Meta-analysis of the related nutritional supplements dimethyl sulfoxide and methylsulfonylmethane in the treatment of osteoarthritis of the knee

Evidence-based Complementary and Alternative Medicine

Volumn 2011, Issue , 2011, Pages

  Brien, Sarah ^a   Prescott, Phil ^a   Lewith, George ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DIMETHYL SULFONE; DIMETHYL SULFOXIDE; PLACEBO;

ARTICLE; DRUG EFFICACY; HUMAN; KNEE OSTEOARTHRITIS; KNEE PAIN; META ANALYSIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); SYSTEMATIC REVIEW; VISUAL ANALOG SCALE;

EID: 79953287776     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1093/ecam/nep045     Document Type: Article

References (67)

1. Sangha O., Epidemiology of rheumatic diseases Rheumatology 2000 39 supplement 2 3 12 (Pubitemid 32186215)
2. Jordan K. M., Arden N. K., Doherty M., EULAR recommendations 2003: an evidence based approach to the management of knee osteoarthritis: report of a Task Force of the Standing Committee for International Clinical Studies including Therapeutic Trials (ESCISIT) Annals of the Rheumatic Diseases 2003 62 1145 1155 (Pubitemid 37500619)
3. Felson D. T., Lawrence R. C., Hochberg M. C., McAlindon T., Dieppe P. A., Minor M. A., Blair S. N., Berman B. M., Fries J. F., Weinberger M., Lorig K. R., Jacobs J. J., Goldberg V., Osteoarthritis: new insightspart 2: treatment approaches Annals of Internal Medicine 2000 133 9 726 737
4. Moskowitz R. W., Abramson S. B., Berenbaum F., Coxibs and NSAIDsclearing the air Osteoarthritis and Cartilage 2005 13 7 545 547
5. Bjordal J. M., Ljunggren A. E., Klovning A., Slordal L., Non-steroidal anti-inflammatory drugs, including cyclo-oxygenase-2 inhibitors, in osteoarthritis knee: meta-analysis of randomised placebo controlled trials British Medical Journal 2000 329 1317 1322
6. Arellano F. M., The withdrawal of rofecoxib Pharmacoepidemiology and Drug Safety 2005 14 3 213 217 (Pubitemid 40360776)
7. Eisenberg D. M., Davis R. B., Ettner S. L., Appel S., Wilkey S., Van Rompay M., Kessler R. C., Trends in alternative medicine use in the United States, 19901997: results of a follow-up national survey Journal of the American Medical Association 1998 280 18 1569 1575 (Pubitemid 28520643)
8. Rao J. K., Mihaliak K., Kroenke K., Bradley J., Tierney W. M., Weinberger M., Use of complementary therapies for arthritis among patients of rheumatologists Annals of Internal Medicine 1999 131 6 409 416 (Pubitemid 29444430)
9. Herman C. J., Allen P., Hunt W. C., Prasad A., Brady T. J., Use of complementary therapies amoung primary care clinic patients with arthritis Preventing Chronic Disease 2004 1 1 15
10. Deal C. L., Moskowittz R. W., Neutriceuticals as therapeutic agents in osteoarthritis. The role of glucosamine, chondrotin sulphate and collagen hydrolysate Rheumatic Disease Clinics of North America 1999 25 379 395 (Pubitemid 29267890)
11. Bertken R., Crystalline DMSO: DMSO2 Arthritis and Rheumatism 1983 26 5 693 694
12. Kolb K. H., Janicke G., Kramer M., Schulze P. E., Adsorption, distribution and elimination of labeled DMSO in man and animal Annals of the New York Academy of Sciences 1967 141 85 95
13. Ameye L. G., Chee W. S. S., Osteoarthritis and nutrition. From nutraceuticals to functional foods: a systematic review of the scientific evidence Arthritis Research and Therapy 2006 8 4, article R127
14. Methylsulfonylmethane (MSM). Monograph Alternative Medicine Review 2003 8 438 441
15. Cronin J. R., Ballen K., The biochemistry of alternative therapies: methylsulfonylmethane: nutraceutical of the next century? Alternative and Complementary Therapies 1999 5 6 386 389 (Pubitemid 30004305)
