Diabetic glucose dyshomeostasis and dyslipidemia in estrogen deficient rats: Melatonin supplementation more potent than estrogen replacement therapy in alleviating the symptoms

Diabetologia Croatica

Volumn 40, Issue 1, 2011, Pages 3-15

  Baxi, Darshee B ^a   Singh, Prem Kumar ^a   Vachhrajani, Kauresh D ^a   Ramachandran, A V ^a  

^a M S UNIVERSITY OF BARODA   (India)

Author keywords

Diabetes; Dyslipidemia; Glycemia; Hrt; Melatonin; Ovariectomy

Indexed keywords

ESTRADIOL; GLUCOSE; GLYCOGEN; INSULIN; LIPID; MELATONIN; PROGESTERONE;

ALTERNATIVE MEDICINE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBOHYDRATE METABOLISM; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DIABETES MELLITUS; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG POTENCY; DYSLIPIDEMIA; ESTROGEN DEFICIENCY; ESTROGEN THERAPY; FEMALE; FLUID INTAKE; FOOD INTAKE; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE TEST; HORMONE SUBSTITUTION; INSULIN RESISTANCE; INSULIN RESPONSE; INSULIN SENSITIVITY; INTERMETHOD COMPARISON; LIPID BLOOD LEVEL; LOW DRUG DOSE; MONOTHERAPY; NONHUMAN; ORGAN WEIGHT; OUTCOME ASSESSMENT; OVARIECTOMY; POSTMENOPAUSE; RAT; SYMPTOM; THERAPY EFFECT; TISSUE LEVEL; WEIGHT GAIN;

