High expression of NPY receptors in the human testis

Molecular and Cellular Endocrinology

Volumn 337, Issue 1-2, 2011, Pages 62-70

  Körner, Meike ^a   Waser, Beatriche ^a   Thalmann, George N ^a   Reubii, Jean Claude ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

Human testis; NPY receptor; Receptor autoradiography; Seminoma

Indexed keywords

NEUROPEPTIDE Y1 RECEPTOR; NEUROPEPTIDE Y2 RECEPTOR;

ADULT; AGED; ARTERY; ARTICLE; AUTORADIOGRAPHY; CONTROLLED STUDY; EMBRYONAL CARCINOMA; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LEYDIG CELL; MALE; NERVE FIBER; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEMINOMA; TESTIS; TESTIS TERATOMA; TISSUE DISTRIBUTION; TUNICA ALBUGINEA; YOLK SAC TUMOR;

ADULT; ARGININE; BENZAZEPINES; BINDING, COMPETITIVE; CELLS, CULTURED; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; LEYDIG CELLS; MALE; MIDDLE AGED; RECEPTORS, NEUROPEPTIDE Y; SEMINOMA; TERATOMA; TESTICULAR NEOPLASMS; TESTIS; YOUNG ADULT;

EID: 79953295937     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2011.01.021     Document Type: Article

References (39)

