메뉴 건너뛰기




Volumn 55, Issue 4, 2011, Pages 644-653

Relative bioavailability of coumarin from cinnamon and cinnamon-containing foods compared to isolated coumarin: A four-way crossover study in human volunteers

Author keywords

Bioavailability; Cinnamon; Coumarin; CYP2A6; Matrix effects

Indexed keywords

7-HYDROXYCOUMARIN; COUMARIN; COUMARIN DERIVATIVE; GLUCURONIDE; UMBELLIFERONE; UMBELLIFERONE DERIVATIVE;

EID: 79953295952     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201000394     Document Type: Article
Times cited : (40)

References (28)
  • 1
    • 0025663358 scopus 로고
    • The pharmacology, metabolism, analysis, and applications of coumarin and coumarin-related compounds
    • Egan, D., O'Kennedy, R., Moran, E., Cox, D. et al., The pharmacology, metabolism, analysis, and applications of coumarin and coumarin-related compounds. Drug Metab. Rev. 1990, 22, 503-529.
    • (1990) Drug Metab. Rev. , vol.22 , pp. 503-529
    • Egan, D.1    O'Kennedy, R.2    Moran, E.3    Cox, D.4
  • 2
    • 0032767738 scopus 로고    scopus 로고
    • Coumarin metabolism, toxicity and carcinogenicity: relevance for human risk assessment
    • Lake, B. G., Coumarin metabolism, toxicity and carcinogenicity: relevance for human risk assessment. Food Chem. Toxicol. 1999, 37, 423-453.
    • (1999) Food Chem. Toxicol. , vol.37 , pp. 423-453
    • Lake, B.G.1
  • 3
    • 15044360544 scopus 로고    scopus 로고
    • Opinion of the scientific panel on food additives, flavourings, processing aids and materials in contacts with food (AFC) on a request from the commission related to coumarin
    • EFSA
    • EFSA, Opinion of the scientific panel on food additives, flavourings, processing aids and materials in contacts with food (AFC) on a request from the commission related to coumarin. EFSA J. 2004, 104, 1-36.
    • (2004) EFSA J. , vol.104 , pp. 1-36
  • 4
    • 79953308177 scopus 로고    scopus 로고
    • BfR, Consumers, who eat a lot of cinnamon, currently have an overly high exposure to coumarin. Health Assessment No. 043/2006
    • BfR, Consumers, who eat a lot of cinnamon, currently have an overly high exposure to coumarin. Health Assessment No. 043/2006, 2006.
    • (2006)
  • 6
    • 80051843972 scopus 로고    scopus 로고
    • Quantification of free coumarin and its liberation from glucosylated precursors by stable isotope dilution assays based on liquid chromatography-tandem mass spectrometric detection
    • Rychlik, M., Quantification of free coumarin and its liberation from glucosylated precursors by stable isotope dilution assays based on liquid chromatography-tandem mass spectrometric detection. J. Agric. Food Chem. 2008, 56, 796-801.
    • (2008) J. Agric. Food Chem. , vol.56 , pp. 796-801
    • Rychlik, M.1
  • 8
    • 78049314259 scopus 로고    scopus 로고
    • Quantification of flavoring constituents in cinnamon: high variation of coumarin in cassia bark from the German retail market and in authentic samples from Indonesia
    • Wöhrlin, F., Fry, H., Abraham, K., Preiss-Weigert, A., Quantification of flavoring constituents in cinnamon: high variation of coumarin in cassia bark from the German retail market and in authentic samples from Indonesia. J. Agric. Food Chem. 2010, 58, 10568-10575.
    • (2010) J. Agric. Food Chem. , vol.58 , pp. 10568-10575
    • Wöhrlin, F.1    Fry, H.2    Abraham, K.3    Preiss-Weigert, A.4
  • 9
    • 84988090440 scopus 로고
    • Solvent-assisted supercritical fluid extraction for the isolation of semivolatile flavor compounds from cinnamons of commerce and their separation by series-coupled column gas chromatography
