Regulation of neuropeptide Y Y1 receptors by testosterone in vascular smooth muscle cells in rat testis

Neuroendocrinology

Volumn 88, Issue 3, 2008, Pages 216-226

  Kopp, Jutta ^a   Collin, Ola ^b   Villar, Marcelo ^c   Mullins, Deborah ^d   Bergh, Anders ^b   Hökfelt, Tomas ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UMEÅ UNIVERSITY   (Sweden)

^c UNIVERSIDAD AUSTRAL   (Argentina)

^d MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Noradrenaline; Pituitary gland; Testosterone; Transmitter coexistence; Vasoconstriction; Vasomotion

Indexed keywords

MESSENGER RNA; NALPHA (DIPHENYLACETYL) N (4 HYDROXYBENZYL) DEXTRO ARGININAMIDE; NEUROPEPTIDE Y1 RECEPTOR; NUCLEAR FACTOR Y; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG MECHANISM; HORMONE SUBSTITUTION; HYPOPHYSECTOMY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN SITU HYBRIDIZATION; MALE; MEAN ARTERIAL PRESSURE; MICROCIRCULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; SMOOTH MUSCLE FIBER; TESTIS; TESTIS BLOOD FLOW; TESTIS WEIGHT; VASCULAR SMOOTH MUSCLE;

EID: 53849128167     PISSN: 00283835     EISSN: None     Source Type: Journal    
DOI: 10.1159/000138250     Document Type: Article

References (92)

