Preschool-aged children with iron deficiency anemia show altered affect and behavior

Journal of Nutrition

Volumn 137, Issue 3, 2007, Pages 683-689

  Lozoff, Betsy ^a   Corapci, Feyza ^b   Burden, Matthew J ^c   Kaciroti, Niko ^a   Angulo Barroso, Rosa ^a   Sazawal, Sunil ^d,e,f   Black, Maureen ^g  

^a UNIVERSITY OF MICHIGAN   (United States)

^b BOGAZICI UNIVERSITY   (Turkey)

^c WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^e Center for Micronutrient Research   (India)

^f ANNAMALAI UNIVERSITY   (India)

^g UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AFFECT; ARTICLE; BEHAVIOR CHANGE; BLOOD CELL COUNT; CONTROLLED STUDY; FEMALE; HUMAN; IRON DEFICIENCY ANEMIA; MAJOR CLINICAL STUDY; MALE; MATERNAL BEHAVIOR; MEAN CORPUSCULAR VOLUME; MOOD CHANGE; MOOD DISORDER; PLAY; PRESCHOOL CHILD; SOCIAL ADAPTATION; SOCIAL BEHAVIOR;

EID: 33947126504     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.1093/jn/137.3.683     Document Type: Article

References (57)

1. Mason J, Bailes A, Beda-Andourou M, Copeland N, Curtis T, Deitchler M, Foster L, Hensely M, Horjus P. Recent trends in malnutrition in developing regions: vitamin A deficiency, anemia, iodine deficiency, and child underweight. Food Nutr Bull. 2005;26:59-108.
2. UNICEF. Micronutrient initiative. A Global Progress Report. 2004.
3. Grantham-McGregor S, Ani C. A review of studies on the effect of iron deficiency on cognitive development in children. J Nutr. 2001;131:649S-68S.
4. Lozoff B, Georgieff MK. Iron deficiency and brain development. Semin Pediatr Neurol. 2006; in press.
5. Lozoff B, Beard J, Connor J, Felt B, Georgieff M, Schallert T. Long-lasting neural and behavioral effects of iron deficiency in infancy. Nutr Rev. 2006;64:S34-43.
6. Pollitt E, Leibel RL, Greenfield DB. Iron deficiency and cognitive test performance in preschool children. Nutr Behav. 1983;1:137-46.
7. Pollitt E, Saco-Pollitt C, Leibel RL, Viteri FE. Iron deficiency and behavioral development in infants and preschool children. Am J Clin Nutr. 1986;43:555-65.
8. Seshadri S, Gopaldas T. Impact of iron supplementation on cognitive functions in preschool and school-aged children: the Indian experience. Am J Clin Nutr. 1989;50:675-86.
9. Metallinos-Katsaras E, Valassi-Adam E, Dewey KG, Lonnerdal B, Stamoulakatou A, Pollitt E. Effect of iron supplementation on cognition in Greek preschoolers. Eur J Clin Nutr. 2004;58:1532-42.
10. Lozoff B, Black M. Impact of micronutrient deficiencies on behavior and development. In: Pettifor J, Zlotkin SH, eds. Nutrition-micronutrient deficiencies during the weaning period and the first years of life. Basel: Karger; 2003;pp. 119-135.
11. Williams J, Wolff A, Daly A, MacDonald A, Aukett A, Booth IW. Iron supplemented formula milk related to reduction in psychomotor decline in infants for inner city areas: randomised study. BMJ. 1999;318:693-8.
12. Honig AS, Oski FA. A clinical risk index for iron deficient infants. Early Child Dev Care. 1984;16:69-84.
13. Walter T, De Andraca I, Chadud P, Perales CG. Iron deficiency anemia: adverse effects on infant psychomotor development. Pediatrics. 1989;84:7-17.
14. Lozoff B, Klein NK, Nelson EC, McClish DK, Manuel M, Chacon ME. Behavior of infants with iron deficiency anemia. Child Dev. 1998;69:24-36.
15. Lozoff B, Klein NK, Prabucki KM. Iron-deficient anemic infants at play. J Dev Behav Pediatr. 1986;7:152-8.
16. Lozoff B, Wolf AW, Urrutia JJ, Viteri FE. Abnormal behavior and low developmental test scores in iron-deficient anemic infants. J Dev Behav Pediatr. 1985;6:69-75.