EID: 79953269643     PISSN: 03510042     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Wedisinghe L, Perera M. Diabetes and menopause. Maturitas 2009;63:200-203.
2. Dorman JS, Steenkiste AR, Foley TP, Strotmeyer ES, Burke JP, Kuller LH, Kwoh CK. Menopause in type I diabetic women: is it premature? Diabetes 2001;50:1857-1862.
3. Shuster LT, Rhodes DJ, Gostout BS, Grossardt BR, Rocca WA. Premature menopause or early menopause: long term health consequences. Maturitas 2010;65:161-166.
4. Grady D, Gebretsadik T, Kerlikowske K, et al. Hormone replacement therapy and endometrial cancer risk: a meta-analysis. Obstet Gynecol 1995;85:304-313.
5. Cagnacci A, Soldani R, Cariero P, Paoletti A, Fioretti P, Melis G. Effects of low doses of transdermal 17â estradiol on carbohydrate metabolism in postmenopausal women. J Clin Endocrinol Metab 1992;74:1396-1400.
6. Feher M, Isaacs A. Is hormone replacement therapy prescribed for postmenopausal diabetic women? Br J Clin Pract 1996;50:431-432.
7. Lawrenson RA, Newson RB, Feher MD. Do women with diabetes receive hormone replacement therapy? Pract Diabetes Int 1998;15:71-72.
8. Bonds DE, Lasser N, Oi L, Brzyski R, Caan B, Heiss G, et al. The effect of conjugated equine estrogen on diabetes incidence: the Women's Health Initiative Hormone Trial. Diabetologia 2006;49:459-468.
9. Simonneaux V, Ribelayga C. Generation of the melatonin endocrine message in mammals: a review of the complex regulation of melatonin synthesis by norepinephrine, peptides, and other pineal transmitters. Pharmacol Rev 2003;55:325-395.
10. Hazlerigg D, Loudon A. New insights into ancient seasonal life timers. Curr Biol 2008;18:795-804.
11. Nakao N, Ono H, Yoshimura T. Thyroid hormones and seasonal reproductive neuroendocrine interactions Reproduction 2008;136:1-8.
12. Reiter RJ, Dun-Xian T, Lucien CM, Sergio DP, Juan CM, Rosa MS. Melatonin and reproduction revisited. Biol Reprod 2009;81:445-456.
13. Tan DX, Manchester LC, Burkhardt S. N1-acetylN2- formyl-5 methoxykynuramine, a biogenic amine and melatonin metabolite, functions as a potent antioxidant. FASEB J 2001;15:2294-2296.
14. Paskaloglu K, Xener G, Ayangolu-Dülger G. Melatonin treatment protects against diabetes-induced functional and biochemical changes in rat aorta and corpus cavernosum. Eur J Pharmacol 2004;499:345-354.
15. Peschke E. Melatonin, endocrine pancreas and diabetes. J Pineal Res 2008;44:26-40.
16. Nishida S. Metabolic effects of melatonin on oxidative stress and diabetes mellitus. Endocrine 2005;27:131-136.
17. Waynfort HB, Flecknell PA. Ovariectomy in experimental and surgical technique - in the rat. 2nd edn. London: Academic Press, 1992;276-278.
18. Singh PK, Baxi DB, Mukherjee R, Potnis KH, Ramachandran AV. Supplementation with a polyherbal extract and melatonin together with exercise effectively reverses diabetic glycaemic status and carbohydrate metabolism and insulin level. Int J Biol Med Res 2010;1(3):54-60.
19. Singh PK, Baxi DB, Mukherjee R, Selvaraj J, Ramachandran AV. Diabetic amelioration by poly herbal supplement and exercise: studies on type I diabetic rat model. J Herbal Med Toxicol 2010;4(1):217-226.
20. Trinder P. Glucose estimation by glucose oxidase method using phenol and 4- aminophenazone. Ann Clin Biochem 1969;6:24-31.
21. Seifter S, Dayton S, Novic B, Muntwyler E. The estimation of glycogen with the anthrone reagent. Arch Biochem Biophys 1950;50:191-200.
22. Cahill GF, Ashmore J, Zottu S, Hastings AB. Studies on carbohydrate metabolism in rat liver slices. IX Ionic and hormonal effects on phosphorylase and glycogen. J Biol Chem 1957;224:237-250.
23. Harper AE. Glucose-6-phosphatase. In: Bergmeyer HU, ed. Methods of enzymatic analysis. New York: Academic Press, 1965.
24. Crawford N. An improved method for the determination of free and total cholesterol using the ferric chloride reaction. Clin Chim Acta 1959;3:357-367.
25. Folch J, Lees M, Sloane Stanley GH. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 1957;226:497.
26. Kamgang R, Mboumi RY, Fondjo AF, Tange MAF, Mengue N dille GPR, Yonkeu JN. Anti hyperglycaemic potential of the water-ethanol extract of Kalanchoe crenata (Crassulaceae). J Nat Med 2008;62:34-40.
27. Duncan MH, Singh BM, Wise PH, Carter G, Alaghband-Zadeh J. A simple measure of insulin resistance. Lancet 1995;346(8967):120-121.