1. Tatemoto K: Neuropeptide Y: complete amino acid sequence of the brain peptide. Proc Natl Acad Sci USA 1982;79:5485-5489.
2. Tatemoto K, Carlquist M, Mutt V: Neuropeptide Y - a novel brain peptide with structural similarities for peptide YY and pancreatic polypeptide. Nature 1982;296:659-660.
3. Kimmel JR, Hayden LJ, Pollock HG: Isolation and characterization of a new pancreatic polypeptide hormone. J Biol Chem 1975;250:9369-9376.
4. Tatemoto K: Isolation and characterization of peptide YY (PYY), a candidate gut hormone that inhibits pancreatic exocrine secretion. Proc Natl Acad Sci USA 1982;79:2514-2518.
5. Allen YS, Adrian TE, Allen JM, et al: Neuropeptide Y distribution in the rat brain. Science 1983;221:877-879.
6. Kalra SP, Kalra PS: NPY - an endearing journey in search of a neurochemical on/off switch for appetite, sex and reproduction. Peptides 2004;25:465-471.
7. Sahu A, Kalra PS, Crowley WR, Kalra SP: Functional heterogeneity in neuropeptide-Y-producing cells in the rat brain as revealed by testosterone action. Endocrinology 1990;127:2307-2312.
8. Sahu A, Phelps CP, White JD, Crowley WR, Kalra SP, Kalra PS: Steroidal regulation of hypothalamic neuropeptide Y release and gene expression. Endocrinology 1992;130:3331-3336.
9. Sahu A, Kalra SP, Crowley WR, Kalra PS: Aging in male rats modifies castration and testosterone-induced neuropeptide Y response in various microdissected brain nuclei. Brain Res 1990;515:287-291.
10. Gruaz NM, Pierroz DD, Rohner-Jeanrenaud F, Sizonenko PC, Aubert ML: Evidence that neuropeptide Y could represent a neuroendocrine inhibitor of sexual maturation in unfavorable metabolic conditions in the rat. Endocrinology 1993;133:1891-1894.
11. Pierroz DD, Gruaz NM, d'Alieves V, Aubert ML: Chronic administration of neuropeptide Y into the lateral ventricle starting at 30 days of life delays sexual maturation in the female rat. Neuroendocrinology 1995;61:293-300.
12. Lundberg JM, Terenius L, Hökfelt T, Goldstein M: High levels of neuropeptide Y in peripheral noradrenergic neurons in various mammals including man. Neurosci Lett 1983;42:167-172.
13. Leblanc GG, Trimmer BA, Landis SC: Neuropeptide Y-like immunoreactivity in rat cranial parasympathetic neurons: coexistence with vasoactive intestinal peptide and choline acetyltransferase. Proc Natl Acad Sci USA 1987;84:3511-3515.
14. Keast JR: Patterns of co-existence of peptides and differences of nerve fibre types associated with noradrenergic and non-noradrenergic (putative cholinergic) neurons in the major pelvic ganglion of the male rat. Cell Tissue Res 1991;266:405-415.
15. Lamano Carvalho TL, Hodson NP, Blank MA, et al: Occurrence, distribution and origin of peptide-containing nerves of guineapig and rat male genitalia and the effects of denervation on sperm characteristics. J Anat 1986;149:121-141.
16. Zhu BC, Chiocchio SR, Suburo AM, Tramezzani JH: Monoaminergic and peptidergic contributions of the superior and the inferior spermatic nerves to the innervation of the testis in the rat. J Androl 1995;16:248-258.
17. Kuntz A, Morris RE: Components and distribution of the spermatic nerves and the nerves of the vas deferens. J Comp Neurol 1946;85:33-44.
18. Hodson N: The Nerves of the Testis, Epididymis and Scrotum. New York, Academic Press, 1970.
19. Santamaría L, Reoyo A, Regadera J, Paniagua R: Histochemistry and ultrastructure of nerve fibres and contractile cells in the tunica albuginea of the rat testis. Acta Anat 1990;139:126-133.
20. Allen JM, Yeats JC, Blank MA, et al: Effect of 6-hydroxydopamine on neuropeptides in the rat female genitourinary tract. Peptides 1985;6:1213.
21. Properzi G, Cordeschi G, Francavilla S: Postnatal development and distribution of peptide-containing nerves in the genital system of the male rat. Histochemistry 1992;97:61-68.
22. Setchell BP, Maddocks S, Brooks DE: Anatomy, vasculature, innervation and fluids of the male reproductive tract; in Knobil E, Neill JD (eds): The Physiology of Reproduction, ed 2. New York, Raven Press, 1994, pp 1063-1175.