16. Demos C. H., Beckloff G. L., Donin M. N., Oliver P. M., Dimethyl sulfoxide in musculoskeletal disorders Annals of the New York Academy of Sciences 1967 141 1 517 523
17. Jimenez R. A. H., Willkens R. F., Dimethyl sulfoxide: a perspective of its use in rheumatic diseases Journal of Laboratory and Clinical Medicine 1982 100 4 489 500 (Pubitemid 12003118)
18. Trice J. M., Pinals R. S., Dimethyl sulfoxide: a review of its use in the rheumatic disorders Seminars in Arthritis and Rheumatism 1985 15 1 45 60 (Pubitemid 15245459)
19. Rosenstein E. D., Topical agents in the treatment of rheumatic disorders Rheumatic Disease Clinics of North America 1999 25 4 899 918 (Pubitemid 29526288)
20. Ely A., Lockwood B., What is the evidence for the safety and efficacy of dimethyl sulfoxide and methylsulfonylmethane in pain relief? Pharmaceutical Journal 2002 269 7223 685 687 (Pubitemid 35364071)
21. Brien S., Prescott P., Bashir N., Lewith H., Lewith G., Systematic review of the nutritional supplements dimethyl sulfoxide (DMSO) and methylsulfonylmethane (MSM) in the treatment of osteoarthritis Osteoarthritis and Cartilage 2008 16 11 1277 1288
22. Evans M. S., Reid K. H., Sharp J. B., Dimethyl sulphoxide blocks conduction in peripheral nerve C fibres: a possible mode of action Neuroscience Letters 1993 150 145 148 (Pubitemid 23153673)
23. Muir M., DMSO: many uses, much controversy Alternative and Complementary Therapies 1996 2 230 235
24. Jacob S. W., Herschler R., Dimethyl sulfoxide after twenty years Annals of the New York Academy of Sciences 1983 411 14 18
25. Beilke M. A., Collins-Lech C., Sohnle P. G., Effects of dimethyl sulphoxide on the oxidative function of human neutraphils Journal of Laboratory and Clinical Medicine 1987 110 91 96 (Pubitemid 17103990)
26. Paulus H. E., FDA Arthritis Advisory Committee meeting: methotrexate; guidelines for the clinical evaluation of antiinflammatory drugs; DMSO in scleroderma Arthritis and Rheumatism 1986 29 10 1289 1290 (Pubitemid 16005522)
27. Muravev I., Venikova M., Pleslovskaia G. N., Riazantseva T. A., Sigidin I. A., Effect of dimethylsulphoxide and dimethyl sulfone on a destructive process in the joints of mice with spontaneous arthritis Patologicheskaia Fiziologiia I Eksperimentalnaia Terapiia 1991 2 37 39
28. Brayton C. F., Dimethyl sulfoxide (DMSO): a review The Cornell Veterinarian 1986 76 1 61 90
29. Ebisuzaki K., Asprin and methylsulphonylmethane (MSM): a search for common mechanisms, with implictions for cancer prevention Anticancer Research 2003 23 453 458 (Pubitemid 36358551)
30. Alam S. S., Layman D. L., Dimethyl sulphoxide inhibition of prostacylin production in culture aortic endothelial cells Annals of the New York Academy of Sciences 1983 411 318 320 (Pubitemid 13072703)
31. Fox R. B., Fox W. K., Dimethyl sulphoxide prevents hydroxyl radical mediated depolymerisation of hyaluronic acid Annals of the New York Academy of Sciences 1983 411 13 17
32. Morton J., Moore R., Lupus nephritis and deaths are diminished in B/W mice drinking 3 water solution of dimethyl sulphoxide or dimethyl sulfone Journal of Leukocyte Biology 1986 40 322
33. Hasegawa T., Ueno S., Kumamoto S., Yoshikai Y., Suppressive effect of methylsulfonylmethane (MSM) on type II collagen-induced arthritis in DBA/1J mice Japanese Pharmacology and Therapeutics 2004 32 7 421 427 (Pubitemid 39100131)