28. L'Hermite M, Simoncini T, Fuller S, Genazzani AR. Could transdermal estradiol + progesterone be a safer postmenopausal HRT? A review. Maturitas 2008;60:185-201.
29. Young Ch, Pinto M. Estrogen receptor [beta] in breast cancer: associations between ER[beta], hormonal receptors, and other prognostic biomarkers applied. Immunohistochem Mol Morphol 2005;13:19-24.
30. Montilla PL, Vargas JF, Tunez IF, et al. Oxidative stress in diabetic rats induced by streptozotocin: protective effects of melatonin. J Pineal Res 1998;25:94-100.
31. Sudnikovich EJ, Maksimchik YZ, Zabrodskaya SV, Kubyshin VL, Lapshina EA, Bryszewska M, Reiter RJ, Zavodnik IB. Melatonin attenuates metabolic disorders due to streptozotocin-induced diabetes in rats. Eur J Pharmacol 2007;569:180-187.
32. Singh PK, Baxi DB, Mukherjee R, Ramachandran AV. Evaluation on the efficacy of a poly herbal supplement along with exercise in alleviating dyslipidemia, oxidative stress and hepatic and renal toxicity associated with type-1 diabetes. J Herbal Med Toxicol 2010;4:207-215.
33. Ordóńez P, Nelson GMD. Value of immunohistochemistry in distinguishing peritoneal mesothelioma from serous carcinoma of the ovary and peritoneum: a review and update. Adv Anatom Pathol 2006;13:16-25.
34. Lui M, Xu X, Rang W, Li Y, Song H. Influence of ovariectomy and 17beta-estradiol treatment on insulin sensitivity, lipid metabolism and post-ischemic cardiac function. Int J Cardiol 2004;97:485-493.
35. Ordóńez P, Moreno M, Alonso A, Fernández R, Díaz F, González C. Insulin sensitivity in streptozotocin-induced diabetic rats treated with different doses of 17â-oestradiol or progesterone. Exp Physiol 2007;92:241-249.
36. Margolis KL, Bonds DE, Rodabough RJ, Tinker L, Phillips LS, Allen C, et al. Effect of oestrogen plus progestin on the incidence of diabetes in postmenopausal women: results from the Women's Health Initiative Hormone Trial. Diabetologia 2004;47:1175-1187.
37. Godsland IF. Oestrogens and insulin secretion Diabetologia 2005;48:2213-2220.
38. Goswami D, Conway GS. Premature ovarian failure. Hum Reprod Update 2005;11(4):391-410.
39. Goswami D, Conway GS. Premature ovarian failure. Horm Res 2007;68:196-202.
40. Sanchez-Mateos SC, Alonso-Gonzalez A, Gonzalez CM, Martinez-Campa MD, Mediavilla S, Cos EJ, Sanchez-Barcelo EJ. Melatonin and estradiol effects on food intake, body weight, and leptin in ovariectomized rats. Maturitas 2007;58:91-101.
41. Van Pelt RE, Gozansky WS, Schwartz RS, Kohrt WM. Intravenous estrogen increase insulin clearance and action in postmenopausal women. Am J Physiol Endocrinol Metab 2003;285:E311-E317.
42. Bhattacharya SM, Jha A. Effects of transdermal estradiol gel and oral tibolone on health related quality of life after surgical menopause. Int J Gynecol Obstet 2010. (in press)
43. Lundeen SG, Carver JM, McKean M, Winneker RC. Characterization of the ovariectomized rat model for the evaluation of estrogen effects on plasma cholesterol levels. Endocrinology 1997;138:1552-1558.
44. Manwaring P, Morfis L, Diamond T, Howes LG. The effect of hormone replacement therapy on plasma lipids in type II diabetes. Maturitas 2000;34:239-247.
45. Crespo CJ, Smit E, Snelling A. Hormone replacement therapy and its relationship to lipid and glucose metabolism in diabetic and non diabetic postmenopausal women. Diabetic Care 2002;25:1675-1680.
46. Tuna V, Alkis I, Safiye AS, Imamoglu N, Bayram N, Ali Ismet T. Variations in blood lipid profile, thrombotic system, arterial elasticity and psychosexual parameters in the cases of surgical and natural menopause. Aust N Z J Obstet Gynaecol 2010;50:194-199.
47. Bolego C, Cingnarella A, Zancan V, Pinna C, Zanardo R, Puglisi L. Diabetes abolishes the vascular protective effects of estrogen in female rats. Life Sci 1999;64:741-749.
48. Verhaeghe J, Oloumi G, Herck V, Bree RV, Dequeker J, Einhorn TA, Bouillon R. Effects of long term diabetes and/or high dose 17 â estradiol on bone formation, bone mineral density, and strength in ovariectomized animals. Bone 1997;20:421-428.
49. Santizo RA, Xu HL, Ye S, Baughman VL, Pelligrino DA. Loss of benefit from estrogen replacement therapy in diabetic ovariectomized female rats subjected to transient forebrain ischemia. Brain Res 2002;956:86-95.
50. Xie HJ, Zhang YF, Yang QD, Liao DF, Yang HL, Yan PK, Liu ZJ. 17β estradiol potentiates ischemia-reperfusion injury in diabetic ovariectomized female rats. Brain Res 2005;1054:192-199.