23. Kopp J, Zhang X, Hökfelt T: Neuropeptide Y1 receptors in the rat genital tract. Regul Pept 1997;70:149-160.
24. Rauchenwald M, Steers WD, Desjardins C: Efferent innervation of the rat testis. Biol Reprod 1995;52:1136-1143.
25. Wang X, Cui Y, Chen Z, Pan O: Expression of neuropeptide Y in rat testes and its significance. Zhonghua Nan Ke Xue 2004;10:334-336, 339.
26. Kanzaki M, Fujisawa M, Okuda Y, Okada H, Arakawa S, Kamidono S: Expression and regulation of neuropeptide Y messenger ribonucleic acid in cultured immature rat Leydig and Sertoli cells. Endocrinology 1996;137:1249-1257.
27. Wahlestedt C, Reis DJ: Neuropeptide Y-related peptides and their receptors - are the receptors potential therapeutic drug targets? Annu Rev Pharmacol Toxicol 1993;32:309-352.
28. Larhammar D: Structural diversity of receptors for neuropeptide Y, peptide YY and pancreatic polypeptide. Regul Pept 1996;65:165-174.
29. Lin S, Boey D, Herzog H: NPY and Y receptors: lessons from transgenic and knockout models. Neuropeptides 2004;38:189-200.
30. Berglund MM, Hipskind PA, Gehlert DR: Recent developments in our understanding of the physiological role of PP-fold peptide receptor subtypes. Exp Biol Med (Maywood) 2003;228:217-244.
31. Pedrazzini T: Importance of NPY Y1 receptor-mediated pathways: assessment using NPY Y1 receptor knockouts. Neuropeptides 2004;38:267-275.
32. Michel MC, Beck-Sickinger A, Cox H, et al: XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors. Pharmacol Rev 1998;50:143-150.
33. Kopp J, Xu ZQ, Zhang X, et al: Expression of the neuropeptide Y Y1 receptor in the CNS of rat and of wild-type and Y1 receptor knock-out mice. Focus on immunohistochemical localization. Neuroscience 2002;111:443-532.
34. Gonzales C, Voirol MJ, Giacomini M, Gaillard RC, Pedrazzini T, Pralong FP: The neuropeptide Y Y1 receptor mediates NPY-induced inhibition of the gonadotrope axis under poor metabolic conditions. FASEB J 2004;18:137-139.
35. Pralong FP, Voirol M, Giacomini M, Gaillard RC, Grouzmann E: Acceleration of pubertal development following central blockade of the Y1 subtype of neuropeptide Y receptors. Regul Pept 2000;95:47-52.
36. Matsuda H, Brumovsky PR, Kopp J, Pedrazzini T, Hökfelt T: Distribution of neuropeptide Y Y1 receptors in rodent peripheral tissues. J Comp Neurol 2002;449:390-404.
37. Lundberg JM, Tatemoto K: Pancreatic polypeptide family (APP, BPP, NPY and PYY) in relation to alpha-adrenoceptor-resistant sympathetic vasoconstriction. Acta Physiol Scand 1982;116:393-402.
38. Westfall TC, Carpentier S, Chen X, Beinfeld MC, Naes L, Meldrum M: Prejunctional and postjunctional effects of neuropeptide Y at the noradrenergic neuroeffector junction of the perfused mesenteric arterial bed of the rat. J Cardiovasc Pharmacol 1987;10:716-722.
39. Wahlestedt C, Yanaihara N, Håkanson R: Evidence for different pre- and post-junctional receptors for neuropeptide Y and related peptides. Regul Pept 1986;13:307-318.
40. Ekblad E, Edvinsson L, Wahlestedt C, Uddman R, Håkanson R, Sundler F: Neuropeptide Y co-exists and co-operates with noradrenaline in perivascular nerve fibres. Regul Pept 1984;8:225-235.
41. Pernow J, Saria A, Lundberg JM: Mechanisms underlying pre- and postjunctional effects of neuropeptide Y in sympathetic vascular control. Acta Physiol Scand 1986;126:239-249.
42. Westfall TC, Yang CL, Curfman-Falvey M: Neuropeptide-Y-ATP interactions at the vascular sympathetic neuroeffector junction. J Cardiovasc Pharmacol 1995;26:682-687.
43. Jørgensen JC: Neuropeptide Y in mammalian genital tract: localization and biological action. Danish Med Bull 1994;41:294-305.
44. Heath M: Neuropeptide Y and Y1-receptor agonists increase blood flow through arteriovenous anastomoses in rat tail. Appl Physiol 1998;85:301-309.
45. Nilsson T, Lind H, Brunkvall J, Edvinsson L: Vasodilation in human subcutaneous arteries induced by neuropeptide Y is mediated by neuropeptide Y Y1 receptors and is nitric oxide dependent. Can J Physiol Pharmacol 2000;78:251-255.
