Asymmetric total synthesis of (+)- and (-)-clusianone and (+)- and (-)-clusianone methyl enol ether via ACC alkylation and evaluation of their anti-HIV activity

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 8, 2011, Pages 2406-2409

  Garnsey, Michelle R ^a   Matous, James A ^b   Kwiek, Jesse J ^b   Coltart, Don M ^a  

^a DUKE UNIVERSITY   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

ACC alkylation; Anti HIV activity; Asymmetric synthesis; Polycyclic polyprenylated acylphloroglucinols; Viral infection

Indexed keywords

ACYLPHLOROGLUCINOL; CLUSIANONE; CLUSIANONE METHYL ENOL ETHER; NATURAL PRODUCT; NEVIRAPINE; PHLOROGLUCINOL DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; ANTIVIRAL ACTIVITY; ARTICLE; ASYMMETRIC SYNTHESIS; CYCLIZATION; HUMAN IMMUNODEFICIENCY VIRUS; IC 50; LEUKEMIA CELL LINE; NONHUMAN; STEREOCHEMISTRY;

ALKYLATION; ANTI-HIV AGENTS; BICYCLO COMPOUNDS; CELL LINE; ETHERS; HIV; HUMANS; STEREOISOMERISM;

EID: 79953282218     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.02.074     Document Type: Article

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