology and therapeutic implications. Am J Pathol 2007;170:1-15. (Pubitemid 47339184)
44. Hess AR, Margaryan NV, Seftor EA, Hendrix MJ. Deciphering the signaling events that promote melanoma tumor cell vasculogenic mimicry and their link to embryonic vasculogenesis: role of the Eph receptors. Dev Dyn 2007;236:3283-96. (Pubitemid 350276386)
45. Lacal PM, Failla CM, Pagani E, Odorisio T, Schietroma C, Falcinelli S, et al. Human melanoma cells secrete and respond to placenta growth factor and vascular endothelial growth factor. J Invest Dermatol 2000;115:1000-7. (Pubitemid 32037443)
46. Appleton BA, Wu P, Maloney J, Yin J, Liang WC, Stawicki S, et al. Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding. Embo J 2007;26: 4902-12.
47. Curreli S, Arany Z, Gerardy-Schahn R, Mann D, Stamatos NM. Polysialylated Neuropilin-2 Is Expressed on the Surface of Human Dendritic Cells and Modulates Dendritic Cell-T Lymphocyte Interactions. J Biol Chem 2007;282:30346-56. (Pubitemid 350035196)
48. Carmeliet P, Tessier-Lavigne M. Common mechanisms of nerve and blood vessel wiring. Nature 2005;436:193-200. (Pubitemid 41021263)
49. Suchting S, Bicknell R, Eichmann A. Neuronal clues to vascular guidance. Exp Cell Res 2006;312:668-75. (Pubitemid 43290343)
50. Makita T, Sucov HM, Gariepy CE, Yanagisawa M, Ginty DD. Endothelins are vascular-derived axonal guidance cues for developing sympathetic neurons. Nature 2008;452:759-63. (Pubitemid 351521084)