46. Stjärne L, Lundberg JM, Åstrand P: Neuropeptide Y - a co-transmitter with noradrenaline and adenosine-5′-triphosphate in the sympathetic nerves of the mouse vas deferens? A biochemical, physical and electropharmacological study. Neuroscience 1986;18:151-166.
47. Collin O, Enfält E, Åström M, Lissbrandt E, Berg A: Unilateral injection of neuropeptide Y decreases blood flow in the injected testis but may also increase blood flow in the contralateral testis. J Androl 1998;19:580-584.
48. Villar MJ, Meister B, Hökfelt T: Reorganization of neural peptidergic systems in the median eminence after hypophysectomy. J Neurosci 1994;10:5996-6012.
49. Dagerlind Å, Friberg K, Bean AJ, Hökfelt T: Sensitive mRNA detection using unfixed tissue: combined radioactive and non-radioactive in situ hybridization histochemistry. Histochemistry 1992;98:39-49.
50. Eva C, Keinänen K, Monyer H, Seeburg P, Sprengel R: Molecular cloning of a novel G protein-coupled receptor that may belong to the neuropeptide receptor family. FEBS Lett 1990;271:81-84.
51. Zamboni L, De Martino C: Buffered picric acid formaldehyde: a new rapid fixative for electron microscopy. J Cell Biol 1967;148A:35.
52. Coons AH: Fluorescent Antibody Methods. New York, Academic Press, 1958.
53. Hartman B, Zide D, Udenfriend S: The use of dopamine β-hydroxylase as a marker for the noradrenergic pathways of the central nervous system in the rat. Proc Natl Acad Sci USA 1972;69:2722-2726.
54. Johnson DG, Nogueria Araujo GM: A simple method of reducing the fading of immunofluorescence during microscopy. J Immunol Methods 1981;43:349-350.
55. Platt JL, Michael AF: Retardation of fading and enhancement of intensity of immunofluorescence by p-phenylenediamine. J Histochem Cytochem 1983;31:840-842.
56. Damber J-E, Bergh A, Fagrell G, Lindahl O, Rooth P: Testicular microcirculation in the rat studied by videophotometric capillaroscopy, fluorescence microscopy and laser Doppler flowmetry. Acta Physiol Scand 1986;126:371-376.
57. Damber JE, Lindahl O, Selstam G, Tenland T: Testicular blood flow measured with a laser Doppler flowmeter: acute effects of catecholamines. Acta Physiol Scand 1982;115:209-215.
58. Damber JE, Lindahl O, Selstam G, Tenland T: Rhythmical oscillations in rat testicular microcirculation as recorded by laser Doppler flowmetry. Acta Physiol Scand 1983;118:117-123.
59. Widmark A: Testicular Microcirculation. An Experimental Study in the Rat. Umeå, Umeå University, 1987.
60. Intaglietta M: Vasomotor activity, time-dependent fluid exchange and tissue pressure. Microvasc Res 1981;21:153-164.
61. Pedrazzini T, Seydoux J: Neuropeptide Y Y1 receptor-deficient mice. Generation and characterization. Methods Mol Biol 2000;153:91-100.
62. Kopp J, Xu Z-Q, Zhang X, et al: Expression of the NPY Y1 receptor in the central nervous system of rat and of wild type and Y1 receptor knock-out mouse with focus on immunohistochemical localization. Neuroscience 2002;111:443-532.
63. Sharpe RM, Maddocks S, Kerr JB: Cell-cell interactions in the control of spermatogenesis as studied using Leydig cell destruction and testosterone replacement. Am J Anat 1990;188:3-20.
64. Collin O, Bergh A, Damber J-E, Widmark A: Control of testicular vasomotion by testosterone and tubular factors in rats. J Reprod Fertil 1993;97:115-121.
65. Sharpe RM, Donachie K, Cooper I: Re-evaluation of the intratesticular level of testosterone required for quantitative maintenance of spermatogenesis in the rat. J Endocrinol 1988;117:19-26.
66. Bergh A, Damber J-E: Immunohistochemical demonstration of androgen receptors on testicular blood vessels. Int J Androl 1992;15:425-434.
67. Vornberger W, Prins G, Musto NA, Suarez-Quian CA: Androgen receptor distribution in rat testis: new implications for androgen regulation of spermatogenesis. Endocrinology 1994;134:2307-2316.