34. Rizzo R., Grandolfo M., Godeas C., Jones K. W., Vittur F., Calcium, sulfur, and zinc distribution in normal and arthritic articular equine cartilage: a synchrotron radiation-induced X-ray emission (SRIXE) study Journal of Experimental Zoology 1995 273 1 82 86
35. Parcell S., Sulfur in human nutrition and applications in medicine Alternative Medicine Review 2002 7 1 22 44 (Pubitemid 34203978)
36. Bookman A. A., Williams S., Shainhouse J. Z., Effects of a topical diclofenac solution for relieving symptoms of primary osteoarthritis of the knee: a randomized controlled trial The Canadian Medical Association Journal 2004 171 333 338 (Pubitemid 39127985)
37. Brown J. H., Clinical experience with DMSO in acute musculoskeletal conditions comparing a noncontrolled series with a controlled double blind study Annals of the New York Academy of Sciences 1967 141 1 496 505
38. Kolb K. H., Jaenicke G., Kramer M., Schulze P. E., Absorption, distribution and elimination of labeled dimethyl sulfoxide in man and animals Annals of the New York Academy of Sciences 1967 141 1 85 95
39. Vuopala U., Isomki H., Kaipainen W. J., Dimethyl sulfoxide (DMSO) ointment in the treatment of rheumatoid arthritis. A double blind study Acta Rheumatologica Scandinavica 1969 15 2 139 144
40. Micromedex Health Care Series 2008 Englewood, Colo, USA Micromedex Inc.. http://lrs.lendac.ie/guides/micromedex/micromedex.html
41. Natural Medicine Comprehensive Database 2003 5th Stockton, Calif, USA Therapeutic Research Faculty
42. Usha P. R., Naidu M. U. R., Randomised double blind, parallel, placebo controlled study of oral glucosamine, methylsulfonymethane and their combination in osteoarthritis Clinical Drug Investigation 2004 24 353 363
43. Kim L. S., Axelrod L. J., Howard P., Buratovich N., Waters R. F., Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial Osteoarthritis and Cartilage 2006 14 3 286 294 (Pubitemid 43329539)
44. Jacobs S., Lawrence R. M., Siegel M., Miracle MSM: The Natural Solution for Pain 1999 New York, NY, USA GP Putnam
45. Patent Storm, September 2008, http://www.patentstorm.us/patents/6399093/ description.html
46. Magnuson B. A., Appleton J., Ames G. B., Pharmacokinetics and distribution of [35S]methylsulfonylmethane following oral administration to rats Journal of Agricultural and Food Chemistry 2007 55 3 1033 1038
47. Otsuki S., Qian W., Ishihara A., Kabe T., Elucidation of dimethylsulfone metabolism in rat using a S35 radioisotope tracer method Nutrition Research 2002 22 3 313 322 (Pubitemid 34233549)
48. Horvth K., Noker P. E., Somfai-Relle S., Glvits R., Financsek I., Schauss A. G., Toxicity of methylsulfonylmethane in rats Food and Chemical Toxicology 2002 40 10 1459 1462 (Pubitemid 35245206)
49. Magnuson B. A., Appleton J., Ryan B., Matulka R. A., Oral developmental toxicity study of methylsulfonylmethane in rats Food and Chemical Toxicology 2007 45 6 977 984 (Pubitemid 46507688)
50. MSM Guide,. September 2008, http://www.msmguide.com/facts/safety
51. Jadad A. R., Moore R. A., Carroll D., Jenkinson C., Reynolds D. J. M., Gavaghan D. J., McQuay H. J., Assessing the quality of reports of randomized clinical trials: is blinding necessary? Controlled Clinical Trials 1996 17 1 1 12 (Pubitemid 26120810)
52. Bellamy N., Buchanan W. W., Goldsmith C. H., Campbell J., Stitt L. W., Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee Journal of Rheumatology 1988 15 12 1833 1840 (Pubitemid 19037656)
53. Follmann D., Elliott P., Suh I., Cutler J., Variance imputation for overviews of clinical trials with continuous response Journal of Clinical Epidemiology 1992 45 7 769 773