17. Lozoff B, Wolf AW, Jimenez E. Iron deficiency anemia and infant development: effects of extended oral iron therapy. J Pediatr. 1996;129:382-9.
18. Lozoff B, De Andraca I, Castillo M, Smith J, Walter T, Pino P. Behavioral and developmental effects of preventing iron-deficiency anemia in healthy full-term infants. Pediatrics. 2003;112:846-54.
19. Feinman S. Social referencing and the social construction of reality in infancy. New York: Plenum Press, 1992.
20. Hornik R, Gunnar MR. A descriptive analysis of infant social referencing. Child Dev. 1988;59:626-34.
21. Klinnert MD. The regulation of infant behavior by maternal facial expression. Infant Behav Dev. 1984;7:447-65.
22. Stenberg G. Effects of maternal inattentiveness on infant social referencing. Infant Child Dev. 2003;12:399-419.
23. Walden TA, Kim G. Infants' social looking toward mothers and strangers. Int J Behav Dev. 2005;29:356-60.
24. Garcia Coll C, Kagan J, Reznick JS. Behavioral inhibition in young children. Child Dev. 1984;55:1005-19.
25. Rubin KH, Hastings PD, Stewart S, Henderson HA, Chen X. The consistency and concomitants of inhibition: some of the children, all of the time. Child Dev. 1997;68:467-83.
26. Kochanska G. Patterns of inhibition to the unfamiliar in children of normal and affectively ill mothers. Child Dev. 1991;62:250-63.
27. Kagan J. Biology and the child. In: Damon W, Eisenberg N, editors. Handbook of child psychology, vol. 3: social, emotional, and personality development. New York: Wiley; 1998;pp. 177-236.
28. Caspi A, Henry B, McGee RO, Moffitt TE, Silva PA. Temperamental origins of child and adolescent behavior problems: from age three to age fifteen. Child Dev. 1995;66:55-68.
29. Rubin KH, Burgess KB, Kennedy AE, Stewart SL. Social withdrawal in childhood. In: Mash EJ, Barkely RA, editors. Child psychopathology. New York: Guilford Press; 2003;pp. 372-408.
30. Schmitz S, Fulker DW, Plomin R, Zahn-Waxler C, Emde R, DeFries JC. Temperament and problem behaviour during early childhood. Int J Behav Dev. 1999;23:333-55.
31. Levitsky DA, Barnes RH. Nutritional and environmental interactions in the behavioral development of the rat: long-term effects. Science. 1972;176:68-71.
32. De Andraca I, Walter T, Castillo M, Pino P, Rivera P, Cobo C. Iron deficiency anemia and its effects upon psychological development at preschool age: a longitudinal study. Nestle Foundation Nutrition Annual Report (1990). Vevey, Switzerland: Nestec Ltd.; 1991:pp. 53-62.
33. Palti H, Pevsner B, Adler B. Does anemia in infancy affect achievement on developmental and intelligence tests? Hum Biol. 1983;55:183-94.
34. Dommergues JP, Archambeaud B, Ducot Y, Gerval Y, Hiard C, Rossignol C, Tchernia G. Iron deficiency and psychomotor development scores: A longitudinal study between ages 10 months and 4 years. Arch Fr Pediatr. 1989;46:487-90.
35. Lozoff B, Jimenez E, Wolf AW. Long-term developmental outcome of infants with iron deficiency. N Engl J Med. 1991;325:687-94.
36. Tamura T, Goldenberg RL, Hou J, Johnston KE, Cliver SP, Ramey SL, Nelson KG. Cord serum ferritin concentrations and mental and psychomotor development of children at five years of age. J Pediatr. 2002;140:165-70.
37. Corapci F, Radan AE, Lozoff B. Iron deficiency in infancy and mother-child interaction at 5 years. J Dev Behav Pediatr. 2006;27:371-8.
