Oral developmental toxicity study of methylsulfonylmethane in rats

Food and Chemical Toxicology

Volumn 45, Issue 6, 2007, Pages 977-984

  Magnuson, B A ^a   Appleton, J ^b   Ryan, B ^c   Matulka, R A ^a  

^a Burdock Group   (United States)

^b Cardinal Nutrition   (United States)

^c Experimur   (United States)

Author keywords

Burdock group; Methylsulfonylmethane; MSM

Indexed keywords

DIMETHYL SULFONE; DIMETHYL SULFOXIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; FEMALE; FETUS; FETUS GROWTH; FETUS MORTALITY; FOOD; GESTATION PERIOD; HISTOGENESIS; INCIDENCE; MALE; MATERNAL NUTRITION; METABOLITE; NONHUMAN; ORGANOGENESIS; PRIMIPARA; RAT; TERATOGENICITY; UTERUS WEIGHT; WEIGHT GAIN;

ANIMALS; BODY WEIGHT; DIETARY SUPPLEMENTS; DIMETHYL SULFOXIDE; EATING; FEMALE; FETAL DEVELOPMENT; FETUS; LITTER SIZE; MALE; MATERNAL EXPOSURE; NO-OBSERVED-ADVERSE-EFFECT LEVEL; ORGAN SIZE; ORGANOGENESIS; PILOT PROJECTS; PREGNANCY; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; SULFONES;

ARCTIUM; RATTUS;

EID: 33947732104     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2006.12.003     Document Type: Article

References (17)

1. 13C NMR. NMR in Biomedicine 18 (2005) 331-336
2. FDA. Toxicological Principles for the Safety Assessment of Direct Food Additives and Color Additives Used in Food ('Redbook') (1982), US Food and Drug Administration, Washington, DC
3. 2) on early gametogenesis in Caenorhabditis elegans: ultrastructural aberrations and loss of synaptonemal complexes from pachytene nuclei. Reproductive Toxicology 6 (1992) 149-159
4. Hasegawa T., Kumanmoto S., Ueno S., and Yoshikai Y. Methylsulfonylmethane (MSM). Suppressive effect of methylsulfonylmethane (MSM) on Type II collagen-induced arthritis in DBA/1J mice. Japanese Journal of Pharmacology and Therapeutics 32 (2004) 420-427
5. Horváth K., Noker P.E., Somfai-Relle S., Glavits R., Financsek I., and Schauss A.G. Toxicity of methylsulfonylmethane in rats. Food and Chemical Toxicology 40 (2002) 1459-1462
6. Imanaka M., Matsunaga K., and Ishida T. Gas chromatography-mass spectroscopy identification of dimethyl sulfone in cow's milk and other livestock products. Journal of Political Science 10 (1985) 549-554
7. Kim L.S., Axelrod L.J., Howard P., Buratovich N., and Waters R.F. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis and Cartilage 14 (2006) 286-294
8. Lee Y., Lee Y., Park J., Lee K.B., and You K. Evaluation of genotoxicity on plant-derived dietary sulfur. Journal of Microbiology and Biotechnology 16 (2006) 817-820
9. 35S]-methylsulfonylmethane following oral administration to rats. Journal of Agricultural and Food Chemistry.
10. OECD, 2006. OECD guideline (No. 414) for developmental toxicity studies. Organisation for Economic Co-operation and Development (OECD). (site visited on September 13, 2006).
11. 35S radioisotope tracer method. Nutrition Research 22 (2002) 313-322
12. Pearson T.W., Dawson H.J., and Lackey H.B. Natural occurring levels of dimethyl sulfoxide in selected fruits, vegetables, grains, and beverages. Journal of Agricultural and Food Chemistry 29 (1981) 1089-1091
13. Richmond V.L. Incorporation of methylsulfonylmethane sulfur into guinea pig serum proteins. Life Sciences 39 (1986) 263-268
14. Silva Ferreira A.C., Rodrigues P., Hogg T., and Guedes D.P. Influence of some technological parameters on the formation of dimethyl sulfide, 2-mercaptoethanol, methionol, and dimethyl sulfone in port wines. Journal of Agricultural and Food Chemistry 51 (2003) 727-732
15. Stuckhardt J.L., and Poppe S.M. Fresh visceral examination of rat and rabbit fetuses used in teratogenicity testing. Teratogenesis, Carcinogenesis, and Mutagenesis 4 (1984) 181-188
16. Taylor P. 9. The head. 10. Skeletal examination. Practical Teratology (1986), Academic Press, London, UK 72-100
17. Williams K.I.H., Burstein S.H., and Layne D.S. Dimethyl sulfone: isolation from human urine. Archives of Biochemistry and Biophysics 13 (1966) 251-252