68. Watkins TW, Keast JR: Androgen-sensitive preganglionic neurons innervate the male rat pelvic ganglion. Neuroscience 1999;93:1147-1157.
69. Melvin JE, Hamill RW: Hypogastric ganglion perinatal development: evidence for androgen specificity via androgen receptors. Brain Res 1989;485:11-19.
70. Keast JR, Saunders RJ: Testosterone has potent, selective effects on the morphology of pelvic autonomic neurons which control the bladder, lower bowel and internal reproductive organs of the male rat. Neuroscience 1998;85:543-556.
71. Hamill RW, Schroeder B: Hormonal regulation of adult sympathetic neurons: The effects of castration on neuropeptide Y, norepinephrine, and tyrosine hydroxylase activity. J Neurobiol 1990;21:731-742.
72. Terado M, Nomura M, Mineta K, Fujimoto N, Matsumoto T: Expression of Neuropeptide Y gene in mouse testes during testicular development. Asian J Androl 2006;8:443-449.
73. Honeyman TW, Goodman HM, Fray JC: The effects of growth hormone on blood pressure and renin secretion in hypophysectomized rats. Endocrinology 1983;112:1613-1617.
74. Boccabella AV: Reinitiation and restoration of spermatogenesis with testosterone propionate and other hormones after a long-term post-hypophysectomy regression period. Endocrinology 1963;72:787-798.
75. Setchell B: Local control of testicular fluids. Reprod Fertil Dev 1990;2:291-309.
76. Damber J-E, Bergh A: Testicular microcirculation - a forgotten essential in andrology. Int J Androl 1992;15:285-292.
77. Bergh A, Damber J-E: Vascular controls in testicular physiology; in de Kretser DM (ed): Molecular Biology of the Male Reproductive system. San Diego, Academic Press, 1993, pp 439-468.
78. Sharpe RM: Local control of testicular function. Q J Exp Physiol 1983;68:265-287.
79. Sharpe RM, Bartlett JMS: Stimulation of Leydig cell function by a polypeptide present in testicular interstitial fluid. Med Biol 1986;63:245-250.
80. Damber J-E, Bergh A, Widmark A: Age-related differences in testicular microcirculation. Int J Androl 1990;13:197-206.
81. Lundell I, Statnick MA, Johnson D, et al: The cloned rat pancreatic polypeptide receptor exhibits profound differences to the orthologous receptor. Proc Natl Acad Sci USA 1996;93:5111-5115.
82. Donoso MV, Delpiano AM, Huidobro-Toro JP: Modulator role of neuropeptide Y in human vascular sympathetic neuroeffector junctions. EXS 2006;95:65-76.
83. Pons J, Lee EW, Li L, Kitlinska J, Neuropeptide Y: multiple receptors and multiple roles in cardiovascular diseases. Curr Opin Investig Drugs 2004;5:957-962.
84. Hu Y, Bloomquist BT, Cornfield LJ, et al: Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior. J Biol Chem 1996;271:26315-26319.
85. Nakamura M, Yokoyama M, Watanabe H, Matsumoto T: Molecular cloning, organization and localization of the gene for the mouse neuropeptide Y-Y5 receptor. Biochim Biophys Acta 1997;1328:83-89.
86. Rudolf K, Eberlein W, Engel W, et al: The first highly potent and selective non-peptide neuropeptide Y Y1 receptor antagonist: BIBP3226. Eur J Pharmacol 1994;271:R11-R13.
87. Wieland HA, Willim KD, Entzeroth M, et al: Subtype selectivity and antagonistic profile of the nonpeptide Y1 receptor antagonist BIBP 3226. J Pharmacol Exp Ther 1995;275:143-149.
88. Doods HN, Wienen W, Entzeroth M, et al: Pharmacological characterization of the selective nonpeptide neuropeptide Y Y1 receptor antagonist BIBP 3226. J Pharmacol Exp Ther 1995;275:136-142.
89. 34]Neuropeptide Y: a specific Y1 receptor agonist. Proc Natl Acad Sci USA 1990;87:182-186.
90. Mullins D, Kirby D, Hwa J, Guzzi M, Rivier J, Parker E: Identification of potent and selective neuropeptide Y Y(1) receptor agonists with orexigenic activity in vivo. Mol Pharmacol 2001;60:534-540.
91. Sainsbury A, Schwarzer C, Couzens M, et al: Y4 receptor knockout rescues fertility in ob/ob mice. Genes Dev 2002;16:1077-1088.
92. Zhang X, Shi T, Holmberg K, et al: Expression and regulation of the neuropeptide Y Y2 receptor in sensory and autonomic ganglia. Proc Natl Acad Sci USA 1997;94:729-734.