38. Sazawal S, Black RE, Menon VP, Dinghra P, Caulfield LE, Dhingra U, Bagati A. Zinc supplementation in infants born small for gestational age reduces mortality: a prospective, randomized, controlled trial. Pediatrics. 2001;108:1280-6.
39. Black MM, Sazawal S, Black RE, Khosla S, Kumar J, Menon V. Cognitive and motor development among small for gestational age infants: Impact of zinc supplementation, birth weight, and caregiving practices. Pediatrics. 2004;113:1297-305.
40. Centers for Disease Control and Prevention. Recommendations to prevent and control iron deficiency in the United States. Morb Mortal Wkly Rep. 1998;47:1-29.
41. Gomber S, Bhawna, Madan N, Lal A, Kela K. Prevalence & etiology of nutritional anaemia among school children of urban slums. Indian J Med Res. 2003;118:167-71.
42. Sarkar A, Marwah D, Dhingra U, Dhingra P, Verma P, Black RE. Prevalence of hemoglobinopathies in North Indian children and its association with anemia. Proceedings of 42nd national conference of Indian academy of pediatrics. Kolkata: 2005. pp. 56.
43. Noldus LPJJ. The observer: a software system for collection and analysis of observational data. Behav Res Methods Instrum Comput. 1991;23:415-29.
44. Thomas A, Chess S. The New York longitudinal study: from infancy to early adult life. In: Plomin R, Dunn J, editors. The study of temperament. Hillsdale, NJ: Erlbaum; 1986. pp. 39-52.
45. Lozoff B, Jimenez E, Hagen J, Mollen E, Wolf AW. Poorer behavioral and developmental outcome more than 10 years after treatment for iron deficiency in infancy. Pediatrics. 2000;105:E51.
46. Beard JL, Connor JR. Iron status and neural functioning. Annu Rev Nutr. 2003;23:41-58.
47. Noble E. D2 dopamine receptor gene in psychiatric and neurologic disorders and its phenotypes. Am J Med Genet. 2003;116B:103-25.
48. Wachs TD. Linking nutrition and temperament. In: Molfese D, Molfese V, editors. Temperament and personality across the life-span. Mahwah, NJ: Lawrence Erlbaum; 2000. pp. 57-84.
49. Schallert T, Petrie BF, Whishaw IQ. Neonatal dopamine depletion: Spared and unspared sensorimotor and attentional disorders and effects of further depletion in adulthood. Psychobiology. 1989;17:386-96.
50. Schallert T, Whishaw IQ. Bilateral cutaneous stimulation of the somatosensory system in hemidecorticate rats. Behav Neurosci. 1984;98:518-40.
51. Beard JL, Felt B, Schallert T, Burhans M, Connor JR, Georgieff MK. Moderate iron deficiency in infancy: biology and behavior in young rats. Behav Brain Res. 2006;170:224-32.
52. Felt BT, Beard JL, Schallert T, Shao J, Aldridge JW, Connor JR, Georgieff, MK, Lozoff B. Persistent neurochemical and behavioral abnormalities in adulthood despite early iron supplementation for perinatal iron deficiency anemia in rats. Behav Brain Res. 2006;171:261-70.
53. Pinero D, Jones B, Beard JL. Variations in dietary iron alter behavior in developing rats. J Nutr. 2001;131:311-8.
54. Wood JJ, McLeod BD, Sigman M, Hwang W, Chu BC. Parenting and childhood anxiety: theory, empirical findings, and future directions. J Child Psychol Psychiatry. 2003;44:134-51.
55. Rapee RM. Potential role of childrearing practices in the development of anxiety and depression. Clin Psychol Rev. 1997;17:47-67.
56. Bowlby J. Attachment and loss, vol. 1. attachment. London: Hogarth, 1982.
57. Ainsworth MD. A consideration of social referencing in the context of attachment theory and research. In: Feinman S, editor. Social referencing and the social construction of reality in infancy. New York: Plenum Press; 1992. pp. 349-70.