Pharmacokinetics and distribution of [ 35S]methylsulfonylmethane following oral administration to rats

Journal of Agricultural and Food Chemistry

Volumn 55, Issue 3, 2007, Pages 1033-1038

  Magnuson, Bernadene A ^a,b   Appleton, Jeremy ^c   Ames, Gregory B ^d  

^a UNIVERSITY OF MARYLAND   (United States)

^b Burdock Group   (United States)

^c Cardinal Nutrition   (United States)

^d Experimur   (United States)

Author keywords

Absorption; Distribution; Methylsulfonylmethane; Pharmacokinetics

Indexed keywords

RATTUS;

DIAGNOSTIC AGENT; DIMETHYL SULFONE; DIMETHYL SULFOXIDE; SULFONE; SULFUR;

ANIMAL; ARTICLE; DIET SUPPLEMENTATION; MALE; RAT; SPRAGUE DAWLEY RAT; TISSUE DISTRIBUTION;

ANIMALS; DIETARY SUPPLEMENTS; DIMETHYL SULFOXIDE; MALE; RATS; RATS, SPRAGUE-DAWLEY; SULFONES; SULFUR RADIOISOTOPES; TISSUE DISTRIBUTION;

EID: 34247895667     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf0621469     Document Type: Article

References (21)

1. Williams, K. I. H.; Burstein, S. H.; Layne, D. S. Dimethyl sulfone: isolation from cows' milk. Proc. Soc. Exp. Biol. Med. 1966, 122, 865-866.
2. Kim, L. S.; Axelrod, L. J.; Howard, P.; Buratovich, N.; Waters, R. F. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthr. Cartil. 2006, 14, 286-294.
3. Ameye, L. G.; Chee, W. S. Osteoarthritis and nutrition. From nutraceuticals to functional foods: a systematic review of the scientific evidence. Arthritis Res. Ther. 2006, 8, R127.
4. Ebisuzaki, K. Aspirin and methylsulfonylmethane (MSM): a search for common mechanisms, with implications for cancer prevention. Anticancer Res. 2003, 23, 453-458.
5. Moh, J. H.; Choi, Y. H.; Lim, K. M.; Lee, K. W.; Shin, S. S.; Choi, J. K.; Koh, H. J.; Chung, S. A prodrug approach to COX-2 inhibitors with methylsulfone. Bioorg. Med. Chem Lett. 2004, 14, 1757-1760.
6. Barrager, E.; Schauss, A. G. Methylsulfonylmethane as a treatment for seasonal allergic rhinitis: additional data on pollen counts and symptom questionnaire. J. Altern. Complement Med. 2003, 9, 15-16.
7. Hendler, S. S.; Rorvik, D. Methylsulfonylmethane (MSM). In PDR for Nutritional Supplements; Medical Economics, Thomson Healthcare: Montvale, NJ, 2001.
8. Parcell, S. Sulfur in human nutrition and applications in medicine. Altern. Med. Rev. 2002, 7, 22-44.
9. Richmond, V. L. Incorporation of methylsulfonylmethane sulfur into guinea pig serum proteins. Life Sci. 1986, 39, 263-268.
10. 13C NMR. NMR Biotned. 2005, 18, 331-336.
11. Egorin, M. J.; Rosen, D. M.; Sridhara, R.; Sensenbrenner, L.; Cottier-Fox, M. Plasma concentrations and pharmacokinetics of dimethylsulfoxide and its metabolites in patients undergoing peripheral-blood stem-cell transplants. Am. J. Clin. Oncol. 1998, 16, 610-615.
12. Cecil, K. M.; Lin, A.; Ross, B. D.; Egelhoff, J. C. Methylsulfonylmethane observed by in vivo proton magnetic resonance spectroscopy in a 5-year-old child with developmental disorder: effects of dietary supplementation. J. Comput. Assist. Tomogr. 2002, 26, 818-820.
13. Lin, A.; Nguy, C. H.; Shic, F.; Ross, B. D. Accumulation of methylsulfonylmethane in the human brain: identification by multinuclear magnetic resonance spectroscopy. Toxicol. Lett. 2001, 123, 169-177.
14. Rose, S. E.; Chalk, J. B.; Galloway, G. J.; Doddrell, D. M. Detection of dimethyl sulfone in the human brain by in vivo proton magnetic resonance spectroscopy. Magn. Resort. Imaging 2000, 18, 95-98.
15. Imanaka, M.; Matsunaga, K.; Ishida, T. Gas chromatography-mass spectroscopy identification of dimethyl sulfone in cow's milk and other livestock products. J. Pestic. Sci. 1985, 10, 549-554.
16. Burger, B. V.; Visser, R.; Moses, A.; Le, Roux, M. Elemental sulfur identified in urine of cheetah, Acinonyx jubatus. J. Chem. Ecol. 2006, 32, 1347-1352.
17. 35S radioisotope tracer method. Nutr. Res. 2002, 22, 313-322.
18. http://las.perkinelmer.com/content/ApplicationNotes/m2678.pdf /2002.
19. http://chem.sis.nlm.nih.gov/chemidplus/1-25-2005.
20. Hucker, H. B.; Ahmad, P. M.; Miller, E. A.; Brobyn, R. Metabolism of dimethyl sulphoxide to dimethyl sulphone in the rat and man. Nature 1966, 209, 619-620.
21. Varshavsky, A. The N-end rule pathway of protein degradation. Genes Cells 1997, 2, 13-28.