    • Miller, K. G., Poole, C. F., Chichila, T. M. P., Solvent-assisted supercritical fluid extraction for the isolation of semivolatile flavor compounds from cinnamons of commerce and their separation by series-coupled column gas chromatography. J. High. Resol. Chromatogr. 1995, 18, 461-471.
    • (1995) J. High. Resol. Chromatogr. , vol.18 , pp. 461-471
    • Miller, K.G.1    Poole, C.F.2    Chichila, T.M.P.3
  • 10
    • 35448990188 scopus 로고    scopus 로고
    • Zimt und Cumarin: eine Klarstellung aus wissenschaftlich-behördlicher Sicht
    • Abraham, K., Zimt und Cumarin: eine Klarstellung aus wissenschaftlich-behördlicher Sicht. Dtsch. Lebensmittel-Rundschau 2007, 103, 480-487.
    • (2007) Dtsch. Lebensmittel-Rundschau , vol.103 , pp. 480-487
    • Abraham, K.1
  • 11
    • 79953328643 scopus 로고    scopus 로고
    • SKLM (Senatskommission zur Beurteilung der gesundheitlichen Unbedenklichkeit von Lebensmitteln), natural constituents of foods: assessing the toxicity of substances administered as pure compounds compared to their ingestion as inherent food components. Statement of the DFG-Senate commission on Food Safety.
    • SKLM (Senatskommission zur Beurteilung der gesundheitlichen Unbedenklichkeit von Lebensmitteln), natural constituents of foods: assessing the toxicity of substances administered as pure compounds compared to their ingestion as inherent food components. Statement of the DFG-Senate commission on Food Safety. 2006.
    • (2006)
  • 12
    • 85078393980 scopus 로고    scopus 로고
    • Guidance on safety assessment of botanicals and botanical preparations intended for use as ingredients in food supplements
    • EFSA Scientific Committee..
    • EFSA Scientific Committee. Guidance on safety assessment of botanicals and botanical preparations intended for use as ingredients in food supplements. EFSA J. 2009, 7, 1249.
    • (2009) EFSA J. , vol.7 , pp. 1249
  • 13
    • 0033521964 scopus 로고    scopus 로고
    • Lack of effect of coumarin in women with lymphedema after treatment for breast cancer
    • Loprinzi, C. L., Kugler, J. W., Sloan, J. A., Rooke, T. W. et al., Lack of effect of coumarin in women with lymphedema after treatment for breast cancer. N. Engl. J. Med. 1999, 340, 346-350.
    • (1999) N. Engl. J. Med. , vol.340 , pp. 346-350
    • Loprinzi, C.L.1    Kugler, J.W.2    Sloan, J.A.3    Rooke, T.W.4
  • 15
    • 79953307346 scopus 로고    scopus 로고
    • EMA (European Medicines Agency). Guideline on the investigation of bioequivalence.
    • EMA (European Medicines Agency). Guideline on the investigation of bioequivalence. 2010.
    • (2010)
  • 16
    • 0017608619 scopus 로고
    • Pharmacokinetics of coumarin and its 7-hydroxy-metabolites upon intravenous and peroral administration of coumarin in man
    • Ritschel, W. A., Brady, M. E., Tan, H. S., Hoffmann, K. A. et al., Pharmacokinetics of coumarin and its 7-hydroxy-metabolites upon intravenous and peroral administration of coumarin in man. Eur. J. Clin. Pharmacol. 1977, 12, 457-461.
    • (1977) Eur. J. Clin. Pharmacol. , vol.12 , pp. 457-461
    • Ritschel, W.A.1    Brady, M.E.2    Tan, H.S.3    Hoffmann, K.A.4
  • 19
    • 0026934672 scopus 로고
    • Interindividual variability of coumarin 7-hydroxylation in healthy volunteers
    • Rautio, A., Kraul, H., Kojo, A., Salmela, E., Pelkonen, O., Interindividual variability of coumarin 7-hydroxylation in healthy volunteers. Pharmacogenetics 1992, 2, 227-233.
    • (1992) Pharmacogenetics , vol.2 , pp. 227-233
    • Rautio, A.1    Kraul, H.2    Kojo, A.3    Salmela, E.4    Pelkonen, O.5
  • 20
    • 0028218139 scopus 로고
    • Grapefruit juice inhibits 7-hydroxylation of coumarin in healthy volunteers
    • Merkel, U., Sigusch, H., Hoffmann, A., Grapefruit juice inhibits 7-hydroxylation of coumarin in healthy volunteers. Eur. J. Clin. Pharmacol. 1994, 46, 175-177.
    • (1994) Eur. J. Clin. Pharmacol. , vol.46 , pp. 175-177