1. Balasubramaniam A. Clinical potentials of neuropeptide Y family of hormones. Am. J. Surg. 2002, 183:430-434.
2. Barreiro M.L., Pineda R., Navarro V.M., Lopez M., Suominen J.S., Señaris R., Toppari J., Aguilar E., Diéguez C., Tena-Sempere M. Orexin 1 receptor messenger ribonucleic acid expression and stimulation of testosterone secretion by orexin-A in rat testis. Endocrinology 2004, 145:2297-2306.
3. Baskin D.G., Wimpy T.H. Calibration of [14C] plastic standards for quantitative autoradiography of [125I] labeled ligands with Amersham Hyperfilm beta-max. Neurosci. Lett. 1989, 104:171-177.
4. Batterham R.L., Cohen M.A., Ellis S.M., Le Roux C.W., Withers D.J., Frost G.S., Ghatei M.A., Bloom S.R. Inhibition of food intake in obese subjects by peptide YY3-36. N. Engl. J. Med. 2003, 349:941-948.
5. Cabrele C., Wieland H.A., Koglin N., Stidsen C., Beck-Sickinger A.G. Ala31-Aib32: identification of the key motif for high affinity and selectivity of neuropeptide Y at the Y5-receptor. Biochemistry 2002, 41:8043-8049.
6. Collin O.E., Aström M., Lissbrant E., Bergh A. Unilateral injection of neuropeptide Y decreases blood flow in the injected testis but may also increase blood flow in the contralateral testis. J. Androl. 1998, 19:580-584.
7. Damber J.E., Lindahl O., Selstam G., Tenland T. Rhythmical oscillations in rat testicular microcirculation as recorded by laser Doppler flowmetry. Acta Physiol. Scand. 1983, 118:117-123.
8. Dumont Y., Jacques D., Bouchard P., Quirion R. Species differences in the expression and distribution of the neuropeptide Y Y1, Y2 Y4, and Y5 receptors in rodents, guinea pig, and primates brains. J. Comp. Neurol. 1998, 402:372-384.
9. Frerker N., Wagner L., Wolf R., Heiser U., Hoffmann T., Rahfeld J.U., Schade J., Karl T., Naim H.Y., Alfalah M., Demuth H.U., von Hörsten S. Neuropeptide Y (NPY) cleaving enzymes: structural and functional homologues of dipeptidyl peptidase 4. Peptides 2007, 28:257-268.
10. Gantz I., Erondu N., Mallick M., Musser B., Krishna R., Tanaka W.K., Snyder K., Stevens C., Stroh M.A., Zhu H., Wagner J.A., Macneil D.J., Heymsfield S.B., Amatruda J.M. Efficacy and safety of intranasal peptide YY3-36 for weight reduction in obese adults. J. Clin. Endocrinol. Metab. 2007, 92:1754-1757.
11. García M.C., López M., Alvarez C.V., Casanueva F., Tena-Sempere M., Diéguez C. Role of ghrelin in reproduction. Reproduction 2007, 133:531-540.
12. Gaytan F., Barreiro M.L., Caminos J.E., Chopin L.K., Herington A.C., Morales C., Pinilla L., Paniagua R., Nistal M., Casanueva F.F., Aguilar E., Diéguez C., Tena-Sempere M. Expression of ghrelin and its functional receptor, the type 1A growth hormone secretagogue receptor, in normal human testis and testicular tumors. J. Clin. Endocrinol. Metab. 2004, 89:400-409.
13. Gong Y.-G., Feng M.-M., Hu X.-N., Wang Y.-Q., Gu M., Zhang W., Ge R.-S. Peptidergic not monoaminergic fibers profusely innervate the young adult human testis. J. Anat. 2009, 214:330-338.
14. Howell S.J., Shalet S.M. Spermatogenesis after cancer treatment: damage and recovery. J. Natl. Cancer Inst. Monogr. 2005, 34:12-17.
15. Ishikawa T., Fujioka H., Ishimura T., Takenaka A., Fujisawa M. Expression of leptin and leptin receptor in the testis of fertile and infertile patients. Andrologia 2007, 39:22-27.
16. Kamiji M.M., Inui A. Neuropeptide y receptor selective ligands in the treatment of obesity. Endocr. Rev. 2007, 28:664-684.
17. Karteris E., Chen J., Randeva H.S. Expression of human prepro-orexin and signaling characteristics of orexin receptors in the male reproductive system. J. Clin. Endocrinol. Metab. 2004, 89:1957-1962.
18. Kempná P., Körner M., Waser B., Hofer G., Nuoffer J.M., Reubi J.C., Flück C.E. Neuropeptide Y modulates steroid production of human adrenal H295R cells through Y1 receptors. Mol. Cell Endocrinol. 2010, 314:101-109.
19. Khan I.U., Beck-Sickinger A.G. Targeted tumor diagnosis and therapy with peptide hormones as radiopharmaceuticals. Anticancer Agents Med. Chem. 2008, 8:186-199.
20. Khan I.U., Zwanziger D., Böhme I., Javed M., Naseer H., Hyder S.W., Beck-Sickinger A.G. Breast-cancer diagnosis by neuropeptide Y analogues: from synthesis to clinical application. Angew. Chem. Int. Ed. Engl. 2010, 49:1155-1158.
21. Kopp J., Collin O., Villar M., Mullins D., Bergh A., Hokfelt T. Regulation of neuropeptide Y Y1 receptors by testosterone in vascular smooth muscle cells in rat testis. Neuroendocrinology 2008, 88:216-226.
22. Kopp J., Zhang X., Hökfelt T. Neuropeptide Y1 receptors in the rat genital tract. Regul. Pept. 1997, 70:149-160.
23. Körner M., Reubi J.C. NPY receptors in human cancer: a review of current knowledge. Peptides 2007, 28:419-425.
24. Körner M., Reubi J.C. NPY receptors in primary human brain tumors: over-expression in high grade tumors. J. Neuropathol. Exp. Neurol. 2008, 67:741-749.
25. Körner M., Waser B., Reubi J.C. High expression of NPY receptors in tumors of the human adrenal gland and extra adrenal paraganglia. Clin. Cancer Res. 2004, 10:8426-8433.
26. Körner M., Waser B., Reubi J.C. Neuropeptide Y receptor expression in human primary ovarian neoplasms. Lab. Invest. 2004, 84:71-80.
27. Körner M., Waser B., Reubi J.C. Neuropeptide Y receptors in renal cell carcinomas and nephroblastomas. Int. J. Cancer 2005, 115:734-741.
28. Körner M., Waser B., Reubi J.C. NPY receptors in human sarcomas: high expression levels of Y1 in Ewing sarcoma family of tumors. Clin. Cancer Res. 2008, 14:5043-5049.
29. Michel M.C., Beck-Sickinger A., Cox H., Doods H.N., Herzog H., Larhammar D., Quirion R., Schwartz T., Westfall T. XVI. International union of pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors. Pharmacol. Rev. 1998, 50:143-150.
30. Miller J.A., Zahniser N.R. The use of 14C-labeled tissue paste standards for the calibration of 125I-labeled ligands in quantitative autoradiography. Neurosci. Lett. 1987, 81:345-350.
31. Pollack S.E., Furth E.E., Kallen C.B., Arakane F., Kiriakidou M., Kozarsky K.F., Strauss J.F Localization of the steroidogenic acute regulatory protein in human tissues. J. Clin. Endocrinol. Metab. 1997, 82:4243-4251.
32. Pralong F.P., Gonzales C., Voirol M.J., Palmiter R.D., Brunner H.R., Gaillard R.C., Seydoux J., Pedrazzini T. The neuropeptide Y Y1 receptor regulates leptin-mediated control of energy homeostasis and reproductive functions. FASEB J. 2002, 16:712-714.
33. Reubi J.C. Peptide receptors as molecular targets for cancer diagnosis and therapy. Endocr. Rev. 2003, 24:389-427.
34. Reubi J.C., Gugger M., Waser B., Schaer J.C. Y1- mediated effect of neuropeptide Y in cancer: breast carcinomas as targets. Cancer Res. 2001, 61:4636-4641.
35. Shaw J.L., Gackenheimer S.L., Gehlert D.R. Functional autoradiography of neuropeptide Y Y1 and Y2 receptor subtypes in rat brain using agonist stimulated [35S]GTPgammaS binding. J. Chem. Neuroanat. 2003, 26:179-193.
36. Sóvágó J., Dupuis D.S., Gulyás B., Hall H. An overview on functional receptor autoradiography using [35S]GTPgammaS. Brain Res. Brain Res. Rev. 2001, 38:149-164.
37. Tainio H. Peptidergic innervation of the human testis and epididymis. Acta Histochem. 1994, 96:415-420.
38. Tena-Sempere M., Manna P.R., Zhang F.P., Pinilla L., González L.C., Diéguez C., Huhtaniemi I., Aguilar E. Molecular mechanisms of leptin action in adult rat testis: potential targets for leptin-induced inhibition of steroidogenesis and pattern of leptin receptor messenger ribonucleic acid expression. J. Endocrinol. 2001, 170:413-423.
39. Zhu H., Zhou Z.M., Lu L., Xu M., Wang H., Li J.M., Sha J.H. Expression of a novel dipeptidyl peptidase 8 (DPP8) transcript variant DPP8-v3, in human testis. Asian J. Androl. 2005, 7:245-255.