54. Cohen J., Statistical Power Analysis for Behavioural Sciences 1988 2nd Hillsdale, NJ, USA Lawrence Erlbaum
55. Koenen N. J., Haag R. F., Bia P., Rose P., Perkutane therapie bei aktivierter Gonarthrose Mnchener Medizinische Wochenschrift 1996 138 534 538
56. Eberhardt R., Zwingers T., Hofmann R., DMSO bei Patienten mit aktivierter Gonathrose. Eine doppeblinde, plazebokontrollierte Phase III Studie Fortschritte der Medizin 1995 113 446 450
57. Roth S. H., Shainhouse J. Z., Efficacy and safety of a topical diclofenac solution (Pennsaid) in the treatment of primary osteoarthritis of the knee: a randomized, double-blind, vehicle-controlled clinical trial Archives of Internal Medicine 2004 164 18 2017 2023 (Pubitemid 39390559)
58. Muravyev Y., Sigidin Y., Alyabyeva A., A multicentre study of the effectiveness of dimethyl sulphoxide in rheumatoid and degenerative arthritis Terapevticheskii Arkhiv 1987 59 106 108
59. Thie N. M. R., Prasad N. G., Major P. W., Evaluation of glucosamine sulfate compared to ibuprofen for the treatment of temporomandibular joint osteoarthritis: a randomized double blind controlled 3 month clinical trial Journal of Rheumatology 2001 28 6 1347 1355 (Pubitemid 32510508)
60. Wood A. M., White I. R., Thompson S. G., Are missing outcome data adequately handled? A review of published randomized controlled trials in major medical journals Clinical Trials 2004 1 4 368 376
61. Tubach F., Ravaud P., Baron G., Falissard B., Logeart I., Bellamy N., Bombardier C., Felson D., Hochberg M., Van Der Heijde D., Dougados M., Evaluation of clinically relevant changes in patient reported outcomes in knee and hip osteoarthritis: the minimal clinically important improvement Annals of the Rheumatic Diseases 2005 64 1 29 33 (Pubitemid 40075270)
62. Angst F., Aeschlimann A., Stucki G., Smallest detectable and minimally clinically important differences of rehabilitation interventions with their implications for required sample sizes using WOMAC and SF36 Quality of life measurement instruments in patients with osteoarthritis of the lower extremities Arthritis Care's Research 2001 45 384 391 (Pubitemid 32738745)
63. Ehrich E. W., Davies G. M., Watson D. J., Bolognese J. A., Seidenberg B. C., Bellamy N., Minimal perceptible clinical improvement with the Western Ontario and McMaster Universities Osteoarthritis Index questionnaire and global assessments in patients with osteoarthritis Journal of Rheumatology 2000 27 11 2635 2641
64. Bellamy N., Kirwan J., Boers M., Brooks P., Strand V., Tugwell P., Altman R., Brandt K., Dougados M., Lequesne M., Recommendations for a core set of outcome measures for future phase III clinical trials in knee, hip, and hand osteoarthritis. Consensus development at OMERACT III Journal of Rheumatology 1997 24 4 799 802 (Pubitemid 27146105)
65. Brooks P., Tugwell P., Strand C. V., Simon L., International consensus conference on outcome measures in rheumatology, gold coast Australia, April 1114 2002 The Journal of Rheumatology 2003 30 866 867 (Pubitemid 36402789)
66. Geba G. P., Weaver A. L., Polis A. B., Dixon M. E., Schnitzer T. J., Efficacy of rofecoxib, celecoxib and acetaminophen in osteoarthritis of the knee: a randomised trial Journal of the American Medical Association 2002 287 64 71 (Pubitemid 34251677)
67. Ehrich E. W., Schnitzer T. J., Mcllwain H., Effect of specific COX-2 inhibition in osteoarthritis of the knee: a 6 week double blind, placebp controlled pilot study of rofecoxib. Rofecoxib Osteoarthritis Pilot Study Group The Journal of Rheumatology 1999 26 2438 2447 (Pubitemid 29528988)