    • Merkel, U.1    Sigusch, H.2    Hoffmann, A.3
  • 21
    • 76749141073 scopus 로고    scopus 로고
    • scientific opinion of the panel on food additives, flavourings, processing aids and materials in contact with food on a request from the European Commission on coumarin in flavourings and other food ingredients with flavouring properties
    • EFSA
    • EFSA, scientific opinion of the panel on food additives, flavourings, processing aids and materials in contact with food on a request from the European Commission on coumarin in flavourings and other food ingredients with flavouring properties. EFSA J. 2008, 793, 1-15.
    • (2008) EFSA J. , vol.793 , pp. 1-15
  • 22
    • 0026454446 scopus 로고
    • Rapid and sensitive determination of coumarin and 7-hydroxycoumarin and its glucuronide conjugate in urine and plasma by high-performance liquid chromatography
    • Egan, D. A., O'Kennedy, R., Rapid and sensitive determination of coumarin and 7-hydroxycoumarin and its glucuronide conjugate in urine and plasma by high-performance liquid chromatography. J Chromatogr. 1992, 582, 137-143.
    • (1992) J Chromatogr. , vol.582 , pp. 137-143
    • Egan, D.A.1    O'Kennedy, R.2
  • 23
    • 46749104406 scopus 로고    scopus 로고
    • Bioavailability and bioequivalence: focus on physiological factors and variability
    • Karalis, V., Macheras, P., Van Peer, A., Shah, V. P., Bioavailability and bioequivalence: focus on physiological factors and variability. Pharm. Res. 2008, 25, 1956-1962.
    • (2008) Pharm. Res. , vol.25 , pp. 1956-1962
    • Karalis, V.1    Macheras, P.2    Van Peer, A.3    Shah, V.P.4
  • 24
    • 0030743727 scopus 로고    scopus 로고
    • Percutaneous absorption and metabolism of coumarin in human and rat skin
    • Yourick, J. J., Bronaugh, R. L., Percutaneous absorption and metabolism of coumarin in human and rat skin. J. Appl. Toxicol. 1997, 17, 153-158.
    • (1997) J. Appl. Toxicol. , vol.17 , pp. 153-158
    • Yourick, J.J.1    Bronaugh, R.L.2
  • 25
    • 0029987971 scopus 로고    scopus 로고
    • Coumarin 7-hydroxylation in long-term adherents of a strict uncooked vegan diet
    • Rauma, A. L., Rautio, A., Pasanen, M., Pelkonen, O. et al., Coumarin 7-hydroxylation in long-term adherents of a strict uncooked vegan diet. Eur. J. Clin. Pharmacol. 1996, 50, 133-137.
    • (1996) Eur. J. Clin. Pharmacol. , vol.50 , pp. 133-137
    • Rauma, A.L.1    Rautio, A.2    Pasanen, M.3    Pelkonen, O.4
  • 27
    • 0032126167 scopus 로고    scopus 로고
    • Determination of 2-hydroxyphenylacetic acid (2HPAA) in urine after oral and parenteral administration of coumarin by gas-liquid chromatography with flame-ionization detection
    • Meineke, I., Desel, H., Kahl, R., Kahl, G. F., Gundert-Remy, U., Determination of 2-hydroxyphenylacetic acid (2HPAA) in urine after oral and parenteral administration of coumarin by gas-liquid chromatography with flame-ionization detection. J. Pharm. Biomed. Anal. 1998, 17, 487-492.
    • (1998) J. Pharm. Biomed. Anal. , vol.17 , pp. 487-492
    • Meineke, I.1    Desel, H.2    Kahl, R.3    Kahl, G.F.4    Gundert-Remy, U.5
  • 28
    • 62549115713 scopus 로고    scopus 로고
    • CYP2A6 genotypes and coumarin-oxidation phenotypes in a Thai population and their relationship to tobacco smoking
    • Mahavorasirikul, W., Tassaneeyakul, W., Satarug, S., Reungweerayut, R. et al., CYP2A6 genotypes and coumarin-oxidation phenotypes in a Thai population and their relationship to tobacco smoking. Eur. J. Clin. Pharmacol. 2009, 65, 377-384.
    • (2009) Eur. J. Clin. Pharmacol. , vol.65 , pp. 377-384
    • Mahavorasirikul, W.1    Tassaneeyakul, W.2    Satarug, S.3    Reungweerayut, R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.